Histone Deacetylase 1 (HDAC1 or EC 3.5.1.98) Drugs in Development by Therapy Areas and Indications, Stages, MoA, RoA, Molecule Type and Key Players, 2022 Update

Histone Deacetylase 1 (HDAC1 or EC 3.5.1.98) Drugs in Development by Therapy Areas and Indications, Stages, MoA, RoA, Molecule Type and Key Players, 2022 Update

Summary

According to the recently published report 'Histone Deacetylase 1 - Drugs In Development, 2022'; Histone Deacetylase 1 (HDAC1 or EC 3.5.1.98) pipeline Target constitutes close to 38 molecules. Out of which approximately 30 molecules are developed by companies and remaining by the universities/institutes.
Histone Deacetylase 1 (HDAC1 or EC 3.5.1.98) - Histone deacetylase 1 is an enzyme encoded by the HDAC1 gene. The protein encoded by this gene belongs to the histone deacetylase family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2 MTA2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. It plays an important role in transcriptional regulation, cell cycle progression and developmental events.
The report 'Histone Deacetylase 1 - Drugs In Development, 2022' outlays comprehensive information on the Histone Deacetylase 1 (HDAC1 or EC 3.5.1.98) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type; that are being developed by Companies / Universities.
It also reviews key players involved in Histone Deacetylase 1 (HDAC1 or EC 3.5.1.98) targeted therapeutics development with respective active and dormant or discontinued projects. Currently, The molecules developed by companies in Pre-Registration, Phase III, Phase II, Phase I, IND/CTA Filed, Preclinical and Discovery stages are 1, 2, 7, 1, 1, 15 and 3 respectively. Similarly, the universities portfolio in Phase I, Preclinical and Discovery stages comprises 1, 6 and 1 molecules, respectively.
Report covers products from therapy areas Oncology, Central Nervous System, Genetic Disorders, Hematological Disorders, Cardiovascular, Gastrointestinal, Immunology, Infectious Disease and Musculoskeletal Disorders which include indications Breast Cancer, Diffuse Large B-Cell Lymphoma, Melanoma, Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma), Non-Small Cell Lung Cancer, Acute Lymphocytic Leukemia (ALL, Acute Lymphoblastic Leukemia), Acute Myelocytic Leukemia (AML, Acute Myeloblastic Leukemia), Follicular Lymphoma, Mycosis Fungoides, Triple-Negative Breast Cancer (TNBC), B-Cell Non-Hodgkin Lymphoma, Burkitt Lymphoma, Colorectal Cancer, Cutaneous T-Cell Lymphoma, Essential Thrombocythemia, Glioblastoma Multiforme (GBM), Human Epidermal Growth Factor Receptor 2 Negative Breast Cancer (HER2- Breast Cancer), Liver Cancer, Pancreatic Cancer, Pediatric Diffuse Intrinsic Pontine Glioma, Post-Polycythemia Vera Myelofibrosis (PPV-MF), Refractory Multiple Myeloma, Relapsed Multiple Myeloma, Unspecified B-Cell Lymphomas, Adenoid Cystic Carcinoma (ACC), Alzheimer's Disease, Anal Cancer, Anaplastic Astrocytoma, Anaplastic Large Cell Lymphoma (ALCL), Angioimmunoblastic T-Cell Lymphoma (AITL)/Immunoblastic Lymphadenopathy, B-Cell Acute Lymphocytic Leukemia (B-Cell Acute Lymphoblastic Leukaemia), Basal Cell Carcinoma (Basal Cell Epithelioma), Becker Muscular Dystrophy, Beta Thalassaemia, Bladder Cancer, Blood Cancer, Bone Disorders, Cervical Cancer, Charcot-Marie-Tooth Disease Type II, Chronic Lymphocytic Leukemia (CLL), CNS Lymphoma, Cognitive Disorders, Colon Cancer, Duchenne Muscular Dystrophy, Gallbladder Cancer, Gliosarcoma, Head And Neck Cancer Squamous Cell Carcinoma, Hematological Tumor, Hemoglobinopathies, High-Grade Glioma, Human Immunodeficiency Virus (HIV) Infections (AIDS), Ischemia Reperfusion Injury, Kidney Cancer (Renal Cell Cancer), Liver Fibrosis, Lung Adenocarcinoma, Lung Cancer, Mantle Cell Lymphoma, Marginal Zone B-cell Lymphoma, Metastatic Breast Cancer, Metastatic Melanoma, Multiple Sclerosis, Muscle Invasive Bladder Cancer (MIBC), Myelodysplastic Syndrome, Myelofibrosis, Natural Killer Cell Lymphomas, Neuroblastoma, Neuroendocrine Carcinoma, Non-Hodgkin Lymphoma, NUT Midline Carcinoma (NMC or Nuclear Protein in Testis Midline Carcinoma), Ovarian Cancer, Parkinson's Disease, Penile Cancer, Peripheral T-Cell Lymphomas (PTCL), Polycythemia Vera, Post-Essential Thrombocythemia Myelofibrosis (Post-ET MF), Prostate Cancer, Rectal Cancer, Recurrent Medulloblastoma, Renal Cell Carcinoma, Rhabdomyosarcoma, Sezary Syndrome, Sickle Cell Disease, Skin Cancer, Small-Cell Lung Cancer, Solid Tumor, Squamous Cell Carcinoma, Systemic Lupus Erythematosus, T-Cell Acute Lymphocytic Leukemia (T-Cell Acute Lymphoblastic Leukaemia), T-Cell Lymphomas, Transitional Cell Cancer (Urothelial Cell Cancer), Unspecified Cancer, Unspecified Central Nervous System Disorders, Ureter Cancer, Urethral Cancer and Vulvar Cancer.

Note:Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.

Scope

  • The report provides a snapshot of the global therapeutic landscape for Histone Deacetylase 1 (HDAC1 or EC 3.5.1.98)
  • The report reviews Histone Deacetylase 1 (HDAC1 or EC 3.5.1.98) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
  • The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
  • The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
  • The report reviews key players involved in Histone Deacetylase 1 (HDAC1 or EC 3.5.1.98) targeted therapeutics and enlists all their major and minor projects
  • The report assesses Histone Deacetylase 1 (HDAC1 or EC 3.5.1.98) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type
  • The report summarizes all the dormant and discontinued pipeline projects
  • The report reviews latest news and deals related to Histone Deacetylase 1 (HDAC1 or EC 3.5.1.98) targeted therapeutics
Reasons to Buy
  • Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
  • Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
  • Identify and understand the targeted therapy areas and indications for Histone Deacetylase 1 (HDAC1 or EC 3.5.1.98)
  • Identify the use of drugs for target identification and drug repurposing
  • Identify potential new clients or partners in the target demographic
  • Develop strategic initiatives by understanding the focus areas of leading companies
  • Plan mergers and acquisitions effectively by identifying key players and it’s most promising pipeline therapeutics
  • Devise corrective measures for pipeline projects by understanding Histone Deacetylase 1 (HDAC1 or EC 3.5.1.98) development landscape
  • Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope


Introduction
Global Markets Direct Report Coverage
Histone Deacetylase 1 (HDAC1 or EC 3.5.1.98) – Overview
Histone Deacetylase 1 (HDAC1 or EC 3.5.1.98) – Therapeutics Development
Products under Development by Stage of Development
Products under Development by Therapy Area
Products under Development by Indication
Products under Development by Companies
Products under Development by Universities/Institutes
Histone Deacetylase 1 (HDAC1 or EC 3.5.1.98) – Therapeutics Assessment
Assessment by Mechanism of Action
Assessment by Route of Administration
Assessment by Molecule Type
Histone Deacetylase 1 (HDAC1 or EC 3.5.1.98) – Companies Involved in Therapeutics Development
4D Pharma Plc
4SC AG
BioMarin Pharmaceutical Inc
Bristol-Myers Squibb Co
Curis Inc
GNT Biotech and Medicals Corp
Italfarmaco SpA
Jubilant Therapeutics Inc
Medibiofarma SL
Medivir AB
MEI Pharma Inc
Merck & Co Inc
Mirati Therapeutics Inc
Neuroene Therapeutics LLC
Oceanyx Pharmaceuticals Inc
OnKure Inc
Regenacy Pharmaceuticals LLC
Shenzhen Chipscreen Biosciences Co Ltd
Shuttle Pharmaceuticals Inc
Syndax Pharmaceuticals Inc
Zhejiang Hisun Pharmaceutical Co Ltd
Histone Deacetylase 1 (HDAC1 or EC 3.5.1.98) – Drug Profiles
ACY-1035 – Drug Profile
ACY-1071 – Drug Profile
ACY-738 – Drug Profile
ACY-957 – Drug Profile
crocetin – Drug Profile
entinostat – Drug Profile
fimepinostat – Drug Profile
givinostat – Drug Profile
GNTbm-04 – Drug Profile
GNTbm-38 – Drug Profile
JBI-128 – Drug Profile
largazole – Drug Profile
MBF-015 – Drug Profile
MitoDak – Drug Profile
mocetinostat – Drug Profile
MRx-0029 – Drug Profile
MRX-1299 – Drug Profile
OKI-179 – Drug Profile
pracinostat – Drug Profile
purinostat mesylate – Drug Profile
RCY-1305 – Drug Profile
RCY-1410 – Drug Profile
remetinostat – Drug Profile
resminostat – Drug Profile
RG-2833 – Drug Profile
Small Molecule to Inhibit HDAC1 and HDAC6 for Breast Cancer – Drug Profile
Small Molecule to Inhibit HDAC1, HDAC2 and HDAC3 for Burkitt Lymphoma – Drug Profile
Small Molecule to Inhibit HDAC1, HDAC3 and HDAC6 for Lung Adenocarcinoma – Drug Profile
Small Molecule to Inhibit KDM1A, HDAC1 and HDAC2 for Melanoma – Drug Profile
Small Molecules to Inhibit BRD4 and HDAC1 for Oncology – Drug Profile
Small Molecules to Inhibit HDAC1 and 2 for Cognitive Dysfunction – Drug Profile
Small Molecules to Inhibit HDAC1 and HDAC2 for Hemoglobinopathies – Drug Profile
Small Molecules to Inhibit HDAC1, HDAC2 and HDAC3 for Oncology – Drug Profile
SP-1161 – Drug Profile
SP-1303 – Drug Profile
Synthetic Peptide to Inhibit HDAC for Prostate Cancer – Drug Profile
tucidinostat – Drug Profile
vorinostat – Drug Profile
Histone Deacetylase 1 (HDAC1 or EC 3.5.1.98) – Dormant Products
Histone Deacetylase 1 (HDAC1 or EC 3.5.1.98) – Discontinued Products
Histone Deacetylase 1 (HDAC1 or EC 3.5.1.98) – Product Development Milestones
Featured News & Press Releases
Jun 25, 2022: Italfarmaco Group announces positive topline data from phase 3 trial showing beneficial effect of givinostat in patients with Duchenne Muscular Dystrophy
Jun 02, 2022: OnKure Therapeutics announces first patient dosed in the phase 1b/2 Nautilus trial of OKI-179 in combination with binimetinib in patients with advanced NRAS-mutated melanoma
May 05, 2022: 4SC – Resminostat and RESMAIN study update
Apr 08, 2022: OnKure Therapeutics announces promising preclinical data on OKI-179 in RAS-mutated tumor models presented in a late-breaking session at AACR
Mar 08, 2022: OnKure Therapeutics to present late-breaking preclinical data on OKI-179 at the AACR Annual Meeting 2022
Feb 22, 2022: 4D pharma announces FDA clearance of IND application for Live Biotherapeutic MRx0029 for the treatment of Parkinson’s disease
Dec 14, 2021: OnKure Therapeutics announces positive topline first-in-human phase 1 results for OKI-179
Dec 01, 2021: Licensing partner of Shenzhen Chipscreen Biosciences - HUYABIO International, receives regulatory approval for Chidamide monotherapy of Peripheral T-Cell Lymphoma(PTCL) in Japan
Nov 30, 2021: HUYABIO International receives regulatory approval for Hiyasta monotherapy of peripheral t-cell lymphoma In Japan
Nov 25, 2021: Approval for additional indication of Hiyasta tablets for relapsed or refractory PTCL treatment in Japan
Nov 18, 2021: Results from investigator-initiated phase II clinical study of remetinostat in patients with squamous cell carcinoma published
Oct 19, 2021: HUYABIO International launches Hiyasta as monotherapy for adult T-cell leukemia/lymphoma in Japan
Oct 07, 2021: Kyowa Kirin announces discontinuation for developing KHK237 (Entinostat)
Sep 21, 2021: HUYABIO announces first patient treated in a pivotal study of HBI-8000 combined with Opdivo (nivolumab) in patients with advanced melanoma
Aug 16, 2021: University of North Carolina Lineberger Comprehensive Cancer Center: Experimental drug that boosts immunotherapy shows promise in bladder cancer study
Appendix
Methodology
Coverage
Secondary Research
Primary Research
Expert Panel Validation
Contact Us
Disclaimer
List of Tables
Table 1: Number of Products under Development by Stage of Development, 2022
Table 2: Number of Products under Development by Therapy Areas, 2022
Table 3: Number of Products under Development by Indications, 2022
Table 4: Number of Products under Development by Indications, 2022 (Contd..1)
Table 5: Number of Products under Development by Indications, 2022 (Contd..2)
Table 6: Number of Products under Development by Indications, 2022 (Contd..3)
Table 7: Number of Products under Development by Indications, 2022 (Contd..4)
Table 8: Number of Products under Development by Companies, 2022
Table 9: Products under Development by Companies, 2022
Table 10: Products under Development by Companies, 2022 (Contd..1)
Table 11: Products under Development by Companies, 2022 (Contd..2)
Table 12: Products under Development by Companies, 2022 (Contd..3)
Table 13: Products under Development by Companies, 2022 (Contd..4)
Table 14: Products under Development by Companies, 2022 (Contd..5)
Table 15: Products under Development by Companies, 2022 (Contd..6)
Table 16: Number of Products under Investigation by Universities/Institutes, 2022
Table 17: Products under Investigation by Universities/Institutes, 2022
Table 18: Number of Products by Stage and Mechanism of Actions, 2022
Table 19: Number of Products by Stage and Route of Administration, 2022
Table 20: Number of Products by Stage and Molecule Type, 2022
Table 21: Pipeline by 4D Pharma Plc, 2022
Table 22: Pipeline by 4SC AG, 2022
Table 23: Pipeline by BioMarin Pharmaceutical Inc, 2022
Table 24: Pipeline by Bristol-Myers Squibb Co, 2022
Table 25: Pipeline by Curis Inc, 2022
Table 26: Pipeline by GNT Biotech and Medicals Corp, 2022
Table 27: Pipeline by Italfarmaco SpA, 2022
Table 28: Pipeline by Jubilant Therapeutics Inc, 2022
Table 29: Pipeline by Medibiofarma SL, 2022
Table 30: Pipeline by Medivir AB, 2022
Table 31: Pipeline by MEI Pharma Inc, 2022
Table 32: Pipeline by Merck & Co Inc, 2022
Table 33: Pipeline by Mirati Therapeutics Inc, 2022
Table 34: Pipeline by Neuroene Therapeutics LLC, 2022
Table 35: Pipeline by Oceanyx Pharmaceuticals Inc, 2022
Table 36: Pipeline by OnKure Inc, 2022
Table 37: Pipeline by Regenacy Pharmaceuticals LLC, 2022
Table 38: Pipeline by Shenzhen Chipscreen Biosciences Co Ltd, 2022
Table 39: Pipeline by Shuttle Pharmaceuticals Inc, 2022
Table 40: Pipeline by Syndax Pharmaceuticals Inc, 2022
Table 41: Pipeline by Zhejiang Hisun Pharmaceutical Co Ltd, 2022
Table 42: Dormant Products, 2022
Table 43: Dormant Products, 2022 (Contd..1)
Table 44: Dormant Products, 2022 (Contd..2)
Table 45: Dormant Products, 2022 (Contd..3)
Table 46: Dormant Products, 2022 (Contd..4)
Table 47: Dormant Products, 2022 (Contd..5)
Table 48: Dormant Products, 2022 (Contd..6)
Table 49: Discontinued Products, 2022
Table 50: Discontinued Products, 2022 (Contd..1)
Table 51: Discontinued Products, 2022 (Contd..2)
List of Figures
Figure 1: Number of Products under Development by Stage of Development, 2022
Figure 2: Number of Products under Development by Therapy Areas, 2022
Figure 3: Number of Products under Development by Top 10 Indications, 2022
Figure 4: Number of Products by Stage and Top 10 Mechanism of Actions, 2022
Figure 5: Number of Products by Routes of Administration, 2022
Figure 6: Number of Products by Stage and Routes of Administration, 2022
Figure 7: Number of Products by Molecule Types, 2022
Figure 8: Number of Products by Stage and Molecule Types, 2022

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