Global Organ-on-Chip Market Size, Share & Industry Trends Analysis Report By Type (Lung on chip, Heart on chip, Human on chip, Kidney on chip, Liver on chip, and Intestine on chip), By Regional Outlook and Forecast, 2022 - 2028

Global Organ-on-Chip Market Size, Share & Industry Trends Analysis Report By Type (Lung on chip, Heart on chip, Human on chip, Kidney on chip, Liver on chip, and Intestine on chip), By Regional Outlook and Forecast, 2022 - 2028

The Global Organ-on-Chip Market size is expected to reach $815.6 million by 2028, rising at a market growth of 30.2% CAGR during the forecast period.

Organs-on-chips are microfluidic chips that contain artificial or natural tiny tissues. To better imitate human physiology, the chips are manufactured to retain tissue-specific cell microenvironments and functionalities. Combining advancements in microfabrication and tissue engineering, OoCs have received interest as a next-generation experimental platform for investigating human pathology and its therapeutic effects on the body. There are as many instances of OoCs as there are implementations, making it challenging for new researchers to comprehend what makes one OoC more suitable than another for a particular application.

Organ-on-a-chip is an artificial organ that mimics human organs. It is a multi-channel, three-dimensional microfluidic cell culture technology that promotes organ functions, processes, and physiological responses. The combination of labs-on-chips and cell biology has enabled researchers to analyze human physiology within an organ-specific environment, leading to the creation of a new model of multicellular human organisms in vitro.

This chip creates a small channel for air and blood flow in organs, such as the lung, digestive tract, liver, brain, and heart. These devices are constructed on a microchip with constantly perfused compartments colonized with living cells designed to stimulate tissue and organ-level physiology. Organ-on-chip is a silicon-based technology that is used to nourish interior organs.

Combining tissue engineering and microfluidics, organ-on-a-chip is a potentially revolutionary technique. It is anticipated that these technologies would provide effective solutions to long-standing problems in drug discovery and tailored illness therapy. It plays a significant part in medication development research, hence bolstering the organ-on-chip sector.

COVID-19 Impact Analysis

The COVID-19 pandemic significantly impacted a number of economies all over the world. various businesses were majorly demolished owing to the widespread infection. Governments in several countries were compelled to impose lockdowns within their countries in order to regulate the diffusion of the virus. Due to this, the manufacturing of numerous products was hampered. In addition, the Healthcare sector was also impacted severely during the initial period of the pandemic. The abrupt emergence of the pandemic. The organ-on-chip market was also disrupted by the pandemic. There was a lack of equipment required to leverage the potential of this approach, which impeded the growth of the market in the initial period of the pandemic.

Market Growth Factor

Rapidly Rising Number of Applications of This Approach

Microfluidic devices and organotypic slices have been combined to improve culture survival. The conventional method for cultivating organotypic brain slices (about 300 microns in thickness) uses semi-porous membranes to form an air-medium interface. Because microfluidic technologies bring the laminar flow of these essential nutrients and gases, tissue viability can be increased and transportation is enhanced. Brain-on-a-chip technologies have enabled the effective culture of thicker brain slices despite a substantial transport barrier due to their thickness. Brain-on-a-chip systems can attain more in vivo-like qualities without sacrificing cell viability, as thicker slices preserve more native tissue architecture.

Increasing Demand for An Alternative to Animal Testing

Animal models were the only means to gather in vivo data that could predict human pharmacokinetic reactions during the early stages of drug development. However, animal experiments are slow, costly, and controversial. For instance, animal models are frequently subjected to chemical or mechanical procedures that replicate human injuries. Concerns exist regarding the validity of such animal models due to a lack of extrapolation between species.

Market Restraining Factor

High Cost Associated with The Deployment of OOCs

In drug discovery and development, OOCs are regarded as more relevant and precise than experimental animals or cell cultures. However, the cost of these chips and the redesigning processes necessary for scale production are substantial. High costs of production are impeding the expansion of the OOC market, as the relatively small enterprises involved may be unable to afford the redesigning process.

Type Outlook

By Type, the Organ-On-Chip Market is segregated into Heart on chip, Human on chip, Intestine on chip, Kidney on chip, Liver on chip, and Lung on chip. In 2021, the lung-on-chip segment acquired the largest revenue share of the organ-on-chip market. Attempts are being made to increase the physiological applicability of current in vitro alveolar-capillary interface models by developing lung-on-chips. Such a multifunctional microdevice can duplicate important structural, functional, and mechanical aspects of the alveolar-capillary interface in humans.

Regional Outlook

Region-Wise, the Organ-On-Chip Market is analyzed across North America, Europe, Asia-Pacific, and LAMEA. In 2021, North America procured the biggest revenue share of the organ-on-chip market. This is due to the increasing prevalence of technologically superior models, the existence of key players, and the increase in drug research and development R&D efforts in regional countries. Furthermore, North American countries are early adopters of a number of novel technologies and approaches.

The market research report covers the analysis of key stake holders of the market. Key companies profiled in the report include AxoSim, Inc., Visikol, Inc., CN Bio Innovations Limited., Elveflow (Elvesys Group), Emulate, Inc., Insphero AG, Mimetas B.V., Nortis Inc., Organovo Holdings, Inc. and TARA Biosystems, Inc.

Scope of the Study

Market Segments covered in the Report:

By Type

• Lung on chip
• Heart on chip
• Human on chip
• Kidney on chip
• Liver on chip
• Intestine on chip

• North America
• US
• Canada
• Mexico
• Rest of North America
• Europe
• Germany
• UK
• France
• Russia
• Spain
• Italy
• Rest of Europe
• Asia Pacific
• China
• Japan
• India
• South Korea
• Singapore
• Malaysia
• Rest of Asia Pacific
• LAMEA
• Brazil
• Argentina
• UAE
• Saudi Arabia
• South Africa
• Nigeria
• Rest of LAMEA

• AxoSim, Inc.
• Visikol, Inc.
• CN Bio Innovations Limited.
• Elveflow (Elvesys Group)
• Emulate, Inc.
• Insphero AG,
• Mimetas B.V.
• Nortis Inc.
• Organovo Holdings, Inc.
• TARA Biosystems, Inc.

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