Osteoporosis Drugs Market - Growth, Trends, COVID-19 Impact, and Forecasts (2022 - 2027)

Osteoporosis Drugs Market - Growth, Trends, COVID-19 Impact, and Forecasts (2022 - 2027)

The osteoporosis drugs market was valued at USD 10.66 billion in 2020, and it is expected to reach USD 13.04 billion by 2026, registering a CAGR of 3.4% during the forecast period, 2021-2026.

Multiple therapeutic regimens are being followed across the world to find a reliable treatment for COVID-19. Several research studies suggested that apart from drugs used for anti-viral treatments, other drugs such as osteoporosis drugs may also prove helpful in COVID-19 treatment, which may boost the market. For instance, as per the study published in 2020 Common osteoporosis treatment may help in reducing the incidence of COVID-19, reported that treatment such as denosumab, zoledronate, and calcium, used for the treatment of osteoporosis, could protect against COVID-19 as well. The research was conducted by Pompeu Fabra University, the Hospital del Mar Medical Research Institute (IMIM), and the Pere Virgili Health Park. As per the study, treatments with osteoporosis drugs could result in a 30 to 40% reduction in the rate of COVID-19 infection. Thus, the studied market is likely to witness a positive impact of COVID-19.

The major factor accrediting to the growth of the market is the increasing incidence of osteoporosis. According to the National Osteoporosis Foundation, in 2018, an estimated 10 million people had osteoporosis and another 44 million had low bone density, placing them at increased risk in the United States. The rising geriatric population globally who are prone to low bone density is another main factor for the growth of the market. For instance, as per the data published by the International Osteoporosis Foundation in 2020, 1 in 5 men and 1 in 3 women, over age 50 years, may experience osteoporosis fractures in their remaining lifetimes across the globe.

Furthermore, the growing investments in research and development by biotechnology and pharmaceutical companies are boosting the market growth. For instance, in October 2020, the Italian pharmaceutical regulatory agency granted permission for human clinical trials on raloxifene, a generic osteoporosis drug that researchers hope may also help reduce COVID-19 symptoms and make patients less infectious. Thus, positive results from clinical trials may lead to new treatment options, thereby boosting the market growth in the future. However, stringent regulations by the governments are the major drawbacks for the market growth.

Key Market TrendsThe RANK Ligand Inhibitors Segment is Expected To Dominate the Market Over the Forecast Period

RANK ligand (RANKL) inhibitors are used for the management of osteoporosis in patients at high risk for bone fractures. The high growth possibility achieved is a result of positive patient results associated with rank ligand inhibitors. The positive patient outcomes can be credited to significant improvements in bone metabolism. Rank ligand inhibitors can also be utilized in combination with other drugs to impart a synergistic effect in the overall treatment regime. The above-mentioned factor is also anticipated to be one of the key factors accountable to present profitable opportunities. Other advantages relating to rank ligand inhibitors are reduced cell bone turnover and increased bone mineral density, thereby implicating high demand.

RANK ligand may be effective as prophylaxis for COVID-19. As per the study conducted at the Hospital Del Mar, a general hospital in Spain in 2020, denosumab targets the RANK/RANKL system, which is involved in the maintenance of balance in the skeletal system. It is involved in lymph node development T cell activation and also affects the immune system. Inhibition of this system reduces pro-inflammatory cytokines in the body and helps in controlling inflammation, which is one of the major causes of life-threatening COVID-19. Thus, owing to the broad applications of RANKL, the segment is likely to grow at a faster pace.

North America Dominates the Market and is Expected to do the Same in the Forecast Period

North America is expected to dominate the overall osteoporosis drugs market throughout the forecast period. The market growth is due to the factors such as the presence of key players, the high prevalence of osteoporosis patients in the region, established healthcare infrastructure, and the availability of branded drugs.

In the North American region, the United States holds the largest market share due to factors such as an increasing geriatric population, a growing patient pool in the country, and several collaborative efforts commenced by major companies to enhance their abilities and guarantee high medical standards. For instance, as per the data published by the National Osteoporosis Foundation (NOF) as of 2020, more than around 10 million people in the United States were suffering from osteoporosis, which is most common in women who have gone through menopause. Thus, an upsurge in incidence as a result of menopause in women is anticipated to be a key growth contributing factor to the regional osteoporosis drug market.

COVID-19 is disrupting and delaying the treatment of many patients with osteoporosis; hence, the American Society for Bone and Mineral Research (ASBMR) set up a steering committee of bone specialists to manage the treatment of targeted disorders amid the pandemic. For instance, in April 2020, a paper on the evidence behind the recommendations was published in the American Society for Bone and Mineral Research (ASBMR) official journal, the Journal of Bone and Mineral Research. The guidelines recommended that the patients should continue osteoporosis medications when possible to do so safely, and that initiation of new oral bisphosphonate therapy can be done remotely and should not be delayed in patients at high risk for fracture. Thus, COVID-19 is expected to have a profound impact on the regional market growth.

The increasing demand is also predicted to be a consequence of collaborative research initiatives implemented by the major healthcare organizations and companies and new product development consistently striving to improve treatment alternatives in the current market space. For instance, in 2019, Amgen announced that the US Food and Drug Administration approved its Evenity (romosozumab-aqqg) to treat osteoporosis in postmenopausal women at high risk of breaking a bone (fracture). This may open up the growth horizon to the regional market.

Competitive Landscape

The osteoporosis drugs market is moderately competitive and consists of several major players. Some of the companies currently dominating the market are Pfizer Inc., Eli Lily and Company, F. Hoffmann La Roche, Merck & Co. Inc., Amgen Inc., Radius Health Inc., Teva Pharmaceutical Industries Ltd, GlaxoSmithKline PLC, Novartis International AG, and Actavis PLC. This industry is anticipated to witness intense competition during the forecast period as a consequence of the rising incorporation of collaborative strategies among the key players to sustain in the competitive position. The other strategies incorporated are high R&D investments, mergers and acquisitions, and agreements for drug development.

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Companies Mentioned

Pfizer Inc.
Eli Lily and Company
F. Hoffmann La Roche
Merck & Co. Inc.
Amgen Inc.
Radius Health Inc.
Teva Pharmaceutical Industries Ltd
GlaxoSmithKline PLC
Novartis International AG
Actavis PLC

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