Amyotrophic Lateral Sclerosis Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update

Amyotrophic Lateral Sclerosis Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update

Summary

Global Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Amyotrophic Lateral Sclerosis - Drugs In Development, 2022, provides an overview of the Amyotrophic Lateral Sclerosis (Central Nervous System) pipeline landscape.

Amyotrophic lateral sclerosis (ALS) is the most common degenerative disease of the motor neuron system. The disorder is named for its underlying pathophysiology, with amyotrophy referring to the atrophy of muscle fibers, which are denervated as their corresponding anterior horn cells degenerate. Lateral sclerosis refers to the changes seen in the lateral columns of the spinal cord as upper motor neuron (UMN) axons in these areas degenerate and are replaced by fibrous astrocytes (gliosis). Symptoms include difficulty breathing, difficulty swallowing, head drop due to weakness of the neck muscles, muscle cramps, speech problems, such as a slow or abnormal speech pattern (slurring of words), voice changes, hoarseness, weight loss.

Report Highlights

Global Markets Direct's Pharmaceutical and Healthcare latest pipeline guide Amyotrophic Lateral Sclerosis - Drugs In Development, 2022, provides comprehensive information on the therapeutics under development for Amyotrophic Lateral Sclerosis (Central Nervous System), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. The guide covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases.

The Amyotrophic Lateral Sclerosis (Central Nervous System) pipeline guide also reviews of key players involved in therapeutic development for Amyotrophic Lateral Sclerosis and features dormant and discontinued projects. The guide covers therapeutics under Development by Companies /Universities /Institutes, the molecules developed by Companies in Pre-Registration, Filing rejected/Withdrawn, Phase III, Phase II, Phase I, IND/CTA Filed, Preclinical, Discovery and Unknown stages are 4, 1, 17, 46, 29, 5, 178, 80 and 4 respectively. Similarly, the Universities portfolio in Phase II, Preclinical and Discovery stages comprises 2, 38 and 14 molecules, respectively.

Amyotrophic Lateral Sclerosis (Central Nervous System) pipeline guide helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. The guide is built using data and information sourced from Global Markets Direct’s proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources. Additionally, various dynamic tracking processes ensure that the most recent developments are captured on a real time basis.

Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.

Scope

  • The pipeline guide provides a snapshot of the global therapeutic landscape of Amyotrophic Lateral Sclerosis (Central Nervous System).
  • The pipeline guide reviews pipeline therapeutics for Amyotrophic Lateral Sclerosis (Central Nervous System) by companies and universities/research institutes based on information derived from company and industry-specific sources.
  • The pipeline guide covers pipeline products based on several stages of development ranging from pre-registration till discovery and undisclosed stages.
  • The pipeline guide features descriptive drug profiles for the pipeline products which comprise, product description, descriptive licensing and collaboration details, R&D brief, MoA & other developmental activities.
  • The pipeline guide reviews key companies involved in Amyotrophic Lateral Sclerosis (Central Nervous System) therapeutics and enlists all their major and minor projects.
  • The pipeline guide evaluates Amyotrophic Lateral Sclerosis (Central Nervous System) therapeutics based on mechanism of action (MoA), drug target, route of administration (RoA) and molecule type.
  • The pipeline guide encapsulates all the dormant and discontinued pipeline projects.
  • The pipeline guide reviews latest news related to pipeline therapeutics for Amyotrophic Lateral Sclerosis (Central Nervous System)
Reasons to Buy
  • Procure strategically important competitor information, analysis, and insights to formulate effective R&D strategies.
  • Recognize emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage.
  • Find and recognize significant and varied types of therapeutics under development for Amyotrophic Lateral Sclerosis (Central Nervous System).
  • Classify potential new clients or partners in the target demographic.
  • Develop tactical initiatives by understanding the focus areas of leading companies.
  • Plan mergers and acquisitions meritoriously by identifying key players and it’s most promising pipeline therapeutics.
  • Formulate corrective measures for pipeline projects by understanding Amyotrophic Lateral Sclerosis (Central Nervous System) pipeline depth and focus of Indication therapeutics.
  • Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope.
  • Adjust the therapeutic portfolio by recognizing discontinued projects and understand from the know-how what drove them from pipeline.


Introduction
Global Markets Direct Report Coverage
Amyotrophic Lateral Sclerosis – Overview
Amyotrophic Lateral Sclerosis – Therapeutics Development
Pipeline Overview
Pipeline by Companies
Pipeline by Universities/Institutes
Products under Development by Companies
Products under Development by Universities/Institutes
Amyotrophic Lateral Sclerosis – Therapeutics Assessment
Assessment by Target
Assessment by Mechanism of Action
Assessment by Route of Administration
Assessment by Molecule Type
Amyotrophic Lateral Sclerosis – Companies Involved in Therapeutics Development
1st Bio Therapeutics Inc
2N Pharma ApS
4B Technologies (Suzhou) Co Ltd
4P-Pharma SAS
AB Science SA
Abbisko Cayman Limited
Above and Beyond Concierge Therapeutics LLC
AC Immune SA
Aclipse One Inc
Aclipse Therapeutics LLC
Actimed Therapeutics Ltd
AcuraStem Inc
Adare Pharma Solutions
Aeterna Zentaris Inc
AgoneX Biopharmaceuticals Inc
AI Therapeutics Inc
AL-S Pharma AG
Alector Inc
Alexion Pharmaceuticals Inc
Allife Medical Science and Technology Co Ltd
Alnylam Pharmaceuticals Inc
AlphaCognition Inc
Alsonex Pty Ltd
Amarna Therapeutics BV
Amicogen Inc
Amplo Biotechnology Inc
Amylyx Pharmaceuticals Inc
Anima Biotech Inc
Ankar Pharma SL
ANLBio Co Ltd
Annexon Inc
Apellis Pharmaceuticals Inc
Apic Bio Inc
Apogenix AG
Applied Genetic Technologies Corp
Aquilus Pharmaceuticals Inc
Aquinnah Pharmaceuticals Inc
AriBio
ArmaGen Inc
ArunA Bio Inc
Asahi Kasei Pharma Corp
Asdera LLC
Asha Therapeutics LLC
Ashvattha Therapeutics LLC
Astellas Pharma Inc
Astrogen Ltd
Athira Pharma Inc
Autotac Bio Inc
Avanir Pharmaceuticals Inc
AviadoBio Ltd
Avrion Therapeutics AG
BenevolentAI Ltd
BioArctic AB
Bioasis Technologies Inc
Biogen Inc
Biohaven Pharmaceutical Holding Company Ltd
Bioleaders Corp
Biolexis Therapeutics Inc
Biorchestra Co Ltd
Bisichem Co Ltd
Bloom Science Inc
BrainEver SAS
BrainStorm Cell Therapeutics Inc
Bruschettini Srl
Calico Life Sciences LLC
Capsida Biotherapeutics Inc
CavoGene LifeSciences
CellCure
Cellenkos Inc
Ceptur Therapeutics Inc
Cerion LLC
Chaperone Therapeutics Inc
Chemigen LLC
Chiesi Farmaceutici SpA
CholesteniX Ltd
Chronos Therapeutics Ltd
Clene Inc
Clevexel Pharma SA
Clinigen Ltd
Coave Therapeutics
Codiak BioSciences Inc
Cogentis Therapeutics Inc
Collaborative Medicinal Development LLC
Constant Therapeutics LLC
Corcept Therapeutics Inc
Corestem Inc
Coya Therapeutics Inc
Curatis AG
CuroNZ Ltd
Cytokinetics Inc
Daiichi Sankyo Co Ltd
Deargen Inc
Denali Therapeutics Inc
Dewpoint Therapeutics Inc
Disarm Therapeutics Inc
DR.Noah Biotech Inc
Eikonizo Therapeutics Inc
Eikonoklastes Therapeutics Inc
Eisai Co Ltd
Eledon Pharmaceuticals Inc
Eli Lilly and Co
Elixiron Immunotherapeutics Inc
Elysium Health Inc
EmendoBio Inc
Emerald Health Sciences Inc
ENCEFA
Enveda Biosciences Inc
Enzerna Biosciences LLC
Eolo Pharma
Everfront Biotech Inc
Exicure Inc
Expansion Therapeutics Inc
Expesicor Inc
Faze medicines
Foshan Rexie Biotechnology Co Ltd
Gene Therapy Research Institution Co Ltd
Generoath Co Ltd
Genervon Biopharmaceuticals LLC
Genetic Intelligence Inc
GeNeuro SA
Genuv Inc
Glialogix Inc
GlyTag LLC
GNT Pharma Co Ltd
Grifols SA
Grupo Ferrer Internacional SA
Guangzhou Magpie Pharmaceutical Co Ltd
Helixmith Co Ltd
Hemostemix Inc
Herantis Pharma Plc
Hope Biosciences LLC
Hopstem Biotechnology LLC
Iltoo Pharma
Immunity Pharma Ltd
ImmunoBrain Checkpoint Inc
ImmunoForge Co Ltd
Implicit Bioscience Ltd
ImStar Therapeutics Inc
InFlectis BioScience SAS
Inmune Bio Inc
InnoMedica Holding AG
InnoPharmaScreen Inc
Io Therapeutics Inc
Ionis Pharmaceuticals Inc
Iron Horse Therapeutics Inc
Jiangsu Ouwei Pharmaceutical Co Ltd
Junaxo Inc
Jupiter Neurosciences Inc
K Pharma Inc
K-Pax Pharmaceuticals Inc
Kadimastem Ltd
Keapstone Therapeutics Ltd
KeifeRx LLC
Klogene Therapeutics Inc
Knopp Biosciences LLC
Kringle Pharma Inc
Kyorin Pharmaceutical Co Ltd
Lascco SA
Lauren Sciences LLC
LifeSplice Pharma LLC
Locanabio Inc
Longboard Pharmaceuticals Inc
Maas Biolab
Maze Therapeutics Inc
MD Healthcare Inc
MedDay SA
MeiraGTx Holdings Plc
Merck & Co Inc
MetrioPharm AG
MetVital Inc
MimeTech Srl
Mitochon Pharmaceuticals Inc
Mitochondria In Motion Inc
Mitoconix Bio Ltd
MitoDys Therapeutics Ltd
Mitsubishi Tanabe Pharma Corp
NeuExcell Therapeutics Inc
Neugen Pharma Inc
Neuracle Genetics Inc
Neuracle Science Co Ltd
Neurevo GmbH
Neurimmune Holding AG
Neurodegeneration Therapeutics Inc
NeuroGenesis Ltd
Neuromagen Pharma Ltd
Neuropath Therapeutics Ltd
Neuroplast BV
Neuropore Therapies Inc
NeuroSense Therapeutics Ltd
Neurotune AG
Neuvivo Inc
Nevrox Ltd
New Biotic Inc
Newron Pharmaceuticals SpA
Nine Square Therapeutics Inc
Nobelpharma Co Ltd
Novartis AG
Novartis Gene Therapies
NovelMed Therapeutics Inc
NuNerve Pty Ltd
NysnoBio LLC
Oncocross Co Ltd
OptiKira LLC
Orchard Therapeutics Plc
Origami Therapeutics Inc
Orpheris Inc
Palisade Bio, Inc
Parnia Stem Cell Knowledge-Based Co
Pasithea Therapeutics Corp
Passage Bio Inc
Pfizer Inc
PharmaTher Holdings Ltd
PharmAust Ltd
PharmEnable Ltd
Pharnext SA
Plex Pharmaceuticals Inc
PRG S&Tech Inc
Priavoid GmbH
Prilenia Therapeutics Development Ltd
Projenx Inc
ProMIS Neurosciences Inc
Prosetta Biosciences Inc
Prothena Corp Plc
Prous Institute for Biomedical Research SA
PTC Therapeutics Inc
PurMinds NeuroPharma Inc
Q Therapeutics Inc
Q-State Biosciences Inc
QurAlis Corporation
Ra Pharmaceuticals Inc
Rapa Therapeutics LLC
RASRx LLC
Reata Pharmaceuticals Inc
ReceptoPharm Inc
Regulus Therapeutics Inc
reMYND NV
ReoStem LLC
ResQ Biotech
Retrotope Inc
Revalesio Corp
Sangamo Therapeutics Inc
SciNeuro Pharmaceuticals
Seelos Therapeutics, Inc.
Shanghai Pharmaceuticals Holding Co Ltd
Shanghai Zhimeng Biopharma Inc
Shinkei Therapeutics LLC
Sio Gene Therapies Inc
SOLA Biosciences LLC
Spedding Research Solutions SAS
Spinogenix Inc
Stealth BioTherapeutics Corp
Suzhou Auzone Biological Technology Co Ltd
Symbinas Pharmaceuticals Inc
Takara Bio Inc
Talon Pharmaceutical Services Inc
Tasly Biopharmaceuticals Co Ltd
Tempero Bio
Thera Neuropharma Inc
Theragen Etex Co Ltd
Theratome Bio Inc
TikoMed AB
Tranquis Therapeutics Inc
Transposon Therapeutics Inc
Treeway BV
Treventis Corp
Triplet Therapeutics Inc
Ultragenyx Pharmaceutical Inc
UniQure NV
Unity Biotechnology Inc
Vanqua Bio Inc
Vaxxinity Inc
VectorY Therapeutics Inc
Velvio GmbH
Verge Genomics
Viridian Therapeutics Inc
Voronoi Group
Voyager Therapeutics Inc
Wave Life Sciences Ltd
Wren Therapeutics Ltd
Xalud Therapeutics Inc
XellSmart Biomedical (Shanghai) Co Ltd
Xonovo Inc
Yantai YenePharma Co Ltd
Yumanity Therapeutics Inc
Zhittya Genesis Medicine Inc
ZZ Biotech LLC
Amyotrophic Lateral Sclerosis – Drug Profiles
(acamprosate calcium + baclofen) – Drug Profile
(borneol + edaravone) – Drug Profile
(celecoxib + ciprofloxacin) – Drug Profile
(dextromethorphan + quinidine sulfate) – Drug Profile
(sodium phenylbutyrate + taurursodiol) – Drug Profile
123C-4 – Drug Profile
1ST-102 – Drug Profile
1ST-103 – Drug Profile
1ST-104 – Drug Profile
3K3A-APC – Drug Profile
4P-019 – Drug Profile
AAD-2004 – Drug Profile
AAV-UPF1 – Drug Profile
AB-200 – Drug Profile
ABBVCLS-7262 – Drug Profile
ABSK-021 – Drug Profile
ACI-5891 – Drug Profile
ACM-002 – Drug Profile
AGS-499 – Drug Profile
AGT-110 – Drug Profile
AGTC-801 – Drug Profile
albumin (human) – Drug Profile
aldesleukin – Drug Profile
ALN-SOD – Drug Profile
ALPHA-0602 – Drug Profile
ALPHA-0603 – Drug Profile
ALS – Drug Profile
ALS PIKFYVE – Drug Profile
ALS Target (Small Molecule/ASO) – Drug Profile
ALS Vaccine – Drug Profile
ALS-205 – Drug Profile
ALS/FTD – Drug Profile
AMA-007 – Drug Profile
ambroxol hydrochloride – Drug Profile
AMP-101 – Drug Profile
AMT-161 – Drug Profile
Amyotrophic Lateral Sclerosis (ALS) – Drug Profile
AMYOTROPHIC LATERAL SCLEROSIS (C9ORF72) – Drug Profile
Amyotrophic lateral sclerosis 2 – Drug Profile
Anhydrous enol oxaloacetate – Drug Profile
ANL-303 – Drug Profile
Antibodies to Inhibit TARDBP for Amyotrophic Lateral Sclerosis – Drug Profile
Antisense Oligonucleotide for Neurodegenerative Diseases – Drug Profile
Antisense Oligonucleotide to Inhibit Tau Protein for Neurodegenerative Disorders – Drug Profile
Antisense Oligonucleotides for Amyotrophic Lateral Sclerosis – Drug Profile
ANX-005 – Drug Profile
AP-101 – Drug Profile
APB-102 – Drug Profile
APB-104 – Drug Profile
APB-105 – Drug Profile
apilimod mesylate – Drug Profile
apomorphine hydrochloride – Drug Profile
AQU-118 – Drug Profile
AR-1001 – Drug Profile
AS-1 – Drug Profile
AS-201 – Drug Profile
AS-202 – Drug Profile
AS-203 – Drug Profile
ASD-005 – Drug Profile
ASHA-624 – Drug Profile
ASR-149 – Drug Profile
AST-011 – Drug Profile
AstroRx – Drug Profile
asunercept – Drug Profile
Ataxin2 – Drug Profile
ATC-104 – Drug Profile
AVR-001 – Drug Profile
AVXS-301 – Drug Profile
B-2069 – Drug Profile
baricitinib – Drug Profile
BEN-9160 – Drug Profile
BEN-XX1 – Drug Profile
BHV-TBD 1 – Drug Profile
BIIB-100 – Drug Profile
biotin – Drug Profile
BL-001 – Drug Profile
BLSM-22 – Drug Profile
BLX-0200 – Drug Profile
BMD-001 – Drug Profile
BMD-002 – Drug Profile
BNN-27 – Drug Profile
bosutinib – Drug Profile
BREN-01 – Drug Profile
BREN-02 – Drug Profile
BSC-3301 – Drug Profile
CALS-01 – Drug Profile
CB-003 – Drug Profile
CC-100 – Drug Profile
Cell Therapy for Autoimmune Disorders, Cardiovascular Disorders, CNS Disorders, Infectious Disease, Musculoskeletal Disorders and Oncology – Drug Profile
Cell Therapy for Central Nervous System and Neurodegenerative Diseases – Drug Profile
censavudine – Drug Profile
Cerium dioxide – Drug Profile
CH1 – Drug Profile
CHEC-9 – Drug Profile
CHX-100xD – Drug Profile
CK-0802 – Drug Profile
CK-0803 – Drug Profile
CL-2020 – Drug Profile
CNMAU-8 – Drug Profile
COYA-101 – Drug Profile
CT-526 – Drug Profile
CTx-FUS – Drug Profile
Cu(II)ATSM – Drug Profile
CVXL-0301 – Drug Profile
cyclosporine – Drug Profile
DAR-004 – Drug Profile
dazucorilant – Drug Profile
debamestrocel – Drug Profile
deferiprone – Drug Profile
deulinoleate ethyl – Drug Profile
DGALST-1 – Drug Profile
DNL-343 – Drug Profile
DNL-788 – Drug Profile
donaperminogene seltoplasmid – Drug Profile
Drug Candidates – Drug Profile
Drug for Alzheimer's Disease and Amyotrophic Lateral Sclerosis (ALS) – Drug Profile
Drug for Amyotrophic Lateral Sclerosis – Drug Profile
Drug for Amyotrophic Lateral Sclerosis (ALS) – Drug Profile
Drug for Neurological Disorders – Drug Profile
Drugs for Amyotrophic Lateral Sclerosis – Drug Profile
Early compounds – Drug Profile
edaravone – Drug Profile
EH-301 – Drug Profile
EHP-102 – Drug Profile
EI-1071 – Drug Profile
EKZ-001 – Drug Profile
EMD-402 – Drug Profile
ENZ-002 – Drug Profile
EOLO-10 – Drug Profile
EPI-589 – Drug Profile
ET-101 – Drug Profile
Exosome Vaccine – Drug Profile
EXP-200 – Drug Profile
fasudil – Drug Profile
FB-1002 – Drug Profile
FB-1006 – Drug Profile
FB-418 – Drug Profile
FGF-1 – Drug Profile
Fusion Protein to Antagonize EPHA4 for CNS Disorders, Cardiovascular Diseases and Sepsis – Drug Profile
GB-1 – Drug Profile
Gene Therapies for Amyotrophic Lateral Sclerosis – Drug Profile
Gene Therapies to Inhibit C9ORF72 for Amyotrophic Lateral Sclerosis and Frontotemporal Dementia – Drug Profile
Gene Therapy 1 for Amyotrophic Lateral Sclerosis (AML) and Frontotemporal Dementia (FTD) – Drug Profile
Gene Therapy for Amyotrophic Lateral Sclerosis – Drug Profile
Gene Therapy for Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) – Drug Profile
Gene Therapy for Amyotrophic Lateral Sclerosis and Dementia – Drug Profile
Gene Therapy for Amyotrophic Lateral Sclerosis and Frontotemporal Dementia – Drug Profile
Gene Therapy for Central Nervous System Disorders – Drug Profile
Gene Therapy for Diabetic Retinopathy, Neurodegenerative Diseases and Wet Macular Degeneration – Drug Profile
Gene Therapy for Genetic Disorders, Neurology, Musculoskeletal and Ophthalmology – Drug Profile
Gene Therapy to Activate GDNF for Amyotrophic Lateral Sclerosis and Retinitis Pigmentosa – Drug Profile
Gene Therapy to Activate Interleukin-10 for ALS – Drug Profile
Gene Therapy to Activate SYT13 for Amyotrophic Lateral Sclerosis and Spinal Muscular Atrophy – Drug Profile
Gene Therapy To Target ATXN2 for Amyotrophic Lateral Sclerosis – Drug Profile
Genetic Form of ALS – Drug Profile
GlyB-4 – Drug Profile
Glycolic acid + D-lactic acid – Drug Profile
GM-6 – Drug Profile
GNK-301 – Drug Profile
GO-102 – Drug Profile
GT-0001X – Drug Profile
histamine dihydrochloride – Drug Profile
HK-001 – Drug Profile
hNPC-02 – Drug Profile
HTL-0014242 – Drug Profile
HYNR-CS-Allo – Drug Profile
ibudilast – Drug Profile
IC-14 – Drug Profile
icerguastat – Drug Profile
IMS-088 – Drug Profile
ION-541 – Drug Profile
IPL-344 – Drug Profile
IPS-07004 – Drug Profile
IRX-4204 – Drug Profile
JAK-4D – Drug Profile
JMF-3464 – Drug Profile
JNS-109 – Drug Profile
JRP-655 – Drug Profile
JRP-900 – Drug Profile
ketamine – Drug Profile
KFRX-03 – Drug Profile
KPAX-002 – Drug Profile
latozinemab – Drug Profile
LAUR-301 – Drug Profile
Library of Oligonucleotides – Drug Profile
LP-143 – Drug Profile
LSPGR-1 – Drug Profile
LSPGR-3 – Drug Profile
M-102 – Drug Profile
macimorelin acetate – Drug Profile
masitinib – Drug Profile
MDH-001 – Drug Profile
MDH-204 – Drug Profile
MDN-0005 – Drug Profile
mecobalamin – Drug Profile
MiM-111 – Drug Profile
Mitometin – Drug Profile
monepantel – Drug Profile
MP-101 – Drug Profile
MP-1032 – Drug Profile
MP-201 – Drug Profile
MR-401 – Drug Profile
MRG-107 – Drug Profile
MT-2 – Drug Profile
MTC-1203 – Drug Profile
NB-001 – Drug Profile
NCB-8 – Drug Profile
NCP-01 – Drug Profile
ND-3014 – Drug Profile
NDBT-3814 – Drug Profile
NDC-011 – Drug Profile
Neuronata-R – Drug Profile
NG-1 – Drug Profile
NG-2 – Drug Profile
NG-201ALS – Drug Profile
NI-205 – Drug Profile
NI-308 – Drug Profile
NP-001 – Drug Profile
NPT-1220312 – Drug Profile
NPT-1220478 – Drug Profile
NPT-52034 – Drug Profile
NRP-2945 – Drug Profile
NSI-566 – Drug Profile
NT-1654 – Drug Profile
NU-9 – Drug Profile
NVP-13 – Drug Profile
NXL-003 – Drug Profile
OC-514 – Drug Profile
Oligonucleotides for Amyotrophic Lateral Sclerosis and Spinocerebellar Ataxia – Drug Profile
omaveloxolone – Drug Profile
OP-101 – Drug Profile
OP-329 – Drug Profile
OP-330 – Drug Profile
OP-401 – Drug Profile
oremepermin alfa – Drug Profile
OTL-205 – Drug Profile
P7-C3A20 – Drug Profile
PAT-103 – Drug Profile
PBAL-05 – Drug Profile
pegcetacoplan – Drug Profile
pegipanermin – Drug Profile
Peptide to Activate GLP1R for CNS Disorders, and Head Trauma – Drug Profile
Peptide to Agonize NTRK2 for Amyotrophic Lateral Sclerosis, Depression and Parkinson's Disease – Drug Profile
Peptides to Activate GLP-1 Receptor for CNS Disorders, Cardiac Diseases and Head Trauma – Drug Profile
perampanel – Drug Profile
PF-1802 – Drug Profile
PRG-CNS-1 – Drug Profile
PRI-003 – Drug Profile
PRI-500 – Drug Profile
pridopidine hydrochloride – Drug Profile
prosetin – Drug Profile
Protein for Amyotrophic Lateral Sclerosis – Drug Profile
Proteins for Immunology and Metabolic Disorders – Drug Profile
PTC-857 – Drug Profile
Q-Cells – Drug Profile
QRA-244 – Drug Profile
QRL-201 – Drug Profile
RACK1 – Drug Profile
RAPA-501 – Drug Profile
RaphaLX – Drug Profile
RASRx-1902 – Drug Profile
RDC-5 – Drug Profile
Recombinant Glutamate Oxaloacetate Transaminase for Brain Stroke, Amyotrophic Lateral Sclerosis, Spinal Cord Injury and Glioblastoma – Drug Profile
Recombinant Peptide for Parkinson's Disease and Amyotrophic Lateral Sclerosis – Drug Profile
Recombinant Peptides to Inhibit Superoxide Dismutase (SOD1) for Amyotrophic Lateral Sclerosis – Drug Profile
Recombinant Peptides to Inhibit TDP-43 for Amyotrophic Lateral Sclerosis – Drug Profile
Recombinant Protein for Amyotrophic Lateral Sclerosis – Drug Profile
Recombinant Protein to Activate TFAM for Ageing and Neurodegenerative Diseases – Drug Profile
reldesemtiv – Drug Profile
riluzole – Drug Profile
RNAi Gene Therapy to Inhibit SOD1 for Amyotrophic Lateral Sclerosis – Drug Profile
RNS-60 – Drug Profile
rolipram – Drug Profile
ropinirole hydrochloride ER – Drug Profile
RPI-78M – Drug Profile
RY-103 – Drug Profile
safinamide mesylate – Drug Profile
SBT-272 – Drug Profile
Scleron – Drug Profile
scopolamine – Drug Profile
Senolytics – Drug Profile
sirolimus – Drug Profile
Small Molecule 2 for Amyotrophic Lateral Sclerosis – Drug Profile
Small Molecule for Amyotrophic Lateral Sclerosis – Drug Profile
Small Molecule for Neurodegenerative Diseases – Drug Profile
Small Molecule to Activate KvLQT2 , KvLQT3 and KvLQT4 for Amyotrophic Lateral Sclerosis – Drug Profile
Small Molecule to Block Cav1.3 and Free Radicals for Central Nervous System, Metabolic Disorders and Cardiovascular Diseases – Drug Profile
Small Molecule to Inhibit Glutamine Synthetase for Amyotrophic Lateral Sclerosis – Drug Profile
Small Molecule to Inhibit HSP90 and FK506 for Amyotrophic Lateral Sclerosis – Drug Profile
Small Molecule to Inhibit Protein Disulfide Isomerase for Amyotrophic Lateral Sclerosis and Huntington Disease – Drug Profile
Small Molecule to Inhibit Rho kinase for Amyotrophic Lateral Sclerosis – Drug Profile
Small Molecules for Alzheimer's Disease and Multiple Sclerosis – Drug Profile
Small Molecules for Amyotrophic Lateral Sclerosis – Drug Profile
Small Molecules for Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Dementia (FTLD) – Drug Profile
Small Molecules for Amyotrophic Lateral Sclerosis and Frontotemporal Dementia – Drug Profile
Small Molecules for Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Dementia (FTLD) – Drug Profile
Small Molecules for Amyotrophic Lateral Sclerosis and Parkinson's Disease – Drug Profile
Small Molecules for Central Nervous System Disorders – Drug Profile
Small Molecules for Mitochondrial and Central Nervous System Disorders – Drug Profile
Small Molecules for Neurodegenerative Disease – Drug Profile
Small Molecules for Neurodegenerative Diseases – Drug Profile
Small Molecules for Neurology – Drug Profile
Small Molecules to Activate HSF-1 for Amyotrophic Lateral Sclerosis – Drug Profile
Small Molecules to Inhibit C9ORF72 for Amyotrophic Lateral Sclerosis – Drug Profile
Small Molecules to Inhibit Dbr1 for Amyotrophic Lateral Sclerosis – Drug Profile
Small Molecules to Inhibit GSK3B for Amyotropic Lateral Sclerosis – Drug Profile
Small Molecules to Inhibit Ire1-Alpha for Amyotrophic Lateral Sclerosis, Idiopathic Pulmonary Fibrosis, Retinitis Pigmentosa and Type 2 Diabetes – Drug Profile
Small Molecules to Inhibit KEAP1 for Amyotrophic Lateral Sclerosis and Parkinson’s Disease – Drug Profile
Small Molecules to Inhibit SARM1 for Neurology and Glaucoma – Drug Profile
Small Molecules to Inhibit SOD1 for Amyotrophic Lateral Sclerosis – Drug Profile
Small Molecules to Inhibit TANA for Amyotrophic Lateral Sclerosis, Alzheimer's Disease and Dementia – Drug Profile
Small Molecules to Inhibit TDP43 for Amyotrophic Lateral Sclerosis – Drug Profile
Small-Molecule Therapeutics – Drug Profile
SMB-001 – Drug Profile
smilagenin – Drug Profile
SNP-203 – Drug Profile
SNP-206 – Drug Profile
SNP-210 – Drug Profile
SOD1 – Drug Profile
SOL-257 – Drug Profile
SOL-258 – Drug Profile
sotuletinib – Drug Profile
SRD-4512 – Drug Profile
Stem Cell Therapy for Amyotrophic Lateral Sclerosis – Drug Profile
Stem Cell Therapy for Amyotrophic Lateral Sclerosis and Duchenne Muscular Dystrophy – Drug Profile
Stem Cell Therapy for Central Nervous System Disorders – Drug Profile
Stem Cell Therapy for Parkinson's Disease – Drug Profile
sulfasalazine – Drug Profile
SYN-1 – Drug Profile
SYN-2 – Drug Profile
SYNCAV-1 – Drug Profile
Synthetic Peptide Agonize TrkA and TrkB Alzheimer's Disease and Amyotrophic Lateral Sclerosis – Drug Profile
Synthetic Peptide for Neurological and Psychiatric Diseases – Drug Profile
Synthetic Peptides for Amyotrophic Lateral Sclerosis and Frontotemporal Dementia – Drug Profile
Synthetic Peptides to Activate PACAP Receptor and Antagonize VPAC1, VPAC2 for Neurological Disorders – Drug Profile
tauroursodeoxycholic acid – Drug Profile
TDI-104 – Drug Profile
TDI-106 – Drug Profile
TDI-142 – Drug Profile
TDI-158 – Drug Profile
TDI-163 – Drug Profile
TDI-168 – Drug Profile
TDI-186 – Drug Profile
TDI-197 – Drug Profile
TDI-201 – Drug Profile
TDI-202 – Drug Profile
TDI-206 – Drug Profile
TDI-207 – Drug Profile
TDI-208 – Drug Profile
TDI-209 – Drug Profile
TDI-210 – Drug Profile
TDI-211 – Drug Profile
TDI-28 – Drug Profile
TDI-53 – Drug Profile
TDP-43 – Drug Profile
tegoprubart – Drug Profile
Thera-101 – Drug Profile
THN-1 – Drug Profile
tiomolibdate choline – Drug Profile
TLSG-1 – Drug Profile
TM-700 – Drug Profile
tofersen sodium – Drug Profile
TQS-168 – Drug Profile
trametinib – Drug Profile
trehalose – Drug Profile
triheptanoin – Drug Profile
TTX-3360 – Drug Profile
TW-002 – Drug Profile
TXA-127 – Drug Profile
ulefnersen sodium – Drug Profile
Undisclosed Target – Drug Profile
Vaccine for Neurodegenerative Diseases – Drug Profile
verdiperstat – Drug Profile
VM-301 – Drug Profile
VRN-042 – Drug Profile
VTx-001 – Drug Profile
VTx-002 – Drug Profile
VYSOD-101 – Drug Profile
VYSOD-102 – Drug Profile
WN-1316 – Drug Profile
WVE-004 – Drug Profile
xB3-Progranulin – Drug Profile
XN-001 – Drug Profile
XS-002 – Drug Profile
XT-101 – Drug Profile
XT-150 – Drug Profile
YSB-201 – Drug Profile
zilucoplan – Drug Profile
Amyotrophic Lateral Sclerosis – Dormant Projects
Amyotrophic Lateral Sclerosis – Discontinued Products
Amyotrophic Lateral Sclerosis – Product Development Milestones
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Sep 22, 2022: Biogen’s tofersen lowers molecular signs of ALS in Phase III trial
Sep 21, 2022: Cellenkos receives FDA clearance of Investigational New Drug (IND) application for CK0803 for the treatment of Amyotrophic Lateral Sclerosis (ALS)
Sep 20, 2022: NeuroSense announces positive PrimeC toxicology data supportive of current phase IIb PARADIGM ALS Clinical Trial
Sep 19, 2022: NeuroSense announces peer-reviewed publication of PrimeC phase IIa ALS study in amyotrophic lateral sclerosis and frontotemporal degeneration
Sep 15, 2022: BioJiva reports results of pilot phase 2 clinical trial of RT001 in patients with amyotrophic lateral sclerosis (ALS)
Sep 14, 2022: Amylyx Pharmaceuticals announces donated CENTAUR clinical trial data now available to help advance science in ALS for future treatments and discoveries
Sep 12, 2022: Amylyx Pharmaceuticals announces publication of preclinical data showing potential synergistic effect of AMX0035 compared to individual compounds
Sep 07, 2022: Helixmith reports Phase IIA data for Engensis to treat ALS
Sep 07, 2022: Amylyx Pharmaceuticals announces FDA advisory committee supports approval of AMX0035 for the treatment of ALS
Sep 07, 2022: Amylyx Pharmaceuticals announces FDA plan to reconvene Advisory Committee to review AMX0035 NDA for the treatment of ALS
Sep 02, 2022: Tranquis Therapeutics to present preclinical data on TQS-168 at ARDD 2022
Sep 02, 2022: Amylyx Pharmaceuticals announces posting of briefing documents for second FDA Advisory Committee Meeting on AMX0035
Sep 01, 2022: Coya Therapeutics announces peer-reviewed publication of phase 2a clinical trial data for COYA 101 in Amyotrophic Lateral Sclerosis (ALS)
Appendix
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Coverage
Secondary Research
Primary Research
Expert Panel Validation
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List of Tables
Table 1: Number of Products under Development for Amyotrophic Lateral Sclerosis, 2022
Table 2: Number of Products under Development by Companies, 2022
Table 3: Number of Products under Development by Companies, 2022 (Contd..1)
Table 4: Number of Products under Development by Companies, 2022 (Contd..2)
Table 5: Number of Products under Development by Companies, 2022 (Contd..3)
Table 6: Number of Products under Development by Companies, 2022 (Contd..4)
Table 7: Number of Products under Development by Companies, 2022 (Contd..5)
Table 8: Number of Products under Development by Companies, 2022 (Contd..6)
Table 9: Number of Products under Development by Companies, 2022 (Contd..7)
Table 10: Number of Products under Development by Companies, 2022 (Contd..8)
Table 11: Number of Products under Development by Companies, 2022 (Contd..9)
Table 12: Number of Products under Development by Companies, 2022 (Contd..10)
Table 13: Number of Products under Development by Companies, 2022 (Contd..11)
Table 14: Number of Products under Development by Companies, 2022 (Contd..12)
Table 15: Number of Products under Development by Companies, 2022 (Contd..13)
Table 16: Number of Products under Development by Companies, 2022 (Contd..14)
Table 17: Number of Products under Development by Universities/Institutes, 2022
Table 18: Number of Products under Development by Universities/Institutes, 2022 (Contd..1)
Table 19: Products under Development by Companies, 2022
Table 20: Products under Development by Companies, 2022 (Contd..1)
Table 21: Products under Development by Companies, 2022 (Contd..2)
Table 22: Products under Development by Companies, 2022 (Contd..3)
Table 23: Products under Development by Companies, 2022 (Contd..4)
Table 24: Products under Development by Companies, 2022 (Contd..5)
Table 25: Products under Development by Companies, 2022 (Contd..6)
Table 26: Products under Development by Companies, 2022 (Contd..7)
Table 27: Products under Development by Companies, 2022 (Contd..8)
Table 28: Products under Development by Companies, 2022 (Contd..9)
Table 29: Products under Development by Companies, 2022 (Contd..10)
Table 30: Products under Development by Companies, 2022 (Contd..11)
Table 31: Products under Development by Companies, 2022 (Contd..12)
Table 32: Products under Development by Companies, 2022 (Contd..13)
Table 33: Products under Development by Companies, 2022 (Contd..14)
Table 34: Products under Development by Companies, 2022 (Contd..15)
Table 35: Products under Development by Companies, 2022 (Contd..16)
Table 36: Products under Development by Companies, 2022 (Contd..17)
Table 37: Products under Development by Companies, 2022 (Contd..18)
Table 38: Products under Development by Companies, 2022 (Contd..19)
Table 39: Products under Development by Companies, 2022 (Contd..20)
Table 40: Products under Development by Companies, 2022 (Contd..21)
Table 41: Products under Development by Universities/Institutes, 2022
Table 42: Products under Development by Universities/Institutes, 2022 (Contd..1)
Table 43: Products under Development by Universities/Institutes, 2022 (Contd..2)
Table 44: Number of Products by Stage and Target, 2022
Table 45: Number o

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