Protein Sequencing Market - Growth, Trends, and Forecasts (2023 - 2028)

Protein Sequencing Market - Growth, Trends, and Forecasts (2023 - 2028)

The protein sequencing market is expected to register a CAGR of 3.6% over the forecast period.

COVID-19 has had a significant impact on the market since the detection of COVID-19 was utilized by the advancements offered by protein sequencing. For instance, as per the article published in July 2022 in Frontiers, the growing number of protein sequences deposited in biological databases on a daily basis, as well as the N protein conservation among viral strains along with computational approaches, were used to identify possible novel targets for SARS-CoV-2 and SARS-CoV-related viruses. Hence, such protein sequencing techniques for identifying the COVID-19 targets significantly impacted the market growth over the forecast period. The market is anticipated to witness growth in the coming years due to the increase in the utilization of protein sequencing in biomedical research.

The major factors for the growth of the protein sequencing market include the rising focus on target-based drug development and technological advancements and increasing funding for proteomics research. For instance, as per the article published in June 2022 in ACS Publications, to selectively target a protein and to design small molecules, knowing the protein structure with all its specific conformation is critical. AlphaFold2, a deep neural network-based machine learning programme, was able to predict unknown protein structures with exceptional accuracy and which helped the drug design more efficiently. Similarly, as per the article published in September 2022 in TechRxiv, the researchers presented a method for identifying single amino acids (AAs) in bulk or with a few molecules from a single binary measurement. It can be used in conjunction with Edman degradation (or another approach) to sequence a peptide or identify the parent protein from a partial sequence. This binary/digital methodology is based on the super specificity property of transfer RNAs (tRNAs), and it differs significantly from the traditional and newer single molecule (SM) sequencing approaches that use analog measurements. Hence, such technological advancements in the field of protein sequencing are likely to fuel market growth over the forecast period.

Furthermore, the rising funding for proteomic research is expected to boost the protein sequencing market over the forecast period. For instance, in June 2021, with USD 6 million in Seed Funding, MIT Spinout Glyphic Biotechnologies planned to build a proteomic platform to tackle the proteomics and protein analysis market. Additionally, in May 2022, Proteomics International Laboratories was awarded approximately USD 286,833 in funding from the Australian Government under the Medical Research Future Fund (MRFF) initiative. The funding is expected to support manufacturing the PromarkerD test in Australia.

Thus, due to the rise in advantages offered by protein sequencing and the increase in research funding, the studied market is anticipated to witness growth in the market over the forecast period. However, the high cost of protein sequencing equipment is anticipated to restrain the market growth over the forecast period.

Protein engineering is the manipulation of the structures of proteins to produce the desired properties or the synthesis of proteins with particular structures. The majority of therapeutic drugs in the current market are bio formulations, such as antibodies, nucleic acid products, and vaccines. The protein engineering segment is anticipated to witness growth in the market due to the rise in research activities in protein engineering and an increase in funding for developing different products involving proteins. For instance, in October 2022, the Upstate Medical University professor was awarded more than USD 1.5 million from the National Institute of General Medical Sciences for combining protein and DNA engineering. In the study, the researcher is building a few select protein switches that have powerful biological activities and using DNA engineering to turn on those activities by DNA or RNA sequences of choice, such as those from coronavirus or cytomegalovirus.

Similarly, in September 2022, a Chemical & Materials Engineering assistant professor at the University of Nevada, received a grant from the NIH’s National Institute on Aging (NIA) to engineer novel enzyme inhibitors (molecules that interact with enzymes that play a role in neurodegenerative disease. The researcher is developing novel enzyme inhibitors using state-of-the-art protein engineering techniques based on a specific protein that will block the enzymes that play a role in neurodegenerative diseases. Hence, such research studies utilizing protein engineering are anticipated to drive market growth over the forecast period. Furthermore, in March 2022, the University of North Texas Department of Biomedical Engineering researcher recently received a USD 1.5 million National Institutes of Health (NIH) Maximizing Investigators’ Research Award (MIRA) to study protein and cellular engineering. The new funding allows the researcher the opportunity to discover and design new functions and properties in biological proteins to ultimately generate new biological behavior.

Thus, an increase in research funding and a rise in future opportunities offered by protein engineering is anticipated to drive the segment growth over the forecast period.

North America is expected to hold a significant share of the protein sequencing market owing to rising technological advancements and the presence of better healthcare infrastructure. Also, government and non-government organizations are providing funds to carry out research in the field of proteomics.

Furthermore, company activities by key players in North America are expected to drive market growth over the forecast period. For instance, in January 2023, United States-based Quantum-Si began commercial shipments of the platinum protein sequencing system and provided business updates at the 41st Annual J.P. Morgan Healthcare Conference. The company partnered with Aviva Systems Biology, a provider of antibody, protein, and immunoassay reagent products, to co-develop sample preparation kits for protein sequencing research workflows with Platinum.

Furthermore, in June 2022, Manitoba Government unveiled the release of the Manitoba Protein Research Strategy, a comprehensive research plan that will form the blueprint for the province’s ultimate success in this burgeoning market segment. The MPRS highlights 46 strategic research projects under four main themes, including climate resilience of sustainable protein food systems, novel sustainable protein product development and processing, digital agriculture to enable sustainable food systems, and waste, water, by-product, and co-product utilization.

Thus, due to the rise in research funding, and the increase in technological advancements in protein sequencing, North America is anticipated to witness growth in the studied market over the forecast period.

The market studied is a fragmented market owing to the presence of various market players. Strategic activities such as mergers, acquisitions, collaboration and partnerships by the key players are likely to bolster the market growth over the forecast period. Some of the market players are Agilent Technologies, Inc., Bioinformatics Solutions, Charles River Laboratories, Proteome Factory, Rapid Novor Inc., Selvita SA, SGS SA, Shimadzu Corporation, Thermo Fisher Scientific Inc., and Waters.

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