Bone Grafts And Substitutes Market Size, Share & Trends Analysis Report By Material Type (Allograft, Synthetic), By Application (Dental, Spinal Fusion), By Region, And Segment Forecasts, 2025 - 2030

Bone Grafts And Substitutes Market Size, Share & Trends Analysis Report By Material Type (Allograft, Synthetic), By Application (Dental, Spinal Fusion), By Region, And Segment Forecasts, 2025 - 2030

Bone Grafts And Substitutes Market Growth & Trends

The global bone grafts and substitutes market size is expected to reach USD 4.54 billion by 2030, registering to grow at a CAGR of 6.6% from 2025 to 2030 according to a new report by Grand View Research, Inc. The increasing prevalence of orthopedic disorders and surge in number of orthopedic surgeries are likely to drive the market growth. In addition, technological advancements in developing advanced orthopedic grafts & substitutes and rising investments by leading players to meet increasing global demand for advanced grafts have further escalated the industry expansion.

Increasing demand for developing biocompatible bone grafts to reduce adverse reactions is driving the market. Increasing use of synthetic bone grafts with Hydroxyapatite and Tricalcium Phosphate, which has shown better biocompatibility as compared to others, is fueling the market growth. Market players are continuously developing new products with better biocompatibility, bioactivity, and suitable mechanical properties. For instance, in October 2020, Graftys received Medical Device Single Audit Program (MDSAP) certification for its Sterile Calcium Phosphate Resorbable Bone Void Fillers and related delivery systems in Australia, Brazil, Canada, and U.S. It also received CE recertification in Europe.

The increasing use of bone grafts in density is propelling the growth of dental bone grafts and substitutes market. The bone grafts are mostly used as a scaffold and filler to facilitate bone formation and promote healing. Dental implant surgery has now become very popular with advanced surgical techniques such as bone grafts and bone regeneration. Moreover, increasing demand and success rates of dental implants are fueling market growth. According to the American Academy of Implant Dentistry, as of 2020, the number of people getting dental implants has risen by 500,000 annually. The source also reported a success rate of 95% in the implant dentistry segment. Around 5 million implant procedures are performed in the U.S. every year.

Synthetic bone graft technology is benefiting advanced medicine, but the cost of such technologies is high, thus restraining market growth. The average price of DBM ranges from USD 600 to USD 865; that of bone morphogenetic protein matrix ranges from USD 3,450 to USD 5,000, and of synthetic ceramic & polymer-based bone grafts ranges from USD 893 to USD 2,000. In addition, reimbursement policies vary based on autografts and bone graft substitutes used, which increase the cost of procedures. This helps avoid incisions and difficulty in obtaining donor grafts. Therefore, the high cost of associated devices and technologies may hinder market growth.

Bone Grafts And Substitutes Market Report Highlights

• Based on material type, the allograft segment held the largest revenue share of 60.2% in 2024 and is anticipated to witness significant growth opportunities during the forecast period. The allograft adoption is significantly increasing owing to its properties such as osteoconductivity, and immediate structural support. The synthetic segment is projected to exhibit the fastest growth over the forecast period
• Based on application, the spinal fusion sub-segment held the largest market share in 2024. The increasing adoption of bone graft materials for spondylosyndesis and rising geriatric population prone to a number of orthopedic ailments are responsible for the higher revenue share of the segment
• North America dominated the global bone grafts and substitutes market in 2024 and is projected to be the leading revenue contributor during the forecast period. The rising geriatric population and increasing incidence of sports injuries & fatal accidents are among the key factors boosting the demand for bone grafts and substitutes in North America
• Some of the leading players include Smith & Nephew, Medtronic, and DePuy Synthes, as they have maintained their market position during the forecast period in terms of product penetration, regional presence, revenue, as well as strategic initiatives.

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