Acute Bacterial Skin and Skin Structure Infection (ABSSSI) Market - Growth, Trends, COVID-19 Impact, and Forecasts (2022 - 2027)

Acute Bacterial Skin and Skin Structure Infection (ABSSSI) Market - Growth, Trends, COVID-19 Impact, and Forecasts (2022 - 2027)

The Acute Bacterial Skin And Skin Structure Infection (ABSSSI) Market is expected to grow at a registered CAGR of 9.9% during the forecast period (2022-2027).

COVID-19 impacted the global supply chain of pharmaceuticals, affecting the acute bacterial skin and skin structure infection (ABSSSI) market. However, according to the study titled "Hospital-acquired Skin and Skin-structure Infection in COVID-19 Infected Patient with Prolonged Hospitalization" published in the Acta Medica Indonesia in January 2021, bacterial skin and skin structure infections are worsened in the COVID-19 patient. They are required to prolong hospitalization rise in the treatment options demand, thereby anticipating market growth during COVID-19. Thus, the acute bacterial skin and skin structure infection (ABSSSI) market was significantly impacted by COVID-19.

The rising prevalence and awareness of acute bacterial skin and skin structure infection, as well as increased research and development activities by pharmaceutical and biopharmaceutical companies to supply new products and novel treatments, all contribute to the global ABSSSI market's growth.

Two of the most common bacteria that cause Acute Bacterial Skin and Skin Structure Infections are Streptococcus pyogenes and Staphylococcus aureus, including methicillin-resistant S. aureus. Gram-negative bacteria, other Streptococcus species, and Enterococcus faecalis are less common causes. According to the study titled "Management of Acute Bacterial Skin and Skin Structure Infections in India: Are We Equipped to Meet the Challenges of the Growing Menace of Methicillin-Resistant Staphylococcus aureus?" published in the International Surgery Journal in July 2020, Staphlococcus aureus (Staphylococcus aureus) is a Gram-positive facultative anaerobic bacteria that colonize human skin and nasal passages. Invasive S. aureus infections have become more common in recent decades and are linked to poor outcomes and high mortality rates. S. aureus causes nearly one-third of all acute bacterial skin and skin structure infections, with methicillin-resistant Staphylococcus aureus (MRSA) accounting for most of these infections.

However, growing pipeline development activity and rising research and development expenditure by pharmaceutical and biotechnology companies are anticipated to drive the market over the forecast period. For instance, as per the clinicaltrials.gov in May 2021, Ceftobiprole Medocarial under Phase III trials is an effective treatment option for acute bacterial skin and skin structure infections. Moreover, according to the same source posted on October 2020, an intravenous formulation of TNP-2092 from TenNor Pharmaceutical Limited is also under clinical development for treating acute bacterial skin and skin structure infections (ABSSSI).

Furthermore, growing product launches and various activities by the key market players such as mergers and acquisitions, collaborations, and partnerships are anticipated to drive the market. For instance, in March 2021, Kimyrsa (oritavancin; Melinta Therapeutics) was approved by the Food and Drug Administration (FDA) to treat adults with acute bacterial skin and skin structure infections (ABSSSI) caused by susceptible isolates of designated Gram-positive microorganisms. In July 2021, Melinta Therapeutics (Melinta), a commercial-stage company providing innovative therapies for acute and life-threatening illnesses, reported the commercial launch of KIMYRSA (oritavancin), a lipoglycopeptide antibiotic that delivers a complete course of therapy for acute bacterial skin and skin structure infections (ABSSSI) in a single, one hour, 1,200 mg infusion.

Thus, all these factors are expected to boost the market over the forecast period.

Key Market TrendsHospital Acquired ABSSI is is Expected to Hold Significant Market Share in the Process Component Segment

Infections acquired in a healthcare setting that was not present before the contact are known as healthcare-associated infections (HCAIs). They may cause (or prolong) stays in acute care hospitals, increase medical and economic burdens, and cause morbidity and mortality. For instance, according to the study titled "Update on the Epidemiology of Healthcare-Acquired Bacterial Infections: Focus on Complicated Skin and Skin Structure Infections," published in the Journal of Antimicrobial Chemotherapy in November 2021, Adult inpatients in National Health Service hospitals in England are estimated to have 834,000 Healthcare-associated infections (HCAIs) each year, accounting for 7.1 million occupied hospital bed days (21 percent of total annual bed days) and a EUR 2.7 billion economic burden.

Furthermore, according to the same source, the prevalence of HCAI is estimated to be 6.0 percent. The most common infections were skin and soft tissue infections (SSTIs), which included surgical site infections (SSIs). Patients in intensive care units had the highest rate of hospital-acquired ABSSSI. Thus growing prevalence of hospital-acquired infection is expected to boost the segment growth.

However, various strategic activities by the key market to boost the market include product launches, pipeline development, and merger and acquisition. For instance, in July 2021, Delafloxacin was approved in the United Kingdom to treat acute bacterial skin and skin structure infections (ABSSSI) in adults when other antibacterial agents are considered inappropriate for the initial treatment of these infections.

North America Holds a Significant Share in the Market and Expected to do Same during the Forecast Period

North America will continue to dominate the acute bacterial skin and skin structure infection market during the forecast period due to extensive research and development activity, R&D spending, product pipeline, and novel product launches. For instance, as per the ClinicalTrials.gov posted on January 2020, study title "Development of a New Critical Pathway for Treatment of Acute Bacterial Skin and Skin Structure Infections (ABSSSI)"under the clinical development for the drug Dalbavancin from the allergen pharmaceutical in the United States. Thus, the number of drugs under clinical trials is expected to increase the product launch over the projected period of anticipated market growth.

However, the growing product pipeline and product approval by regulatory authorities are expected to boost the market over the forecast period. For instance, in July 2021, the Food and Drug Administration (FDA) expanded the approval of Dalvance (dalbavancin) to include treatment of acute bacterial skin and skin structure infections (ABSSSI) caused by designated susceptible strains of Gram-positive microorganisms in pediatric patients. Previously, the treatment was only approved for adults 18 and older. Additionally, in January 2022, Paladin Labs Inc., a subsidiary of Endo International plc launched Xydalba (dalbavancin for injection), a 30-minute intravenous (IV) therapy in Canada for acute bacterial skin and skin structure infections (ABSSSI) that can be administered as a single- or two-dose regimen.

Thus, all such factors are expected to boost the market in North America over the forecast period.

Competitive Landscape

The gram-positive Bacterial Infections market is moderately competitive. The market is comprised of many small and large market players. However, with technological advancements and product innovations, mid-size to smaller companies increase their market presence by introducing new products at lower prices. Some of the market players are Glenmark Pharmaceuticals Ltd, Teva Pharmaceutical Industries Ltd, Melinta Therapeutics, Inc., Sandoz Inc. (a subsidiary of Novartis), Paratek Pharmaceuticals, Inc., Allergan plc, Merck & Co., Inc., Accord Healthcare Ltd. (a subsidiary of Intas Pharmaceuticals Ltd), and Cadila Healthcare Ltd.

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