Serine/Threonine Protein Kinase A Raf (Proto Oncogene A Raf or Proto Oncogene Pks or ARAF or EC 2.7.11.1) Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update

Serine/Threonine Protein Kinase A Raf (Proto Oncogene A Raf or Proto Oncogene Pks or ARAF or EC 2.7.11.1) Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update

Serine/Threonine Protein Kinase A Raf (Proto Oncogene A Raf or Proto Oncogene Pks or ARAF or EC 2.7.11.1) Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update

Summary

According to the recently published report 'SerineThreonine Protein Kinase A Raf - Drugs In Development, 2022'; Serine/Threonine Protein Kinase A Raf (Proto Oncogene A Raf or Proto Oncogene Pks or ARAF or EC 2.7.11.1) pipeline Target constitutes close to 6 molecules. Out of which approximately 3 molecules are developed by companies and remaining by the universities/institutes.

Serine/Threonine Protein Kinase A Raf (Proto Oncogene A Raf or Proto Oncogene Pks or ARAF or EC 2.7.11.1) - Serine/threonine-protein kinase A-Raf is an enzyme that in humans is encoded by the ARAF gene. It is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. It regulates the TOR signaling cascade.

The report 'SerineThreonine Protein Kinase A Raf - Drugs In Development, 2022' outlays comprehensive information on the Serine/Threonine Protein Kinase A Raf (Proto Oncogene A Raf or Proto Oncogene Pks or ARAF or EC 2.7.11.1) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type; that are being developed by Companies / Universities.

It also reviews key players involved in Serine/Threonine Protein Kinase A Raf (Proto Oncogene A Raf or Proto Oncogene Pks or ARAF or EC 2.7.11.1) targeted therapeutics development with respective active and dormant or discontinued projects. Currently, The molecules developed by companies in Phase II, Phase I and Preclinical stages are 1, 1 and 1 respectively. Similarly, the universities portfolio in Preclinical stages comprises 3 molecules, respectively. Report covers products from therapy areas Oncology and Genetic Disorders which include indications Colorectal Cancer, Melanoma, Solid Tumor, Blood Cancer, Craniopharyngioma, Glioma, Letterer-Siwe Disease (Multifocal and multisystemic (disseminated) Langerhans-cell histiocytosis), Low-Grade Glioma, Malignant Glioma, Non-Small Cell Lung Cancer and Unspecified Cancer.

Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.

Scope

  • The report provides a snapshot of the global therapeutic landscape for Serine/Threonine Protein Kinase A Raf (Proto Oncogene A Raf or Proto Oncogene Pks or ARAF or EC 2.7.11.1)
  • The report reviews Serine/Threonine Protein Kinase A Raf (Proto Oncogene A Raf or Proto Oncogene Pks or ARAF or EC 2.7.11.1) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
  • The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
  • The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
  • The report reviews key players involved in Serine/Threonine Protein Kinase A Raf (Proto Oncogene A Raf or Proto Oncogene Pks or ARAF or EC 2.7.11.1) targeted therapeutics and enlists all their major and minor projects
  • The report assesses Serine/Threonine Protein Kinase A Raf (Proto Oncogene A Raf or Proto Oncogene Pks or ARAF or EC 2.7.11.1) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type
  • The report summarizes all the dormant and discontinued pipeline projects
  • The report reviews latest news and deals related to Serine/Threonine Protein Kinase A Raf (Proto Oncogene A Raf or Proto Oncogene Pks or ARAF or EC 2.7.11.1) targeted therapeutics
Reasons to Buy
  • Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
  • Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
  • Identify and understand the targeted therapy areas and indications for Serine/Threonine Protein Kinase A Raf (Proto Oncogene A Raf or Proto Oncogene Pks or ARAF or EC 2.7.11.1)Identify the use of drugs for target identification and drug repurposing
  • Identify potential new clients or partners in the target demographic
  • Develop strategic initiatives by understanding the focus areas of leading companies
  • Plan mergers and acquisitions effectively by identifying key players and it’s most promising pipeline therapeutics
  • Devise corrective measures for pipeline projects by understanding Serine/Threonine Protein Kinase A Raf (Proto Oncogene A Raf or Proto Oncogene Pks or ARAF or EC 2.7.11.1) development landscape
  • Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope


Introduction
Global Markets Direct Report Coverage
Serine/Threonine Protein Kinase A Raf (Proto Oncogene A Raf or Proto Oncogene Pks or ARAF or EC 2.7.11.1) – Overview
Serine/Threonine Protein Kinase A Raf (Proto Oncogene A Raf or Proto Oncogene Pks or ARAF or EC 2.7.11.1) – Therapeutics Development
Products under Development by Stage of Development
Products under Development by Therapy Area
Products under Development by Indication
Products under Development by Companies
Products under Development by Universities/Institutes
Serine/Threonine Protein Kinase A Raf (Proto Oncogene A Raf or Proto Oncogene Pks or ARAF or EC 2.7.11.1) – Therapeutics Assessment
Assessment by Mechanism of Action
Assessment by Route of Administration
Assessment by Molecule Type
Serine/Threonine Protein Kinase A Raf (Proto Oncogene A Raf or Proto Oncogene Pks or ARAF or EC 2.7.11.1) – Companies Involved in Therapeutics Development
Jazz Pharmaceuticals Plc
Samjin Pharm Co Ltd
Takeda Pharmaceutical Co Ltd
Serine/Threonine Protein Kinase A Raf (Proto Oncogene A Raf or Proto Oncogene Pks or ARAF or EC 2.7.11.1) – Drug Profiles
INU-152 – Drug Profile
JZP-815 – Drug Profile
SJP-601 – Drug Profile
Small Molecule to Inhibit Pan-RAF Kinase for Oncology – Drug Profile
Small Molecules to Inhibit RAF for Unspecified Cancer – Drug Profile
tovorafenib – Drug Profile
Serine/Threonine Protein Kinase A Raf (Proto Oncogene A Raf or Proto Oncogene Pks or ARAF or EC 2.7.11.1) – Dormant Products
Serine/Threonine Protein Kinase A Raf (Proto Oncogene A Raf or Proto Oncogene Pks or ARAF or EC 2.7.11.1) – Discontinued Products
Serine/Threonine Protein Kinase A Raf (Proto Oncogene A Raf or Proto Oncogene Pks or ARAF or EC 2.7.11.1) – Product Development Milestones
Featured News & Press Releases
Nov 11, 2022: Day One announces upcoming presentations at 2022 Society for Neuro-Oncology Annual Meeting
Jun 15, 2022: FDA grants IND clearance for Jazz and Redx’s cancer drug application
Jun 12, 2022: Day One announces positive initial data from pivotal FIREFLY-1 trial of tovorafenib (DAY101) in relapsed pediatric low-grade glioma
May 23, 2022: Day One announces first patients dosed in phase 1b/2 combination study with tovorafenib (DAY101) and pimasertib in RAF-altered solid tumors
Apr 08, 2022: Jazz Pharmaceuticals presents pre-clinical data for pan-RAF inhibitor JZP815, including pharmacokinetic properties and efficacy in multiple solid tumor types
Mar 08, 2022: Jazz Pharmaceuticals to present Pan-RAF inhibitor pre-clinical data at American Association for Cancer Research (AACR) 2022 Annual Meeting
Nov 22, 2021: Day One announces first patient dosed in phase 2 monotherapy study in RAF-altered solid tumors
Nov 03, 2021: Day One announces presentation at 2021 Connective Tissue Oncology Society (CTOS) Virtual Annual Meeting
Sep 02, 2021: Redx Pharma announces milestone payment from Jazz Pharmaceuticals
Jul 27, 2021: Day One receives FDA rare pediatric disease designation for DAY101 for the treatment of pediatric low-grade glioma
Jun 21, 2021: Day One receives orphan designation from the European Commission for DAY101 for the treatment of glioma
May 11, 2021: Day One announces first patient dosed in FIREFLY-1 pivotal phase 2 clinical trial of DAY101 in pediatric progressive low-grade glioma
Nov 19, 2020: Day One announces preliminary phase 1 results for DAY101 in pediatric low-grade glioma, receipt of breakthrough therapy designation (BTD) and new phase 2 study
Sep 26, 2011: Sunesis Initiates Phase I Study Of MLN2480 In Advanced Solid Tumors
Jul 13, 2009: Sunesis Pharmaceuticals Receives Milestone Payment From Biogen Idec
Appendix
Methodology
Coverage
Secondary Research
Primary Research
Expert Panel Validation
Contact Us
Disclaimer
List of Tables
Table 1: Number of Products under Development by Stage of Development, 2022
Table 2: Number of Products under Development by Therapy Areas, 2022
Table 3: Number of Products under Development by Indication, 2022
Table 4: Number of Products under Development by Companies, 2022
Table 5: Products under Development by Companies, 2022
Table 6: Number of Products under Investigation by Universities/Institutes, 2022
Table 7: Products under Investigation by Universities/Institutes, 2022
Table 8: Number of Products by Stage and Mechanism of Actions, 2022
Table 9: Number of Products by Stage and Route of Administration, 2022
Table 10: Number of Products by Stage and Molecule Type, 2022
Table 11: Pipeline by Jazz Pharmaceuticals Plc, 2022
Table 12: Pipeline by Samjin Pharm Co Ltd, 2022
Table 13: Pipeline by Takeda Pharmaceutical Co Ltd, 2022
Table 14: Dormant Projects, 2022
Table 15: Discontinued Products, 2022
List of Figures
Figure 1: Number of Products under Development by Stage of Development, 2022
Figure 2: Number of Products under Development by Therapy Areas, 2022
Figure 3: Number of Products under Development by Top 10 Indications, 2022
Figure 4: Number of Products by Stage and Mechanism of Actions, 2022
Figure 5: Number of Products by Stage and Route of Administration, 2022
Figure 6: Number of Products by Stage and Molecule Type, 2022

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