Leber’s Hereditary Optic Neuropathy (Leber Optic Atrophy) Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update

Leber’s Hereditary Optic Neuropathy (Leber Optic Atrophy) Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update

Summary

Global Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Leber’s Hereditary Optic Neuropathy – Drugs In Development, 2022, provides an overview of the Leber’s Hereditary Optic Neuropathy (Ophthalmology) pipeline landscape.

Leber’s hereditary optic neuropathy (LHON) is an inherited form of vision loss. This condition usually begins in a person's teens or twenties, rare cases may appear in early childhood or later in adulthood. Males are affected much more often than females. Symptoms include eye pain or discomfort, numbness, tingling and clouding of vision. Predisposing factors include age, tobacco smoke, alcohol, cancer treating drugs, stress related chemicals, some antibiotics and cyanogens.

Report Highlights

Global Markets Direct's Pharmaceutical and Healthcare latest pipeline guide Leber’s Hereditary Optic Neuropathy – Drugs In Development, 2022, provides comprehensive information on the therapeutics under development for Leber’s Hereditary Optic Neuropathy (Ophthalmology), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. The guide covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases.

The Leber’s Hereditary Optic Neuropathy (Ophthalmology) pipeline guide also reviews of key players involved in therapeutic development for Leber’s Hereditary Optic Neuropathy (Leber Optic Atrophy) and features dormant and discontinued projects. The guide covers therapeutics under Development by Companies /Universities /Institutes, the molecules developed by Companies in Pre-Registration, Phase III, Phase II, Phase I, Phase 0, Preclinical and Discovery stages are 1, 1, 1, 1, 1, 9 and 2 respectively. Similarly, the Universities portfolio in Phase I stages comprises 1 molecules, respectively.

Leber’s Hereditary Optic Neuropathy (Ophthalmology) pipeline guide helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. The guide is built using data and information sourced from Global Markets Direct’s proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources. Additionally, various dynamic tracking processes ensure that the most recent developments are captured on a real time basis.

Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.

Scope

  • The pipeline guide provides a snapshot of the global therapeutic landscape of Leber’s Hereditary Optic Neuropathy (Ophthalmology).
  • The pipeline guide reviews pipeline therapeutics for Leber’s Hereditary Optic Neuropathy (Ophthalmology) by companies and universities/research institutes based on information derived from company and industry-specific sources.
  • The pipeline guide covers pipeline products based on several stages of development ranging from pre-registration till discovery and undisclosed stages.
  • The pipeline guide features descriptive drug profiles for the pipeline products which comprise, product description, descriptive licensing and collaboration details, R&D brief, MoA & other developmental activities.
  • The pipeline guide reviews key companies involved in Leber’s Hereditary Optic Neuropathy (Ophthalmology) therapeutics and enlists all their major and minor projects.
  • The pipeline guide evaluates Leber’s Hereditary Optic Neuropathy (Ophthalmology) therapeutics based on mechanism of action (MoA), drug target, route of administration (RoA) and molecule type.
  • The pipeline guide encapsulates all the dormant and discontinued pipeline projects.
  • The pipeline guide reviews latest news related to pipeline therapeutics for Leber’s Hereditary Optic Neuropathy (Ophthalmology)
Reasons to Buy
  • Procure strategically important competitor information, analysis, and insights to formulate effective R&D strategies.
  • Recognize emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage.
  • Find and recognize significant and varied types of therapeutics under development for Leber’s Hereditary Optic Neuropathy (Ophthalmology).
  • Classify potential new clients or partners in the target demographic.
  • Develop tactical initiatives by understanding the focus areas of leading companies.
  • Plan mergers and acquisitions meritoriously by identifying key players and it’s most promising pipeline therapeutics.
  • Formulate corrective measures for pipeline projects by understanding Leber’s Hereditary Optic Neuropathy (Ophthalmology) pipeline depth and focus of Indication therapeutics.
  • Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope.
  • Adjust the therapeutic portfolio by recognizing discontinued projects and understand from the know-how what drove them from pipeline.


Introduction
Global Markets Direct Report Coverage
Leber’s Hereditary Optic Neuropathy (Leber Optic Atrophy) – Overview
Leber’s Hereditary Optic Neuropathy (Leber Optic Atrophy) – Therapeutics Development
Pipeline Overview
Pipeline by Companies
Pipeline by Universities/Institutes
Products under Development by Companies
Products under Development by Universities/Institutes
Leber’s Hereditary Optic Neuropathy (Leber Optic Atrophy) – Therapeutics Assessment
Assessment by Target
Assessment by Mechanism of Action
Assessment by Route of Administration
Assessment by Molecule Type
Leber’s Hereditary Optic Neuropathy (Leber Optic Atrophy) – Companies Involved in Therapeutics Development
Astellas Pharma Inc
Biovista Inc
Evvia Therapeutics Inc
GenSight Biologics SA
Imbria Pharmaceuticals Inc
Ixchel Pharma LLC
Metro International Biotech LLC
Mitotech SA
Neurophth Therapeutics Inc
Neuroptika Inc
PYC Therapeutics Ltd
Stealth BioTherapeutics Corp
Leber’s Hereditary Optic Neuropathy (Leber Optic Atrophy) – Drug Profiles
BVA-202 – Drug Profile
BVA-203 – Drug Profile
elamipretide hydrochloride – Drug Profile
Gene Therapy to Activate ND4 for Leber's Hereditary Optic Neuropathy – Drug Profile
GS-011 – Drug Profile
IMB-203 – Drug Profile
IXC-103 – Drug Profile
IXC-109 – Drug Profile
lenadogene nolparvovec – Drug Profile
MIB-626 – Drug Profile
NFS-01 – Drug Profile
NFS-02 – Drug Profile
NRO-1 – Drug Profile
plastoquinone decyl triphenylphosphonium bromide – Drug Profile
Small Molecules for Mitochondrial and Central Nervous System Disorders – Drug Profile
Small Molecules to Activate AMPK for Leber's Hereditary Optic Neuropathy – Drug Profile
VP-002 – Drug Profile
Leber’s Hereditary Optic Neuropathy (Leber Optic Atrophy) – Dormant Projects
Leber’s Hereditary Optic Neuropathy (Leber Optic Atrophy) – Product Development Milestones
Featured News & Press Releases
Jun 16, 2022: GenSight Biologics announces participation and presentation of GS010 clinical data at EUNOS 2022
May 19, 2022: GenSight Biologics announces publication of a study of the impact of LHON disease on the lives of patients and relatives in Journal of Neuro-Ophthalmology
Apr 14, 2022: GenSight Biologics granted six-month extension in LUMEVOQ European Regulatory review
Apr 07, 2022: GenSight Biologics provides update on LUMEVOQ manufacturing timeline
Feb 14, 2022: GenSight Biologics to present REFLECT phase III data with LUMEVOQ at the NANOS 2022 Meeting
Jan 25, 2022: Neurophth Therapeutics treatment of Leber's Hereditary Optic Neuropathy gene therapy NR082 was granted orphan drug designation by EMA
Jan 24, 2022: GenSight Biologics reports clinically meaningful vision improvement is maintained 4 years after one-time treatment with LUMEVOQ gene therapy
Dec 14, 2021: GenSight Biologics confirms sustained efficacy and safety of bilateral LUMEVOQ injections at 2-year follow-up of REFLECT phase III trial
Dec 01, 2021: GenSight Biologics announces publication of non-human primate study reporting presence of Lumevoq vector DNA in contralateral eyes after unilateral injection
Nov 22, 2021: GenSight Biologics to host Key Opinion Leader Webcast on outcomes among compassionate use patients treated bilaterally with LUMEVOQ in the US
Nov 15, 2021: GenSight Biologics announces extension of day 120 clock stop of LUMEVOQ EMA regulatory filing; MAA Review to resume in April 2022
Nov 12, 2021: GenSight Biologics to present new clinical data of LUMEVOQ gene therapy at the American Academy of Ophthalmology 2021 Meeting
Nov 04, 2021: GenSight Biologics provides update on manufacturing timeline needed for LUMEVOQ regulatory filing
Oct 06, 2021: GenSight Biologics announces the publication of a review of gene therapy trials for LHON in International Ophthalmology Clinics
Oct 04, 2021: Clinical Data on GenSight Biologics’ LUMEVOQ to be presented at 2021 ASRS, ESGCT and several investor and industry meetings in October
Appendix
Methodology
Coverage
Secondary Research
Primary Research
Expert Panel Validation
Contact Us
Disclaimer
List of Tables
Table 1: Number of Products under Development for Leber’s Hereditary Optic Neuropathy (Leber Optic Atrophy), 2022
Table 2: Number of Products under Development by Companies, 2022
Table 3: Number of Products under Development by Universities/Institutes, 2022
Table 4: Products under Development by Companies, 2022
Table 5: Products under Development by Universities/Institutes, 2022
Table 6: Number of Products by Stage and Target, 2022
Table 7: Number of Products by Stage and Mechanism of Action, 2022
Table 8: Number of Products by Stage and Route of Administration, 2022
Table 9: Number of Products by Stage and Molecule Type, 2022
Table 10: Leber’s Hereditary Optic Neuropathy (Leber Optic Atrophy) – Pipeline by Astellas Pharma Inc, 2022
Table 11: Leber’s Hereditary Optic Neuropathy (Leber Optic Atrophy) – Pipeline by Biovista Inc, 2022
Table 12: Leber’s Hereditary Optic Neuropathy (Leber Optic Atrophy) – Pipeline by Evvia Therapeutics Inc, 2022
Table 13: Leber’s Hereditary Optic Neuropathy (Leber Optic Atrophy) – Pipeline by GenSight Biologics SA, 2022
Table 14: Leber’s Hereditary Optic Neuropathy (Leber Optic Atrophy) – Pipeline by Imbria Pharmaceuticals Inc, 2022
Table 15: Leber’s Hereditary Optic Neuropathy (Leber Optic Atrophy) – Pipeline by Ixchel Pharma LLC, 2022
Table 16: Leber’s Hereditary Optic Neuropathy (Leber Optic Atrophy) – Pipeline by Metro International Biotech LLC, 2022
Table 17: Leber’s Hereditary Optic Neuropathy (Leber Optic Atrophy) – Pipeline by Mitotech SA, 2022
Table 18: Leber’s Hereditary Optic Neuropathy (Leber Optic Atrophy) – Pipeline by Neurophth Therapeutics Inc, 2022
Table 19: Leber’s Hereditary Optic Neuropathy (Leber Optic Atrophy) – Pipeline by Neuroptika Inc, 2022
Table 20: Leber’s Hereditary Optic Neuropathy (Leber Optic Atrophy) – Pipeline by PYC Therapeutics Ltd, 2022
Table 21: Leber’s Hereditary Optic Neuropathy (Leber Optic Atrophy) – Pipeline by Stealth BioTherapeutics Corp, 2022
Table 22: Leber’s Hereditary Optic Neuropathy (Leber Optic Atrophy) – Dormant Projects, 2022
List of Figures
Figure 1: Number of Products under Development for Leber’s Hereditary Optic Neuropathy (Leber Optic Atrophy), 2022
Figure 2: Number of Products under Development by Companies, 2022
Figure 3: Number of Products by Targets, 2022
Figure 4: Number of Products by Stage and Targets, 2022
Figure 5: Number of Products by Mechanism of Actions, 2022
Figure 6: Number of Products by Stage and Mechanism of Actions, 2022
Figure 7: Number of Products by Routes of Administration, 2022
Figure 8: Number of Products by Stage and Routes of Administration, 2022
Figure 9: Number of Products by Molecule Types, 2022
Figure 10: Number of Products by Stage and Molecule Types, 2022

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