Glucokinase (Hexokinase D or Hexokinase 4 or GCK or EC 2.7.1.2) Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update

Glucokinase (Hexokinase D or Hexokinase 4 or GCK or EC 2.7.1.2) Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update

Summary

Glucokinase (Hexokinase D or Hexokinase 4 or GCK or EC 2.7.1.2) pipeline Target constitutes close to 21 molecules. Out of which approximately 19 molecules are developed by companies and remaining by the universities/institutes. The latest report Glucokinase - Drugs In Development, 2022, outlays comprehensive information on the Glucokinase (Hexokinase D or Hexokinase 4 or GCK or EC 2.7.1.2) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.

Glucokinase (Hexokinase D or Hexokinase 4 or GCK or EC 2.7.1.2) - Glucokinase is an enzyme that catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage. The molecules developed by companies in Pre-Registration, Phase III, Phase II and Preclinical stages are 1, 1, 4 and 13 respectively. Similarly, the universities portfolio in Preclinical stages comprises 2 molecules, respectively.

Report covers products from therapy areas Metabolic Disorders, Central Nervous System, Gastrointestinal and Infectious Disease which include indications Type 2 Diabetes, Type 1 Diabetes (Juvenile Diabetes), Alzheimer's Disease, Coronavirus Disease 2019 (COVID-19), Diabetes, Diabetic Nephropathy, Non-Alcoholic Steatohepatitis (NASH), Obesity and Unspecified Metabolic Disorders.

Furthermore, this report also reviews key players involved in Glucokinase (Hexokinase D or Hexokinase 4 or GCK or EC 2.7.1.2) targeted therapeutics development with respective active and dormant or discontinued projects. Driven by data and information sourced from proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources.

Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.

Scope

  • The report provides a snapshot of the global therapeutic landscape for Glucokinase (Hexokinase D or Hexokinase 4 or GCK or EC 2.7.1.2)
  • The report reviews Glucokinase (Hexokinase D or Hexokinase 4 or GCK or EC 2.7.1.2) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
  • The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
  • The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
  • The report reviews key players involved in Glucokinase (Hexokinase D or Hexokinase 4 or GCK or EC 2.7.1.2) targeted therapeutics and enlists all their major and minor projects
  • The report assesses Glucokinase (Hexokinase D or Hexokinase 4 or GCK or EC 2.7.1.2) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type
  • The report summarizes all the dormant and discontinued pipeline projects
  • The report reviews latest news and deals related to Glucokinase (Hexokinase D or Hexokinase 4 or GCK or EC 2.7.1.2) targeted therapeutics
Reasons to Buy
  • Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
  • Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
  • Identify and understand the targeted therapy areas and indications for Glucokinase (Hexokinase D or Hexokinase 4 or GCK or EC 2.7.1.2)Identify the use of drugs for target identification and drug repurposing
  • Identify potential new clients or partners in the target demographic
  • Develop strategic initiatives by understanding the focus areas of leading companies
  • Plan mergers and acquisitions effectively by identifying key players and it’s most promising pipeline therapeutics
  • Devise corrective measures for pipeline projects by understanding Glucokinase (Hexokinase D or Hexokinase 4 or GCK or EC 2.7.1.2) development landscape
  • Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope


Introduction
Global Markets Direct Report Coverage
Glucokinase (Hexokinase D or Hexokinase 4 or GCK or EC 2.7.1.2) – Overview
Glucokinase (Hexokinase D or Hexokinase 4 or GCK or EC 2.7.1.2) – Therapeutics Development
Products under Development by Stage of Development
Products under Development by Therapy Area
Products under Development by Indication
Products under Development by Companies
Products under Development by Universities/Institutes
Glucokinase (Hexokinase D or Hexokinase 4 or GCK or EC 2.7.1.2) – Therapeutics Assessment
Assessment by Mechanism of Action
Assessment by Route of Administration
Assessment by Molecule Type
Glucokinase (Hexokinase D or Hexokinase 4 or GCK or EC 2.7.1.2) – Companies Involved in Therapeutics Development
AstraZeneca Plc
Eli Lilly and Co
Hua Medicine Shanghai Ltd
Impetis Biosciences Ltd
Kriya Therapeutics Inc
Ligand Pharmaceuticals Inc
Merck & Co Inc
Pfizer Inc
Sanwa Kagaku Kenkyusho Co Ltd
vTv Therapeutics Inc
Glucokinase (Hexokinase D or Hexokinase 4 or GCK or EC 2.7.1.2) – Drug Profiles
(dorzagliatin + empagliflozin) – Drug Profile
(dorzagliatin + glucagon like peptide-1) – Drug Profile
(dorzagliatin + insulin) – Drug Profile
(dorzagliatin + metformin) – Drug Profile
(dorzagliatin + pioglitazone) – Drug Profile
(dorzagliatin + sitagliptin) – Drug Profile
2nd Generation GKA – Drug Profile
AZD-1656 – Drug Profile
cadisegliatin – Drug Profile
dorzagliatin – Drug Profile
Gene Therapy to Activate Glucokinase and Insulin for Diabetes and Obesity – Drug Profile
GKM-001 – Drug Profile
KTA-112 – Drug Profile
Liver Specific Glucokinase Activator – Drug Profile
LY-2608204 – Drug Profile
PF-04937319 – Drug Profile
Small Molecule to Activate Glucokinase for Type 2 Diabetes – Drug Profile
Small Molecules 1 to Activate Glucokinase for Type 2 Diabetes – Drug Profile
Small Molecules to Activate Glucokinase for Type 2 Diabetes – Drug Profile
Glucokinase (Hexokinase D or Hexokinase 4 or GCK or EC 2.7.1.2) – Dormant Products
Glucokinase (Hexokinase D or Hexokinase 4 or GCK or EC 2.7.1.2) – Discontinued Products
Glucokinase (Hexokinase D or Hexokinase 4 or GCK or EC 2.7.1.2) – Product Development Milestones
Featured News & Press Releases
Aug 18, 2022: Arcadia clinical trial results published for Cizzle Biotechnology's royalty bearing interest in AZD1656
Jun 07, 2022: Hua Medicine announces dorzagliatin can restore glucose sensitivity and early phase insulin secretion in T2DM and GCK-MODY Patients at ADA 2022
Jun 04, 2022: vTv Therapeutics announces publication in diabetes obesity and metabolism of complete results for the mechanistic study assessing effects of TTP399 on Ketones during acute insulin withdrawal in patients with type 1 diabetes
Mar 07, 2022: Further positive outcomes from the Arcadia Clinical Trial by SGSC and Excalibur Medicines for Cizzle Biotechnology's Royalty Bearing interest in AZD1656
Dec 06, 2021: vTv Therapeutics announces restructuring to prioritize its lead program and focus operations
Oct 12, 2021: vTv Therapeutics announces positive results from mechanistic study indicating no increased risk of ketoacidosis with TTP399 during acute insulin withdrawal in patients with type 1 diabetes
Sep 26, 2021: Researchers present key research results on diabetes remission of dorzagliatin
Sep 09, 2021: Results from ARCADIA phase II clinical trial of a potential therapy for COVID-19
Apr 23, 2021: Hua Medicine announces acceptance of a New Drug Application for Dorzagliatin in China - First glucokinase activator (GKA) globally
Apr 13, 2021: vTv Therapeutics receives FDA breakthrough therapy designation for TTP399 for the treatment of type 1 diabetes
Apr 12, 2021: TTP399 SimpliciT-1 study results to be presented at a scientific symposium in celebration of the 100th anniversary of the discovery of insulin
Mar 23, 2021: vTv Therapeutics announces issuance of U.S. patent covering methods of treatment using TTP399
Mar 19, 2021: Milestone development achieved in clinical trials and commercialization, Hua medicine's dorzagliatin readying for NDA submission
Mar 18, 2021: vTv Therapeutics announces initiation of study evaluating TTP399’s potential to reduce risk of diabetic ketoacidosis in patients with type 1 diabetes
Feb 23, 2021: vTv Therapeutics announces publication in diabetes care of results from SimpliciT-1 study of TTP399 in patients with type 1 diabetes
Appendix
Methodology
Coverage
Secondary Research
Primary Research
Expert Panel Validation
Contact Us
Disclaimer
List of Tables
Table 1: Number of Products under Development by Stage of Development, 2022
Table 2: Number of Products under Development by Therapy Areas, 2022
Table 3: Number of Products under Development by Indication, 2022
Table 4: Number of Products under Development by Companies, 2022
Table 5: Products under Development by Companies, 2022
Table 6: Products under Development by Companies, 2022 (Contd..1)
Table 7: Number of Products under Investigation by Universities/Institutes, 2022
Table 8: Products under Investigation by Universities/Institutes, 2022
Table 9: Number of Products by Stage and Mechanism of Actions, 2022
Table 10: Number of Products by Stage and Route of Administration, 2022
Table 11: Number of Products by Stage and Molecule Type, 2022
Table 12: Pipeline by AstraZeneca Plc, 2022
Table 13: Pipeline by Eli Lilly and Co, 2022
Table 14: Pipeline by Hua Medicine Shanghai Ltd, 2022
Table 15: Pipeline by Impetis Biosciences Ltd, 2022
Table 16: Pipeline by Kriya Therapeutics Inc, 2022
Table 17: Pipeline by Ligand Pharmaceuticals Inc, 2022
Table 18: Pipeline by Merck & Co Inc, 2022
Table 19: Pipeline by Pfizer Inc, 2022
Table 20: Pipeline by Sanwa Kagaku Kenkyusho Co Ltd, 2022
Table 21: Pipeline by vTv Therapeutics Inc, 2022
Table 22: Dormant Projects, 2022
Table 23: Discontinued Products, 2022
List of Figures
Figure 1: Number of Products under Development by Stage of Development, 2022
Figure 2: Number of Products under Development by Therapy Areas, 2022
Figure 3: Number of Products under Development by Top 10 Indications, 2022
Figure 4: Number of Products by Stage and Mechanism of Actions, 2022
Figure 5: Number of Products by Routes of Administration, 2022
Figure 6: Number of Products by Stage and Routes of Administration, 2022
Figure 7: Number of Products by Molecule Types, 2022
Figure 8: Number of Products by Stage and Molecule Types, 2022

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