Gene Synthesis Market - Growth, Trends, COVID-19 Impact, and Forecasts (2022 - 2027)

Gene Synthesis Market - Growth, Trends, COVID-19 Impact, and Forecasts (2022 - 2027)

The Gene Synthesis market is expected to register a CAGR of nearly 8% during the forecast period (2022-2027).

The COVID-19 pandemic has impacted the gene synthesis market in both ways, negatively and positively. At the start of the COVID-19 pandemic, most of the businesses and research activities around the world ceased due to the increasing rate of infection from the SARS-CoV-2 virus which not only reduced the use of gene synthesizers in laboratories but also the demand for it in the market. But in the quest for developing vaccines against the virus infection, which was rising in every corner of the world, the gene synthesizers played a very crucial role in the research and development of the vaccine as some of the vaccines are mRNA based and due to its efficiency too. For example, in January 2022, the Food and Drug Administration provided second approval to the mRNA-based COVID-19 vaccine from Moderna called Spikevax. Therefore, gene synthesis played a crucial role during the COVID-19 pandemic, and the market is expected to grow further.

The factors that are responsible for the growth of the Gene Synthesis market include increasing research and development in the field of genomics and next-generation sequencing, increased government funding for genomics, and increasing demand for personalized medicine and therapeutics for different chronic diseases. As personalized medicine aims to provide tailor-made therapies to individual patients, depending on the molecular basis of the disease, it has become popular over recent years. Healthcare technology, genomics, connected devices, big data analytics, and artificial intelligence are generating vast amounts of health-related data and insights which is enabling healthcare providers to offer better and faster diagnostics and treatment services by making more informed treatment decisions. In addition, gene synthesis is also finding its applications in the molecular diagnosis of infectious and genetic diseases. Genetic tests, which can detect genetic variations and predict how a person is likely to respond to certain drugs, are becoming commercially available. Therefore, increasing focus on personalized medicine and other factors, such as a patient-centered approach, are driving the growth of the gene synthesis market.

Factors, such as the aging global population and the rising prevalence of chronic diseases, are putting unrelenting pressure on the capacity and financial viability of the healthcare systems across the world and will also play a role in the driving growth of the gene synthesis market. Personalized medicine holds the promise of providing better patient care and a high safety margin while lowering total healthcare costs. As per the data published in December 2021 by International Diabetes Federation (IDF), there were about 537 million adults (20-79 years) who were living with diabetes in 2021 all over the globe and the federation projected that this number would rise to 783 million by 2045. The lack of skilled professional is the major restraining factor for the growth of the gene synthesis market as the devices are overly complex and needs special attention while handling and it’s very difficult to find an expert professional for handling. Another factor that will also have a role in the inhibition of the market growth is the excessive cost and complexity of the devices.

Key Market TrendsPCR-mediated Assembly is Expected to Occupy a Major Share in the Studied Market Over Forecast Period

PCR-mediated recombination is a general method applied to construct chimeric infectious molecular clones of plasma-derived HIV–1 RNA. In the gene synthesis process, chemical synthesis is typically used to create oligonucleotides of up to 120-150 nucleotides (nt) in length. Therefore, generally, gene assembly techniques are utilized to connect small oligonucleotides, to synthesize the gene of the required length. Over the past three decades, several methods have been developed to assemble relatively short synthetic oligonucleotides into longer gene sequences. And the polymerase chain reaction (PCR) - mediated assembly represents one of the most prominent approaches to the mediating assembly of the desired DNA sequence.

About the broad applications of polymerase chain reaction (PCR) systems, such as in molecular diagnostics, forensics, and epidemiology studies, the demand and acceptance of polymerase chain reaction technologies are high, which, in turn, acts as a favorable factor for the development and adoption of PCR-mediated assembly methodologies, by academia and research institutes alike. The polymerase chain reaction (PCR) technique played a very important role in concluding the Human Genome Project in 2003. Also, the key market players are working towards improving the polymerase chain reaction technique to expand its nucleic acid synthesis capacity. For example, in April 2020, Biolytic Lab announced the launch of its advanced oligo synthesizer, for high-throughput nucleic acid synthesis, called Dr. Oligo 768XLc DNA RNA Synthesizer. Therefore, owing to the above-mentioned factors, the segment is expected to witness significant growth in the future.

North America Region is Expected to Hold a Significant Share in the Gene Synthesis Market

North America is comprised of the United States, Canada, and Mexico. Currently, North America dominates the market for gene synthesis and is expected to continue its stronghold in the coming future.

In the North American region, the United States holds the largest market share as compared to Canada and Mexico. The increasing prevalence of genetic and chronic disorders, such as cancer, the aging population, increasing demand for targeted and personalized medicine, and favorable government initiatives are the primary factors responsible for the large market. Another factor responsible for the dominance of the United States is the presence of key market players in the region and the high volume of ongoing scientific research activities. In the fiscal year of 2021, the National Cancer Institute of the United States was allocated a budget of USD 6.56 billion solely for cancer research.

Hence, owing to the increased funding for certain diseases and the well-established healthcare, the United States is believed to dominate the market studied.

Competitive Landscape

The gene synthesis market is moderately competitive and consists of several major players. In terms of the market share, few of the major players currently dominate the market. Owing to the increasing number of diseases and rising drug discovery processes, few other smaller players are expected to enter the market. Some of the major players of the market are Merck KGaA, Genscript, Genewiz Inc., Eurofins Genomics, and Bio Basic Inc., among others.

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