Asthma Disease

Asthma Disease


The asthma market refers to the market for products that are used to address this condition through the creation, manufacturing, and sale of drugs, devices, and therapies that help control and treat asthma, a long-term illness that results in inflammation of airways and constriction of the bronchi. There is a growing focus on respiratory diseases and the development of new treatments wherein the growth of the market is attributed to the increasing incidences of asthma, the growing awareness among people about respiratory wellness, and the emerging options in the form of new inhalers and biologics. Also, there are more favorable governmental policies and higher consumer demand for individualized treatment, which complements conceptions of therapy adherence and results in better asthma management market trends.

The asthma market is expected to grow around ~5% during the forecast period (2024-2032). The Increasing incidence of asthma globally is due to environmental factors, allergens, and lifestyle changes that drive the growth of the asthma market. Also, ongoing research and development of new drugs and biologics targeting asthma control. For instance, in February 2023, Pulmatrix initiated a Phase 2b trial, dosing the first patient with PUR1900 for Allergic Bronchopulmonary Aspergillosis (ABPA) and asthma. The global study will assess safety, tolerability, and efficacy over 16 weeks, supporting Pulmatrix's collaboration with Cipla to bring therapy to patients with asthma, with proof-of-concept data expected by mid-2024.
  • Based on the marketed therapies, the market has been divided into TEZSPIRE, TRELEGY ELLIPTA, ARNUITY ELLIPTA, CINQAIR (reslizumab), FASENRA, (benralizumab), DUPIXENT (dupilumab), NUCALA (mepolizumab), AIRSUPRA (albuterol and budesonide), and XOLAIR (omalizumab). Among them, the TEZSPIRE held a significant market share in 2023. TEZSPIRE, a marketed therapy for severe asthma, is significantly driving the asthma market by offering a novel and effective treatment option for patients with uncontrolled asthma despite standard therapies. Its unique mechanism of action targets and inhibits thymic stromal lymphopoietin (TSLP), a key driver of asthma inflammation, providing broader efficacy across various types of severe asthma. The development of TEZSPIRE responds to a therapeutic need and contributes to the enhancement of the patient’s status and the decrease in the number of exacerbations. Besides broadening the therapeutic approach, this therapy contributes to market development by increasing the use of new medical products by physicians and increasing investment in the development of innovative biologicals for respiratory diseases.
  • For a better understanding of the market adoption of asthma disease, the market is analyzed based on its 7MM presence in countries such as The U.S., Germany, the UK, France, Italy, Spain, and Japan. The U.S. held a dominant share of the market in 2023. The U.S. market for asthma diseases is substantial, driven by the high prevalence and significant healthcare burden of the disease. For instance, the current asthma prevalence among adults in the U.S. increased from 6.9% in 2001 to 8.0% in 2021. Larger populations aware and diagnosed, coupled with improved treatment choices, are the factors that help in the expansion of the market. The presence of novel treatment, including biologics, in combination with the common inhalers and tablets improves the control of both intermittent and severe asthma. The demand for healthcare facilities and innovations to decrease air pollution and enhance existing structures along with strong investment in pharmaceutical production by governments and companies also stimulate the market.
  • Some of the major players operating in the market include AstraZeneca, GSK plc, Cipla, Teva Pharmaceutical Industries Ltd., Sanofi, Avillion LLP, Novartis AG, CHIESI Farmaceutici S.p.A., Boehringer Ingelheim International GmbH, and AB Science.


1 MARKET INTRODUCTION
1.1. Market Definitions
1.2. Main Objective
1.3. Stakeholders
1.4. Limitation
2 RESEARCH METHODOLOGY OR ASSUMPTION
2.1. Research Process of the Asthma Market
2.2. Research Methodology of the Asthma Market
2.3. Respondent Profile
3 EXECUTIVE SUMMARY
3.1. Industry Synopsis
3.2. Segmental Outlook
3.2.1. Market Growth Intensity
3.3. Regional Outlook
4 MARKET DYNAMICS
4.1. Drivers
4.2. Opportunity
4.3. Restraints
4.4. Trends
5 DISEASE BACKGROUND AND OVERVIEW
5.1. Introduction
5.2. Classification
5.3. Causes
5.4. Risk Factors
5.5. Signs and Symptoms
5.5.1. Early Signs and Symptoms
5.5.2. Progressed Symptoms
5.6. Diagnosis
5.6.1. Physical exam
5.6.2. Lung Function Tests
6 TREATMENT
6.1. First Line Treatment – Inhaled corticosteroids (ICS)
6.2. Bronchial Thermoplasty
6.3. Anti-inflammatory
6.4. Combination Medicines
6.5. Anticholinergics
6.6. Biologics
6.7. Antibiotics
6.8. Others
6.9. Emerging Therapies
6.9.1. Immunotherapy
6.9.2. Others
7 PATIENT JOURNEY
8 GUIDELINES ON ASTHMA
8.1. NICE Recommendations for Asthma Management
8.2. British Guidelines on the Management of Asthma
8.3. International ERS/ATS Guidelines on the Definition, Evaluation, and Treatment of Severe Asthma
8.4. Other Guidelines for Asthma
9 EPIDEMIOLOGY & PATIENT POPULATION, 2022-2032F
9.1. Assumptions and Rationale
9.2. Epidemiology of Asthma in 7MM
9.2.1. Total Prevalent Population of Asthma in the 7MM
9.2.2. Severity-specific cases of Asthma
9.2.3. Type-specific cases of Severe Asthma
9.2.4. Age-specific Prevalent Population of Asthma in the 7MM
10 EPIDEMIOLOGY OF ASTHMA BY COUNTRY
10.1. The United States
10.1.1. Total Prevalent Population of Asthma in the 7MM
10.1.2. Severity-specific cases of Asthma
10.1.3. Type-specific cases of Severe Asthma
10.1.4. Age-specific Prevalent Population of Asthma in the 7MM
10.2. Germany
10.3. UK
10.4. France
10.5. Italy
10.6. Spain
10.7. Japan
11 ASTHMA MARKET INSIGHTS, MARKETED THERAPIES
11.1. TEZSPIRE (tezepelumab-ekko): Amgen/AstraZeneca
11.1.1. Drug Profile
11.1.2. Regulatory Achievements
11.1.3. Other Development Activities
11.1.4. Clinical Development
11.1.5. Safety and Efficacy
11.2. TRELEGY ELLIPTA (fluticasone furoate/umeclidinium/vilanterol): GlaxoSmithKline
11.3. ARNUITY ELLIPTA (fluticasone furoate inhalation powder): GlaxoSmithKline
11.4. CINQAIR (reslizumab): Teva Pharmaceutical
11.5. FASENRA (benralizumab): AstraZeneca
11.6. DUPIXENT (dupilumab): Sanofi and Regeneron Pharmaceutical
11.7. NUCALA (mepolizumab): GlaxoSmithKline (GSK)
11.8. AIRSUPRA (albuterol and budesonide): AstraZeneca/Avillion
11.9. XOLAIR (omalizumab): Novartis
Complete List in the report
12 ASTHMA MARKET INSIGHTS, EMERGING THERAPIES
12.1. GSK3511294 (Depemokimab): GlaxoSmithKline
12.1.1. Drug Profile
12.1.2. Clinical Development
12.1.3. Safety and Efficacy
12.2. Givinostat: Italfarmaco
12.3. Masitinib (AB07105): AB Science
12.4. PT010: AstraZeneca
12.5. Dexpramipexole Dihydrochloride: Areteia Therapeutics
12.6. PBF-680: Palobiofarma SL/Pivotal S.L.
12.7. ARS 1: ARS Pharmaceuticals, Inc.
12.8. MEDI3506 (tozorakimab): AstraZeneca
12.9. AZD1402 (PRS-060): Pieris Pharma/AstraZeneca
12.10. Atuliflapon (AZD5718): AstraZeneca
12.11. Amlitelimab: Sanofi
Complete List in the report
13 ASTHMA MARKET: 7MM ANALYSIS
13.1. Key Findings
13.2. Total Market Size of Asthma in the 7MM, 2022-2032F
13.3. Market Size of Asthma by Marketed Therapies in the 7MM
13.4. Market Size of Asthma by Emerging Therapies in the 7MM
13.5. United States Market Size, 2022-2032F
13.5.1. Total Market Size of Asthma in the United States
13.5.2. Market Size of Asthma by Marketed Therapies in the United States
13.5.3. Market Size of Asthma by Emerging Therapies in the United States
13.6. Germany
13.7. UK
13.8. France
13.9. Italy
13.10. Spain
13.11. Japan
14 UNMET NEEDS
15 COMPETITIVE LANDSCAPE
15.1. Key Competitors – Marketed Therapies
15.2. Key Competitors – Phase III Drugs
15.3. Key Competitors – Phase II Drugs
16 COMPANY PROFILES
16.1. AstraZeneca
16.1.1. Company Overview
16.1.2. Key Financials
16.1.3. SWOT Analysis
16.1.4. Product Portfolio
16.1.5. Recent Developments
16.2. GSK plc
16.3. Cipla
16.4. Teva Pharmaceutical Industries Ltd.
16.5. Sanofi
16.6. Avillion LLP
16.7. Novartis AG
16.8. CHIESI Farmaceutici S.p.A.
16.9. Boehringer Ingelheim International GmbH
16.10. AB Science
17 ACRONYMS & ASSUMPTION
18 ANNEXURE

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