Global Amebocyte Lysate Market Research Report 2023-Competitive Analysis, Status and Outlook by Type, Downstream Industry, and Geography, Forecast to 2029

Global Amebocyte Lysate Market Research Report 2023-Competitive Analysis, Status and Outlook by Type, Downstream Industry, and Geography, Forecast to 2029

Amebocyte Lysate is an extract obtained from the blue blood of the marine arthropod Limulus. Amebocyte Lysate can accurately and rapidly detect the presence of bacterial endotoxin and (1,3)-beta-glucan in samples.

Market Overview:

The latest research study on the global Amebocyte Lysate market finds that the global Amebocyte Lysate market reached a value of USD 562.97 million in 2022. It’s expected that the market will achieve USD 1077.95 million by 2028, exhibiting a CAGR of 11.43% during the forecast period.

Market Opportunities

Since the outbreak of the new crown pneumonia epidemic, more than 500 million people have been infected worldwide and more than 6.27 million people have died. The new crown pneumonia epidemic is a major public health emergency facing the world. It spreads rapidly, infects a wide range, and is difficult to prevent and control. According to statistics from Our World in Data, as of May 9, 2022, 65.5% of the world's population currently has at least one dose of the COVID-19 vaccine. 11.65 billion doses have been administered worldwide. But vaccination rates in many low-income countries remain very low. At present, the new crown pneumonia epidemic is still prevalent in the world. In order to prevent and control the epidemic, countries around the world are constantly increasing the vaccination rate of the new crown vaccine. The market demand for new crown vaccines continues to rise. During the production of the new crown vaccine, Amebocyte Lysate is the key to testing the safety of the new crown pneumonia vaccine. Relevant data show that in order to ensure the safety of vaccines, at least 600,000 safety trials are required for every 5 billion doses of vaccines. In general, with the increasing demand for new crown vaccines in various countries around the world, the market is eager for Amebocyte Lysate Demand will continue to rise, which will be one of the driving forces for the development of the industry.

Market Risk

At present, there are only four types of turtles in the world, including the American horseshoe crab, the scorpion king crab, the giant king crab, and the Chinese king crab. At present, Amebocyte Lysate is derived from the blood of American horseshoe crab and Chinese horseshoe crab. However, due to marine environmental pollution, human hunting and other factors, there is still a risk of continuous reduction in the number of horseshoe crabs, which in turn affects the continuity of the blood supply of horseshoe crabs. In 2012, IUCN (International Union for Conservation of Nature) listed Limulus americanus as Vulnerable (VU), and in 2019, IUCN listed it as Endangered (EN). The source of Limulus mainly depends on the fishing of fishermen, and the technology of artificial cultivation of Limulus is not mature enough at present. During the horseshoe crab breeding season, on the Atlantic beaches of the United States, pharmaceutical companies capture tens of thousands of horseshoe crabs, take them for blood in the laboratory, and then release them. However, some researchers have found that the mortality rate of horseshoe crabs after blood drawing is very high, as high as 30%. As a result, the number of horseshoe crabs is in danger of decreasing, leading to a crisis in the supply of raw materials for Amebocyte Lysate. The supply crisis of raw materials will be one of the important challenges facing the industry.

Market Driving Force

When exposed to the toxin of the bacteria, the amoebocytes in the blood of the horseshoe crab release a coagulation protein, which causes the blood to coagulate rapidly, forming a barrier that prevents the bacteria from multiplying and prevents the invasion of other bacteria. Amebocyte Lysate can detect a contaminant called endotoxin (a type of bacteria), and can be widely used in the fields of medicine and hygiene, food hygiene, environmental hygiene, molecular biology, and microbiology. In the pharmaceutical industry, for example, even small amounts of endotoxin can be fatal in vaccines, injectable drugs, or other sterile medical items such as artificial knees and hip joints. Amebocyte Lysate can be used to test the safety of these products. In food hygiene, Amebocyte Lysate can be used to detect whether drinking water, milk, canned food and other foods are contaminated by bacteria. As people's safety awareness continues to rise, the government's supervision on medical hygiene and food hygiene will become more and more strict. The demand for Amebocyte Lysate in the market will continue to rise, thereby increasing the demand for Amebocyte Lysate. Overall, the wide application of Amebocyte Lysate is an important reason for the development of the industry.

Region Overview:

North America had the highest growth rate of all regions.

Company Overview:

LONZA is one of the major players operating in the Amebocyte Lysate market, holding a share of 48.56% in 2022.

Segmentation Overview:

Among different product types, Tachypleus Amebocyte Lysate segment is anticipated to contribute the largest market share in 2027.

According to the source of raw materials, one is called Limulus Amebocyte Lysate, abbreviated as LAL, which is extracted from the blood of Limulus polyphemus. The other is the abbreviation of Tachypleus Amebocyte Lysate, which is extracted from the blood of the Tachypleus tridentatus, written as TAL.

Application Overview:

By application, the Drug Testing segment occupied the biggest share from 2017 to 2022.

Amebocyte Lysate is widely used in drug testing. The amebocyte lysate has been widely used for ~30 years for the detection of endotoxin in the quality assurance of injectable drugs and medical devices. The LAL constitutes a cascade of serine proteases which are triggered by trace levels of endotoxin, culminating in a gel clot at the end of the reaction.

In clinical diagnosis, Amebocyte Lysate can be used to determine rapidly and specifically the cumulative content of Gram-negative bacteria in foods.

Key Companies in the global Amebocyte Lysate market covered in Chapter 3:

LONZA
Associates of Cape Cod
Zhanjiang A&C Biological Ltd.
Zhanjiang Bokang Marine Biological Co. Ltd.
Fuzhou Xinbei Biochemical Industrial Co., Ltd
Charles River Laboratories
Xiamen Bioendo Technology Co., Ltd.

In Chapter 4 and Chapter 14.2, on the basis of types, the Amebocyte Lysate market from 2018 to 2029 is primarily split into:

Limulus Amebocyte Lysate
Tachypleus Amebocyte Lysate

In Chapter 5 and Chapter 14.3, on the basis of Downstream Industry, the Amebocyte Lysate market from 2018 to 2029 covers:

Drug Testing
Clinical Diagnosis
Other

Geographically, the detailed analysis of consumption, revenue, market share and growth rate, historic and forecast (2018-2029) of the following regions are covered in Chapter 8 to Chapter 14:

North America (United States, Canada)
Europe (Germany, UK, France, Italy, Spain, Russia, Netherlands, Turkey, Switzerland, Sweden)
Asia Pacific (China, Japan, South Korea, Australia, India, Indonesia, Philippines, Malaysia)
Latin America (Brazil, Mexico, Argentina)
Middle East & Africa (Saudi Arabia, UAE, Egypt, South Africa)