Sepsis is a life-threatening complication arising from an infection, which occurs when the body’s response to the infection damages its own tissues and organs. Sepsis causes multiple organ failure and death, especially if it is not recognized early and treated promptly (Elfeky et al., 2017; Rudd et al., 2020). Anyone can develop sepsis, but the condition is more common in children younger than one year of age, older adults, and those with weakened immune systems (Elfeky et al., 2017). Although any type of infection (bacterial, viral, or fungal) can lead to sepsis, people suffering from pneumonia, abdominal infection, kidney infection, and bloodstream infection (bacteremia) are more likely to develop sepsis. The most common pathogens for sepsis include bacteria (Gram-positive, Gram-negative), and fungi (Quenot et al., 2013).
Sepsis and septic shock are life-threatening conditions with an extremely high mortality rate (Shankar-Hari et al., 2017; Dupuis et al., 2020). Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection (Singer et al., 2016; Shankar-Hari et al., 2017). Septic shock is defined as a state of acute circulatory failure characterized by persistent arterial hypotension that cannot be successfully rescued by fluid resuscitation (Singer et al., 2016; Shankar-Hari et al., 2017). A constellation of clinical, laboratory, physiologic, and microbiologic data is needed for the diagnosis of sepsis and septic shock (Singer et al., 2016).Scope
This report provides an overview of the risk factors and the global and historical epidemiological trends for sepsis and septic shock in the eight major markets (8MM: US, France, Germany, Italy, Spain, UK, Japan, and China).
Additionally, this report includes a 10-year epidemiological forecast of sepsis for men and women from 2023-33 for the following segmentations in all ages across the 8MM: diagnosed incident cases of sepsis segmented by sex and age (ages 0-28 days, 1 month-17 years, 18-64 years, and 65 years and older), diagnosed incident cases of sepsis by causative agent (Gram positive and Gram negative bacteria, fungi, and other organism), diagnosed incident cases of sepsis by organ dysfunction (acute kidney dysfunction, acute respiratory dysfunction, disseminated intravascular coagulopathy [DIC], hepatic dysfunction, and cardiovascular dysfunction), and in-hospital mortality of sepsis.
This report also includes a 10-year epidemiological forecast of septic shock for men and women from 2023-33 for the following segmentations in all ages across the 8MM: diagnosed incident cases of septic shock segmented by sex and age (0-28 days, 1 month-17 years, 18-64 years, and 65 years and older), diagnosed incident cases of septic shock by causative agent, agent (gram positive and gram negative bacteria, fungi, and other organism) diagnosed incident cases of septic shock by organ dysfunction (acute kidney dysfunction, acute respiratory dysfunction, DIC, hepatic dysfunction, and cardiovascular dysfunction), and in-hospital mortality of septic shock.
Reasons to Buy
Sepsis Epidemiology series will allow you to:
Develop business strategies by understanding the trends shaping and driving the global sepsis markets.
Quantify patient populations in the global sepsis markets to improve product design, pricing, and launch plans.
Organize sales and marketing efforts by identifying the age groups and sex that present the best opportunities for sepsis therapeutics in each of the markets covered.
Understand magnitude of the sepsis population by age, sex, causative agent, and organ dysfunction.
1 Renal Cell Carcinoma (RCC): Executive Summary
1.1 Catalyst
1.2 Related reports
1.3 Upcoming reports
2 Epidemiology
2.1 Disease background
2.2 Risk factors and comorbidities
2.3 Global and historical trends
2.4 8MM forecast methodology.
2.4.1 Sources
2.4.2 Forecast assumptions and methods.
2.4.3 Forecast assumption and methods: diagnosed incident cases of RCC
2.4.4 Forecast assumptions and methods: diagnosed incident cases of RCC by stage at diagnosis.
2.4.5 Forecast assumptions and methods: diagnosed incident cases of stage IV ccRCC by risk group.
2.4.6 Forecast assumptions and methods: diagnosed incident cases of stage IV nccRCC.
2.4.7 Forecast assumptions and methods: diagnosed incident cases of RCC by subtypes, papillary and chromophobe RCC.
2.4.8 Forecast assumptions and methods: diagnosed incident cases of RCC with VHL mutation by RCC subtype.
2.4.9 Forecast assumptions and methods: diagnosed incident cases RCC by BAP1 gene mutation.
2.4.10 Forecast assumptions and methods: diagnosed incident cases RCC by SETD2 gene mutation.
2.4.11 Forecast assumptions and methods: diagnosed incident cases RCC by ARID1A gene mutation.
2.5 Epidemiological forecast for RCC (2023-33)
2.5.1 Diagnosed incident cases of RCC.
2.5.2 Age-specific diagnosed incident cases of RCC
2.5.3 Sex-specific diagnosed incident cases of RCC
2.5.4 Diagnosed incident cases of RCC by stage at diagnosis.
2.5.5 Diagnosed incident cases of RCC by risk group.
2.5.6 Diagnosed incident cases of stage IV nccRCC.
2.5.7 Diagnosed incident cases of RCC by subtype - papillary and chromophobe RCC.
2.5.8 Diagnosed incident cases of RCC with VHL gene mutation by RCC subtype.
2.5.9 Diagnosed incident cases of RCC with genetic mutations BAP1, SETD2, and ARID1A
2.5.10 Five-year diagnosed prevalent cases of RCC
2.6 Discussion
2.6.1 Epidemiological forecast insight
2.6.2 COVID-19 impact.
2.6.3 Limitations of the analysis
2.6.4 Strengths of the analysis
3 Appendix
3.1 Bibliography
3.2 About the Authors
3.2.1 Epidemiologist
3.2.2 Reviewers
3.2.3 Vice President of Disease Intelligence and Epidemiology
3.2.4 Global Head of Pharma Research, Analysis and Competitive Intelligence
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List of Tables
Table 1: Summary of updated data types
Table 2: Risk factors and comorbidities for sepsis
List of Figures
Figure 1: 8MM, diagnosed incident cases of sepsis, both sexes, N, all ages, 2023 and 2033
Figure 2: 8MM, diagnosed incident cases of septic shock, both sexes, N, all ages, 2023 and 2033
Figure 3: 8MM, diagnosed incidence of sepsis, all ages, both sexes, cases per 100,000 population, 2013‒33
Figure 4: 8MM, diagnosed incidence of septic shock, all ages, both sexes, cases per 100,000 population, 2013‒33
Figure 5: 8MM, sources used and not used to forecast diagnosed incident cases of sepsis and septic shock
Figure 6: 8MM, sources used to forecast the diagnosed incident cases of neonatal sepsis and septic shock
Figure 7: 8MM, sources used to forecast the diagnosed incident cases of sepsis/septic shock by causative agents
Figure 8: 8MM, sources used to forecast organ dysfunction in the diagnosed incident cases of sepsis
Figure 9: 8MM, sources used to forecast organ dysfunction in the diagnosed incident cases of septic shock
Figure 10: 8MM, sources used for sepsis/septic shock in-hospital mortality cases
Figure 11: 8MM, diagnosed incident cases of sepsis, both sexes, all ages, N, 2023
Figure 12: 8MM, age-specific diagnosed incident cases of sepsis, all ages, N, 2023
Figure 13: 8MM, sex-specific diagnosed incident cases of sepsis, all ages, N, 2023
Figure 14: 8MM, diagnosed incident cases of sepsis by causative agent, both sexes, all ages, N, 2023
Figure 15: 8MM, organ dysfunction in diagnosed incident cases of sepsis, both sexes, all ages, N, 2023
Figure 16: 8MM, sepsis in-hospital mortality cases, both sexes, all ages, N, 2023
Figure 17: 8MM, diagnosed incident cases of septic shock, both sexes, all ages, N, 2023
Figure 18: 8MM, age-specific diagnosed incident cases of septic shock, both sexes, N, 2023
Figure 19: 8MM, sex-specific diagnosed incident cases of septic shock, all ages, N, 2023
Figure 20: 8MM, diagnosed incident cases of septic shock by causative agent, both sexes, all ages, N, 2023
Figure 21: 8MM, organ dysfunction in diagnosed incident cases of septic shock, both sexes, all ages, N, 2023
Figure 22: 8MM, septic shock in-hospital mortality cases, both sexes, all ages, N, 2023