Precision Cancer Therapeutics, 2022

Precision Cancer Therapeutics, 2022

Despite advances in cancer treatment, cancer continues to affect about 18.1 million people annually, generating a significant loss of life, financial burden and overall strain on the health industry. Worldwide between 35 and 40 million people are living with cancer and nearly 10 million people lose the battle annually. The most common cancers affecting the world population include lung, breast, colon/rectum, stomach, liver, prostate, cervical, esophageal, and bladder. Cancer deaths occur in about 50% of people who develop cancer in developed countries; this is in contrast to 80% death rate in cancer patients in underdeveloped countries.

The demand for more effective and tolerable cancer treatments has led to the development of novel therapeutic agents that specifically target the malignant cells. Today, advanced precision cancer therapies are available, and more are being developed each year. Although there are some older precision therapies on the market, the industry is now expanding the use of these treatments to better treat cancer victims. Precision treatments are less invasive and less damaging to the body, and they promise improved outcomes in many cases.

This report Precision Cancer Therapeutics, 2022 specifically focuses on five leading segments of precision therapies:

  • Monoclonal antibodies
  • Kinase inhibitors
  • Angiogenesis inhibitors
  • Proteasome inhibitors
  • CAR-T therapies
  • Other precision therapies
Additionally, smaller areas of precision therapies are covered including mTOR inhibitors, PI3K inhibitors, PARP inhibitors, apoptosis inhibitors, histone deacetylase inhibitors, CDK inhibitors, hedgehog signaling pathway inhibitors and several others.

Scope and Methodology

Kalorama Information has watched the cancer treatment market evolve over the past two decades and evaluated the impact new technologies are making on the market. Precision Cancer Therapeutics, 2022 focuses on the expanding area of precision cancer therapies and includes current products available and discusses some of the most exciting developments in progress.

This report covers precision cancer therapies that do at least one of the following:
  • Block or turn off chemical signals that tell the cancer cell to grow and divide
  • Change proteins within the cancer cells so the cells die
  • Stop making new blood vessels to feed the cancer cells
  • Trigger the immune system to kill the cancer cells
  • Carry toxins to the cancer cells to kill them, but not normal cells
The report includes statistical information for cancers by type on a global level. Specifically, cancers where there are current products available or are in development and/or have significant incidence/mortality rates are profiled. The market segments provide an overview of disease epidemiology, leading product sales, market estimates and forecasts, and competitive summary of leading providers. The report also includes a list of Phase 3 precision therapies in development. Throughout the report, several market indicators, trends and barriers are discussed.


  • Executive Summary
    • Overview
    • Scope and Methodology
    • Market Overview and Analysis
      • Table Global Precision Cancer Therapeutic Market Size and Forecast, 2017-2027 ($millions)
  • Introduction
    • Global Cancer Burden
      • Table Incidence of Cancer by Type, 2020
      • Table Distribution of Cancer Incidence by Type, 2020
    • Introduction to Cancer
      • Biochemistry of Cancer Cells
    • Causes of Cancer Growth May Shed Light on Treatment
      • Environmental Factors, DNA, RNA
        • Table Virus Association with Human Cancer
      • Cellular Oncogenes
      • Tumor Suppressor Genes
    • Cancer Treatment Approaches
      • Table Characteristics of Cancer Treatment Approaches (chemotherapy, hormone therapy, Precision therapy)
    • What is Precision Cancer Therapy?
    • Trends in Research and Development of Precision Cancer Therapeutics
    • Monoclonal Antibodies: The Leading Area of Cancer Precision Therapy
  • Precision Cancer Therapies: Monoclonal Antibodies
    • Monoclonal Antibody Overview
    • Market Outlook
      • Table Cancer Monoclonal Antibody Market, 2017-2027 ($ millions)
    • Principal Products
      • Table Top 10 Cancer Indicated Monoclonal Antibodies, 2021 and 2022 Sales (millions $)
      • Avastin (bevacizumab)
      • Blincyto (blinatuomab)
      • Darzalex (daratumumab)
      • Erbitux (cetuximab)
      • Herceptin (trastuzumab)
      • Kadcyla (ado-trastuzumab emtansine)
      • Keytruda (pembrolizumab)
      • Libtayo (cemiplimab-rwlc)
      • Opdivo (nivolumab)
      • Padcev (enfortumab vedotin-jfv)
      • Perjeta (pertuzumab)
      • Rituxan (rituximab)
      • Sarclisa (isatuximab)
      • Tivdak (tisolumab vedotin-tftv)
      • Tecentriq (atezolizumab)
      • Vectibix (panitumumab)
      • Xgeva (denosumab)
      • Yervoy (ipilimumab)
        • Table Selected Monoclonal Antibodies in Cancer Therapy
    • Late-Stage Monoclonal Antibodies Development
      • Table Selected Late-Stage Monoclonal Antibodies in Phase 3 Development
    • Market Breakdown of Monoclonal Antibodies
      • Cancer Monoclonal Antibody Market by Target
        • Table Cancer Monoclonal Antibody Market by Target, 2022 and Forecast 2027 ($ millions)
        • Table Cancer Monoclonal Antibody Market Distribution by Target, 2022 (%)
        • Table Cancer Monoclonal Antibody Market Distribution by Target, 2027 (%)
      • Cancer Monoclonal Antibody Market by Type
        • Table Development of the mAb Cancer Treatment Market, 2010-2027 ($ millions)
        • Table Cancer Treatment mAb Market by Type, 2022-2027 ($ millions)
        • Table Monoclonal Antibody Market by Cancer Type, 2022 and 2027 ($ millions)
        • Table Monoclonal Antibody Market, Distribution by Cancer Type, 2022 (%)
        • Table Monoclonal Antibody Market Distribution by Indication, 2027 (%)
    • Regional Market Summary
      • Table Cancer Monoclonal Antibody Market Summary by Geographic Region, 2022 and 2027 ($ millions)
    • Competitor Summary
      • Merck & Co.
      • Genentech/Roche
      • Bristol-Myers Squibb
      • Janssen Biotech/J&J
      • Amgen
      • AstraZeneca
      • EMD Serono
        • Table Cancer Monoclonal Antibody Competitor Market Share - Top Seven, 2022 ($ millions)
  • Precision Cancer Therapies: Kinase Inhibitors
    • Kinase Inhibitor Overview
    • Market Outlook
      • Table Kinase Inhibitor Market, 2022-2027: CAGR 8.8% ($ millions)
    • Principal Products
      • Table Top 10 Cancer Indicated Kinase Inhibitors, 2021 and Forecast 2022 Sales (millions $)
      • Alecensa (alectinib)
      • Alunbrig (brigatinib)
      • Imbruvica (ibrutinib)
      • Inlyta (axitinib)
      • Sprycel (dasatinib)
      • Tasigna (nilotinib)
      • Tagrisso (osimertinib)
      • Gleevec (imatinib)
      • Mekinist+Tafinlar (trametinib + dabrafenib)
      • Sutent (sunitinib)
      • Jakafi/Jakavi (ruxolitinib)
      • Nexavar (sorafenib)
      • Tukysa (tucatinib)
      • Votrient (pazopanib)
        • Table Kinase Inhibitors in Cancer Therapy
    • Late-Stage Kinase Inhibitors Development
      • Table Selected Phase 3 Kinase Inhibitors in Development
    • Market Breakdown of Kinase Inhibitors
      • Cancer Kinase Inhibitor Market by Target
        • Table Cancer Kinase Inhibitor Market by Target, 2022 and Forecast 2027 ($ millions)
        • Table Cancer Kinase Inhibitor Market by Target, 2022 and 2027 ($ millions)
        • Table Kinase Inhibitor Market Distribution by Target, 2022 (%)
        • Table Kinase Inhibitor Market Distribution by Target, 2027 (%)
      • Cancer Kinase Inhibitor Market by Type
        • Table Development of the Kinase Inhibitor Cancer Treatment Market, 2010-2027 ($ millions)
        • Table Cancer Treatment Kinase Inhibitor Market by Type, 2022-2027 ($ millions)
        • Table Kinase Inhibitor Market by Cancer Indication, 2022 and 2027 ($ millions)
        • Table Kinase Inhibitor Market Distribution by Cancer Indication, 2022 (%)
        • Table Kinase Inhibitor Market Distribution by Cancer Indication, 2027 (%)
    • Regional Market Summary
      • Table Cancer Kinase Inhibitor Market Summary by Geographic Region, 2022 and 2027 ($ millions)
    • Competitor Summary
      • Novartis
      • AstraZeneca
      • AbbVie
      • Johnson & Johnson
      • Pfizer
      • Bristol-Myers Squibb
      • Roche/Genentech
        • Table Cancer Kinase Inhibitor Competitor Market Share, 2022 ($ millions)
  • Precision Cancer Therapies: Angiogenesis Inhibitors
    • Angiogenesis Inhibitor Overview
    • Market Outlook
      • Table Angiogenesis Inhibitor Market, 2017-2027 ($ millions)
    • Principal Products
      • Pomalyst/Imnovid (pomalidomide)
      • Revlimid (lenalidomide)
      • Thalomid (thalidomide)
      • Zaltrap (ziv-aflibercept)
        • Table Angiogenesis Inhibitors in Cancer Therapy
    • Late-Stage Angiogenesis Inhibitor Phase 3 Development
      • Table Selected Phase 3 Angiogenesis Inhibitor Development
    • Regional Market Summary
      • Table Cancer Angiogenesis Inhibitor Market Summary by Geographic Region, Estimated 2022 and 2027 ($ millions)
    • Competitor Summary
  • Precision Cancer Therapies: CAR-T Therapies
    • CAR-T Overview
    • Manufacturing Process for CAR-T
      • Leukapheresis
      • Activation
      • Transduction
      • Expansion
    • Regulatory Developments
    • Market Outlook
      • Table CAR-T Market, 2017-2027 ($ millions)
    • Principal Products
      • Abecma
      • Breyanzi
      • Carvykti
      • Kymriah
      • Tecartus
      • Yescarta
    • Late-Stage CAR-T Therapies Development
      • Table Phase III Development CAR-T Therapies, Select Projects
    • Regional Market Summary
      • Table Cancer CAR-T Market Summary by Geographic Region, Estimated 2022 and 2027 ($ millions)
    • Competitor Summary
  • Precision Cancer Therapies: Proteasome Inhibitors
    • Proteasome Inhibitor Overview
    • Market Outlook
      • Table Proteasome Inhibitor Market, 2022-2027 ($ millions)
    • Principal Products
      • Kyprolis (carfilzomib)
      • Ninlaro (ixazomib)
      • Velcade (bortezomib)
        • Table Proteasome Inhibitors in Cancer Therapy
    • Regional Market Summary
      • Table Cancer Proteasome Inhibitor Market Summary by Geographic Region, Estimated 2022 and 2027 ($ millions)
    • Competitor Summary
      • Takeda
      • Amgen
        • Table Cancer Proteasome Inhibitor Competitor Market Share, 2022 ($ millions)
  • Precision Cancer Therapies: Other Precision Therapies
    • Other Precision Therapies Overview
    • Market Outlook
      • Table Other Precision Therapies Market, 2017-2027 ($ millions)
    • Principal Products
      • mTOR Inhibitor Afinitor (everolimus)
      • mTOR Inhibitor Torisel (temsirolimus)
      • PI3K Inhibitor Zydelig
      • PARP Inhibitor Lynparza
      • PARP Inhibitor Zejula
      • Apoptosis Inducer Venclexta
      • CDK Inhibitors - Ibrance (palbociclib)
      • CDK Inhibitors - Kisqali (ribociclib)
        • Table Other Precision Cancer Therapies
    • Late-Stage Other Therapies Development
      • Table Select Phase 3 Other Therapies Development
    • Regional Market Summary
      • Table Other Precision Therapies Market Summary by Geographic Region, Estimated 2022 and 2027 ($ millions)
  • Market Summary
    • Market Influences
      • Global Demographics
        • Table Global Population, through 2050 (population in millions)
      • Aging Population
        • Table Global Population Trends, Total Population vs. Age 65+ Population, 2000-2050
      • Cancer: A Growing Economic Burden
      • Cost Containment
        • Table The Cost of Monoclonal Antibodies (2020-2021)
      • Reimbursement Landscape: A Deciding Factor for Success
      • The Biosimilar Movement
    • Regional Market Overview
      • Table Precision Cancer Therapeutics Market Summary by Geographical Region, 2022-2027 ($ millions)
    • United States and Canada
      • Table Precision Cancer Therapeutics Market Summary for U.S. and Canada, 2022-2027 ($ millions)
      • Table Precision Cancer Therapeutics for U.S. and Canada, Distribution by Therapy Type (monoclonal antibodies, kinase inhibitors, angiogenesis inhibitors, proteasome inhibitors, CAR-T, other Precision therapies), 2022 %
    • EMEA
      • Table Precision Cancer Therapeutics Market Summary for EMEA, 2022-2027 ($ millions)
      • Table Precision Cancer Therapeutics for EMEA, Distribution by Therapy Type (monoclonal antibodies, kinase inhibitors, angiogenesis inhibitors, proteasome inhibitors, CAR-T, other Precision therapies), 2022 (%)
    • Asia Pacific
      • Table Precision Cancer Therapeutics Market Summary for Asia Pacific, 2022-2027 ($ millions)
      • Table Precision Cancer Therapeutics for Asia Pacific, Distribution by Therapy Type (monoclonal antibodies, kinase inhibitors, angiogenesis inhibitors, proteasome inhibitors, CAR-T, other Precision therapies), 2022 (%)
    • Latin America
      • Table Precision Cancer Therapeutics Market Summary for Latin America, 2022-2027 ($ millions)
      • Table Precision Cancer Therapeutics for Latin America, Distribution by Therapy Type (monoclonal antibodies, kinase inhibitors, angiogenesis inhibitors, proteasome inhibitors, CAR-T, other Precision therapies), 2022 (%)
  • Market Participants
    • Top 15 Overview
      • Table Global Market Participants for Precision Cancer Therapeutics, Top 15 Companies, 2022 ($ in millions)
      • Table Global Market Share for Precision Cancer Therapeutics, 2022 %
      • Table Growth in Precision Cancer Therapeutics by Company 2010 vs. 2022 ($ in millions)
      • Table Growth Trend by Company, 2010-2022 CAGR: Precision Cancer Therapeutics
    • AbbVie, Inc.
      • Table AbbVie Corporate Summary
      • Company Summary
    • Amgen
      • Table Amgen Corporate Summary
      • Company Summary
    • Astellas Pharma U.S., Inc
      • Table Astellas Corporate Summary
      • Company Summary
    • AstraZeneca PLC
      • Table AstraZeneca Corporate Summary
      • Company Summary
    • Bayer AG
      • Table Bayer Corporate Summary
      • Company Summary
    • Bristol-Myers Squibb Company
      • Table Bristol-Myers Squibb Corporate Summary
      • Company Summary
    • Clovis Oncology, Inc.
      • Table Clovis Oncology Corporate Summary
      • Company Summary
    • Dendreon Pharmaceuticals LLC
      • Table Dendreon Corporate Summary
      • Company Summary
    • Eli Lilly & Company
      • Table Eli Lilly Corporate Summary
      • Company Summary
    • EMD Serono, Inc. (Merck KgaA)
      • Table EMD Serono Corporate Summary
      • Company Summary
    • Eisai Co., Ltd.
      • Table Eisai Corporate Summary
      • Company Summary
    • Exelixis, Inc.
      • Table Exelixis Corporate Summary
      • Company Summary
    • Gilead Sciences, Inc.
      • Table Gilead Sciences Corporate Summary
      • Company Summary
    • GlaxoSmithKline
      • Table GSK Corporate Summary
      • Company Summary
    • Johnson & Johnson
      • Table Johnson & Johnson Corporate Summary
      • Company Summary
    • Merck & Co., Inc.
      • Table Merck & Co. Corporate Summary
      • Company Summary
    • Novartis AG
      • Table Novartis Corporate Summary
      • Company Summary
    • Otsuka Holdings Co., Ltd.
      • Table Otsuka Corporate Summary
      • Company Summary
    • Pfizer, Inc.
      • Table Pfizer Corporate Summary
      • Company Summary
    • Puma Biotechnology, Inc.
      • Table Puma Biotechnology Corporate Summary
      • Company Summary
    • Roche (F. Hoffman-La Roche, Ltd.)
      • Table Roche Corporate Summary
      • Company Summary
    • Sanofi/Genzyme
      • Table Sanofi/Genzyme Corporate Summary
      • Company Summary
    • Seagen Inc.
      • Table Seagen Corporate Summary
      • Company Summary
    • Takeda Oncology - Millennium Pharmaceuticals
      • Table Takeda Oncology Corporate Summary
      • Company Summary

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