Protein Purification and Isolation Market - Growth, Trends, COVID-19 Impact, and Forecasts (2022 - 2027)

Protein Purification and Isolation Market - Growth, Trends, COVID-19 Impact, and Forecasts (2022 - 2027)

The protein purification and isolation market are expected to register a CAGR of 10.9% over the forecast period (2022-2027).

The main challenge for the healthcare industry in many countries was to limit the spread of COVID-19 among people and provide the best care to infected patients and decrease the number of possible deaths. A profound impact on the protein purification and isolation market was observed as well.

The disruption in the supply chain during COVID-19 and delay in delivery of essential products required for the manufacturing of the protein purification and isolation kits reagents and consumables imposed an adverse effect on the protein purification and isolation market. Some major issues faced by the market during a pandemic include trucking bottlenecks and port checkpoints slowing down their deliveries including critical supplies, export bans imposed in many countries, only a few manufacturing units functional, and a lack of healthcare workers to transport and produce products. Therefore, such a scenario hindered the market growth initially. However, in later times the demand for protein purification and isolation procedures increased as it is used for the analysis and researh work related to evere acute respiratory syndrome coronavirus (SARS-CoV-2). For instance, according to the study titled, " Recombinant Protein Expression and Purification of N, S1, and RBD of SARS-CoV-2 from Mammalian Cells and Their Potential Applications" published by National Library of Medicine in September 2021, there is a strong demand for diagnostic and serological supplies across the global, as it is necessary for countries to establish their own technologies for the production of high-quality biomolecules. The two main viral antigens used for diagnosis of SARS-CoV-2 are the structural proteins spike (S) protein and nucleocapsid (N) protein. Since, protein purification and isolation is one of the initial and essential step needs to be followed in order to proceed with furthur diagnosis and reasearch work, therefore, such facts indicates that the market has witnessed considerable growth during the pandemic.

Increasing in investment in pharmaceutical and biotechnological research and development and rising need for more accurate and rapid purification kits are some of the major factors driving the market growth. For instance, as per the report published by the Congressional Budget Office of the United States, in April 2021, private spending on pharmaceutical research and development and the approval of new drugs has increased significantly from the past years. It also stated that, the number of newly approved drugs has also increased from the last years. Modern drug discovery uses libraries of purified proteins. The proteins used in the initial steps of drug discovery should be highly purified ones and structural features of proteins must be preserved because protein function is highly dependent on tertiary structure. Thus, protein purification is an essential steps for drug discovery and development. Therefore, such facts are anticipated to propel the demand of protein purification and isolation procedures, thereby postively impacting the market growth over the forecast period.

However, high cost of purification instruments and lack of skilled professionals are likely to impede the market growth over the forecast period.

Key Market TrendsUltrafiltration Segment is Expected to Witness Growth Over the Forecast Period

Ultrafiltration is the process of separating extremely small particles and dissolved molecules from liquids. The primary basis for separation is the size of the molecules, although the permeability of the filter can be affected by the chemical, molecular or electrostatic properties of the sample. To be separated by ultrafiltration, molecules must differ in size by at least an order of magnitude and have a molecular weight between 1 kDa and 1000 kDa. Ultrafiltration membranes can be used either to clean the filtrate or to collect the retentate. Ultrafiltration is typically used for the separation of proteins from buffer components for buffer exchange, concentration, or desalting.

The advantages of ultrafiltration and wide application of ultrafiltration for protein purification and isolation are the major drivers for the segment growth over the forecast period. For instance, according to the study titled, "Recent Advancements of UF-Based Separation for Selective Enrichment of Proteins and Bioactive Peptides—A Review" published in January 2021, proteins could be beneficial in their concentrated products or isolates, of which membrane filtration methods such as ultrafiltration include application in a wide range of protein sources. Furthermore, advantages of ultrafiltration technology such as, the high product throughput and ability to generate rapid results are also boosting the use of ultrafiltration. Moreover, traditional techniques such as chromatography require complex instrumentation support to run efficiently and yield low throughput of product at an extremely high cost owing to which ultrafiltration technique is becoming more popular as it overcome such disadvantages.

Therefore, due to the above mentioned factors considerable segment growth is anticipated over the forecast period.

North America is Expected to Dominate the Protein Purification and Isolation Market Over the Forecast Period

North America is expected to dominate the protein purification and isolation market, over the forecast period. The growth is due to factors such as increasing research work and rising investments in R&D by the public and private sectors. For instance, as per the report published by Research America in January 2022, the estimated Medical and Health R&D Investment in the United States were USD 245,127 million in 2020, whereas in 2019 it was around USD 221,438 million. It also reported that the investment in R&D by industrial players has also increased from the previous years. In 2020, the investment by industry was USD 161,766 million whereas in 2019 it was around USD 148,205 million. Therefore, increased investment indicates that both public and private sectors are focusing on developing new and advanced products. Therefore, such a factor is anticipated to promote market growth in North America.

Key product launches, high concentration of market players or manufacturer's presence, and acquisition & partnerships among major players, and increased investments by biopharmaceutical companies in R&D in the United States are some of the factors driving the growth of protein purification and isolation market in the country. For instance, according to the report published by the Research America in January 2022, the biopharmaceutical companies invested around USD 122,204 million in 2020, wheras in 2019 the investment was around USD 110,932 million in R&D. Therefore, such fact is anticipated to drive the growth of the market in the country

Therefore, owing to the aforesaid factors the growth of the studied market is anticipated in the North America Region.

Competitive Landscape

The protein purification ad isolation market is fragmented in nature due to the presence of several companies operating globally as well as regionally. The competitive landscape includes an analysis of a few international as well as local companies which hold the market shares and are well known including Thermo Fisher Scientific Inc., Merck KGaA, QIAGEN, Bio-Rad Laboratories, Inc., Agilent Technologies, Inc., Promega Corporation, and Danaher Corporation (Cytiva) among others.

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