Acute Intermittent Porphyria Market: Epidemiology, Industry Trends, Share, Size, Growth, Opportunity, and Forecast 2024-2034

Acute Intermittent Porphyria Market: Epidemiology, Industry Trends, Share, Size, Growth, Opportunity, and Forecast 2024-2034


The 7 major acute intermittent porphyria markets reached a value of US$ 1.7 Million in 2023. Looking forward, IMARC Group expects the 7MM to reach US$ 2.4 Million by 2034, exhibiting a growth rate (CAGR) of 3.46% during 2024-2034.

The acute intermittent porphyria market has been comprehensively analyzed in IMARC's new report titled "Acute Intermittent Porphyria Market: Epidemiology, Industry Trends, Share, Size, Growth, Opportunity, and Forecast 2024-2034". Acute intermittent porphyria (AIP) is a rare genetic condition that impairs the body's ability to produce heme, a molecule essential for the function of many enzymes and the formation of hemoglobin in red blood cells. Some of the common symptoms of AIP are abdominal pain, nausea, vomiting, constipation, diarrhea, etc. Various other signs indicative of the disease can include tingling or numbness in the limbs, muscle weakness, psychiatric disturbances, such as anxiety or depression, seizures, respiratory failure, etc. Diagnosing acute intermittent porphyria (AIP) can be challenging, as its symptoms can be non-specific and overlap with those of other medical conditions. The diagnosis of AIP is typically based on a combination of factors, including the person's medical history, physical exam, laboratory tests, and genetic testing. Numerous diagnostic procedures help identify abnormal levels of porphyrins in the urine, blood, and stool, and genetic testing aids in confirming the presence of mutations in the porphobilinogen deaminase (PBGD) gene. In some cases, a liver biopsy may be performed to assess the extent of porphyrin accumulation in the liver.

The increasing incidence of rare metabolic disorders and the rising prevalence of numerous associated risk factors, including excessive alcohol consumption, hormonal changes, certain medications, etc., are primarily driving the acute intermittent porphyria market. Furthermore, the escalating utilization of several biomarkers, such as urinary porphobilinogen and aminolevulinic acid levels, to confirm AIP and monitor disease activity is also bolstering the market growth. In addition to this, the growing focus on raising disease awareness among healthcare professionals, patients, and the general public to ensure that individuals with AIP receive timely and appropriate care is further augmenting the market. Moreover, various key players are making extensive investments in the development of novel drugs and therapies for AIP, including those that target specific enzymes involved in heme biosynthesis or modulate the immune system. This, in turn, is acting as another significant growth-inducing factor. Additionally, the widespread adoption of next-generation sequencing to screen for multiple genes associated with AIP, which can help identify rare genetic variants that may be missed by conventional genetic testing, is creating a positive outlook for the market. Furthermore, ongoing advancements in the formulation technology of hematin have led to the introduction of more convenient and easier-to-use hematin products, including lyophilized powder and ready-to-use liquid formulations. This, in turn, is expected to drive the acute intermittent porphyria market in the coming years.

IMARC Group's new report provides an exhaustive analysis of the acute intermittent porphyria market in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan. This includes treatment practices, in-market, and pipeline drugs, share of individual therapies, market performance across the seven major markets, market performance of key companies and their drugs, etc. The report also provides the current and future patient pool across the seven major markets. According to the report the United States has the largest patient pool for acute intermittent porphyria and also represents the largest market for its treatment. Furthermore, the current treatment practice/algorithm, market drivers, challenges, opportunities, reimbursement scenario and unmet medical needs, etc. have also been provided in the report. This report is a must-read for manufacturers, investors, business strategists, researchers, consultants, and all those who have any kind of stake or are planning to foray into the acute intermittent porphyria market in any manner.

Time Period of the Study

Base Year: 2023
Historical Period: 2018-2023
Market Forecast: 2024-2034

Countries Covered

United States
Germany
France
United Kingdom
Italy
Spain
Japan

Analysis Covered Across Each Country

Historical, current, and future epidemiology scenario
Historical, current, and future performance of the acute intermittent porphyria market
Historical, current, and future performance of various therapeutic categories in the market
Sales of various drugs across the acute intermittent porphyria market
Reimbursement scenario in the market
In-market and pipeline drugs
Competitive Landscape:
This report also provides a detailed analysis of the current acute intermittent porphyria marketed drugs and late-stage pipeline drugs.

In-Market Drugs

Drug Overview
Mechanism of Action
Regulatory Status
Clinical Trial Results
Drug Uptake and Market Performance

Late-Stage Pipeline Drugs

Drug Overview
Mechanism of Action
Regulatory Status
Clinical Trial Results
Drug Uptake and Market Performance
Key Questions Answered in this Report:
Market Insights

How has the acute intermittent porphyria market performed so far and how will it perform in the coming years?
What are the markets shares of various therapeutic segments in 2023 and how are they expected to perform till 2034?
What was the country-wise size of the acute intermittent porphyria market across the seven major markets in 2023 and what will it look like in 2034?
What is the growth rate of the acute intermittent porphyria market across the seven major markets and what will be the expected growth over the next ten years?
What are the key unmet needs in the market?

Epidemiology Insights

What is the number of prevalent cases (​2018-2034​) of acute intermittent porphyria across the seven major markets?
What is the number of prevalent cases (​2018-2034​) of acute intermittent porphyria by age across the seven major markets?
What is the number of prevalent cases (​2018-2034​) of acute intermittent porphyria by gender across the seven major markets?
How many patients are diagnosed (​2018-2034​) with acute intermittent porphyria across the seven major markets?
What is the size of the acute intermittent porphyria patient pool (2018-2023) across the seven major markets?
What would be the forecasted patient pool (2024-2034) across the seven major markets?
What are the key factors driving the epidemiological trend of acute intermittent porphyria?
What will be the growth rate of patients across the seven major markets?

Acute Intermittent Porphyria: Current Treatment Scenario, Marketed Drugs and Emerging Therapies

What are the current marketed drugs and what are their market performance?
What are the key pipeline drugs and how are they expected to perform in the coming years?
How safe are the current marketed drugs and what are their efficacies?
How safe are the late-stage pipeline drugs and what are their efficacies?
What are the current treatment guidelines for acute intermittent porphyria drugs across the seven major markets?
Who are the key companies in the market and what are their market shares?
What are the key mergers and acquisitions, licensing activities, collaborations, etc. related to the acute intermittent porphyria market?
What are the key regulatory events related to the acute intermittent porphyria market?
What is the structure of clinical trial landscape by status related to the acute intermittent porphyria market?
What is the structure of clinical trial landscape by phase related to the acute intermittent porphyria market?
What is the structure of clinical trial landscape by route of administration related to the acute intermittent porphyria market?


1 Preface
2 Scope and Methodology
2.1 Objectives of the Study
2.2 Stakeholders
2.3 Data Sources
2.3.1 Primary Sources
2.3.2 Secondary Sources
2.4 Market Estimation
2.4.1 Bottom-Up Approach
2.4.2 Top-Down Approach
2.5 Forecasting Methodology
3 Executive Summary
4 Acute Intermittent Porphyria - Introduction
4.1 Overview
4.2 Regulatory Process
4.3 Epidemiology (2018-2023) and Forecast (2024-2034)
4.4 Market Overview (2018-2023) and Forecast (2024-2034)
4.5 Competitive Intelligence
5 Acute Intermittent Porphyria - Disease Overview
5.1 Introduction
5.2 Symptoms and Diagnosis
5.3 Pathophysiology
5.4 Causes and Risk Factors
5.5 Treatment
6 Patient Journey
7 Acute Intermittent Porphyria - Epidemiology and Patient Population
7.1 Epidemiology - Key Insights
7.2 Epidemiology Scenario - Top 7 Markets
7.2.1 Epidemiology Scenario (2018-2023)
7.2.2 Epidemiology Forecast (2024-2034)
7.2.3 Epidemiology by Age (​2018-2034​)
7.2.4 Epidemiology by Gender (​2018-2034​)
7.2.5 Diagnosed Cases (​2018-2034​)
7.2.6 Patient Pool/Treated Cases (​2018-2034​)
7.3 Epidemiology Scenario - United States
7.3.1 Epidemiology Scenario (2018-2023)
7.3.2 Epidemiology Forecast (2024-2034)
7.3.3 Epidemiology by Age (​2018-2034​)
7.3.4 Epidemiology by Gender (​2018-2034​)
7.3.5 Diagnosed Cases (​2018-2034​)
7.3.6 Patient Pool/Treated Cases (​2018-2034​)
7.4 Epidemiology Scenario - Germany
7.4.1 Epidemiology Scenario (2018-2023)
7.4.2 Epidemiology Forecast (2024-2034)
7.4.3 Epidemiology by Age (​2018-2034​)
7.4.4 Epidemiology by Gender (​2018-2034​)
7.4.5 Diagnosed Cases (​2018-2034​)
7.4.6 Patient Pool/Treated Cases (​2018-2034​)
7.5 Epidemiology Scenario - France
7.5.1 Epidemiology Scenario (2018-2023)
7.5.2 Epidemiology Forecast (2024-2034)
7.5.3 Epidemiology by Age (​2018-2034​)
7.5.4 Epidemiology by Gender (​2018-2034​)
7.5.5 Diagnosed Cases (​2018-2034​)
7.5.6 Patient Pool/Treated Cases (​2018-2034​)
7.6 Epidemiology Scenario - United Kingdom
7.6.1 Epidemiology Scenario (2018-2023)
7.6.2 Epidemiology Forecast (2024-2034)
7.6.3 Epidemiology by Age (​2018-2034​)
7.6.4 Epidemiology by Gender (​2018-2034​)
7.6.5 Diagnosed Cases (​2018-2034​)
7.6.6 Patient Pool/Treated Cases (​2018-2034​)
7.7 Epidemiology Scenario - Italy
7.7.1 Epidemiology Scenario (2018-2023)
7.7.2 Epidemiology Forecast (2024-2034)
7.7.3 Epidemiology by Age (​2018-2034​)
7.7.4 Epidemiology by Gender (​2018-2034​)
7.7.5 Diagnosed Cases (​2018-2034​)
7.7.6 Patient Pool/Treated Cases (​2018-2034​)
7.8 Epidemiology Scenario - Spain
7.8.1 Epidemiology Scenario (2018-2023)
7.8.2 Epidemiology Forecast (2024-2034)
7.8.3 Epidemiology by Age (​2018-2034​)
7.8.4 Epidemiology by Gender (​2018-2034​)
7.8.5 Diagnosed Cases (​2018-2034​)
7.8.6 Patient Pool/Treated Cases (​2018-2034​)
7.9 Epidemiology Scenario - Japan
7.9.1 Epidemiology Scenario (2018-2023)
7.9.2 Epidemiology Forecast (2024-2034)
7.9.3 Epidemiology by Age (​2018-2034​)
7.9.4 Epidemiology by Gender (​2018-2034​)
7.9.5Diagnosed Cases (​2018-2034​)
7.9.6 Patient Pool/Treated Cases (​2018-2034​)
8 Acute Intermittent Porphyria - Treatment Algorithm, Guidelines, and Medical Practices
8.1 Guidelines, Management and Treatment
8.2 Treatment Algorithm
9 Acute Intermittent Porphyria - Unmet Needs
10 Acute Intermittent Porphyria - Key Endpoints of Treatment
11 Acute Intermittent Porphyria - Marketed Products
11.1 List of Acute Intermittent Porphyria Marketed Drugs Across the Top 7 Markets
11.1.1 Panhematin
11.1.1.1 Drug Overview
11.1.1.2 Mechanism of Action
11.1.1.3 Regulatory Status
11.1.1.4 Clinical Trial Results
11.1.1.5 Sales Across Major Markets
Kindly note that the above only represents a partial list of marketed drugs, and the complete list has been provided in the report.
12 Acute Intermittent Porphyria - Pipeline Drugs
12.1 List of Acute Intermittent Porphyria Pipeline Drugs Across the Top 7 Markets
12.1.1 Drug Name – Company Name
12.1.1.1 Drug Overview
12.1.1.2 Mechanism of Action
12.1.1.3 Clinical Trial Results
12.1.1.4 Safety and Efficacy
12.1.1.5 Regulatory Status
Kindly note that the complete list of pipeline drugs has been provided in the report.
13. Acute Intermittent Porphyria - Attribute Analysis of Key Marketed and Pipeline Drugs
14. Acute Intermittent Porphyria – Clinical Trial Landscape
14.1 Drugs by Status
14.2 Drugs by Phase
14.3 Drugs by Route of Administration
14.4 Key Regulatory Events
15 Acute Intermittent Porphyria - Market Scenario
15.1 Market Scenario - Key Insights
15.2 Market Scenario - Top 7 Markets
15.2.1 Acute Intermittent Porphyria - Market Size
15.2.1.1 Market Size (2018-2023)
15.2.1.2 Market Forecast (2024-2034)
15.2.2 Acute Intermittent Porphyria - Market Size by Therapies
15.2.2.1 Market Size by Therapies (2018-2023)
15.2.2.2 Market Forecast by Therapies (2024-2034)
15.3 Market Scenario - United States
15.3.1 Acute Intermittent Porphyria - Market Size
15.3.1.1 Market Size (2018-2023)
15.3.1.2 Market Forecast (2024-2034)
15.3.2 Acute Intermittent Porphyria - Market Size by Therapies
15.3.2.1 Market Size by Therapies (2018-2023)
15.3.2.2 Market Forecast by Therapies (2024-2034)
15.3.3 Acute Intermittent Porphyria - Access and Reimbursement Overview
15.4 Market Scenario - Germany
15.4.1 Acute Intermittent Porphyria - Market Size
15.4.1.1 Market Size (2018-2023)
15.4.1.2 Market Forecast (2024-2034)
15.4.2 Acute Intermittent Porphyria - Market Size by Therapies
15.4.2.1 Market Size by Therapies (2018-2023)
15.4.2.2 Market Forecast by Therapies (2024-2034)
15.4.3 Acute Intermittent Porphyria - Access and Reimbursement Overview
15.5 Market Scenario - France
15.5.1 Acute Intermittent Porphyria - Market Size
15.5.1.1 Market Size (2018-2023)
15.5.1.2 Market Forecast (2024-2034)
15.5.2 Acute Intermittent Porphyria - Market Size by Therapies
15.5.2.1 Market Size by Therapies (2018-2023)
15.5.2.2 Market Forecast by Therapies (2024-2034)
15.5.3 Acute Intermittent Porphyria - Access and Reimbursement Overview
15.6 Market Scenario - United Kingdom
15.6.1 Acute Intermittent Porphyria - Market Size
15.6.1.1 Market Size (2018-2023)
15.6.1.2 Market Forecast (2024-2034)
15.6.2 Acute Intermittent Porphyria - Market Size by Therapies
15.6.2.1 Market Size by Therapies (2018-2023)
15.6.2.2 Market Forecast by Therapies (2024-2034)
15.6.3 Acute Intermittent Porphyria - Access and Reimbursement Overview
15.7 Market Scenario - Italy
15.7.1 Acute Intermittent Porphyria - Market Size
15.7.1.1 Market Size (2018-2023)
15.7.1.2 Market Forecast (2024-2034)
15.7.2 Acute Intermittent Porphyria - Market Size by Therapies
15.7.2.1 Market Size by Therapies (2018-2023)
15.7.2.2 Market Forecast by Therapies (2024-2034)
15.7.3 Acute Intermittent Porphyria - Access and Reimbursement Overview
15.8 Market Scenario - Spain
15.8.1 Acute Intermittent Porphyria - Market Size
15.8.1.1 Market Size (2018-2023)
15.8.1.2 Market Forecast (2024-2034)
15.8.2 Acute Intermittent Porphyria - Market Size by Therapies
15.8.2.1 Market Size by Therapies (2018-2023)
15.8.2.2 Market Forecast by Therapies (2024-2034)
15.8.3 Acute Intermittent Porphyria - Access and Reimbursement Overview
15.9 Market Scenario - Japan
15.9.1 Acute Intermittent Porphyria - Market Size
15.9.1.1 Market Size (2018-2023)
15.9.1.2 Market Forecast (2024-2034)
15.9.2 Acute Intermittent Porphyria - Market Size by Therapies
15.9.2.1 Market Size by Therapies (2018-2023)
15.9.2.2 Market Forecast by Therapies (2024-2034)
15.9.3 Acute Intermittent Porphyria - Access and Reimbursement Overview
16 Acute Intermittent Porphyria - Recent Events and Inputs From Key Opinion Leaders
17 Acute Intermittent Porphyria Market - SWOT Analysis
17.1 Strengths
17.2 Weaknesses
17.3 Opportunities
17.4 Threats
18 Acute Intermittent Porphyria Market – Strategic Recommendations
19 Appendix

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