Plasma Protease C1-inhibitor Market Size, Share & Trends Analysis Report By Drug Class (C1-inhibitors, Kallikrein Inhibitor), By Dosage Form (Lyphophlised, Injectables), By Distribution Channel, By Region, And Segment Forecasts, 2024 - 2030

Plasma Protease C1-inhibitor Market Size, Share & Trends Analysis Report By Drug Class (C1-inhibitors, Kallikrein Inhibitor), By Dosage Form (Lyphophlised, Injectables), By Distribution Channel, By Region, And Segment Forecasts, 2024 - 2030


Plasma Protease C1-inhibitor Market Growth & Trends

The global plasma protease C1-inhibitor market size is anticipated to reach USD 6.21 billion by 2030, expanding at a CAGR of 9.79% from 2024 to 2030, according to a new report by Grand View Research, Inc. The global market for plasma protease C1-inhibitor is propelled by multiple pivotal factors such as the rising incidence of hereditary angioedema (HAE), a rare genetic disorder, increases the demand for effective therapies such as C1-inhibitor. Furthermore, advancements in biotechnology improve production efficiency, making these therapies more accessible.

Increased awareness and improved diagnosis of HAE and related conditions further contribute to substantial market growth. HAE affects approximately 1 in 50,000 individuals worldwide, underscoring the urgent need for therapies to alleviate symptoms and improve patient quality of life. Furthermore, advancements in biotechnology have enabled the development of recombinant products, which promise enhanced efficacy and accessibility for patients globally. These drivers are pivotal in shaping the landscape of the C1-INH industry, facilitating greater adoption and investment in novel treatment options.

Innovations in therapies are set to redefine treatment standards across various conditions. For instance, the introduction of long-acting formulations offers extended therapeutic effects, reducing treatment frequency and improving patient compliance. Additionally, ongoing research into new indications beyond HAE, such as antibody-mediated autoimmune diseases, showcases the versatility and potential of therapies in addressing unmet medical needs. These advancements underscore the dynamic nature of the industry, driven by continuous research and development efforts aimed at expanding therapeutic applications and optimizing patient outcomes.

Industry continues to expand; market players are increasingly focused on addressing key challenges and seizing opportunities for growth. Regulatory advancements and favorable reimbursement policies are anticipated to further propel market expansion, facilitating greater accessibility to C1-INH therapies for patients globally. Market players are leveraging these regulatory developments to streamline industry entry processes and ensure timely access to innovative treatments. Companies such as CSL Behring and Takeda Pharmaceutical are actively investing in expanding production capacities to meet escalating demand and ensure global supply chain resilience. Moreover, partnerships with research institutions and regulatory bodies are fostering innovation and accelerating the approval process for new C1-INH therapies. These proactive measures underscore a commitment to advancing treatment options and reinforcing market leadership, positioning stakeholders for sustained growth and success in the evolving healthcare landscape.

Plasma Protease C1-inhibitor Market Report Highlights
  • Based on drug class, C1-inhibitors dominated the market and accounted for the largest share in 2023. Selective bradykinin B2 receptor antagonist anticipated to grow at the fastest growth rate over the forecast period owing to undergoing R&D initiatives being undertaken by major players
  • Based on dosage form, the lyophilized segment held a dominant share in 2023 due to their stability, longer shelf life, and ease of storage and transportation, making them preferred for plasma protease C1-inhibitor therapies, ensuring efficacy and convenience for patients and healthcare providers alike
  • Based on distribution channel, hospital pharmacies dominated the market in 2023 due to their widespread accessibility, regulatory compliance, and ability to handle specialized therapies like plasma protease C1-inhibitor effectively
  • North America dominated the market and accounted for the largest share in 2023 owing to high healthcare spending, advanced healthcare infrastructure, robust research, and significant adoption of Plasma Protease C1-inhibitor therapies for various rare diseases like hereditary angioedema.
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Chapter 1. Methodology and Scope
1.1. Market Segmentation & Scope
1.2. Segment Definitions
1.2.1. Drug Class
1.2.2. Dosage form
1.2.3. Distribution Channel
1.2.4. Regional scope
1.2.5. Estimates and forecasts timeline
1.3. Research Methodology
1.4. Information Procurement
1.4.1. Purchased database
1.4.2. GVR’s internal database
1.4.3. Secondary sources
1.4.4. Primary research
1.4.5. Details of primary research
1.4.5.1. Data for primary interviews in North America
1.4.5.2. Data for primary interviews in Europe
1.4.5.3. Data for primary interviews in Asia Pacific
1.4.5.4. Data for primary interviews in Latin America
1.4.5.5. Data for Primary interviews in MEA
1.5. Information or Data Analysis
1.5.1. Data analysis models
1.6. Market Formulation & Validation
1.7. Model Details
1.7.1. Commodity flow analysis (Model 1)
1.7.2. Approach 1: Commodity flow approach
1.7.3. Volume price analysis (Model 2)
1.7.4. Approach 2: Volume price analysis
1.8. List of Secondary Sources
1.9. List of Primary Sources
1.10. Objectives
Chapter 2. Executive Summary
2.1. Market Snapshot
2.2. Drug Class and Dosage Form Snapshot
2.3. Distribution Channel Snapshot
2.4. Competitive Landscape Snapshot
Chapter 3. Plasma Protease C1-inhibitor Market Variables, Trends, and Scope
3.1. Plasma Protease C1-inhibitor Market Lineage Outlook
3.1.1. Parent Market Outlook
3.1.2. Ancillary market outlook
3.2. Market Dynamics
3.2.1. Market Driver Analysis
3.2.1.1. Increasing Disease Awareness
3.2.1.2. Advancements in Treatment Options
3.2.1.3. Expansion of Indications
3.2.2. Market Restraint Analysis
3.2.2.1. High Cost of Treatment
3.2.2.2. Side Effects and Safety Concerns
3.2.2.3. Regulatory Challenges
3.3. Plasma Protease C1-inhibitor Market Analysis Tools
3.3.1. Porter’s Five Forces Analysis
3.3.2. PESTLE Analysis
Chapter 4. Plasma Protease C1-inhibitor Market Analysis, by Drug Class, 2018 - 2030 (USD Million)
4.1. Drug Class Market Share, 2023 & 2030
4.2. Segment Dashboard
4.3. Plasma Protease C1-inhibitor Market by Drug Class Outlook
4.3.1. C1-inhibitors
4.3.1.1. Market Estimates and Forecasts, 2018 - 2030 (USD Million)
4.3.1.2. C1-esterase Inhibitor
4.3.1.2.1. Market Estimates and Forecasts, 2018 - 2030 (USD Million)
4.3.1.3. Recombinant Inhibitor
4.3.1.3.1. Market Estimates and Forecasts, 2018 - 2030 (USD Million)
4.3.2. Kallikrein Inhibitor
4.3.2.1. Market Estimates and Forecasts, 2018 - 2030 (USD Million)
4.3.3. Selective Bradykinin B2 Receptor Antagonist
4.3.3.1. Market Estimates and Forecasts, 2018 - 2030 (USD Million)
Chapter 5. Plasma Protease C1-inhibitor Market Analysis, by Dosage Form, 2018 - 2030 (USD Million)
5.1. Dosage Form Market share, 2023 & 2030
5.2. Segment Dashboard
5.3. Plasma Protease C1-inhibitor Market by Dosage Form Outlook
5.3.1. Lyphophlised
5.3.1.1. Market Estimates and Forecasts, 2018 - 2030 (USD Million)
5.3.2. Injectables
5.3.2.1. Market Estimates and Forecasts, 2018 - 2030 (USD Million)
Chapter 6. Plasma Protease C1-inhibitor Market Analysis, by Distribution Channel, 2018 - 2030 (USD Million)
6.1. Distribution Channel Market Share, 2023 & 2030
6.2. Segment Dashboard
6.3. Plasma Protease C1-inhibitor Market by Distribution Channel Outlook
6.3.1. Hospital Pharmacies
6.3.1.1. Market Estimates and Forecasts, 2018 - 2030 (USD Million)
6.3.2. Retail Pharmacies
6.3.2.1. Market Estimates and Forecasts, 2018 - 2030 (USD Million)
6.3.3. Online Pharmacies
6.3.3.1. Market Estimates and Forecasts, 2018 - 2030 (USD Million)
Chapter 7. Plasma Protease C1-inhibitor Market: Regional Estimates and Trend Analysis by Drug Class, by Dosage Form
7.1. Plasma Protease C1-inhibitor Market: Regional Outlook
7.2. North America
7.2.1. North America Plasma Protease C1-inhibitor Market Estimates and Forecasts, 2018 - 2030 (USD Million)
7.2.2. U.S.
7.2.2.1. Key Country Dynamics
7.2.2.2. U.S. Plasma Protease C1-inhibitor Market Estimates and Forecasts, 2018 - 2030 (USD Million)
7.2.2.3. Competitive/Market Scenario
7.2.2.4. Regulatory Framework
7.2.2.5. Reimbursement scenario
7.2.3. Canada
7.2.3.1. Key Country Dynamics
7.2.3.2. Canada Plasma Protease C1-inhibitor Market Estimates and Forecasts, 2018 - 2030 (USD Million)
7.2.3.3. Competitive/Market Scenario
7.2.3.4. Regulatory Framework
7.2.3.5. Reimbursement Scenario
7.2.4. Mexico
7.2.4.1. Key Country Dynamics
7.2.4.2. Mexico Plasma Protease C1-inhibitor Market Estimates and Forecasts, 2018 - 2030 (USD Million)
7.2.4.3. Competitive/Market Scenario
7.2.4.4. Regulatory Framework
7.2.4.5. Reimbursement Scenario
7.3. Europe
7.3.1. Europe Plasma Protease C1-inhibitor Market Estimates and Forecasts, 2018 - 2030 (USD Million)
7.3.2. UK
7.3.2.1. Key Country Dynamics
7.3.2.2. UK Plasma Protease C1-inhibitor Market Estimates and Forecasts, 2018 - 2030 (USD Million)
7.3.2.3. Competitive/Market Scenario
7.3.2.4. Regulatory Framework
7.3.2.5. Reimbursement Scenario
7.3.3. Germany
7.3.3.1. Key Country Dynamics
7.3.3.2. Germany Plasma Protease C1-inhibitor Market Estimates and Forecasts, 2018 - 2030 (USD Million)
7.3.3.3. Competitive/Market Scenario
7.3.3.4. Regulatory Framework
7.3.3.5. Reimbursement Scenario
7.3.4. France
7.3.4.1. Key Country Dynamics
7.3.4.2. France Plasma Protease C1-inhibitor Market Estimates and Forecasts, 2018 - 2030 (USD Million)
7.3.4.3. Competitive/Market Scenario
7.3.4.4. Regulatory Framework
7.3.4.5. Reimbursement Scenario
7.3.5. Spain
7.3.5.1. Key Country Dynamics
7.3.5.2. Spain Plasma Protease C1-inhibitor Market Estimates and Forecasts, 2018 - 2030 (USD Million)
7.3.5.3. Competitive/Market Scenario
7.3.5.4. Regulatory Framework
7.3.5.5. Reimbursement Scenario
7.3.6. Italy
7.3.6.1. Key Country Dynamics
7.3.6.2. Italy Plasma Protease C1-inhibitor Market Estimates and Forecasts, 2018 - 2030 (USD Million)
7.3.6.3. Competitive/Market Scenario
7.3.6.4. Regulatory Framework
7.3.6.5. Reimbursement Scenario
7.3.7. Denmark
7.3.7.1. Key Country Dynamics
7.3.7.2. Denmark Plasma Protease C1-inhibitor Market Estimates and Forecasts, 2018 - 2030 (USD Million)
7.3.7.3. Competitive/Market Scenario
7.3.7.4. Regulatory Framework
7.3.7.5. Reimbursement Scenario
7.3.8. Sweden
7.3.8.1. Key Country Dynamics
7.3.8.2. Sweden Plasma Protease C1-inhibitor Market Estimates and Forecasts, 2018 - 2030 (USD Million)
7.3.8.3. Competitive/Market Scenario
7.3.8.4. Regulatory Framework
7.3.8.5. Reimbursement Scenario
7.3.9. Norway
7.3.9.1. Key Country Dynamics
7.3.9.2. Norway Plasma Protease C1-inhibitor Market Estimates and Forecasts, 2018 - 2030 (USD Million)
7.3.9.3. Competitive/Market Scenario
7.3.9.4. Regulatory Framework
7.3.9.5. Reimbursement Scenario
7.4. Asia Pacific
7.4.1. Asia Pacific Plasma Protease C1-inhibitor Market Estimates And Forecasts, 2018 - 2030 (USD Million)
7.4.2. Japan
7.4.2.1. Key Country Dynamics
7.4.2.2. Japan Plasma Protease C1-inhibitor Market Estimates and Forecasts, 2018 - 2030 (USD Million)
7.4.2.3. Competitive/Market Scenario
7.4.2.4. Regulatory Framework
7.4.2.5. Reimbursement Scenario
7.4.3. China
7.4.3.1. Key Country Dynamics
7.4.3.2. China Plasma Protease C1-inhibitor Market Estimates and Forecasts, 2018 - 2030 (USD Million)
7.4.3.3. Competitive/Market Scenario
7.4.3.4. Regulatory Framework
7.4.3.5. Reimbursement Scenario
7.4.4. India
7.4.4.1. Key Country Dynamics
7.4.4.2. India Plasma Protease C1-inhibitor Market Estimates and Forecasts, 2018 - 2030 (USD Million)
7.4.4.3. Competitive/Market Scenario
7.4.4.4. Regulatory Framework
7.4.4.5. Reimbursement Scenario
7.4.5. Australia
7.4.5.1. Key Country Dynamics
7.4.5.2. Australia Plasma Protease C1-inhibitor Market Estimates and Forecasts, 2018 - 2030 (USD Million)
7.4.5.3. Competitive/Market Scenario
7.4.5.4. Regulatory Framework
7.4.5.5. Reimbursement Scenario
7.4.6. Thailand
7.4.6.1. Key Country Dynamics
7.4.6.2. Thailand Plasma Protease C1-inhibitor Market Estimates and Forecasts, 2018 - 2030 (USD Million)
7.4.6.3. Competitive/Market Scenario
7.4.6.4. Regulatory Framework
7.4.6.5. Reimbursement Scenario
7.4.7. South Korea
7.4.7.1. Key Country Dynamics
7.4.7.2. South Korea Plasma Protease C1-inhibitor Market Estimates and Forecasts, 2018 - 2030 (USD Million)
7.4.7.3. Competitive/Market Scenario
7.4.7.4. Regulatory Framework
7.4.7.5. Reimbursement Scenario
7.5. Latin America
7.5.1. Latin America Plasma Protease C1-inhibitor Market Estimates and Forecasts, 2018 - 2030 (USD Million)
7.5.2. Brazil
7.5.2.1. Key Country Dynamics
7.5.2.2. Brazil Plasma Protease C1-inhibitor Market Estimates and Forecasts, 2018 - 2030 (USD Million)
7.5.2.3. Competitive/Market Scenario
7.5.2.4. Regulatory Framework
7.5.2.5. Reimbursement Scenario
7.5.3. Argentina
7.5.3.1. Key Country Dynamics
7.5.3.2. Argentina Plasma Protease C1-inhibitor Market Estimates and Forecasts, 2018 - 2030 (USD Million)
7.5.3.3. Competitive/Market Scenario
7.5.3.4. Regulatory Framework
7.5.3.5. Reimbursement Scenario
7.6. MEA
7.6.1. MEA Plasma Protease C1-inhibitor Market Estimates and Forecasts, 2018 - 2030 (USD Million)
7.6.2. South Africa
7.6.2.1. Key Country Dynamics
7.6.2.2. South Africa Plasma Protease C1-inhibitor Market Estimates and Forecasts, 2018 - 2030 (USD Million)
7.6.2.3. Competitive/Market Scenario
7.6.2.4. Regulatory Framework
7.6.2.5. Reimbursement Scenario
7.6.3. Saudi Arabia
7.6.3.1. Key Country Dynamics
7.6.3.2. Saudi Arabia Plasma Protease C1-inhibitor Market Estimates and Forecasts, 2018 - 2030 (USD Million)
7.6.3.3. Competitive/Market Scenario
7.6.3.4. Regulatory Framework
7.6.3.5. Reimbursement Scenario
7.6.4. UAE
7.6.4.1. Key Country Dynamics
7.6.4.2. UAE Plasma Protease C1-inhibitor Market Estimates and Forecasts, 2018 - 2030 (USD Million)
7.6.4.3. Competitive/Market Scenario
7.6.4.4. Regulatory Framework
7.6.4.5. Reimbursement Scenario
7.6.5. Kuwait
7.6.5.1. Key Country Dynamics
7.6.5.2. Kuwait Plasma Protease C1-inhibitor Market Estimates and Forecasts, 2018 - 2030 (USD Million)
7.6.5.3. Competitive/Market Scenario
7.6.5.4. Regulatory Framework
7.6.5.5. Reimbursement Scenario
Chapter 8. Competitive Landscape
8.1. Market Participant Categorization
8.2. Key Company Profiles
8.2.1. CSL
8.2.1.1. Company overview
8.2.1.2. Financial performance
8.2.1.3. Product benchmarking
8.2.1.4. Strategic initiatives
8.2.2. Takeda Pharmaceutical Company Limited
8.2.2.1. Company overview
8.2.2.2. Financial performance
8.2.2.3. Product benchmarking
8.2.2.4. Strategic initiatives
8.2.3. Pharming
8.2.3.1. Company overview
8.2.3.2. Financial performance
8.2.3.3. Product benchmarking
8.2.3.4. Strategic initiatives
8.2.4. KalVista Pharmaceuticals.
8.2.4.1. Company overview
8.2.4.2. Financial performance
8.2.4.3. Product benchmarking
8.2.4.4. Strategic initiatives
8.2.5. Sanquin
8.2.5.1. Company overview
8.2.5.2. Financial performance
8.2.5.3. Product benchmarking
8.2.5.4. Strategic initiatives
8.2.6. BioCryst Pharmaceuticals, Inc.
8.2.6.1. Company overview
8.2.6.2. Financial performance
8.2.6.3. Product benchmarking
8.2.6.4. Strategic initiatives
8.2.7. CENTOGENE N.V.
8.2.7.1. Company overview
8.2.7.2. Financial performance
8.2.7.3. Product benchmarking
8.2.7.4. Strategic initiatives

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