Key Highlights Gestational diabetes is initially managed through non-pharmacologic methods such as dietary changes, exercise, and monitoring glucose levels. The American Diabetes Association (ADA) advises personalized nutritional counseling by a registered dietitian, tailored to the patient's BMI. W ...

Key Highlights Limb-girdle muscular dystrophy (LGMD) is a diverse group of disorders with many subtypes categorized by disease gene and inheritance, it usually manifests in the proximal muscles around the hips and shoulders. According to DelveInsight’s estimates, the total prevalent cases of Limb Gi ...

Key Highlights In the United States, over 42 million people are infected with HPV, including approximately 13 million new infections each year. More than 90% of condyloma (anogenital warts) cases are caused by low-risk HPV types 6 or 11, whereas around 10% of cases are associated with other strains ...

Key Highlights IBM remains one of the most underrepresented subtypes within idiopathic inflammatory myopathies (IIMs), with rheumatologists citing it as particularly underserved amid increasing calls for faster, safer, and steroid-sparing treatments. There are currently no FDA-approved therapies for ...

Key Highlights Metastasis is not uncommon; in fact, approximately 40% to 50% of individuals with STS will eventually develop metastatic disease. Among all possible sites, the lungs are by far the most common destination for metastases, accounting for nearly 80% of first metastatic occurrences. Patie ...

Key Highlights Prediabetes is a significant but silent incubator of future morbidity. It affects over one-third of US adults and over one-fifth of adults in Europe, making it a widespread condition. There is a huge unmet need in the prediabetes market for approved therapies since its effective treat ...

Key Highlights Hypoactive sexual desire disorder (HSDD) is defined in the DSM-IV-TR as a persistent or recurrent absence of sexual fantasies and desire for sexual activity. HSDD treatment involves a multifaceted approach, including sex therapy, psychotherapy, pharmacological interventions, and hormo ...

Key Highlights Diverticulitis occurs when small bulging pouches in the colon, called diverticula, become inflamed, causing symptoms such as abdominal pain, fever, nausea, and changes in bowel habits. While diverticula are common with age and usually harmless (diverticulosis), inflammation can lead t ...

Key Highlights Hypereosinophilic syndrome (HES) is a rare, complex group of heterogeneous disorders characterized by persistently elevated eosinophil counts and associated tissue infiltration leading to organ damage. Glucocorticoids remain the first-line treatment, achieving remission in most patien ...

Key Highlights Ischemia-reperfusion injury (IRI) is defined as the paradoxical worsening of cellular dysfunction and death that occurs following the restoration of blood flow to previously ischemic tissues. Major causes of IRI include organ transplantation, recovery from cardiac arrest, and thrombol ...

Key Highlights Lumbar radiculopathy is a self-limited injury to the nerve roots of the lumbar spine. It can present as excruciating, burning, or stinging pain, radiating down the leg, decreased sensation of the legs, numbness and tingling, and in more severe cases, muscle weakness. According to Delv ...

Key Highlights Lymphatic malformations result from abnormalities in the development of the lymphatic vascular system during embryonic growth. In a large number of patients, the lymphatic malformations have an activating mutation in the PIK3CA gene. There are currently no treatments approved by the U ...

Key Highlights Lymphocytopenia, also called lymphopenia, occurs when the lymphocyte count in the blood is lower than usual. Severe or chronic low counts can indicate a possible infection or other illness. Lymphocytes are a kind of white blood cell. According to the findings, lymphopenia was present ...

Key Highlights Lamellar ichthyosis is a rare genetic skin disorder present at birth and is one of three types of autosomal recessive congenital ichthyoses (ARCI). Babies born with LI are often referred to as ""collodion babies"" due to the distinctive collodion membrane covering their skin at birth ...

Key Highlights For patients with RLS, superficial heat-cold application could pave the way towards better sleep quality. This approach additionally represents a cost-effective, medication-free method for many patients. Recently in 2025, the new guidelines downgrade a previous strong recommendation f ...

Key Highlights CIS is a first neurological episode caused by central nervous system inflammation and demyelination, often serving as an early indicator of multiple sclerosis. It highlights the risk of progression to clinically definite multiple sclerosis. Secondary analysis estimates the incidence o ...

Key Highlights Klinefelter syndrome is the most common form of aneuploidy, characterized by an abnormal number of chromosomes in the affected individual's cells. This underdiagnosis is likely due to clinicians' lack of awareness of the variable clinical features of Klinefelter syndrome, as well as i ...

Key Highlights Mantle cell lymphoma (MCL) is a rare B-cell non-Hodgkin lymphoma (NHL) that most often affects men over the age of 60. MCL represents about 5% of NHLs, and it often starts out as an indolent (slow-growing) disease but can become more aggressive (fast-growing) over time. MCL is diagnos ...

Key Highlights The rising incidence of coccidioidomycosis is linked to a growing population of immunocompromised individuals, including those with HIV/AIDS, organ transplants, or on immunosuppressive therapies. Additional risk factors include diabetes, older age, male sex, and genetic immune deficie ...

Key Highlights Hypogonadism is often underreported, improperly diagnosed, and overtreated. The condition can be hypergonadotropic (primary, resulting when the gonads fail) or hypogonadotropic. The Endocrine Society Clinical Practice Guideline defines male hypogonadism as “a clinical syndrome that re ...

Key Highlights Although patch testing remains the diagnostic gold standard, its application and interpretation continue to pose challenges. Management centers on allergen avoidance, supported by topical therapies, systemic treatments, and emerging biologics. Severe allergic contact dermatitis (ACD) ...

Key Highlights In Disseminated Intravascular Coagulation (DIC), excessive fibrin deposition blocks small vessels, disrupting microcirculation and causing ischemic injury in organs like kidneys and lungs, which often progresses to organ failure from impaired blood flow and oxygen delivery. Secondary ...

Key Highlights Gaucher Disease is a rare inherited lysosomal disorder caused by mutations in the GBA1 gene, leading to deficiency of the enzyme glucocerebrosidase. This results in the accumulation of glucosylceramide (Gb1) and glucosylsphingosine (Lyso-Gb1) in cells, causing enlargement of the liver ...

Key Highlights Dementia refers to a group of symptoms affecting memory, thinking, and social abilities severely enough to interfere with daily life. It is not a single disease, but rather an umbrella term that encompasses a range of specific medical conditions. Many medical conditions can cause or b ...

Key Highlights Functional constipation is defined as constipation without an organic aetiology and is diagnosed according to the Rome criteria. In adults, differentiating between subtypes of functional constipation (normal transit, slow transit, and evacuation disorders) through additional testing i ...