Innovation Insights: Antibody-drug conjugates

Innovation Insights: Antibody-drug conjugates

Summary

Antibody-drug conjugates (ADCs) are a type of targeted cancer therapy that combines the specificity of monoclonal antibodies with the cytotoxic effects of chemotherapy drugs. The antibodies are designed to target specific antigens on cancer cells, allowing the attached chemotherapy drug to be delivered directly to the tumor cells while sparing healthy cells. This targeted approach reduces side effects and improves the efficacy of the treatment. ADCs have shown promising results in clinical trials for various types of cancer, including breast cancer, lymphoma, and leukemia. Ongoing research is focused on optimizing the design and delivery of ADCs to further improve their effectiveness in treating cancer.

Antibody-drug conjugates (ADCs) are a cutting-edge class of biopharmaceutical drugs that combine monoclonal antibodies (mABs) with cytotoxic drugs for targeted therapy. Analysis of patents, patent trends, and related literature indicates that ADCs are a highly impactful innovation in the medium-term. This innovation is primarily driven by major pharmaceutical companies, which account for 37% of all patents. The commercial impact is evident from a robust drug pipeline, recent global drug approvals, and various investment activities such as mergers and acquisitions, corporate venture funding, and licensing agreements.

Patenting trends experienced a significant increase in 2017 and have continued to grow since then. While oncology remains the dominant indication, there is a noticeable rise in new therapy areas such as autoimmune diseases and infectious diseases, potentially leading to the entry of new players into the market. The United States remains the leading geography for ADC innovation, closely followed by China.

The innovation landscape is highly competitive, with over 100 public companies identified. Leading patent filers include Roche, Seagen (Pfizer), AstraZeneca, and Abbvie. Among big pharma companies, Daiichi Sankyo, AstraZeneca, and Abbvie have the strongest patent portfolios. In China, Jiangsu Hengrui, Biocytogen, and GeneQuantum lead among the 30+ companies in the space.

There are over 70 startups and small biotech companies in the ADC space, with nearly a quarter of them based in China. GeneQuantum, Oncomatryx, Glykos, and DAC Biotech are leading in terms of patent volumes among startups.

The Antibody Drug Conjugate drug landscape includes 1,172 drugs, primarily focused on oncology (94%) and immunology (1.8%) therapies. The most common route of administration is intravenous. Companies like Biocytogen Pharmaceuticals (Beijing) Co Ltd and Hangzhou DAC Biotech Co Ltd are at the forefront of drug development, particularly in preclinical and Phase II trials. The concentration of drugs in Phase I and Phase II suggests a maturing pipeline with potential market entry in the near future.

There have been 2,847 clinical trials for Antibody Drug Conjugate drugs, with Pfizer and Daiichi Sankyo leading as top sponsors. Oncology trials dominate, with Hodgkin Lymphoma being the top indication. In terms of deals, there have been 809 deals totaling US$227 billion, with the United States leading in both deal volume and value. The market saw a decline in deals from 2020-2022, followed by a slight increase in 2023, indicating market adjustments and strategic consolidations.

Key Highlights

  • Antibody Drug Conjugate report is a high-impact innovation area in the Pharma industry, with a growing number of patents being filed and a focus on new indications such as Oncology and Autoimmune Diseases.
  • Big pharma companies like Roche dominate the patent activity in Antibody Drug Conjugate with a dip in new companies filing patents in recent years.
  • Competitive intelligence shows that Merck and seagen in terms of portfolio size are among the leaders with strong innovation portfolios in Antibody Drug Conjugate.
  • The drug landscape for Antibody Drug Conjugate is dominated by innovator drugs, with a focus on Infectious Disease and Immunology, and major players like Biocytogen Pharma and Hangzhou Biotech leading in drug development.
  • Clinical trials in Antibody Drug Conjugate are dominated by Immunology trials, with the Pfizer Inc and Daiichi Sankyo Ltd leading in the number of trials.
Scope
  • Innovation Insights: innovation examples by each use cases segment of various sectors to present key trends.
  • Key player: This represents a sample list of key players in each use case highlighted in the report.
  • Startups: This represents a sample list of emerging starups in each use case highlighted in the report.
  • University: This represents a sample list of leading universities in each use case highlighted in the report.
Reasons to Buy

Accelerate Innovation with Our Antibody-Drug Conjugates Report -
  • Emerging technologies like antibody-drug conjugates (ADCs) are transforming the biotech and pharmaceutical landscape. Our comprehensive report delivers critical insights into the latest research, patents, clinical trials, and market trends, empowering strategic decision-making.
  • Gain a competitive edge with data on leading pharma companies, startups, and academic institutions, helping you identify growth opportunities and potential threats.
  • The report also highlights regulatory and compliance developments, essential for navigating complex healthcare frameworks. Whether optimizing R&D strategies or uncovering market opportunities, this report is an invaluable resource for making informed, data-driven decisions in today’s fast-evolving therapeutic landscape


  • Executive Summary
  • Insights from Technology Foresights
    • Innovation Radar - key focus areas of antibody-drug conjugate
    • Innovation S-curve - key focus areas of antibody-drug conjugate
    • Antibody-drug conjugates: innovation deep dive
    • Trends in indications for antibody-drug conjugates
    • Antibody-drug conjugates - top companies by portfolio strength indicators
    • Antibody-drug conjugates - top companies by temporal indicators
    • Leading innovators in antibody-drug conjugates
    • Leading startup innovators in antibody-drug conjugates
    • Antibody-drug conjugates: University innovation landscape
    • Antibody-drug conjugates: most cited patents
    • Insights from AI hub
  • Drugs - Antibody Drug Conjugate
    • Antibody Drug Conjugate Drugs in numbers, 2020 - 2024*
    • Antibody drug conjugate drug types and route of administration
    • Antibody drug conjugate drugs
    • Top target by top 10 player in antibody-drug conjugate treatment
    • Drug development activity in engineered multispecific antibodies
    • Top 12 global players, indications & drugs in antibody-drug conjugate
    • Antibody-drug conjugate drug trends by therapy area and indications
  • Clinical Trials - Antibody Drug Conjugate
    • Antibody Drug Conjugate Clinical Trials in numbers, 2015 - 2024*
    • Top sponsor in antibody-drug conjugate drugs
    • Top 10 clinical trials of antibody-drug conjugate by therapy area (excluding oncology)
    • Top clinical trials by indication
    • Clinical trial trends in antibody-drug conjugate drugs trials
    • Clinical trials landscape
  • Deals - Antibody Drug Conjugate
    • Antibody drug conjugate in numbers, 2020 - 2024*
    • Top acquirers in antibody-drug conjugate
    • Trends in antibody-drug conjugate deals (2020-2024)
    • Top country for investment in monoclonal antibody-drug conjugate
    • Deal trends
    • Deal type in antibody-drug conjugate
    • The top four M&A deals in pharma in 2020 - 2024*
    • Fluctuations and trends in antibody-drug conjugate deals (2020-2024)
  • Appendix
    • Sources for AI insights
    • Methodology for company ratings
    • Classifying companies by ratings
    • Antibody-drug conjugate - companies with < 10 patents
    • Antibody-drug conjugate - companies with less than 5 patents
    • Methodology for Alternative Data
    • Glossary

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