Bone Grafts and Substitutes Market - Growth, Trends, COVID-19 Impact, and Forecasts (2022 - 2027)

Bone Grafts and Substitutes Market - Growth, Trends, COVID-19 Impact, and Forecasts (2022 - 2027)

The Bone Graft and Substitutes market is anticipated to grow with a CAGR of 4% during the forecast period (2022-2027).

The emergence of the COVID-19 pandemic had its impact on the bone graft and substitutes market due to the decline in visits to hospitals, ambulatory surgical centers, and dental clinics because of lockdown restrictions imposed by various governments globally. Due to these restrictions, non-emergency procedures were halted in the hospitals, which have impacted the patient's life. For instance, the American Dental Association (ADA) recommended that elective dental procedures be postponed until April 6, 2020, and dental practices should provide emergency-only dental services. Additionally, a research study published by the Spine Journal, in December 2021, titled "COVID-19 pandemic and elective spinal surgery cancelations - what happens to the patients?" stated that due to the reallocation of resources to the care of COVID-19 patients, the COVID-19 pandemic resulted in a suspension of elective procedures. Following the start of elective surgeries, a considerable number of patients continued to postpone surgery, with many still waiting to be rescheduled, potentially prolonging their discomfort and impairment of function. The study concluded that over one-third of the elective spine procedures that were canceled due to COVID-19 had not been performed in the eight months since the procedures were resumed. Such instances are anticipated to have an adverse impact on the surgical procedures further decreasing the demand for bone grafting, thereby impacting the market growth.

The major factors driving the growth of the bone graft and substitutes market include the rising number of road injuries and joint disorders, development of biocompatible synthetic bone grafts and increase in demand for dental bone grafts.

The rising incidence and prevalence of road injuries and joint disorders respectively are the key factor driving the demand for bone grafting. For instance, as per the United States Department of Transportation’s National Highway Traffic Safety Administration 2021 data, an estimated 20,160 traffic fatalities occurred in the first half of 2021 in the United States, an increase of 18.4% from the previous year. In addition, in comparison to the projected rate of 1.28 fatalities per 100 million vehicle miles travelled (VMT) in the first half of 2020, the fatality rate for the first half of 2021 increased to 1.34 fatalities per 100 million vehicle miles travelled (VMT). Thus, the growing burden of road accidents and the subsequent increase in bone related injuries is expected to drive the market growth.

Also, according to an article published by the Journal of Family Medicine and Primary Care, in January 2021, titled "Prevalence of knee osteoarthritis, its determinants, and impact on the quality of life in elderly persons in rural Ballabgarh, Haryana", it has been observed that 64.3% of the elder population were suffering from knee osteoarthritis in 2020. In addition, the elderly patients with knee osteoarthritis have considerably poorer quality-of-life. Similarly, according to the October 2021 data published by the Centers for Disease Control and Prevention, about 78.4 million adults aged 18 years and older are expected to have doctor-diagnosed arthritis by 2040. Thus, the increasing number of joint disorders among population is expected to increase the demand for bone grafting procedure to correct the altered bone or replace the inflammed or non-functional bone, thereby boosting the market growth over the forecast period.

Furthermore, the rising company activities in launching advanced products is expected to increase the demand for bone graft and substitutes for the treatment, thereby boosting the market growth. For instance, in August 2021, Karolinska Development launched OssDsign Catalyst, a synthetic bone graft that stimulates the formation of healthy bone tissue in spinal fusion surgeries, in the United States. This launch is likely to assist the company to establish itself on the bone graft market in the largest geographic market for medical device innovations.

However, the factors such as the high cost of surgeries and ethical issues related to bone grafting are likely to restrain the market growth over the forecast period.

Key Market TrendsDental Segment is Poised to Grow Rapidly in the Bone Graft and Substitutes Market Over the Forecast Period

Certain factors that are propelling the segment growth are the rising incidence of dental diseases among the population, and increasing dental visits.

The increasing burden of dental diseases of tooth and cavities such as dental caries and periodontal diseases among the population is likely to increase the demand for dental surgeries that add volume and density to the jaws in areas where bone loss has occurred. For instance, according to an article published by the Clinical and Experimental Dental Research, in January 2022, titled "Periodontal disease prevalence, extent, and risk associations in untreated individuals", the prevalence of moderate-severe and severe periodontitis were 78.4% and 31.1%, respectively in 2020 (September to December 2020). In addition, as per the same source, it has been observed that periodontitis was prevalent and severe in untreated patients and the risk associated with untreated periodontitis included age ≥35 years, males, lower income, lower education, current cigarette smoking, uncontrolled diabetes mellitus, and lower perceived stress. Additionally, according to an article published by the International Dental Journal, in February 2021, titled, "Risk Indicators of Tooth Loss among the Mexican Adult Population: A Cross-Sectional Study", it has been observed that 57.2% of the tooth loss was due to tooth decay in Mexico, in 2020. This is expected to increase the demand for filling the void caused by the tooth which is expected to increase the demand for dental bone grafting, thereby fueling the market segment over the forecast period.

Furthermore, the rising adoption of various business strategies such as acquisition, collaboration, and product launches by the companies is also contributing to the growth of the market. For instance, in March 2022, Biocomposites signed an agreement with Zimmer Biomet to distribute the Genex Bone Graft Substitute. It is a biphasic composite of extraordinary purity that was created to achieve the ideal balance between osteoconductive scaffold strength and persistence in the body for bone architecture remodeling. Also, in January 2021, Dentsply Sirona acquired Datum Dental Ltd. With this acquisition, the company promotes the complete OSSIX portfolio, including OSSIX Plus, OSSIX Volumax, and OSSIX Bone, in the United States, Canada, and several other countries.

Thus, the aforementioned factors are expected to increase the segment growth, thereby boosting the market growth over the forecast period.

North America is Expected to Have the Significant Market Share Over the Forecast Period

North America is expected to dominate the bone graft and substitutes market over the forecast period owing to the factors such as the increasing prevalence of joint disorders and dental diseases, growing dental visits, rising technological advancement, and the presence of a well-established healthcare infrastructure.

The rising burden of dental diseases and joint-related disorders such as osteoarthritis, arthritis, and rheumatoid arthritis among the population is increasing rapidly which is likely to increase the demand for bone grafting procedures for removing small bones from grinding against each other to provide relief and remove the inflamed bone from the area, thereby propelling the market growth. For instance, according to Statistics Canada 2021, approximately 5.9 million adult Canadians had arthritis in 2020. The prevalence of arthritis increases with age and is higher among females. In addition, according to the updated data published by the Centers for Disease Control and Prevention (CDC), in October 2021, 23.7% (or about 58.5 million) people have doctor-diagnosed arthritis. Additionally, according to the Centers for Disease Control and Prevention (CDC) data updated in January 2021, 1 in 4 adults between 20-64 years of age suffer from at least one cavity, and almost 57% of adolescents aged 12-19 have had a hole in their permanent teeth.

Furthermore, with an increase in the geriatric population, there is a rise in the number of people suffering from various arthritis problems which increases the demand for bone grafting procedures thereby increasing the market growth. For instance, according to the data published by America's Health Ranking in 2021 Senior Report, more than 54 million adults aged 65 and older were living in the United States in 2021 which accounted for 16.5% of the total population in the same year. In addition, as per the same source, this number is projected to rise to an estimated 85.7 million, accounting approximately 20% of the total population, by 2050.

Moreover, the rising company's focus on research and development activities and increasing product launches are also contributing to the growth of the market. For instance, in July 2021, Orthofix Medical launched fiberFUSE Strip, an advanced demineralized fiber bone-graft solution containing cancellous bone. The fiberFUSE Strip is designed as an easy-to-apply premade bone-graft strip that can be used for degenerative spinal surgeries including posterior cervical, posterior lumbar, and thoracic procedures. Also, in September 2020, Spine Wave launched the Tornado Bioactive Bone Graft Matrix, a bioactive, osteoconductive, porous implant with the optimal composition and particle distribution of carbonate apatite anorganic bovine bone mineral, 45S5 bioactive glass, and highly purified Type I collagen. This launch strengthens the company’s growing spinal biologics portfolio and marks its entry into the market for synthetic bioactive bone graft matrix implants.

Thus, considering the rising incidences of dental diseases and joint disorders, the growing geriatric population, and increasing product launches in the region, the bone grafts, and substitutes market is expected to grow rapidly over the forecast period.

Competitive Landscape

The market studied is moderately competitive and several local, as well as international companies, are present in the market. There is a rising technological development in the field of bone grafts and substitutes. Some of the key players in the market are Medtronic Plc, Medtronic Plc, Stryker Corporation, Stryker Corporation, Smith and Nephew, Integra Lifesciences Holdings Corporation, and SeaSpine.

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