The Market for Sample Preparation for Next Generation Sequencing (NGS)
The Market for Sample Preparation for Next Generation Sequencing (NGS) covers trends, challenges, strategies, manufacturers, and products, and provides estimates of revenue share and market growth, which includes NGS hardware and consumables. Data presented include NGS sample preparation market and growth rate, 2015-2020; market by geographic region, 2015 (North America, Europe, Asia-Pacific, rest-of-world); market by product type, 2015 (enrichment, libr prep kits panels, etc.; automation/ hardware; nucleic acid extraction; total); and NGS sample preparation leading manufacturer sales and market shares, 2015.
This report notes the direction in which the market for library preparation and target enrichment for NGS is heading, including significant efforts in automation and miniaturization, rapid adoption of smaller sequencers driving applications, and expanding clinical adoption sustaining high growth. Leading manufacturers, such as Agilent Technologies, F. Hoffmann-La Roche AG, Illumina, and Thermo Fisher Scientific, are analyzed, with the competitive situation, deals, and litigation covered in respective chapters.
- Executive Summary
- INTRODUCTION
- PRODUCT INTRODUCTIONS, INDICATIONS OF PRICE PRESSURE
- STABILITY IN SEQUENCERS APPEARS TO BE CONTINUING
- A PERIOD OF RAPID ADOPTION, BUT LOWER PRICES
- HIGH LIKELIHOOD OF LONGER-TERM CHALLENGES
- GROWTH -- BUT COMPETITIVE, CONCENTRATED, AND UNPREDICTABLE
- BACKGROUND
- SCOPE AND METHODOLOGY
- APPLICATIONS AND DEFINITIONS
- Trends
- SIGNIFICANT EFFORTS IN AUTOMATION, MINIATURIZATION
- MERGERS, ACQUISITIONS, EQUITY INVESTMENTS INCREASING
- RAPID ADOPTION OF SMALLER SEQUENCERS DRIVING APPLICATIONS
- EXPECTED SEQUENCER PLATFORMS STALLED OR CANCELLED
- STABILITY DESPITE POSSIBILITY OF DISRUPTIVE TECHNOLOGIES
- SEQUENCER UNIT SALES CONTINUEMOMENTUM
- EXPANDING CLINICAL ADOPTION SUSTAINS HIGH GROWTH
- CHINA BECOMING MAJOR PLAYER IN MARKET
- DISTRIBUTION DEALS INCREASE AS SMALLER COMPANIES ENTER MARKET
- REGULATORY SITUATION UNCLEAR BUT EVOLVING SOMEWHAT
- Products
- Table DNA Extraction, Purification, and Isolation Products
- Table RNA Extraction, Purification, and Isolation Products
- Table Panels, Exome Kits, and Other Target Enrichment Products
- Table DNA Library Construction/ Preparation Products
- Table RNA-Seq, Transcriptome, and Gene Expression Products
- Table Small RNA NGS Sample Preparation Products
- Table ChIP-Seq Products
- Table Methylation and Other Epigenetics Products
- Table Single-Cell NGS Products
- Table Synthetic/ Novel Long Read NGS Technologies/ Products
- Table Library Quantitation / Quality Control Products
- Table Shearing and Fragmentation Products
- Table Fragment/ Size Selection Products
- Table Automated Systems, Liquid Handlers, Other Hardware
- RECENT PRODUCT INTRODUCTIONS
- 2016
- 2015
- 2014
- 2013
- 2012
- NGS Sample Preparation Market Revenues
- REVENUES FORECAST
- Table NGS Sample Preparation Revenues and Growth Rate, 2015-2020
- REVENUES BY REGION
- Table Revenues by Region, 2015
- REVENUES BY PRODUCT TYPE
- Table Revenues by Product Type, 2015
- ILLUMINA CONSUMABLES REVENUES
- Table Illumina Quarterly Consumables Revenues (2012-2015)
- Table Illumina Annual Consumables Revenues (2012-2015)
- Table Illumina Consumables Growth Rates (2013-2015)
- REVENUES FORECAST
- Competitive Analysis
- INTRODUCTION
- RELATIVE STABILITY IN SEQUENCER PLATFORMS
- NGS SAMPLE PREPARATION MARKET SHARES
- Table NGS Sample Preparation Leading Company Revenues and Market Shares, 2015
- SMALLER COMPANIES EXPERIENCING MIXED SUCCESS
- Intellectual Property and Litigation
- SEQUENOM, SEVERAL NIPT COMPANIES FIGHTING
- Ariosa Diagnostics (Roche) Files Suit against Sequenom
- Natera Sues Sequenom; Sequenom Sues Natera
- Verinata Health and Stanford File Against Sequenom
- Verinata Health Against Ariosa and LabCorp
- Illumina Sues Ariosa Diagnostics For NIPT Test
- Illumina Sues Premaitha Health for NIPT Test
- Illumina Sues Premaitha and Ariosa Partners
- Sequenom and Illumina Settle and Pool Patents
- Sequenom Petitions Supreme Court
- ILLUMINA'S CONFLICTS WITH OXFORD NANOPORE
- ENZO BIOCHEM BRINGS SUIT AGAINST NUMEROUS COMPANIES
- 454 (ROCHE) SUES ION TORRENT (THERMO FISHER)
- RAINDANCE TECHNOLOGIES SUES 10X GENOMICS
- 10X GENOMICS' DISPUTE WITH BIO-RAD
- SEQUENOM SHAREHOLDER SUES OVER PRICE "CAPPING"
- CLASS ACTION SHAREHOLDER LAWSUIT FILED AGAINST PACIFIC BIOSCIENCES
- HELICOS' PATENT INFRINGEMENT SUIT AGAINST PACBIO, LIFE TECHNOLOGIES, AND ILLUMINA
- ILLUMINA'S TWO LAWSUITS AGAINST COMPLETE GENOMICS FOR INFRINGEMENT
- LIFE TECHNOLOGIES AND ILLUMINA DISPUTE OVER AMPLIFICATION ON SOLID SURFACES
- LIFE TECHNOLOGIES FILES INFRINGEMENT SUIT AGAINST PROMEGA
- ENZO BIOCHEM DISPUTES SEQUENCING PATENTS
- AZCO BIOTECH SUES QIAGEN AND INTELLIGENT BIO-SYSTEMS
- INTELLIGENT BIO-SYSTEMS (QIAGEN) AND COLUMBIA UNIVERSITY SUE ILLUMINA FOR INFRINGEMENT
- LABCORP'S ESOTERIX SUES LIFE TECHNOLOGIES
- GENETIC TECHNOLOGIES SUES SEVERAL FIRMS FOR INFRINGEMENT OF HAPLOTYPE DETERMINATION TECHNIQUE
- ILLUMINA SUES LIFE TECHNOLOGIES OVER ION TORRENT SYSTEMS
- AFFYMETRIX DISMISSES SUIT AGAINST PACIFIC BIOSCIENCES AND FORMER EMPLOYEES
- LIFE TECHNOLOGIES DEFEATS VISIGEN STAKEHOLDERS AFTER ARBITRATION
- CATALYST ASSETS SUES LIFE TECHNOLOGIES FOR INFRINGEMENT
- PATENT INTERFERENCE BETWEEN LIFE TECHNOLOGIES AND PACIFIC BIOSCIENCES
- LADATECH SUES ILLUMINA OVER DNA AMPLIFICATION PATENT
- ILLUMINA FILES `841 PATENT INFRINGEMENT SUIT AGAINST AFFYMETRIX
- AFFYMETRIX AND ILLUMINA SETTLE CASE OVER `243, `432, `531, `365, AND `716
- APPLIED BIOSYSTEMS AND ILLUMINA CLAIMS AND COUNTER-CLAIMS OVER SEQUENCING-BY-LIGATION BOTH UNSUCCESSFUL
- SEQUENOM, SEVERAL NIPT COMPANIES FIGHTING
- Deals
- Table Significant Collaborations in Recent Years
- Corporate Profiles
- 10X GENOMICS
- AGILENT TECHNOLOGIES
- F. HOFFMANN-LA ROCHE AG
- FLUIDIGM
- ILLUMINA
- NEW ENGLAND BIOLABS
- OXFORD NANOPORE
- PACIFIC BIOSCIENCES
- QIAGEN
- THERMO FISHER SCIENTIFIC
- Challenges and Strategic Recommendations
- CHALLENGES
- Unknown Effects of Closed Systems, Automation, Streamlining
- Medical/ Scientific Discoveries Can Reduce Markets
- Highly Concentrated Sequencer Market Increases Risks
- Dropping Sequencing Costs Create Complex Situations
- Sample Preparation Customer Loyalty Lacking
- Shortcomings and Pitfalls Require Solutions
- Low Barriers Cause Increased Competition Short-Term
- Uncertainty and Debate with LDT Regulation and Adoption
- Complexity and Difficulty Restrains Broad Adoption
- Many Labs Opting for Services over Purchasing Sequencers
- STRATEGIC RECOMMENDATIONS
- Expanding Market Requires Technical Support
- Reduce Bias, Compensate, or Characterize It
- Capitalize on Stability While Preparing for Contingencies
- Address or Anticipate Price Pressure
- Benefit from Partnering or Communicating
- Complementary Products, Other Ways to Hedge
- Use Services for Visibility and Monetization
- Address or Ease Data Analysis Challenges
- Anticipate or Position for Global Adoption
- CHALLENGES
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