Atrial Fibrillation Market Size and Trend Report including Epidemiology, Disease Management, Pipeline Analysis, Competitor Assessment, Unmet Needs, Clinical Trial Strategies and Forecast to 2032

Atrial Fibrillation Market Size and Trend Report including Epidemiology, Disease Management, Pipeline Analysis, Competitor Assessment, Unmet Needs, Clinical Trial Strategies and Forecast to 2032


Summary

This report covers the 8MM (US, France, Germany, Italy, Spain, UK, Japan, Canada) and provides an Excel-based forecast model for the Atrial Fibrillation (AF) market through 2032.

In 2022, GlobalData estimated that the global AF market reached $14.53 billion across the 8MM. The US makes up the majority of total global sales, contributing $10.75 billion (74%) due to the large prevalent AF population in the US, early adoption of the new oral anticoagulants (NOACs), and higher prices for AF medications in this market. GlobalData anticipates that the AF market will decline at a negative compound annual growth rate (CAGR) of 1.3%, to be worth approximately $12.8 billion by 2032. The US is expected to maintain its position as the market leader in 2032, contributing 74% towards the total global sales.

The major growth drivers in the AF market during the forecast period include the following:
  • A total of five pipeline products, including four anticoagulants and one cardioversion agent, will launch during the forecast period, each of which will have a higher annual cost of therapy (ACOT) when compared with the cost of generic NOACs and the commonly used pharmacological agents, respectively.
  • Factor XI (FXI)/FXIa inhibitors, including abelacimab, asundexian, and milvexian, will be welcomed by the many AF patients who are not treated with the currently available anticoagulants due to bleeding concerns.
  • In the 8MM, the number of 12-month total prevalent cases of AF treated is expected to increase during the forecast period, which will drive sales.
  • Continued increases in AF awareness will improve diagnosis rates.
The major barriers to growth in the AF market during the forecast period include the following:
  • All four NOACs will face generic erosion as their patents expire over the forecast period.
  • The AF market is crowded with inexpensive generic products for the maintenance of rate and rhythm control. The high use of these products is expected to continue throughout the forecast period, presenting a stiff barrier of entry for pipeline drugs.
  • High cost of FXI/FXIa inhibitors compared to the NOAC generics will likely hinder patient uptake.
Key Highlights
  • In 2022, GlobalData estimated that the global AF market reached $14.53 billion across the 8MM, and anticipates that it will decline at a negative compound annual growth rate (CAGR) of 1.3%, to be worth approximately $12.8 billion by 2032.
  • This decline in sales is due to the fact that novel oral anticoagulants (NOACs) will face generic erosion as their patents expire over the forecast period. In addition, the high cost of upcoming FXI/FXIa inhibitors compared to the NOAC generics will likely hinder patient uptake.
Scope
  • Overview of AF, including epidemiology, symptoms, diagnosis, and disease management.
  • Annualized AF therapeutics market revenue, cost of therapy per patient, and treatment usage patterns forecast from 2022 to 2032.
  • Key topics covered include strategic competitor assessment, market characterization, unmet needs, clinical trial mapping, and implications of these factors for the AF therapeutics market.
  • Pipeline analysis: comprehensive data assessing emerging trends and mechanisms of action under development for AF treatment. The most promising candidates in late-stage development are profiled.
  • Analysis of the current and future market competition in the global AF therapeutics market. Insightful review of the key industry drivers, restraints and challenges. Each trend is independently researched to provide qualitative analysis of its implications.
Reasons to Buy
  • Develop and design your in-licensing and out-licensing strategies through a review of pipeline products and technologies, and by identifying the companies with the most robust pipeline.
  • Develop business strategies by understanding the trends shaping and driving the 8MM AF therapeutics market.
  • Drive revenues by understanding the key trends, innovative products and technologies, market segments, and companies likely to impact the 7MM AF therapeutics market in the future.
  • Formulate effective sales and marketing strategies by understanding the competitive landscape and by analyzing the performance of various competitors.
  • Identify emerging players with potentially strong product portfolios and create effective counter-strategies to gain a competitive advantage.
  • Organize your sales and marketing efforts by identifying the market categories and segments that present maximum opportunities for consolidations, investments and strategic partnerships.
Please note: this is delivered as a zip file.


1 Atrial Fibrillation: Executive Summary
1.1 AF market will decline at a negative CAGR of 1.3%
1.2 Bayer and Bristol Myers Squibb will continue to lead the AF market over the forecast period
1.3 While outlook in AF improves, opportunities remain to improve patient outcomes
1.4 Bayer’s FXIa inhibitor asundexian will be a key driver of growth
1.5 What do physicians think?
2 Introduction
2.1 Catalyst
2.2 Related reports
2.3 Upcoming reports
3 Disease Overview
3.1 Etiology and pathophysiology
3.2 Classification
4 Epidemiology
4.1 Disease Background
4.2 Risk Factors and Comorbidities
4.3 Global and Historical Trends
4.4 8MM Forecast Methodology
4.5 Epidemiological Forecast for atrial fibrillation
4.6 Discussion
5 Disease Management
5.1 Diagnosis and treatment overview
5.2 KOL insights on disease management
6 Competitive Assessment
6.1 Overview
7 Unmet Needs and Opportunity Assessment
7.1 Overview
7.2 Development of anticoagulants with reduced risk of bleeding
7.3 Therapies for atrial fibrillation patients with ESRD
7.4 Safer antiarrhythmic drugs for the maintenance of sinus rhythm
7.5 Effective and rapid-acting cardioversion drugs
8 R&D Strategies
8.1 Overview
8.2 Clinical trials design
9 Pipeline Assessment
9.1 Overview
9.2 Promising drugs in clinical development
10 Pipeline Valuation Analysis
10.1 Overview
10.2 Competitive assessment
11 Current and Future Players
11.1 Overview
11.2 Deal-making trends
12 Market Outlook
12.1 Global markets
12.2 US
12.3 5EU
12.4 Japan
12.5 Canada
13 Appendix
13.1 Bibliography
13.2 Abbreviations
13.3 Methodology
13.4 Primary research - KOLs interviewed for this report
13.5 Primary research - prescriber survey
13.6 About the Authors
Contact Us
List of Tables
Table 1: Atrial fibrillation: key metrics in the 8MMTable 2: Common cardiac and non-cardiac causes of AFTable 3: Classification of AFTable 4: Risk factors and comorbidities for AFTable 5: CHADS2 index for stroke risk assessmentTable 6: CHA₂DS₂-VASc index for stroke risk assessmentTable 7: Treatment guidelines for atrial fibrillationTable 8: Atrial fibrillation market - global drivers and barriers, 2022-32Table 9: Key events impacting sales for atrial fibrillation in the US, 2022-32Table 10: Atrial fibrillation market - drivers and barriers in the US, 2022-32Table 11: Key events impacting sales for atrial fibrillation in the 5EU, 2022-32Table 12: Atrial fibrillation market - drivers and barriers in the 5EU, 2022-32Table 13: Key events impacting sales for atrial fibrillation in Japan, 2022-32Table 14: Atrial fibrillation market - drivers and barriers in Japan, 2022-32Table 15: Key events impacting sales for atrial fibrillation in Canada, 2022-32Table 16: Atrial fibrillation market - drivers and barriers in Canada, 2022-32Table 17: High-prescribing physicians (non-KOLs) surveyed, by country
List of Figures
Figure 1: Global sales forecast by country for atrial fibrillation in 2022 and 2032Figure 2: Analysis of the company portfolio gap in atrial fibrillation during the forecast periodFigure 3: Competitive assessment of the pipeline anticoagulant drugs benchmarked against the current SOCFigure 4: Competitive assessment of the pipeline drugs for pharmacological cardioversion benchmarked against the SOCFigure 5: 8MM, diagnosed prevalence of AF (%), men and women, ages ≥40 years, 2022Figure 6: 8MM, sources used and not used to forecast the diagnosed prevalent cases of AFFigure 7: 8MM, sources used to forecast the diagnosed prevalent cases of AF by temporal pattern of arrhythmiaFigure 8: 8MM, sources used to forecast the diagnosed prevalent cases of AF by CHADS2 stroke risk scoreFigure 9: 8MM, sources used to forecast the diagnosed prevalent cases of AF by CHA2DS2 - VASc score in menFigure 10: 8MM, sources used to forecast the diagnosed prevalent cases of AF by CHA2DS2 - VASc score in womenFigure 11: 8MM, sources used to forecast the diagnosed prevalent cases of AF with/without moderate-to-severe mitral stenosis and/or an artificial (mechanical) heart valveFigure 12: 8MM, sources used to forecast the diagnosed prevalent cases of AF with CKDFigure 13: 8MM, sources used to forecast the diagnosed prevalent cases of AF with major bleeding risk by HAS‐BLED scoreFigure 14: 8MM, sources used to forecast the diagnosed prevalent cases of AF admitted to the EDFigure 15: 8MM, sources used to forecast the diagnosis rate of AFFigure 16: 8MM, total prevalent cases of AF, N, both sexes, ages ≥40 years, 2022Figure 17: 8MM, diagnosed prevalent cases of AF, N, both sexes, ages ≥40 years, 2022Figure 18: 8MM, diagnosed prevalent cases of AF by age, N, both sexes, 2022Figure 19: 8MM, diagnosed prevalent cases of AF by sex, N, ages ≥40 years, 2022Figure 20: 8MM, diagnosed prevalent cases of AF by temporal pattern of arrhythmia, N, both sexes, ages ≥40 years, 2022Figure 21: 8MM, diagnosed prevalent cases of AF by CHADS2 stroke risk score, N, both sexes, ages ≥40 years, 2022Figure 22: 8MM, diagnosed prevalent cases of AF by CHA2DS2 - VASc stroke risk score in men, N, men, ages ≥40 years, 2022Figure 23: 8MM, diagnosed prevalent cases of AF by CHA2DS2 - VASc stroke risk score in women, N, women, ages ≥40 years, 2022Figure 24: 8MM, diagnosed prevalent cases of AF with and without moderate-to-severe mitral stenosis and/or an artificial (mechanical) heart valve, N, both sexes, ≥40 years, 2022Figure 25: 8MM, diagnosed prevalent cases of AF with CKD by stage, N, both sexes, ages ≥40 years, 2022Figure 26: 8MM, diagnosed prevalent cases of AF by HAS‐BLED score, N, both sexes, ages ≥40 years, 2022Figure 27: 8MM, diagnosed prevalent cases of AF admitted to ED, N, both sexes, ages ≥40 years, 2022Figure 28: General treatment algorithm for stroke prevention in AFFigure 29: CCS guideline recommendations for choosing an anticoagulantFigure 30: General treatment algorithm for long-term ventricular rate control in AF patientsFigure 31: Treatment algorithm for the maintenance of sinus rhythm in AF patientsFigure 32: Unmet needs and opportunities in AFFigure 33: Overview of the development pipeline in atrial fibrillationFigure 34: Key late-stage trials for the promising pipeline agents that GlobalData expects to be licensed for atrial fibrillation in the 8MM during the forecast periodFigure 35: Competitive assessment of the marketed and pipeline drugs for anticoagulation benchmarked against the SOCFigure 36: Competitive assessment of the marketed and pipeline drugs for pharmacological cardioversion benchmarked against the SOCFigure 37: Analysis of the company portfolio gap in AF during the forecast periodFigure 38: Global (8MM) sales forecast by country for atrial fibrillation in 2022 and 2032Figure 39: Sales forecast by class for atrial fibrillation in the US in 2022 and 2032Figure 40: Sales forecast by class for atrial fibrillation in the 5EU in 2022 and 2032Figure 41: Sales forecast by class for atrial fibrillation in Japan in 2022 and 2032Figure 42: Sales forecast by class for atrial fibrillation in Canada in 2022 and 2032

Download our eBook: How to Succeed Using Market Research

Learn how to effectively navigate the market research process to help guide your organization on the journey to success.

Download eBook
Cookie Settings