MarketVue®: Tardive Dyskinesia (TD)
The MarketVue®: Tardive Dyskinesia (TD) market landscape report combines primary (KOL interviews and survey data) and secondary market research to empower strategic decision-making and provide a complete view of the market.
Every MarketVue® includes a disease overview, epidemiology (US and EU5), current treatment, unmet needs, pipeline and access and reimbursement chapter.
Topics covered in this report:• Disease overview: Review the disease pathophysiology and potential druggable targets
• Epidemiology: Understand prevalence, diagnosed and drug-treated prevalence of the population and key market segments
• Current treatment: Understand the treatment decision tree and strengths and weaknesses of current on-label and off-label treatment
• Unmet needs: Identify opportunities to address treatment or disease management gaps
• Pipeline analysis: Compare current and emerging therapy clinical development strategy; their performance on efficacy, safety, and delivery metrics; and their potential to address unmet needs
• Value and access: Review the evidence needed to assess and communicate value to key stakeholders (e.g., providers, payers, regulators) and learn what competitors have done or are doing
Methodology:Research for the MarketVue®: Tardive Dyskinesia (TD) report is supported by 7 qualitative interviews with key opinion leaders, a quantitative survey with 24 U.S. physicians and secondary research.
Geographies covered:United States plus epidemiology for EU5 (France, Germany, Italy, Spain, United Kingdom)
Key companies mentioned:• Teva Pharmaceuticals
• Neurocrine Biosciences
• Luye Pharma Group
Key drugs mentioned:• Deutetrabenazine (Austedo)
• Valbenazine (Ingrezza)
• Clonazepam (Klonopin, Rivotril)
• Botulinum toxin injections (Botox)
• Reserpine (Serpasil)
• Tetrabenazine (Nitoman, Xenazine)
• LY03015
• Acamprosate calcium
• Sarizotan
Key takeaways from the report:
Tardive dyskinesia (TD) is a medication-induced neurological disorder which disrupts patients’ quality of life with complications that include:
• Tapping or shaking of the fingers and hands
• Puckering and frowning of the mouth and darting tongue
• Rapid or constant blinking
• Movements of the trunk
According to TD experts interviewed by REACH, most TD patients are well-controlled with one of the two FDA-approved VMAT2 inhibitors. Austedo and Ingrezza are viewed as comparable options due to their similar efficacy, side effect profiles, and now, dosing convenience with the introduction of Austedo extended-release tablets. Consequently, individual physician preference is driven most often by prior experience and familiarity with a drug.
Psychiatrist, U.S.: “I mean it’s amazing to see what they [VMAT2 inhibitors] can do to people who had suffered for many years and whose lives had been very much destroyed by [TD].”
The report indicates that given the success of Austedo and Ingrezza, clinicians do not perceive a high unmet need for novel TD treatments, which is also reflected in the sparse TD pipeline. However, experts say they have observed a rise in prescriptions for dopamine receptor blocking agents beyond use in schizophrenia, expanding to wider use in other conditions:
• Major depressive disorder
• Bipolar disorder
• Gastroparesis
• Behavior conditions (e.g., autism)
This suggests a potential surge in TD cases in the future which underscores the growing demand for efficacious medications that avoid directly inhibiting the dopamine pathway, working to effectively prevent TD.
Psychiatrist, U.S.: “The future is not treating TD. I think the future is not inducing it… we may solve the problem by just not having drugs that cause the problem to begin with.”
Please note: the online download version of this report is for a global site license.