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Global chromatography instruments market is projected to witness a CAGR of 5.51% during the forecast period 2024-2031, growing from USD 10.55 billion in 2023 to USD 16.20 billion in 2031. Growth in the market is influenced by increasing R&D spending in biotechnology, the rising prevalence of chronic diseases necessitating sophisticated drug testing, and instrument miniaturization and automation. Other drivers influencing market growth during the forecast period include increased adoption in emerging chemical manufacturing and quality control markets.

Chromatography instruments are increasingly being adopted in the pharmaceutical, petrochemical, and life sciences sectors to separate and analyze chemical mixtures. The pharmaceutical industry needs chromatography to ensure drug safety and efficacy. Such importance drives the demand in the pharmaceutical industry. With increased investment in advanced testing methods, companies look for regulatory compliance and develop drugs more rapidly. Thus, this trend is propelling market growth for chromatography instruments. In December 2023, QPS Holdings, LLC (QPS), a global contract research organization, strengthened its presence in Europe to support the development of gene therapy and protein drugs. QPS invested in advanced mass spectrometry, including the addition of a TripleTOF 6600+ for GLP quantitation at its Groningen, Netherlands lab. This further enhances QPS's longstanding capabilities in oligonucleotide drug development, originally developed in Newark, USA, by the integration of Ultra High-Performance Liquid Chromatography-High-Resolution Mass Spectrometry specifically for the European market. This demonstrates the increasing demand for chromatography during drug development. Pharmaceutical and biotechnology companies, therefore, are focusing more on advanced chromatography tools to facilitate innovations in therapeutic development.

Furthermore, the surge in investment is largely due to the growing need for advanced analytical techniques, which are also supporting market growth. In July 2024, CatSci Ltd. (CatSci) acquired Reach Separations Ltd to strengthen its end-to-end separation science capabilities from discovery to manufacturing. Its advanced HPLC and Supercritical Fluid Chromatography (SFC) systems create added value to the services offered by CatSci with specialized small molecules, oligonucleotides, and other complex drug analyses, supporting both screening and high-quality problem-solving needs.

However the market is expanding, but the chromatography systems are expensive enough that many laboratories can hardly afford them, mainly those in developing countries or limited-budget laboratories, though the method is essential.

Advancements in Proteomics to Influence Market Growth

Advancements in proteomics fuel the growth of the chromatography instruments market. Proteomics is a large-scale study of proteins, and coupled with metabolomics, that is, the analysis of metabolites in biological samples, requires high-resolution chromatography methods such as High-Performance Liquid Chromatography (HPLC) and Gas Chromatography-Mass Spectrometry (GC-MS). These techniques enable precise separation and identification of complex biological mixtures, which is necessary for proper analysis. Owing to this increasing demand, most companies have launched newer innovative products and extended portfolios that cater to these areas and further fuel the growth of chromatography instrumentation. For instance, in August 2022, Bruker Corporation launched the nanoElute two nano-liquid chromatography (nano-LC) system. The company launched new versions of the MetaboScape and TASQ 2023 software, focusing on supporting fluxomics and enhanced capabilities in PaSER's intelligent acquisition. These will support advanced research in protein-protein interactions (PPIs) and metaproteomics applications.

Technological Advancements to Drive Chromatography Instruments Market Growth

Technological innovation drives the growth of the chromatography instruments market through increased automation, miniaturization, and data management. Analyzing samples faster and more accurately through high throughput systems has become easier. It reduces the time required to process complicated samples. Further, enhanced sample preparation techniques and advanced software improved data handling, increasing lab productivity. Increasingly, pharmaceuticals, food safety, and environmental monitoring utilize these instruments with greater sensitivity and accuracy. These innovations not only enhance the quality and accessibility of chromatography but also increase its use in diverse applications, hence pushing the market. Technological advancement has improved accuracy and reduced lab errors. For instance, in March 2023, Waters Corporation launched the Alliance iS HPLC System, a next-generation high-performance liquid chromatography (HPLC) system, anticipated to eradicate up to 40% of common lab mistakes. Paired with Waters' Empower Chromatography Software and eConnect HPLC Columns, it improves accuracy by proactively identifying and resolving errors. This innovation reflects the progress in chromatography, which drives market growth through improvements in quality, compliance, and efficiency in lab workflows.

Growing Research Fundings to Fuel Market Growth

Pharmaceutical research is growing at an exponential rate, which further fuels the growth of chromatography instruments. Pharmaceutical firms and researchers are now probing into complex drug compounds and novel therapies, which demand quality control and analysis, increasing the need for superior chromatography systems. Chromatography instruments are utilized for the analysis of compound purity, stability, and concentration. The process becomes an important step in drug discovery, formulation, and testing for safety. Further regulatory standards compliance creates more demand for advanced chromatography technologies to satisfy all such requirements. As the world advances in research and standards of regulation improve, so does the usage of chromatography equipment, which proves to be essential to stimulate growth in the market. Therefore, the government invests more in research. For instance, in August 2023, India's Health Minister allocated USD 50.48 million (INR 4,250 crore) to research and development in the pharmaceutical and medical technology sectors. This government investment forms a commitment towards advancing scientific innovation, fueling growth within the chromatography instruments market, and driving industry expansion through the improved technology and infrastructure of the region.

Liquid Chromatography to Dominate the Chromatography Instruments Market Share

Liquid Chromatography (LC) holds the major share of the chromatography instruments market mainly due to its versatility and ability to analyze a wide range of compounds, especially in pharmaceuticals, environmental science, and biotechnology. High-performance liquid chromatography (HPLC) and ultra-high-performance liquid chromatography (UHPLC) are among these instruments that claim to deliver high-resolution accuracy with sensitivity to the extent that complex mixtures can be separated and detect trace compounds. Further advances in LC columns and detectors have expanded their application to biomolecular analysis and quality control. As the demand for compliance rises, especially in pharmaceutical and food safety areas, the demand for LC systems increases because of LC's friendly compliance capabilities, a position that has cemented market leadership. To fulfill these demands, key players are introducing advanced liquid chromatography systems.

For instance, in October 2024, Agilent Technologies Inc. launched the next-generation Agilent InfinityLab LC Series, which features 1290 Infinity III LC, 1260 Infinity III Prime LC, and 1260 Infinity III LC, with biocompatible versions. These HPLC systems are featured with Agilent InfinityLab Assist Technology, which simplifies lab work by automating routine operations, maintenance, and troubleshooting, allowing labs to focus on results and minimize manual errors. It reflects Agilent's intent on better lab efficiency, which fuels the chromatography instruments market through advanced features enhancing accuracy and consumer confidence.

North America Dominates Chromatography Instruments Market Share

North America is the leader in the chromatography instruments market. This is largely due to strong demand from all sectors, especially the pharmaceutical, biotechnology, and environmental fields. In the pharmaceutical sector, huge R&D investments ensure a healthy demand for high-end chromatography for drug discovery and testing. Moreover, regulatory compliance by agencies such as the FDA necessitates testing, which increases demand for systems that can be trusted. Also, North America is leading in R&D investments, with significant government funding aimed at enhancing healthcare infrastructure. Additionally, with the increasing food safety awareness and environmental monitoring in North America, applications of chromatography increased, and it has led to solidifying North America's position as the world leader. The increasing use of chromatography in North America is driving market growth. For instance, in May 2024, Eurofins Scientific SE’s CDMO Alphora Inc. expanded its Drug Product Analytical Services Laboratory in Mississauga, Canada. Specialized equipment for drug product programs, such as water activity measurement, HPLC, stability chambers, and gas chromatography, were introduced in this expansion. Growth in the CDMO market points to the fact that it is a key player in the chromatography instruments market, which, with drug development innovation, demands increasing with time.

Future Market Scenario (2024 – 2031F)

It is anticipated that several factors will propel the chromatography instruments market over the next few years. Miniaturization and automation technologies will improve efficiency while bringing down costs. The rise of personalized medicine will require more sophisticated analyses for individualized drug therapies.

In July 2024, Repligen Corporation (Repligen) acquired Tantti Laboratory Inc., the renowned chromatography innovator. This is a promising acquisition in the chromatography instruments market since companies such as Repligen continue to enhance their capabilities to meet stringent demands for advanced purification solutions in biopharmaceuticals.

Furthermore, in February 2024, Waters Corporation launched the HPLC-CONNECT software, a comprehensive platform for integrating its high- and ultra-performance liquid chromatography (HPLC/UPLC) systems with multi-angle light scattering instruments. This software enhances ease of use, efficiency, and reliability in size exclusion chromatography and MALS (SEC-MALS) analyses, which are critical to the development of complex biopharmaceuticals such as antibody-drug conjugates, protein conjugates, and gene therapies. This launch projects a promising future in the chromatography instrumentation market, driven by increased demand for advanced analytics in biopharmaceutical innovation.

Key Players Landscape and Outlook

Key players lead this market through investments in innovation and technological advancements. They have adopted strategies that include strategic collaborations, product upgrades, portfolio expansion, mergers and acquisitions, driving growth, and fostering innovations in the market.

In June 2024, Agilent Technologies, Inc. partnered with ePrep Pty Ltd to distribute the ePrep ONE workstation, with improvements in automated chromatography sample preparation, especially when it comes to mass spectrometry analyses. It uses analytical syringes for better reliability and precision, allowing flexibility when handling several types of samples and different workflows. Through this partnership, the goal has been to expand its market presence in pharmaceuticals, environmental, and food applications, further solidifying its position in advancing research and testing capabilities.

In September 2024, SCION Instruments NL BV (Scion) partnered strategically with Gulf Scientific Corporation (GSC). The strategic collaboration will allow GSC to offer customized solutions to the market and represent Scion in Saudi Arabia, Kuwait, and Qatar, thereby improving access to advanced products for easier use. Scion’s GC-MS systems and Compass CDS software will make labs more capable, while spare parts help to ensure reliability, allowing innovation and productivity to prevail in the region.