Cell and Gene Therapy Market and Deals Analysis, 2023: Financings, Partnering, Mergers and Acquisitions, Tech Transfers, IPOs, and Other Deals
This report, Kalorama's Cell and Gene Deals and Market Analysis, tracks the dealmaking and market opportunity for cell and gene therapy companies. A lot of attention is being given to the areas related to cell and gene therapy (CGT) recently. Kalorama's latest report finds that the volume of deals between companies and other funding entities involving CGT is up, and companies have continued to receive large amounts of investment despite a decline from 2021 levels of investment.
Kalorama's CGT deals amounted to a staggering $40 billion in 2022.
While the concepts of gene therapy and cell therapy have been investigated for decades, there were major challenges in the early years. Through incremental progress, and the gradual introduction of enabling tools such as CRISPR and next-generation sequencing (NGS), cell and gene therapy has emerged into a highly active area. There are now many approved therapies with proven track records.
As the new tools have lowered the barriers to entry for the industry, over 1,500 companies have been created or have become involved.
The following is just some of the information in this report:
Most Active Deal-Making Companies
Deals per Month, April 2021-March 2023
Deals by Type - Technology/Research/Strategic Collaboration; Venture Capital/Private Investment; Acquisition, Merger, Strategic Investment; Licensing; Public Offering/SPAC; Manufacturing, Supply Chain; Outreach, Philanthropy, Education; Distribution, Co-Marketing; Spinout, Restructure; Conclude/Terminate Deal; Joint Venture; and Settle Litigation
Venture Capital and Private Funding Deals by Month, January 2021-March 2023 (Total count)
Total Number of Mergers and Acquisitions, By Month
Average Merger/Acquisition Amount, By Quarter [Q1 2021-Q1 2023] ($M)
List of M&As [Company 1, Company 2, Details, Amount, w/Milestones, Date]
Most Frequent Types of Deals, by Quarter, by Category [Technology/Research/Strategic Collaboration; Venture Capital/Private Investment; Acquisition, Merger, Strategic Investment; Licensing; Public Offering/SPAC; and Manufacturing, Supply Chain] (Total number)
Most Active Companies in Acquisition/Merger/ Strategic Investment
Most Active Companies in Overall Deals, Collaborations
Estimated Market Forecasts for Cell and Gene Therapies by Type (Gene Therapy, Cell Therapy)
Estimated Market Forecasts by Region (North America, EU, APAC, Other)
Estimated Market Forecasts for CGT by Disease Category (Oncology, Other)
No report published by a major market research publisher has tackled the Cell and Gene Therapy dealmaking space as it exists in 2023 in a more comprehensive fashion. As Cell and Gene Therapy is a highly competitive marketplace, hundreds of companies are referenced in this report.
Executive Summary
Introduction
$40.2 Billion in Funding During 2022
Table Total Deals per Month, April 2021-March 2023 (Total count)
Table Total Deals per Month by Type, Apr 2021-Mar 2023 [VC/ Private, IPO/FPO/SPAC; and All Other Deals] (Total count)
Quarterly Funding Amounts
Table Total Quarterly Funding, by Type, Q1 2021-Q4 2021 [M&A; Venture Capital/Private; IPO/FPO; Collab; SPAC; and Strat inv] ($M)
Table Total Quarterly Funding, by Type, Q1 2022-Q1 2023 [M&A; Venture Capital/Private; IPO/FPO; Collab; SPAC; and Strat inv] ($M)
Table Total Quarterly Funding, Q1 2021- Q1 2023 ($M)
Table Total Quarterly Funding, by Type, Q1 2021-Q1 2023 [M&A; Venture Capital/Private; IPO/FPO; Collab; SPAC; and Strat inv] ($M)
Quarterly Funding Category Shares, Q1 2021 Through Q1 2023
Table Total Quarterly Funding Share, by Type, 2021 [M&A; Venture Capital/Private; IPO/FPO; Collab; SPAC; and Strat inv] (%)
Table Total Quarterly Funding Share, by Type, Q1 2022-Q1 2023 [M&A; Venture Capital/Private; IPO/FPO; Collab; SPAC; and Strat inv] (%)
Table Q1 2022 Funding Share, by Type of Funding [M&A; Venture Capital/Private; IPO/FPO; Collab; SPAC; and Strat inv] (%)
Table Q2 2022 Funding Share, by Type of Funding [M&A; Venture Capital/Private; IPO/FPO; Collab; SPAC; and Strat inv] (%)
Table Q3 2022 Funding Share, by Type of Funding [M&A; Venture Capital/Private; IPO/FPO; Collab; SPAC; and Strat inv] (%)
Table Q4 2022 Funding Share, by Type of Funding [M&A; Venture Capital/Private; IPO/FPO; Collab; SPAC; and Strat inv] (%)
Table Q1 2023 Funding Share, by Type of Funding [M&A; Venture Capital/Private; IPO/FPO; Collab; SPAC; and Strat inv] (%)
Quarterly Deal Counts by Category, Q1 2021 - Q1 2023
Table Quarterly Count of Deals, By 2021 Quarter, By Category [Technology/Research/Strategic Collaboration; Venture Capital/Private Investment; Acquisition, Merger, Strategic Investment; Licensing; Public Offering/SPAC; Manufacturing, Supply Chain; Outreach, Philanthropy, Education; Distribution, Co-Marketing; Spinout, Restructure; Conclude/Terminate Deal; Joint Venture; and Settle Litigation] (total number) (%)
Table Quarterly Count of Deals, by Quarter Q1 2022-Q1 2023, By Category [Technology/Research/Strategic Collaboration; Venture Capital/Private Investment; Acquisition, Merger, Strategic Investment; Licensing; Public Offering/SPAC; Manufacturing, Supply Chain; Outreach, Philanthropy, Education; Distribution, Co-Marketing; Spinout, Restructure; Conclude/Terminate Deal; Joint Venture; and Settle Litigation] (total number) (%)
Growth in Collaborations, Manufacturing/Supply Chain Deals, Licensing, Distribution/ Co-Marketing Highlight Activity in Cell and Gene Therapy
Table Most Frequent Types of Deals, by Quarter, by Category [Technology/Research/Strategic Collaboration; Venture Capital/Private Investment; Acquisition, Merger, Strategic Investment; Licensing; Public Offering/SPAC; and Manufacturing, Supply Chain] (Total number)
A Look at Less Frequent CGT Deal Types
Table Lower Frequency Deal Types, by Quarter, by Category [Outreach, Philanthropy, Education; Distribution, Co-Marketing; Spinout, Restructure; Conclude/Terminate Deal; Joint Venture; and Settle Litigation] (total number)
Table Average Collaboration Upfront Payment, By Quarter [Q1 2021-Q1 2023] ($M)
Table Total Collaboration Upfront Payments, By Quarter [Q1 2021-Q1 2023] ($M)
Table Average Collaboration Future/ Milestone Payments, By Quarter [Q1 2021-Q1 2023] ($M)
Table Total Collaboration Future/ Milestone Payments, By Quarter [Q1 2021-Q1 2023] ($M)
Table Technology/Research/Strategic Collaboration Deals, January 2022-April 2023
Most Active Companies
Table Most Active in Research/Strategic Collaborations
Licensing
Stable Levels of Licensing in the Cell and Gene Therapy Market
Table Total Number of Licensing Deals, By Month [Jan 2021-Mar 2023] (Total count)
Table Licensing Deals, January 2022-April 2023
Most Active Companies
Table Most Active Companies in Licensing Deals
Manufacturing and Supply Chain
Major Growth in Manufacturing and Supply Chain Management Activity in CGT
Table Total Number of Supply/ Manufacturing Deals, By Month [Jan 2021-Mar 2023] (Total count)
Table Manufacturing and Supply Chain Deals, January 2022-March 2023
Most Active Companies
Table Most Active Companies in Manufacturing/Supply Deals
Public Outreach, Education, &Philanthropy
CGT Market Focusing Less on Public Outreach, Patient/ Consumer/ Trainee Education, and Philanthropy
Table Total Number of Outreach/ Philanthropy/ Education Deals, By Month [Jan 2021-Mar 2023] (Total count)
Table Outreach, Education, &Philanthropy Deals, January 2022-Apr 2023
Distribution & Co-Marketing
A Look at CGT Distribution and Co-Marketing Deals
Table Total Number of Distribution/ Co-Marketing Deals, by Month [Jan 2021-Mar 2023] (Total count)
Table Distribution & Co-Marketing Deals, January 2022-Mar 2023
Most Active Companies
Table Most Active Companies in Distribution/Co-Marketing Deals
Other - JV, Restructuring, Termination, Spinoffs
A Look at Other Types of Deals Impacting Cell and Gene Therapy
Table Total Number of JV, Restructuring, Termination, By Month [Jan 2021-Mar 2023] (Total count)
Table Restructuring, JV, Termination, Spinoffs, January 2022-April 2023
Other - New Facilities, Expansion; Real Estate
Expansion, New Facilities and Related Announcements
Table New Facilities, Expansion; Real Estate Deals, January 2022-April 2023
Cell and Gene Therapy Market Assessment
Market Outlook, 2022-2032
Table Cell and Gene Therapy Market Revenues by Product Type, 2022 and Projected 2027 and 2032 ($ millions)
Table Cell and Gene Therapy Market Revenue Share, by Product Type [Cardiovascular-Blood, Dermatological, Musculoskeletal, Neurology, Oncology, Ophthalmic, Other Conditions] (%)
Regional Market
Table Cell and Gene Therapy Market by Country/Region [Europe, United States, Other Countries],
Products on the Market
Table Major Cell and Gene Therapy Product Approvals, FDA
Top Companies in Cell and Gene Therapy
Table Leading Companies in Cell and Gene Therapy, By Company [Amylan, Bristol Myers, Dendreon, Gilead, Novartis, Smith and Nephew, Others]