Next Generation Sequencing (NGS) Kits Market, 2021-2035

Next Generation Sequencing (NGS) Kits Market, 2021-2035

INTRODUCTION

The field of genomic data collection and analysis has evolved significantly since the introduction of a gene sequencing method by Frederick Sanger in 1977. Advances in DNA sequencing technologies have led to significant developments in a variety of healthcare-focused research fields, such as precision medicine and diagnostics. Particularly, the impact of next generation sequencing (NGS) methods, enabling whole genome and whole exome sequencing, has been the most profound. This high throughput, parallel genome sequencing technology has greatly reduced the overall cost and time investment. In fact, compared to the Human Genome Project (~USD 3 billion), the cost of sequencing a single genome has decreased considerably (to USD 1,000), for currently available technologies. , Given the ongoing innovation in this field, stakeholders further believe that, over the next decade, the aforementioned cost may further get reduced to USD 100. It is worth mentioning that this decrease in genome sequencing cost has led to an increase in the number of genomes being sequenced, across the globe.

Despite the recent advances in the field of genomics, the nucleotide library preparation process is still marred with several challenges, including requirement of large amounts of input samples, low volume of yield and concerns related to quality of the product. In addition, the manual DNA / RNA library preparation process is time consuming, requiring extensive manipulation and expensive reagents. , Therefore, innovators in the pharmaceutical industry are constantly identifying / developing ways to improve the process of DNA / RNA library preparation. Amidst other alternatives, the use of NGS library preparation kits has emerged as a viable option for various drug developers and academic / research institutes to overcome the existing challenges associated with conventional DNA / RNA library preparation methods. These kits require less input material and are capable of generating precise DNA / RNA libraries with minimum errors. Presently, more than 280 NGS library preparation kits are available in the market; these are compatible with a broad range of sequencing platforms, including Illumina®, Ion Torrent® and BGI NGS platforms. It is worth mentioning that over 3,200 patents related to NGS library preparation kits have been filed / granted in the past few years, demonstrating the continued innovation in this domain. Driven by the increasing demand for gene therapies and the introduction of novel and advanced NGS techniques, the NGS library preparation kits market is anticipated to witness steady growth in the coming years.

SCOPE OF THE REPORT

The “Next Generation Sequencing (NGS) Kits Market: Distribution by Type of Nucleotide Sequenced (DNA and RNA), Type of End User (Academic and Research Institutes, Pharmaceutical and Biotechnology Companies, Hospitals and Clinics, and Others) and Key Geographies (North America, Europe, Asia Pacific, Latin America, Middle East and North Africa, and Rest of the World) – Industry Trends and Global Forecasts, 2021-2035” report features an extensive study of the current market landscape and future potential of NGS library preparation kits over the next decade. The study features an in-depth analysis of the key drivers and trends related to this domain. Amongst other elements, the report includes:

A detailed assessment of the current market landscape of NGS library preparation kits, featuring information on the type of nucleotide sequenced (DNA and RNA), kit components (control total RNA / DNA, adapters, primers, enzyme mixes, buffers, RNA / DNA probes and others), quantity of sample required (less than 5 ng, 5 ng to 10 ng and more than 10 ng), turnaround time (less than 5 hours, 5 hours to 10 hours and more than 10 hours), storage temperature (deep freeze, cold and room temperature), type of sample used (purified RNA / DNA, plasma, serum, urine, cells, blood, saliva and others), kit shelf life (0.5 year and 1 year), type of sequencing (whole genome sequencing, targeted sequencing, transcriptome sequencing, RNA sequencing, ChIP sequencing, exome sequencing, bisulphite sequencing, methyl sequencing, amplicon sequencing, de novo sequencing, resequencing and shotgun sequencing) and type of sequencing platform used (Illumina, BGI, Ion Torrent, Fluidigm and Oxford Nanopore Technologies). In addition, the chapter features analysis related to NGS library preparation kit providers based on parameters, such as year of establishment, company size, location of headquarters and leading players (in terms of number of products).

A competitiveness analysis of NGS library preparation kits based on various relevant parameters, namely supplier power (based on the experience of the developer) and product competitiveness (based on parameters, including type of nucleotide sequenced, kit components, quantity of sample required, turnaround time, type of sample used, kit shelf life, type of sequencing and type of sequencing platform used).

Elaborate profiles of prominent players offering NGS library preparation kits, based in North America, Europe and Asia Pacific. Each profile features a brief overview of the company, details related to its financials (if available), product portfolio, recent developments and an informed future outlook.

An in-depth analysis of the various patents that have been filed / granted related to NGS library preparation kits and reagents, from January 2020 to October 2021, taking into consideration parameters, such as publication year, geographical region, CPC symbols, patent focus areas, type of applicant and leading players (in terms of size of intellectual property portfolio). It also includes a patent benchmarking analysis and a detailed valuation analysis.

A case study on the history and evolution of genome sequencing with details on first, second and third generation sequencing platforms. The chapter includes information on the NGS technologies that are available till date. Further, it presents information on the various NGS service providers (industry and non-industry players) that are engaged in providing whole genome, whole exome and targeted sequencing services.

One of the key objectives of the report was to estimate the existing market size and identify potential growth opportunities for NGS library preparation kits over the coming decade. We have provided an informed estimate on the likely evolution of the market over the period 2021-2035. The report features sales forecasts for the overall NGS library preparation kits market, wherein both the current and upcoming opportunity is segmented across [A] type of nucleotide sequenced (DNA and RNA), [B] type of end user (academic and research institutes, pharmaceutical and biotechnology companies, hospitals and clinics, and others) and [C] key geographies (North America, Europe, Asia Pacific, Middle East and North Africa, Latin America and Rest of the world). In order to account for future uncertainties and to add robustness to our model, we have provided three market forecast scenarios, namely conservative, base and optimistic scenarios, representing different tracks of the industry’s growth.

RESEARCH METHODOLOGY

The data presented in this report has been gathered via secondary and primary research. For all our projects, we conduct interviews / surveys with experts in the area (academia, industry and other associations) to solicit their opinions on emerging trends in the market. This is primarily useful for us to draw out our own opinion on how the market will evolve across different regions and segments. Where possible, the available data has been checked for accuracy from multiple sources of information.

The secondary sources of information include:

Annual reports

Investor presentations

SEC filings

Industry databases

News releases from company websites

Government policy documents

Industry analysts’ views

All actual figures have been sourced and analyzed from publicly available information forums and primary research discussions. Financial figures mentioned in this report are in USD, unless otherwise specified.

KEY QUESTIONS ANSWERED

Who are the key players engaged in offering NGS library preparation kits?

What is the relative competitiveness of different NGS library preparation kits?

How is the intellectual property landscape for next generation sequencing kits likely to evolve in the foreseen future?

What are the factors that are likely to influence the evolution of this market?

How is the current and future market opportunity likely to be distributed across key segments?

CHAPTER OUTLINES

Chapter 2 is an executive summary of the key insights captured in our report. It offers a high-level view of the current state of NGS library preparation kits market and its likely evolution in the short term, mid-term, and long term.

Chapter 3 provides a general overview of genome sequencing and its different types, including whole genome sequencing, whole exome sequencing, targeted sequencing, epigenetics, metagenomics and RNA sequencing. Further, the chapter features an elaborate discussion on NGS, along with its advantages and applications in the pharmaceutical industry. Furthermore, it provides information on the various steps involved in NGS procedure. The chapter also includes the NGS kit components that are currently available in the market.

Chapter 4 provides a comprehensive review of the current market landscape of NGS library preparation kits, featuring information on the type of nucleotide sequenced (DNA and RNA), kit components (control total RNA / DNA, adapters, primers, enzyme mixes, buffers, RNA / DNA probes and others), quantity of sample required (less than 5 ng, 5 ng to 10 ng and more than 10 ng), turnaround time (less than 5 hours, 5 hours to 10 hours and more than 10 hours), storage temperature (deep freeze, cold and room temperature), type of sample used (purified RNA / DNA, plasma, serum, urine, cells, blood, saliva and others), kit shelf life (0.5 year and 1 year), type of sequencing (whole genome sequencing, targeted sequencing, transcriptome sequencing, RNA sequencing, ChIP sequencing, exome sequencing, bisulphite sequencing, methyl sequencing, amplicon sequencing, de novo sequencing, resequencing and shotgun sequencing) and type of sequencing platform used (Illumina, BGI, Ion Torrent, Fluidigm and Oxford Nanopore Technologies). In addition, the chapter features analysis related to NGS library preparation kit providers, based on parameters, such as year of establishment, company size, location of headquarters and leading players (in terms of number of products).

Chapter 5 presents a detailed competitiveness analysis of NGS library preparation kits, based on various relevant parameters, namely supplier power (based on the experience of the developer) and product competitiveness (based on parameters, including type of nucleotide sequenced, kit components, quantity of sample required, turnaround time, type of sample used, kit shelf life, type of sequencing and type of sequencing platform used).

Chapter 6 features detailed profiles of the prominent companies that offer NGS library preparation kits in North America. Each company profile features a brief overview of the company, details related to its financials (if available), NGS kit portfolio, recent developments and an informed future outlook.

Chapter 7 features detailed profiles of the prominent companies that offer NGS library preparation kits in Europe. Each company profile features a brief overview of the company, details related to its financials (if available), NGS kit portfolio, recent developments and an informed future outlook.

Chapter 8 features detailed profiles of the prominent companies that offer NGS library preparation kits in Asia Pacific. Each company profile features a brief overview of the company, details related to its financials (if available), NGS kit portfolio, recent developments and an informed future outlook.

Chapter 9 provides an in-depth patent analysis to provide an overview of how the industry is evolving from the R&D perspective. For this analysis, we considered those patents that have been filed / granted related to NGS library preparation kits and reagents, from January 2020 to October 2021, taking into consideration parameters, such as publication year, geographical region, CPC symbols, patent focus areas, type of applicant and leading industry players (in terms of size of intellectual property portfolio). It also includes a patent benchmarking analysis and a detailed valuation analysis.

Chapter 10 presents a comprehensive market forecast analysis, highlighting the future potential of the market till 2035. We have segregated the current and upcoming opportunity based on [A] type of nucleotide sequenced (DNA and RNA), [B] type of end user (academic and research institutes, pharmaceutical and biotechnology companies, hospitals and clinics, and others) and [C] key geographies (North America, Europe, Asia Pacific, Middle East and North Africa, Latin America and Rest of the world). It is worth mentioning that we adopted a top-down approach for this analysis, backing our claims with relevant datapoints and credible inputs from primary research.

Chapter 11 presents a detailed case study on the history and evolution of genome sequencing with details on first, second and third generation sequencing platforms. The chapter includes information on the NGS technologies that are available till date. Further, it presents information on the various NGS service providers (industry and non-industry players) that are engaged in providing whole genome, whole exome and targeted sequencing services.

Chapter 12 summarizes the overall report. In this chapter, we have provided a list of key takeaways from the report, and expressed our independent opinion related to the research and analysis described in the previous chapters.

Chapter 13 is a collection of interview transcripts of the discussions held with key stakeholders in this market. In this chapter, we have presented the details of interview held with Len Goren (General Manager, Tecan).

Chapter 14 is an appendix, which provides tabulated data and numbers for all the figures provided in the report.

Chapter 15 is an appendix, which contains the list of companies and organizations mentioned in the report.