Organs-on-Chips Market by Type of Product (organ based and disease based), Type of Organ (single organ based and multi organ based), Type of Single Organ based Model (liver, lung, brain, heart, intestine, kidney and other organs), Type of Material of Cons

ORGANS-ON-CHIPS MARKET

As per Roots Analysis, the global organ on a chip market size is estimated to grow from USD 77 million in the current year to USD 944 million by 2035, at a CAGR of 25. 6% during the forecast period, till 2035.

The opportunity for organ on a chip market has been distributed across the following segments:

Type of Product

Organ based

Disease based

Type of Organ

Single organ based

Multi organ based

Type of Single Organ based Model

Liver

Lung

Brain

Heart

Intestine

Kidney

Other organs

Type of Material of Construction

Polydimethylsiloxane

Other polymer

Glass

Others

Purpose

Research

Therapeutic

Application Area

Drug discovery / toxicity testing

Cancer research

Stem cell research

Tissue engineering / regenerative medicine

Others

End User

Pharmaceutical and biotech companies

Academic and research players

Cosmetic industry players

Other end users

Key Geographical Regions

North America

Europe

Asia-Pacific

Latin America

Middle East and North Africa

Leading Players

ORGANS-ON-CHIPS MARKET: GROWTH AND TRENDS

Organ-on-chips are the miniature copies of the vital human organs (such as, liver, lungs, kidneys, intestines, and other vital organs) that have been developed by researchers / start-ups for several medical research and therapy development purposes. These miniature copies are remodeled using microfabrication techniques and have chambers with live cells (continually perfused with cell culture media) that mimic the physio-chemical microenvironment of tissues in the human body.

According to research, 1 out of 1,000 drug candidates proceed to clinical trials post preclinical testing. Of these, 90% of the candidates fail to enter the market, primarily due to the lack of efficacy / unforeseen toxicity observed during the clinical trials and the limitation of animal based preclinical models to precisely predict human responses (owing to the difficulty in mimicking the exact and intricate human biology / mechanisms). Therefore, to address these issues / limitations and in an effort to reduce the healthcare burden due to drug failures, several researchers are striving to adopt alternative testing methods, such as organ-on-a-chip technology. Currently, 75 integrated organ-on-chip technologies and models are available in the market, offering distinct advantages over the traditional cell culture and animal-based testing methods, such as enhanced accuracy in predicting physiological responses like humans, high in vivo replicability, reduced trial costs and dependency on animal models.

Driven by these benefits and the interest of industry stakeholders, the adoption of these advanced models in the R&D of novel drugs and ADME toxicology testing is steadily increasing and is anticipated to improve the success rates of drugs in clinical trials. Moreover, as the global organ-on-chip market matures, the development and application of these models will expand, driving innovation and positioning the market for steady growth in the forthcoming years.

ORGANS-ON-CHIPS MARKET: KEY INSIGHTS

The report delves into the current state of the organs-on-chips market and identifies potential growth opportunities within the industry. Some key findings from the report include:

1. More than 70 organ-on-chip technologies and models have been launched / approved or are currently under development; the market landscape features the presence of both established players and new entrants.

2. Majority of the technologies and models support both organ-based and disease-based applications; of these, 98% of the technologies / models are preferred for drug discovery and toxicity testing studies.

3. Presently, 25 players (established players as well as start-ups) claim to provide organ-on-chips and plates; more than 60% of these firms have been established post-2013.

4. Over 50% of organ-on-chips products are microfluidic plates; interestingly, majority of these chips and plates are constructed from polymers due to their flexibility and moldability.

5. More than 600 patents related to organ-on-chip have been filed / granted by industry and non-industry stakeholders, indicating a growing intellectual capital in the domain.

6. The growing interest of stakeholders is evident from the increasing partnership activities; technology / product utilization agreements emerged as the most prevalent partnership model adopted by organ-on-chip providers.

7. Close to 350 grants have been awarded for ongoing research and development efforts for organ-on-chip products and technologies; National Center for Advancing Translational Sciences has awarded the maximum grant amount.

8. Since 2017, over USD 350 million have been invested by several investors across various funding rounds, thereby presenting lucrative growth opportunities within this emerging segment.

9. In recent years, stakeholders have established strong brand positions to cater to the increasing demand for organ-on-chips; several players have introduced efficient, easy to use, and advanced products.

10. The growing demand for animal free testing and advancements in microfluidics has emerged as key driving factors supporting the rapid evolution of the organ-on-chip market.

11. Owing to the ability of organ-on-chips to provide animal free testing models and substantially reduce the costs associated with drug testing, the market is anticipated to witness a growth of 25. 6% over the next decade.

ORGANS-ON-CHIPS MARKET: KEY SEGMENTS

Disease-based Model is the Fastest Growing Segment of the Organs-on-Chips Market

Based on the type of product, the global market for organs-on-chips is segmented into organ based and disease-based models. Currently, majority share of the organ-on-chip market is captured by organ-based models. It is worth mentioning that the disease-based model segment is likely to grow at a higher CAGR (around 27%) in the coming years.

Organ-on-Chip Products Supporting Single Organ-based Models are Likely to Dominate the Organs-on-Chips Market During the Forecast Period

Based on the type of organ, the global organs-on-chips market is distributed across single organ and multi organ-based models. Whilst the organs-on-chip products supporting single organ-based models hold the majority of the market share, it is worth noting that organ-on-chip market for multi-organ-based models is likely to grow at a relatively higher CAGR during the forecast period. This can be attributed to the capability of multi-organ models to efficiently track metabolic pathways and assess organ-organ crosstalk.

Liver-on-a-Chip Models are Likely to Hold the Largest Share of the Organs-on-Chips Market During the Forecast Period

Based on the type of single organ-based model, the global market is segmented into liver, lung, brain, heart, intestine, kidney and other organs-based models. Currently, the liver-on-a-chip models are likely to dominate and drive the overall market growth. It is worth noting that the lung, brain, and heart-on-a-chip models are likely to flourish during the forecast period. This can be attributed to the ability of these models to mimic the exact and intricate human biology / mechanisms.

Organs-on-Chips Market for Other Polymers is Likely to Grow at a Relatively Faster Pace During the Forecast Period

Based on the type of material, the global market value is segmented across polydimethylsiloxane (PDMS), other polymers, glass and other materials. Notably, owing to the high flexibility, transparency and gas permeability of PDMS, it is likely to dominate the organs-on-chips market during the forecast period.

Organs-On-Chips Market for Therapeutic Purposes is Likely to Grow at a Higher CAGR During the Forecast Period

Based on purpose, the global market is segmented into research and therapeutic purposes. Currently, organ-on-chips focussed on research purposes hold a larger share of the overall market. However, this trend is likely to change during the forecast period due to the expanding application of such chips across multiple therapeutic areas.

By Application Area, Organs-on-Chips for Cancer Research are Likely to Dominate the Market During the Forecast Period

Based on the application area, the global market for organs on chips is distributed across drug discovery and toxicity testing, cancer research, stem cell research and tissue engineering and regenerative medicines. Whilst the organs-on-chip models and plates for cancer research will be the primary drivers of the overall market, it is worth highlighting that the market for organ-on-chips models used in stem cell research and tissue engineering is likely to grow at a relatively higher CAGR.

Currently, Pharmaceutical and Biotech Companies Hold the Largest Share of the Organs-On-Chips Market

Based on end users, the global market is segmented into pharmaceutical and biotech companies, academic and research players, cosmetic industry players, and other end users. Currently, pharmaceutical and biotech companies hold the largest market share. However, organ-on-chip market for cosmetic industry is expected to witness substantial growth in the coming years.

North America Accounts for the Largest Share of the Market

Based on key geographical regions, the market is segmented into North America, Europe, Asia-Pacific, Latin America and Middle East and North Africa. In the current scenario, North America is likely to capture the largest market share. However, owing to the ban on animal model testing in European countries, the organ-on-chip market in Europe is expected to grow at a higher CAGR during the forecast period.

Example Players in the Organs-on-Chips Market

4DCell

Aim biotech

Beonchip

Bi/ond

CN BIO

Emulate

InSphero

Jiksak Bioengineering

Kirkstall

Lena Biosciences

Merck Millipore

MesoBio Tech

MicroBrain Biotech

Mimetas

Numa Biosciences

Qureator

SynVivo

TissUse

Visikol

Xona microfluidics

Primary Research Overview

The opinions and insights presented in this study were influenced by discussions conducted with multiple stakeholders. The research report features detailed transcripts of interviews held with the following industry stakeholders:

Chief Executive Officer, Small Company, US

Chief Executive Officer, Mid-sized Company, France

Chief Executive Officer, Small Company, South Korea

Chief Executive Officer, Small Company, Italy

Chief Executive Officer, Small Company, Scotland

Chief Technology Officer, Mid-sized Company, The Netherlands

Chief Business Development Officer, Mid-sized Company, France

President, Mid-sized Company, US

ORGANS-ON-CHIPS MARKET: RESEARCH COVERAGE

The report on Organs-on-Chips Market features insights on various sections, including:

Market Sizing and Opportunity Analysis: An in-depth analysis of the organ-on-chip market, focusing on key market segments, including [A] type of product, [B] type of organ, [C] type of single organ-based model, [D] type of material of construction, [E] purpose, [F] application area, [G] end user, [H] key geographical regions and [I] leading players.

Market Impact Analysis: A thorough analysis of various factors, such as drivers, restraints, opportunities, and existing challenges that are likely to impact market growth.

Organ-on-Chip Technologies and Models Market Landscape: A comprehensive evaluation of organ-on-chips and plates, based on several relevant parameters, such as [A] type of model, [B] compatible organ, and [C] application area.

Organ-on-Chip Technologies and Models Developer Landscape: The report features a list of players engaged in the development of organ-on-chips and plates offered, along with analyses based on [A] year of establishment, [B] company size, [C] location of headquarters and [D] leading technology providers.

Organ-on-Chip and Plates Market Landscape: A comprehensive evaluation of organ-on-chips and plates, based on several relevant parameters, such as [A] type of product, [B] type of model, [C] compatible organs, [D] application area, [E] material of construction, [F] type of polymer and [G] status of development.

Organ-on-Chip and Plates Developer Landscape: The report features a list of players engaged in the development of organ-on-chips and plates offered, along with analyses based on [A] year of establishment, [B] company size, [C] location of headquarters and [D] leading chips and plate providers.

Company Profiles: In-depth profiles of key industry players offering big data analytics solutions across various geographies, focusing on [A] company overviews, [B] financial information (if available), [C] organ-on-chip portfolio, [D] recent developments and [E] an informed future outlook.

Patents Analysis: An in-depth analysis of patents filed / granted till date in the organ-on-chip domain, based on various relevant parameters, such as [A] type of patent, [B] publication year, [C] application year, [D] patent jurisdiction, [E] CPC symbols, [F] type of applicant, [G] patent age, [H] leading inventors, [I] leading industry and non-industry players, [J] patent benchmarking, and [K] patent valuation analysis.

Brand Positioning Analysis: A detailed analysis of the [A] organ-on-chip technology and model providers and [B] organ-on-chips and plate providers, highlighting the current perceptions regarding their proprietary technologies, models, chips and plates by taking into consideration several relevant aspects, such as portfolio strength, portfolio diversity, years of experience, and company size.

Academic Grants Analysis: A comprehensive assessment of grants that have been awarded to research institutes in the organ-on-chip domain, based on various relevant parameters, such as [A] year of award, [B] amount awarded, [C] administering institute center, [D] support period, [E] type of grant application, [F] purpose of grant, [G] activity code, [H] emerging focus area, [I] study section involved, [J] popular NIH departments, [K] type of recipient organization, [L] leading recipient organizations and [M] location of recipient organization.

Partnerships and Collaborations: An insightful analysis of the deals inked by stakeholders in organs-on-chips market, based on several parameters, such as [A] year of partnership, [B] type of partnership, [C] type of organ, [D] geographical regions, [E] purpose of partnership, [F] most active players and [G] geographical distribution of partnership activity.

Funding and Investment Analysis: An in-depth analysis of the fundings raised by organ on a chip companies, based on relevant parameters, such as [A] year of funding, [B] type of funding, [C] amount invested (USD million), [D] purpose of funding, [E] associated organ / system, [F] therapeutic area, [G] geographical area, and [H] most active players.

Case Study: A detailed assessment of scaffold-free 3D cell culture products, featuring a list of more than 60 products that are being used for research and pharmaceutical testing, based on a number of relevant parameters, such as [A] status of development, [B] type of system, [C] type of product and [D] material used for fabrication.

KEY QUESTIONS ANSWERED IN THIS REPORT

How many companies are currently engaged in this market?

Which are the leading companies in this market?

What factors are likely to influence the evolution of this market?

What is the current and future market size?

What is the CAGR of this market?

How is the current and future market opportunity likely to be distributed across key market segments?

What kind of partnership models are commonly adopted by industry stakeholders?

What is the ongoing investment trend in this market?

What is the patent filing activity trend in the market?

REASONS TO BUY THIS REPORT

The report provides a comprehensive market analysis, offering detailed revenue projections of the overall market and its specific sub-segments. This information is valuable to both established market leaders and emerging entrants.

Stakeholders can leverage the report to gain a deeper understanding of the competitive dynamics within the market. By analyzing the competitive landscape, businesses can make informed decisions to optimize their market positioning and develop effective go-to-market strategies.

The report offers stakeholders a comprehensive overview of the market, including key drivers, barriers, opportunities, and challenges. This information empowers stakeholders to stay abreast of market trends and make data-driven decisions to capitalize on growth prospects.

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