The global bone graft substitute (BGS) market was valued at approximately $2.83 billion in 2024 and is expected to grow at a CAGR of 4.1%, reaching approximately $3.75 billion by 2031. The market includes various types of bone graft substitutes used in orthopedic, trauma, and reconstructive surgeries.
The BGS market is segmented into:
Allograft BGS
Demineralized Bone Matrix (DBM) Allograft BGS
Synthetic BGS
The market is further categorized based on indication type:
Spine (Cervical, Thoracolumbar)
Trauma (Non-union, Fresh Fracture)
Large Joint Reconstruction (Hip, Knee)
Craniomaxillofacial
Oncology
Foot Bone Reconstructions
Market Insights
Unit Sales & Average Selling Prices
Market Size & Growth Trends
Procedure Numbers
Market Drivers & Limiters
Market Forecasts Until 2031
Recent Mergers & Acquisitions
Competitive Landscape
Company Profiles & Product Portfolios
Market Trends
The COVID-19 pandemic caused a decline in BGS sales due to postponed elective surgeries. However, the market recovered strongly by 2022 and resumed steady growth.
Minimally invasive techniques are driving the adoption of synthetic and DBM-based grafts over traditional bone grafting procedures.
Rising orthopedic procedures due to an aging population and increasing trauma-related injuries are fueling market growth.
Technological advancements in bioengineered bone grafts are increasing graft efficiency and patient outcomes.
Market Share Insights
Top Competitors in the Global Bone Graft Substitute Market (2024):
1 Medtronic
Market leader due to a dominant share in the DBM and synthetic BGS segments.
Grafton® – The first fiber-based DBM allograft BGS and one of the most widely used.
MASTERGRAFT® – Synthetic BGS product line available in granules, moldable putty, flexible strip, and matrix EXT.
2 Stryker
Second-largest competitor in the market.
Offers multiple BGS products including Vitoss™, ALLOMATRIX®, FUSIONFLEX®, and PRO-STIM®.
3 DePuy Synthes (Johnson & Johnson)
Third-largest competitor in the BGS market.
Competes with its DBX® DBM product line and chronOS® synthetic BGS.
Global Research Scope
Regions Covered:
North America: United States, Canada
Latin America: Brazil, Mexico, Chile, Colombia
Western Europe: Germany, France, Italy, Spain, United Kingdom
Central & Eastern Europe: Poland, Russia, Turkey
Middle East: Saudi Arabia, UAE, Israel
Asia Pacific: China, Japan, India, South Korea
Africa: South Africa, Egypt, Nigeria
Base Year: 2024
Forecast Period: 2025-2031
Historical Data: 2021-2023
Quantitative Coverage
Market Size
Market Shares
Market Forecasts
Market Growth Rates
Units Sold
Average Selling Prices
Procedure Numbers
Qualitative Coverage
COVID-19 Impact
Market Growth Trends
Market Limiters
Competitive Analysis & SWOT for Top Competitors
Mergers & Acquisitions
Company Profiles
Product Portfolios
FDA Recalls
Disruptive Technologies
Disease Overviews
Data Sources
Primary Interviews with Industry Leaders
Government Physician Data
Regulatory Data
Hospital Private Data
Import & Export Data
iData Research Internal Database
- 4.1 Executive Summary
- 4.1.1 Global Orthopedic Bone Graft Substitute Market Overview
- 4.1.2 Competitive Analysis
- 4.1.3 Regions Included
- 4.2 Introduction
- 4.3 Procedure Numbers
- 4.3.1 Total Orthopedic Bone Grafting Procedures
- 4.3.2 Allograft Procedures
- 4.3.3 Demineralized Bone Matrix Procedures
- 4.3.4 Synthetic Procedures
- 4.4 Market Overview
- 4.4.1 By Segment
- 4.4.2 By Region
- 4.5 Market Analysis and Forecast
- 4.5.1 Total Orthopedic Bone Graft Substitute Market
- 4.5.2 Allograft Bone Graft Substitute Market
- 4.5.3 Demineralized Bone Matrix Allograft Bone Graft Substitute Market
- 4.5.4 Synthetic Bone Graft Substitute Market
- 4.5.4.1 Synthetic Bone Graft Substitute Market by Generation Type
- 4.6 Unit Analysis
- 4.6.1 Allograft Bone Graft Substitute Unit Analysis
- 4.6.1.1 Allograft Bone Graft Substitute Units Sold by Indication
- 4.6.1.1.1 Spine Allograft Bone Graft Substitute Units Sold
- 4.6.1.1.2 Trauma Allograft Bone Graft Substitute Units Sold
- 4.6.1.1.3 Large Joint Reconstruction Allograft Bone Graft Substitute Units Sold
- 4.6.2 Demineralized Bone Matrix Allograft Bone Graft Substitute Unit Analysis
- 4.6.2.1 Demineralized Bone Matrix Allograft Bone Graft Substitute Units Sold by Indication
- 4.6.2.1.1 Spine Demineralized Bone Matrix Allograft Bone Graft Substitute Units Sold
- 4.6.2.1.2 Trauma Demineralized Bone Matrix Allograft Bone Graft Substitute Units Sold
- 4.6.2.1.3 Large Joint Reconstruction Demineralized Bone Matrix Allograft Bone Graft Substitute Units Sold
- 4.6.3 Synthetic Bone Graft Substitute Unit Analysis
- 4.6.3.1 Synthetic Bone Graft Substitute Units Sold by Indication
- 4.6.3.1.1 Spine Synthetic Bone Graft Substitute Units Sold
- 4.6.3.1.2 Trauma Synthetic Bone Graft Substitute Units Sold
- 4.6.3.1.3 Large Joint Reconstruction Synthetic Bone Graft Substitute Units Sold
- 4.7 Drivers and Limiters
- 4.7.1 Market Drivers
- 4.7.2 Market Limiters
- 4.8 Competitive Market Share Analysis
- Chart 4-1: Orthopedic Bone Graft Substitute Market, Global, 2024 & 2031
- Chart 4-2: Orthopedic Bone Graft Substitute Procedures, Global, 2024
- Chart 4-3: Orthopedic Bone Grafting Procedures by Segment, Global, 2021– 2031
- Chart 4-4: Orthopedic Bone Graft Substitute Device Market by Segment, Global, 2021 – 2031
- Chart 4-5: Orthopedic Bone Graft Substitute Device Market by Region, Global, 2021 – 2031
- Chart 4-6: Leading Competitors, Orthopedic Bone Graft Substitute Market, Global, 2024
- Figure 4-1: Orthopedic Bone Graft Substitute Regions Covered, Global (1 of 2)
- Figure 4-2: Orthopedic Bone Graft Substitute Regions Covered, Global (2 of 2)
- Figure 4-3: Orthopedic Bone Grafting Procedures by Segment, Global, 2021 – 2031
- Figure 4-4: Orthopedic Bone Grafting Procedures by Region, Global, 2021 – 2031
- Figure 4-5: Orthopedic Bone Grafting Procedures by Country, North America, 2021 – 2031
- Figure 4-6: Orthopedic Bone Grafting Procedures by Country, Latin America, 2021 – 2031 (1 of 2)
- Figure 4-7: Orthopedic Bone Grafting Procedures by Country, Latin America, 2021 – 2031 (2 of 2)
- Figure 4-8: Orthopedic Bone Grafting Procedures by Country, Western Europe, 2021– 2031
- Figure 4-9: Orthopedic Bone Grafting Procedures by Country, Central & Eastern Europe, 2021 – 2031 (1 of 2)
- Figure 4-10: Orthopedic Bone Grafting Procedures by Country, Central & Eastern Europe, 2021 – 2031 (2 of 2)
- Figure 4-11: Orthopedic Bone Grafting Procedures by Country, Middle East, 2021 – 2031
- Figure 4-12: Orthopedic Bone Grafting Procedures by Country, Asia-Pacific, 2021– 2031 (1 of 3)
- Figure 4-13: Orthopedic Bone Grafting Procedures by Country, Asia-Pacific, 2021 – 2031 (2 of 3)
- Figure 4-14: Orthopedic Bone Grafting Procedures by Country, Asia-Pacific, 2021 – 2031 (3 of 3)
- Figure 4-15: Orthopedic Bone Grafting Procedures by Country, Africa, 2021 – 2031
- Figure 4-16: Allograft Procedures by Region, Global, 2021– 2031
- Figure 4-17: Allograft Procedures by Country, North America, 2021– 2031
- Figure 4-18: Allograft Procedures by Country, Latin America, 2021– 2031 (1 of 2)
- Figure 4-19: Allograft Procedures by Country, Latin America, 2021– 2031 (2 of 2)
- Figure 4-20: Allograft Procedures by Country, Western Europe, 2021 – 2031
- Figure 4-21: Allograft Procedures by Country, Central & Eastern Europe, 2021 – 2031 (1 of 2)
- Figure 4-22: Allograft Procedures by Country, Central & Eastern Europe, 2021 – 2031 (2 of 2)
- Figure 4-23: Allograft Procedures by Country, Middle East, 2021– 2031
- Figure 4-24: Allograft Procedures by Country, Asia-Pacific, 2021 – 2031 (1 of 3)
- Figure 4-25: Allograft Procedures by Country, Asia-Pacific, 2021 – 2031 (2 of 3)
- Figure 4-26: Allograft Procedures by Country, Asia-Pacific, 2021 – 2031 (3 of 3)
- Figure 4-27: Allograft Procedures by Country, Africa, 2021– 2031
- Figure 4-28: Demineralized Bone Matrix Procedures by Region, Global, 2021– 2031
- Figure 4-29: Demineralized Bone Matrix Procedures by Country, North America, 2021– 2031
- Figure 4-30: Demineralized Bone Matrix Procedures by Country, Latin America, 2021– 2031 (1 of 2)
- Figure 4-31: Demineralized Bone Matrix Procedures by Country, Latin America, 2021– 2031 (2 of 2)
- Figure 4-32: Demineralized Bone Matrix Procedures by Country, Western Europe, 2021 – 2031
- Figure 4-33: Demineralized Bone Matrix Procedures by Country, Central & Eastern Europe, 2021 – 2031 (1 of 2)
- Figure 4-34: Demineralized Bone Matrix Procedures by Country, Central & Eastern Europe, 2021 – 2031 (2 of 2)
- Figure 4-35: Demineralized Bone Matrix Procedures by Country, Middle East, 2021 – 2031
- Figure 4-36: Demineralized Bone Matrix Procedures by Country, Asia-Pacific, 2021– 2031 (1 of 3)
- Figure 4-37: Demineralized Bone Matrix Procedures by Country, Asia-Pacific, 2021– 2031 (2 of 3)
- Figure 4-38: Demineralized Bone Matrix Procedures by Country, Asia-Pacific, 2021 – 2031 (3 of 3)
- Figure 4-39: Demineralized Bone Matrix Procedures by Country, Africa, 2021 – 2031
- Figure 4-40: Synthetic Procedures by Region, Global, 2021 – 2031
- Figure 4-41: Synthetic Procedures by Country, North America, 2021 – 2031
- Figure 4-42: Synthetic Procedures by Country, Latin America, 2021 – 2031 (1 of 2)
- Figure 4-43: Synthetic Procedures by Country, Latin America, 2021 – 2031 (2 of 2)
- Figure 4-44: Synthetic Procedures by Country, Western Europe, 2021– 2031
- Figure 4-45: Synthetic Procedures by Country, Central & Eastern Europe, 2021 – 2031 (1 of 2)
- Figure 4-46: Synthetic Procedures by Country, Central & Eastern Europe, 2021 – 2031 (2 of 2)
- Figure 4-47: Synthetic Procedures by Country, Middle East, 2021 – 2031
- Figure 4-48: Synthetic Procedures by Country, Asia-Pacific, 2021 – 2031 (1 of 3)
- Figure 4-49: Synthetic Procedures by Country, Asia-Pacific, 2021 – 2031 (2 of 3)
- Figure 4-50: Synthetic Procedures by Country, Asia-Pacific, 2021 – 2031 (3 of 3)
- Figure 4-51: Synthetic Procedures by Country, Africa, 2021 – 2031
- Figure 4-52: Orthopedic Bone Graft Substitute Device Market by Segment, Global, 2021 – 2031 (US$M)
- Figure 4-53: Orthopedic Bone Graft Substitute Device Market by Region, Global, 2021 – 2031 (US$M)
- Figure 4-54: Orthopedic Bone Graft Substitute Market, Global, 2021 – 2031
- Figure 4-55: Units Sold by Region, Orthopedic Bone Graft Substitute Market, Global, 2021 – 2031
- Figure 4-56: Average Selling Price by Region, Orthopedic Bone Graft Substitute Market, Global, 2021– 2031 (US$)
- Figure 4-57: Market Value by Region, Orthopedic Bone Graft Substitute Market, Global, 2021 – 2031 (US$M)
- Figure 4-58: Allograft Bone Graft Substitute Market, Global, 2021 – 2031
- Figure 4-59: Units Sold by Region, Allograft Bone Graft Substitute Market, Global, 2021 – 2031
- Figure 4-60: Average Selling Price by Region, Allograft Bone Graft Substitute Market, Global, 2021 – 2031 (US$)
- Figure 4-61: Market Value by Region, Allograft Bone Graft Substitute Market, Global, 2021 – 2031 (US$M)
- Figure 4-62: Demineralized Bone Matrix Allograft Bone Graft Substitute Market, Global, 2021 – 2031
- Figure 4-63: Units Sold by Region, Demineralized Bone Matrix Allograft Bone Graft Substitute Market, Global, 2021 – 2031
- Figure 4-64: Average Selling Price by Region, Demineralized Bone Matrix Allograft Bone Graft Substitute Market, Global, 2021 – 2031 (US$)
- Figure 4-65: Market Value by Region, Demineralized Bone Matrix Allograft Bone Graft Substitute Market, Global, 2021 – 2031 (US$M)
- Figure 4-66: Synthetic Bone Graft Substitute Market, Global, 2021 – 2031
- Figure 4-67: Units Sold by Region, Synthetic Bone Graft Substitute Market, Global, 2021 – 2031
- Figure 4-68: Average Selling Price by Region, Synthetic Bone Graft Substitute Market, Global, 2021 – 2031 (US$)
- Figure 4-69: Market Value by Region, Synthetic Bone Graft Substitute Market, Global, 2021 – 2031 (US$M)
- Figure 4-70: Generation 1 Synthetic Bone Graft Substitute Market, Global, 2021 – 2031
- Figure 4-71: Units Sold by Region, Generation 1 Synthetic Bone Graft Substitute Market, Global, 2021 – 2031
- Figure 4-72: Average Selling Price by Region, Generation 1 Synthetic Bone Graft Substitute Market, Global, 2021 – 2031 (US$)
- Figure 4-73: Market Value by Region, Generation 1 Synthetic Bone Graft Substitute Market, Global, 2021 – 2031 (US$M)
- Figure 4-74: Generation 2 Synthetic Bone Graft Substitute Market, Global, 2021 – 2031
- Figure 4-75: Units Sold by Region, Generation 2 Synthetic Bone Graft Substitute Market, Global, 2021 – 2031
- Figure 4-76: Average Selling Price by Region, Generation 2 Synthetic Bone Graft Substitute Market, Global, 2021 – 2031 (US$)
- Figure 4-77: Market Value by Region, Generation 2 Synthetic Bone Graft Substitute Market, Global, 2021 – 2031 (US$M)
- Figure 4-78: Allograft Bone Graft Substitute Units Sold by Indication, Global, 2021 – 2031
- Figure 4-79: Spine Allograft Bone Graft Substitute Units Sold, Global, 2021 – 2031
- Figure 4-80: Trauma Allograft Bone Graft Substitute Units Sold, Global, 2021 – 2031
- Figure 4-81: Large Joint Reconstruction Allograft Bone Graft Substitute Units Sold, Global, 2021– 2031
- Figure 4-82: Demineralized Bone Matrix Allograft Bone Graft Substitute Units Sold by Indication, Global, 2021 – 2031
- Figure 4-83: Spine Demineralized Bone Matrix Allograft Bone Graft Substitute Units Sold, Global, 2021 – 2031
- Figure 4-84: Trauma Demineralized Bone Matrix Allograft Bone Graft Substitute Units Sold, Global, 2021 – 2031
- Figure 4-85: Large Joint Reconstruction Demineralized Bone Matrix Allograft Bone Graft Substitute Units Sold, Global, 2021 – 2031
- Figure 4-86: Synthetic Bone Graft Substitute Units Sold by Indication, Global, 2021 – 2031
- Figure 4-87: Spine Synthetic Bone Graft Substitute Units Sold, Global, 2021 – 2031
- Figure 4-88: Trauma Synthetic Bone Graft Substitute Units Sold, Global, 2021 – 2031
- Figure 4-89: Large Joint Reconstruction Synthetic Bone Graft Substitute Units Sold, Global, 2021 – 2031
- Figure 4-90: Leading Competitors, Orthopedic Bone Graft Substitute Market, Global, 2024
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