US Organoids and Spheroids Market Size, Share, Trends, Industry Analysis Report: By Type (Organoids and Spheroids), Application, and End Use; Market Forecast, 2025–2034

US Organoids and Spheroids Market Size, Share, Trends, Industry Analysis Report: By Type (Organoids and Spheroids), Application, and End Use; Market Forecast, 2025–2034

The US organoids and spheroids market size is expected to reach USD 2,488.22 million by 2034, according to a new study by Polaris Market Research. The report “US Organoids and Spheroids Market Size, Share, Trends, Industry Analysis Report: By Type (Organoids and Spheroids), Application, and End Use; Market Forecast, 2025–2034” gives a detailed insight into current market dynamics and provides analysis on future market growth.

An increasing number of biotechnology companies focused on therapeutic development and disease mechanism research drives the US organoids and spheroids market growth. As the prevalence of chronic health issues continues to rise across the country, there is a heightened need for innovative research methodologies to understand these conditions better. Organoids and spheroids provide valuable models for studying disease dynamics and testing potential treatments, fueling biotechnological research activities. Consequently, increasing research activities in the biotechnology segment is expected to boost the US organoids and spheroids market growth in the coming years.

Ongoing research into tissue models to better understand disease dynamics is expected to propel the growth of the US organoids and spheroids market significantly. The increasing incidence of abnormal organ development in infants highlights the urgent need for effective healthcare screening models. Approximately 30% of newborns with congenital diaphragmatic hernia are anticipated to face severe challenges, often resulting in prolonged hospital stays. This alarming statistic underscores the necessity for innovative disease detection methods, motivating researchers to develop advanced organoid and spheroid technologies that can enhance early diagnosis and treatment strategies.

The rising incidence of opioid use disorders is underscoring the critical role of spheroids in drug research and development. According to the World Drug Report 2023 by the United Nations Office on Drugs and Crime (UNODC), opioid consumption in India among individuals aged 10 to 75 ranges from 0.2% to 25.2%, with opioid disorders affecting ∼0.1% to 6.9% of the population. This alarming trend is driving innovative research in drug discovery. A November 2023 study published in Communications Biology explored a brain-regional-specific model using spheroids to investigate neurological diseases, including opioid use disorders and Alzheimer’s, enhancing therapeutic screening efforts.

US Organoids and Spheroids Market Report Highlights

By type, the spheroids segment is anticipated to witness a higher growth rate during the forecast period due to its potential to promote cell-to-cell interactions.

In terms of application, the developmental biology segment accounted for the largest market share in 2024, owing to the increasing research studies exploring cancer and neurodegenerative diseases.

Texas is projected to register the highest growth rate during 2025–2034, attributable to the rising research collaborations of the major companies.

3D Biotek, 3D Biomatrix, Aragen Bioscience, Cell Microsystems, Corning Incorporated, Danaher, Perkin Elmer, and Prellis Biologics are among the major market players.

Polaris Market Research has segmented the US organoids and spheroids market report on the basis of type, application, and end use:

By Type Outlook (Revenue – USD Million, 2020–2034)

Organoids

• Type
• Neural Organoids
• Hepatic Organoids
• Intestinal Organoids
• Other
• Method
• General Submerged Method for Organoid Culture
• Crypt Organoid Culture Techniques
• Air Liquid Interface (ALI) Method for Organoid Culture
• Clonal Organoids from Lgr5+ Cells
• Brain and Retina Organoid Formation Protocol
• Other
• Source
• Primary Tissues
• Stem Cells

Spheroids

• Type
• Multicellular Tumor Spheroids (MCTS)
• Neurospheres
• Mammospheres
• Hepatospheres
• Embryoid Bodies
• Method
• Micropatterned Plates
• Low Cell Attachment Plates
• Hanging Drop Method
• Others
• Source
• Cell Line
• Primary Cell
• iPSCs Derived Cells

By Application Outlook (Revenue – USD Million, 2020–2034)

Developmental Biology

Personalized Medicine

Regenerative Medicine

Disease Pathology Studies

Drug Toxicity & Efficacy Testing

By End User Outlook (Revenue – USD Billion, 2020–2034)

Biotechnology and Pharmaceutical Industries

Academic & Research Institutes

Hospitals and Diagnostic Centers