Global Cell-free Protein Expression Market Research Report 2023-Competitive Analysis, Status and Outlook by Type, Downstream Industry, and Geography, Forecast to 2029

Global Cell-free Protein Expression Market Research Report 2023-Competitive Analysis, Status and Outlook by Type, Downstream Industry, and Geography, Forecast to 2029

The cell-free protein synthesis system is an in vitro system that uses exogenous mRNA or DNA as a template to add substrates and energy to the cell extract's enzyme system to synthesize proteins. Compared with traditional in vivo recombinant expression systems, in vitro cell-free synthesis systems have multiple advantages, such as the ability to express special proteins that are toxic to cells or contain unnatural amino acids (such as D-amino acids), and can directly use PCR products as templates Simultaneously synthesize multiple proteins in parallel to carry out high-throughput drug screening and proteomics research.

Market Overview:

The latest research study on the global Cell-free Protein Expression market finds that the global Cell-free Protein Expression market reached a value of USD 244.52 million in 2022. It’s expected that the market will achieve USD 366.2 million by 2028, exhibiting a CAGR of 6.96% during the forecast period.

Large R & D investment and high production cost

High R & D costs are a factor limiting corporate growth. In addition to research and development costs, product production costs are high, and difficult to quantify production is also a factor hindering market development. Compared with other commonly used protein expression systems, cell-free protein production is expensive to quantify, so the current trend to replace other commonly used protein expression systems is not obvious.

R & D in the field of proteomics and genomics has increased, and the market application prospect is good

In the past 20 years, players in the industry have done a lot of research on the reaction mechanism and regulation of protein synthesis in cell-free systems, energy supply, genetic template stability, reactor design and operation, etc. Not only can the PCR product be used as a template to synthesize proteins directly, but it also shows good application prospects in the aspects of in vitro recombinant protein production, high-throughput protein synthesis, functional proteome research, and directed evolution of proteins in vitro. Increasing investment in research and development promotes wider application of the product and provides more opportunities for players in the industry.

Excellent nature promotes market development

Compared with the traditional intracellular expression system, the cell-free protein expression system does not require induction culture, which greatly simplifies the operation steps and downstream experimental procedures, and can be used for high-throughput and large-scale expression experiments; in vitro expression eliminates physiological limitations and significantly improves It is functional, soluble, and the overall yield of full-length proteins; Because it can achieve phosphorylation modification and is not affected by protein toxicity, the system is very suitable for the expression of toxic proteins such as kinases and membrane proteins; and can be modified in specific Insert a non-natural amino acid tag at the site.

Region Overview:

In global comparison, a significant portion of the revenue was generated in North America (49.01% in 2022).

Company Overview:

Thermo Fisher Scientific is one of the major players operating in the Cell-free Protein Expression market, holding a share of 22.31% in 2023.

Thermo Fisher Scientific

Thermo Fisher Scientific, Inc. manufactures scientific instruments, consumables, and chemicals. The Company offers analytical instruments, laboratory equipment, software, services, consumables, reagents, chemicals, and supplies to pharmaceutical and biotech companies, hospitals and clinical diagnostic labs, universities, research institutions, and government agencies.

Promega Corporation

Promega Corporation provides biological and pharmacy products. The Company offers reagents, instrumentations, and enzyme systems. Promega serves customers worldwide.

Segmentation Overview:

By type, E. Coli Lysate segment accounted for the largest share of market in 2022.

Application Overview:

The market's largest segment by application is the segment Protein-Protein Interaction, with a market share of 37.49% in 2022.

Key Companies in the global Cell-free Protein Expression market covered in Chapter 3:

Biotechrabbit
Thermo Fisher Scientific
CellFree Sciences Co.
New England Biolabs
creative biolaps
Cube Biotech GmbH
Takara Bio Inc
Jena Bioscience GmbH
Sutro Biopharma
Promega Corporation
Bioneer Corporation

In Chapter 4 and Chapter 14.2, on the basis of types, the Cell-free Protein Expression market from 2018 to 2029 is primarily split into:

E. Coli Lysate
Wheat Germ Extract Lysate
Rabbit Reticulocyte Lysate
Insect Cell Lysate
Human Cell Lysate

In Chapter 5 and Chapter 14.3, on the basis of Downstream Industry, the Cell-free Protein Expression market from 2018 to 2029 covers:

Enzyme Engineering
High Throughput Production
Protein Labeling
Protein-Protein Interaction
Other Applications

Geographically, the detailed analysis of consumption, revenue, market share and growth rate, historic and forecast (2018-2029) of the following regions are covered in Chapter 8 to Chapter 14:

North America (United States, Canada)
Europe (Germany, UK, France, Italy, Spain, Russia, Netherlands, Turkey, Switzerland, Sweden)
Asia Pacific (China, Japan, South Korea, Australia, India, Indonesia, Philippines, Malaysia)
Latin America (Brazil, Mexico, Argentina)
Middle East & Africa (Saudi Arabia, UAE, Egypt, South Africa)