Cryo-Electron Microscopy Market Forecasts to 2030 - Global Analysis By Product Type (Instruments, Software, Services and Other Product Types), Method (Cryo-electron Tomography, Electron Crystallography, Single Particle Analysis (SPA) and Other Methods), N

Cryo-Electron Microscopy Market Forecasts to 2030 - Global Analysis By Product Type (Instruments, Software, Services and Other Product Types), Method (Cryo-electron Tomography, Electron Crystallography, Single Particle Analysis (SPA) and Other Methods), Nano Formulations, Voltage, Technology, Application and By Geography


According to Stratistics MRC, the Global Cryo-Electron Microscopy Market is accounted for $1.42 billion in 2024 and is expected to reach $3.05 billion by 2030 growing at a CAGR of 13.60% during the forecast period. Due to its ability to enable researchers to see bio molecular structures in unprecedented detail, cryo-electron microscopy, or cryo-EM, has completely changed the field of structural biology. Using an electron microscope at extremely low temperatures, samples are imaged using this technique, which involves rapidly freezing them to preserve their natural state. High-resolution images of biological macromolecules in their natural habitat can be obtained using cryo-EM without the need for chemical fixation or staining. Moreover, significant advancements in the domains of biochemistry, pharmacology, and virology have resulted from its capacity to capture dynamic molecular structures.

According to the World Health Organization (WHO), access to essential medicines is a fundamental human right, and ensuring equitable distribution and affordability of these medicines is critical for achieving global health goals.

Market Dynamics:

Driver:

Growing need for drug development and discovery

Cryo-EM has become a potent tool in the pharmaceutical industry for lead optimization, structural elucidation of drug targets, and rational drug design. The capacity to observe dynamic protein-drug interactions and macromolecular complexes at near-atomic resolution provides significant insight into the potential therapeutics' mechanisms of action. Additionally, Cryo-EM services and expertise are in high demand as drug discovery pipelines shift to focus more on biologics, membrane proteins, and difficult drug targets, which is driving market expansion.

Restraint:

Complexity of data analysis and sample preparation

The preparation of grids, vitrification, and imaging conditions for cryo-EM samples necessitates specific knowledge and tools. A major barrier to entry for inexperienced users is the laborious and complicated workflows involved in sample preparation, in addition to the requirement for proficiency in data analysis and cryo-EM techniques. Furthermore, cryo-EM experiments produce massive amounts of raw data, which calls for sophisticated image processing algorithms and a reliable computing infrastructure for data analysis and structural refinement.

Opportunity:

Technological progress in hardware and software

There are many chances for businesses to be creative and provide cutting-edge cryo-EM hardware and software. This involves developing and producing next-generation electron microscopes with enhanced automation, sensitivity, and resolution. Moreover, there is a growing need for user-friendly software platforms for image processing, data acquisition, and structural analysis. This presents opportunities for software developers to create tools that are efficient and easy to use, which can improve the user experience and streamline the cryo-EM workflow.

Threat:

Market saturation and competitive pressures

There are a growing number of manufacturers, service providers, and research institutions offering cryo-EM solutions, which is congesting the cryo-EM market. Price wars, shrinking profit margins, and the commoditization of cryo-EM goods and services are possible outcomes of fierce competition. Additionally, the industry may experience slower revenue growth, lower profitability, and more industry consolidation as a result of market saturation, as smaller firms find it more difficult to compete with more established, larger firms.

Covid-19 Impact:

The cryo-electron microscopy (cryo-EM) market has been impacted by the COVID-19 pandemic in a number of ways. The pandemic increased demand for cryo-EM in researching the virus's structure, host interactions, and drug development, even though it initially disrupted supply chains, manufacturing operations, and research activities, causing delays in instrument installations, service contracts, and cooperative projects. Cryo-EM has become widely used in COVID-19 research due to the pressing need to comprehend the molecular mechanisms of SARS-CoV-2 and expedite the development of vaccines, therapeutics, and diagnostics. Moreover, the adoption of cloud-based cryo-EM data analysis platforms and remote access solutions has been accelerated by the shift towards remote work and virtual collaboration.

The Lipid Nanoparticle Formulations (LNFS) segment is expected to be the largest during the forecast period

Due to their extensive application in the delivery of genetic materials like mRNA for vaccines and therapeutics, Lipid Nanoparticle Formulations (LNFs) command the largest market share in cryo-electron microscopy (Cryo-EM). These lipid nanoparticles can be imaged at high resolution using cryo-electron microscopy (Cryo-EM), providing information about their size, composition, and structural honesty. Additionally, advanced pharmaceutical development requires the use of liposome-forming factors (LNFs) due to their biocompatibility and capacity to encapsulate and safeguard delicate payloads.

The Transmission Electron Microscopy (TEM) segment is expected to have the highest CAGR during the forecast period

The transmission electron microscopy (TEM) segment is expected to have the highest CAGR in the cryo-electron microscopy (Cryo-EM) market. The need for high-resolution imaging and structural analysis of biological macromolecules is growing, and this growth is being driven by the need to advance materials science, structural biology, and drug discovery. Furthermore, researchers attempting to comprehend intricate biological processes and molecular structures find that TEM is invaluable due to its capacity to produce detailed images at the atomic level in their native state, especially when used in conjunction with cryo-TEM.

Region with largest share:

The market for cryo-electron microscopy, or cryo-EM, is dominated by North America due in large part to the region's concentration of major industry players, solid infrastructure for research, and large investments in cutting-edge technology. The region's emphasis on science and technology, along with strong funding initiatives from both public and private entities, drives advancements in the use of cryo-EM in a variety of fields, such as materials science, pharmaceuticals, and structural biology. Moreover, the concentration of top academic institutions and biopharmaceutical firms encourages cooperation and creativity, which strengthens North America's position as the market leader for cryo-EM products.

Region with highest CAGR:

The cryo-electron microscopy (Cryo-EM) market is growing at the highest CAGR in the Asia-Pacific region due to rapid industrialization, rising R&D spending, and a growing uptake of cutting-edge technologies in a variety of industries. The demand for cryo-EM solutions is driven by the region's growing biotechnology and pharmaceutical industries as well as growing government initiatives to support scientific research and innovation. Additionally, cryo-EM market growth in the Asia-Pacific region is further accelerated by the presence of a large pool of highly skilled researchers and scientists, as well as partnerships with international organizations and academia.

Key players in the market

Some of the key players in Cryo-Electron Microscopy market include Charles River Laboratories, Hitachi High-Technologies Corporation, Intertek Group Plc, Caliber Imaging & Diagnostics, Lasertec Corporation, HORIBA, Ltd, Olympus Corporation, Gatan, Inc., JEOL Ltd, Oxford Instruments, Nikon Instruments Inc, Keyence Corporation, Helmut Hund Gmbh, Danaher, Creative Biostructure, ZEISS International and Thermo Fisher Scientific.

Key Developments:

In May 2024, Intertek announced an agreement to acquire Base Metallurgical Laboratories and Base Met Labs US on Monday, which provides metallurgical testing services within the minerals sector in North America, for an undisclosed sum. The AIM-traded firm said the acquisition came ahead of expected heightened demand for diverse energy sources and minerals to sustain a growing global population.

In May 2024, Hitachi High-Tech and Roche have extended their partnership, committing to at least 10 years of additional collaboration. Bringing together the companies' expertise and track record in diagnostics innovation, engineering and manufacturing, the renewed contract further strengthens the two companies' long lasting partnership.

In February 2024, Charles River Laboratories International, Inc. announced a strategic agreement with Wheeler Bio, Inc., an antibody contract development and manufacturing organization (CDMO) focused on preclinical and early clinical supply of recombinant proteins, providing clients access to Wheeler’s Portable CMC platform.

Product Types Covered:
• Instruments
• Software
• Services
• Other Product Types

Methods Covered:
• Cryo-electron Tomography
• Electron Crystallography
• Single Particle Analysis (SPA)
• Other Methods

Nano Formulations Covered:
• Lipid Nanoparticle Formulations (LNFS)
• Metal Oxide Formulations
• Metal Formulations
• Other Nano Formulations

Voltages Covered:
• 300 kV
• 200 kV
• 120 kV

Technologies Covered:
• Transmission Electron Microscopy (TEM)
• Scanning Electron Microscopy (SEM)
• Nuclear Magnetic Resonance (NMR) Microscopy
• Other Technologies

Applications Covered:
• Life Science Research and Academia
• Cancer Research
• Omics Research
• Pharma and Biotech Manufacturing
• Cell and Gene Therapy
• Pathology
• Preclinical and Clinical Research
• Healthcare/Medical Applications
• Disease Diagnosis and Pathology
• Toxicology Studies
• Material Analysis
• Nanotechnology
• Clinical Trials
• Other Applications

Regions Covered:
• North America
US
Canada
Mexico
• Europe
Germany
UK
Italy
France
Spain
Rest of Europe
• Asia Pacific
Japan
China
India
Australia
New Zealand
South Korea
Rest of Asia Pacific
• South America
Argentina
Brazil
Chile
Rest of South America
• Middle East & Africa
Saudi Arabia
UAE
Qatar
South Africa
Rest of Middle East & Africa

What our report offers:
- Market share assessments for the regional and country-level segments
- Strategic recommendations for the new entrants
- Covers Market data for the years 2022, 2023, 2024, 2026, and 2030
- Market Trends (Drivers, Constraints, Opportunities, Threats, Challenges, Investment Opportunities, and recommendations)
- Strategic recommendations in key business segments based on the market estimations
- Competitive landscaping mapping the key common trends
- Company profiling with detailed strategies, financials, and recent developments
- Supply chain trends mapping the latest technological advancements


1 Executive Summary
2 Preface
2.1 Abstract
2.2 Stake Holders
2.3 Research Scope
2.4 Research Methodology
2.4.1 Data Mining
2.4.2 Data Analysis
2.4.3 Data Validation
2.4.4 Research Approach
2.5 Research Sources
2.5.1 Primary Research Sources
2.5.2 Secondary Research Sources
2.5.3 Assumptions
3 Market Trend Analysis
3.1 Introduction
3.2 Drivers
3.3 Restraints
3.4 Opportunities
3.5 Threats
3.6 Product Analysis
3.7 Technology Analysis
3.8 Application Analysis
3.9 Emerging Markets
3.10 Impact of Covid-19
4 Porters Five Force Analysis
4.1 Bargaining power of suppliers
4.2 Bargaining power of buyers
4.3 Threat of substitutes
4.4 Threat of new entrants
4.5 Competitive rivalry
5 Global Cryo-Electron Microscopy Market, By Product Type
5.1 Introduction
5.2 Instruments
5.2.1 Fully Automated
5.2.2 Semi-automated
5.3 Software
5.4 Services
5.5 Other Product Types
6 Global Cryo-Electron Microscopy Market, By Method
6.1 Introduction
6.2 Cryo-electron Tomography
6.3 Electron Crystallography
6.4 Single Particle Analysis (SPA)
6.5 Other Methods
7 Global Cryo-Electron Microscopy Market, By Nano Formulations
7.1 Introduction
7.2 Lipid Nanoparticle Formulations (LNFS)
7.3 Metal Oxide Formulations
7.4 Metal Formulations
7.5 Other Nano Formulations
8 Global Cryo-Electron Microscopy Market, By Voltage
8.1 Introduction
8.2 300 kV
8.3 200 kV
8.4 120 kV
9 Global Cryo-Electron Microscopy Market, By Technology
9.1 Introduction
9.2 Transmission Electron Microscopy (TEM)
9.3 Scanning Electron Microscopy (SEM)
9.4 Nuclear Magnetic Resonance (NMR) Microscopy
9.5 Other Technologies
10 Global Cryo-Electron Microscopy Market, By Application
10.1 Introduction
10.2 Life Science Research and Academia
10.3 Cancer Research
10.4 Omics Research
10.5 Pharma and Biotech Manufacturing
10.6 Cell and Gene Therapy
10.7 Pathology
10.8 Preclinical and Clinical Research
10.9 Healthcare/Medical Applications
10.10 Disease Diagnosis and Pathology
10.11 Toxicology Studies
10.12 Material Analysis
10.13 Nanotechnology
10.14 Clinical Trials
10.15 Other Applications
11 Global Cryo-Electron Microscopy Market, By Geography
11.1 Introduction
11.2 North America
11.2.1 US
11.2.2 Canada
11.2.3 Mexico
11.3 Europe
11.3.1 Germany
11.3.2 UK
11.3.3 Italy
11.3.4 France
11.3.5 Spain
11.3.6 Rest of Europe
11.4 Asia Pacific
11.4.1 Japan
11.4.2 China
11.4.3 India
11.4.4 Australia
11.4.5 New Zealand
11.4.6 South Korea
11.4.7 Rest of Asia Pacific
11.5 South America
11.5.1 Argentina
11.5.2 Brazil
11.5.3 Chile
11.5.4 Rest of South America
11.6 Middle East & Africa
11.6.1 Saudi Arabia
11.6.2 UAE
11.6.3 Qatar
11.6.4 South Africa
11.6.5 Rest of Middle East & Africa
12 Key Developments
12.1 Agreements, Partnerships, Collaborations and Joint Ventures
12.2 Acquisitions & Mergers
12.3 New Product Launch
12.4 Expansions
12.5 Other Key Strategies
13 Company Profiling
13.1 Charles River Laboratories
13.2 Hitachi High-Technologies Corporation
13.3 Intertek Group Plc
13.4 Caliber Imaging & Diagnostics
13.5 Lasertec Corporation
13.6 HORIBA, Ltd
13.7 Olympus Corporation
13.8 Gatan, Inc.
13.9 JEOL Ltd
13.10 Oxford Instruments
13.11 Nikon Instruments Inc
13.12 Keyence Corporation
13.13 Helmut Hund Gmbh
13.14 Danaher
13.15 Creative Biostructure
13.16 ZEISS International
13.17 Thermo Fisher Scientific
List of Tables
Table 1 Global Cryo-Electron Microscopy Market Outlook, By Region (2022-2030) ($MN)
Table 2 Global Cryo-Electron Microscopy Market Outlook, By Product Type (2022-2030) ($MN)
Table 3 Global Cryo-Electron Microscopy Market Outlook, By Instruments (2022-2030) ($MN)
Table 4 Global Cryo-Electron Microscopy Market Outlook, By Fully Automated (2022-2030) ($MN)
Table 5 Global Cryo-Electron Microscopy Market Outlook, By Semi-automated (2022-2030) ($MN)
Table 6 Global Cryo-Electron Microscopy Market Outlook, By Software (2022-2030) ($MN)
Table 7 Global Cryo-Electron Microscopy Market Outlook, By Services (2022-2030) ($MN)
Table 8 Global Cryo-Electron Microscopy Market Outlook, By Other Product Types (2022-2030) ($MN)
Table 9 Global Cryo-Electron Microscopy Market Outlook, By Method (2022-2030) ($MN)
Table 10 Global Cryo-Electron Microscopy Market Outlook, By Cryo-electron Tomography (2022-2030) ($MN)
Table 11 Global Cryo-Electron Microscopy Market Outlook, By Electron Crystallography (2022-2030) ($MN)
Table 12 Global Cryo-Electron Microscopy Market Outlook, By Single Particle Analysis (SPA) (2022-2030) ($MN)
Table 13 Global Cryo-Electron Microscopy Market Outlook, By Other Methods (2022-2030) ($MN)
Table 14 Global Cryo-Electron Microscopy Market Outlook, By Nano Formulations (2022-2030) ($MN)
Table 15 Global Cryo-Electron Microscopy Market Outlook, By Lipid Nanoparticle Formulations (LNFS) (2022-2030) ($MN)
Table 16 Global Cryo-Electron Microscopy Market Outlook, By Metal Oxide Formulations (2022-2030) ($MN)
Table 17 Global Cryo-Electron Microscopy Market Outlook, By Metal Formulations (2022-2030) ($MN)
Table 18 Global Cryo-Electron Microscopy Market Outlook, By Other Nano Formulations (2022-2030) ($MN)
Table 19 Global Cryo-Electron Microscopy Market Outlook, By Voltage (2022-2030) ($MN)
Table 20 Global Cryo-Electron Microscopy Market Outlook, By 300 kV (2022-2030) ($MN)
Table 21 Global Cryo-Electron Microscopy Market Outlook, By 200 kV (2022-2030) ($MN)
Table 22 Global Cryo-Electron Microscopy Market Outlook, By 120 kV (2022-2030) ($MN)
Table 23 Global Cryo-Electron Microscopy Market Outlook, By Technology (2022-2030) ($MN)
Table 24 Global Cryo-Electron Microscopy Market Outlook, By Transmission Electron Microscopy (TEM) (2022-2030) ($MN)
Table 25 Global Cryo-Electron Microscopy Market Outlook, By Scanning Electron Microscopy (SEM) (2022-2030) ($MN)
Table 26 Global Cryo-Electron Microscopy Market Outlook, By Nuclear Magnetic Resonance (NMR) Microscopy (2022-2030) ($MN)
Table 27 Global Cryo-Electron Microscopy Market Outlook, By Other Technologies (2022-2030) ($MN)
Table 28 Global Cryo-Electron Microscopy Market Outlook, By Application (2022-2030) ($MN)
Table 29 Global Cryo-Electron Microscopy Market Outlook, By Life Science Research and Academia (2022-2030) ($MN)
Table 30 Global Cryo-Electron Microscopy Market Outlook, By Cancer Research (2022-2030) ($MN)
Table 31 Global Cryo-Electron Microscopy Market Outlook, By Omics Research (2022-2030) ($MN)
Table 32 Global Cryo-Electron Microscopy Market Outlook, By Pharma and Biotech Manufacturing (2022-2030) ($MN)
Table 33 Global Cryo-Electron Microscopy Market Outlook, By Cell and Gene Therapy (2022-2030) ($MN)
Table 34 Global Cryo-Electron Microscopy Market Outlook, By Pathology (2022-2030) ($MN)
Table 35 Global Cryo-Electron Microscopy Market Outlook, By Preclinical and Clinical Research (2022-2030) ($MN)
Table 36 Global Cryo-Electron Microscopy Market Outlook, By Healthcare/Medical Applications (2022-2030) ($MN)
Table 37 Global Cryo-Electron Microscopy Market Outlook, By Disease Diagnosis and Pathology (2022-2030) ($MN)
Table 38 Global Cryo-Electron Microscopy Market Outlook, By Toxicology Studies (2022-2030) ($MN)
Table 39 Global Cryo-Electron Microscopy Market Outlook, By Material Analysis (2022-2030) ($MN)
Table 40 Global Cryo-Electron Microscopy Market Outlook, By Nanotechnology (2022-2030) ($MN)
Table 41 Global Cryo-Electron Microscopy Market Outlook, By Clinical Trials (2022-2030) ($MN)
Table 42 Global Cryo-Electron Microscopy Market Outlook, By Other Applications (2022-2030) ($MN)
Note: Tables for North America, Europe, APAC, South America, and Middle East & Africa Regions are also represented in the same manner as above.

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