The global Long Read Sequencing Market was valued at 1.5 billion in 2022 and it is anticipated to grow up to USD 6.0 billion by 2032, at a CAGR of 14.8% during the forecast period.
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Market Trends and DriversRising utilization of sequence analysis methodologies.
The increasing acceptance of modern approaches for medical diagnostics, represents one of the key factors bolstering the market growth. The escalating demand for LRS technology can also be attributed to its portability and real-time speed. It is also used to produce an accurate reference map of the centromere of the chromosomes. Apart from this, various biotech companies are developing innovative technologies that combine a new library prep method and genome analysis tools. In line with this, several studies indicate that LRS technology plays a crucial role in discovering novel pathogenic mutations in human diseases with unknown genetic causes. This presents numerous opportunities to researchers for using the technology in whole-genome sequencing (WGS) and enabling advancements in medical genetics. Furthermore, the rising utilization of sequence analysis methodologies in medical institutes for academic purposes, in confluence with the increasing investments in research and development (R&D) activities, is anticipated to drive the market growth further.
Market Restraints and ChallengesHigher cost per base relative to short read sequencing
Long-read sequencing market is facing trials due to lack of highly cutting-edge genomic testing centers, expensive installation process, and absence of expert specific with progressive diagnostic abilities.
Disease control
According to the Centers of Disease Control and Prevention, the estimated amount of persons suffering Downsyndrome is rising rapidly. It is specified to be the maximum mutual chromosomal disorder. This long read sequencing market report provides details of new recent developments, trade regulations, import-export analysis, production analysis, value chain optimization, market share, impact of domestic and localized market players, analyses opportunities in terms of emerging revenue pockets, changes in market regulations, strategic market growth analysis, market size, category market growths, application niches and dominance, product approvals, product launches, geographic expansions, technological innovations in the market. To gain more info on the long read sequencing market contact Data Bridge Market Research for an Analyst Brief, our team will help you take an informed market decision to achieve market growth..
The report analyses the global Long Read Sequencing Market based on technology, workflow, application, end-use, and region.
Global Long Read Sequencing Market by Technology
Based on technology, the Long Read Sequencing market is divided into Single-Molecule Real-Time Sequencing (SMRT), and Nanopore Sequencing. The single-molecule real-time (SMRT) sequencing segment is anticipated to grow at a significant rate of xx% from 2022-2030. This can be attributed to its longer read lengths and low systematic bias leading to achieving high consensus accuracy. Additionally, during sample preparation for SMRT, amplification is not necessary, thereby increasing its adoption in the research community.
On the other hand, nanopore sequencing technology is in its nascent stage. The technology is expected to grow considerably in the future and is expected to revolutionize the long-read sequencing market. Currently, Oxford Nanopore develops array chips that comprise protein nanopores that are fixed onto an electrically resistant polymer. This arrangement allows parallel runs of multiple experiments onto a single chip. The company is currently taking several efforts to enhance the utility of nanopore technology in the future.
Global Long Read Sequencing Market by Workflow
By workflow, the industry is categorised into Pre-sequencing, Sequencing, Data Analysis. The sequencing segment accounted for the largest revenue generation of USD xx million in 2022. This trend is anticipated to continue throughout the projection period. This is mostly due to the fact that it is one of the most crucial components of the workflow. Without using PCR amplification, long read technique enables library creation and real-time sequence analysis. This permits scientists to investigate the genetic material in its natural state and eliminates PCR-related bias from the genome. This makes it possible for long read technologies to directly identify methylation and other base changes.
A high number of algorithms and tools have been developed to carry out base calling, variant discovery, data handling, de novo assembly, and read mapping. Advancements in data analysis tools are expected to boost the market growth throughout the forecast period. Key players are expanding their market presence with the help of the development of novel tools and products. For instance, Pacific Biosciences launched Sequel Systems v9.0 Software in July 2020. The SMRT Analysis Software provides flexible command-line options, easy-to-use graphical user interface, and an extensive set of APIs.
Global Long Read Sequencing Market by Application
Based on application, the industry is categorized into Identification & fine mapping of structural variation, Tandem Repeat Sequencing, Pseudogene discrimination, Cancer, and Others. The cancer segment dominated the long-read sequencing market in 2021. SMRT sequencing has been found to be useful in cancer research as it provides access to a complete size spectrum of genetic variation in whole genomes, transcripts, and genes. The exceptionally long reads of SMRT sequencing allow researchers to discover the hidden biology of cancer samples by resolving isoform diversity, alternative splice sites, gene fusions, and retained introns.
Similarly, advancements in the field of nanopore sequencing have revealed novel areas in the field of cancer biology. In April 2019, researchers from Oxford University collaborated with Ontario Institute for Cancer Research to use nanopore sequencing to understand the mechanisms and patterns of DNA replication. The initiative was undertaken to understand the mechanism of DNA replication in cancerous cells. Researchers from both institutions co-developed D-NAscent, a computational tool and a sophisticated laboratory protocol, which allows the study and detection of DNA replication in cancerous cells.
Global Long Read Sequencing Market by End-use
Based on end-use, the Long Read Sequencing market is divided into Academic Research, Clinical Research, Hospitals & Clinics, Pharma & Biotech Entities, and Other. In 2022, academic research captured a significant market share. This is owing to the presence of numerous biotechnology research centers that study molecular biology and genome sequencing techniques. Along with this, academic workshops, on-site bioinformatics courses provided by universities, and the rising use of sequence analysis approaches in research are anticipated to strengthen the academic research sector.
On the other hand, the clinical research market is likely to be driven by the demand for cutting-edge technology for clinical diagnostics. Long read sequencing technology's potential clinical applications in clinical settings are anticipated to drive category growth. In order to deploy the approach in clinical practice with a streamlined laboratory workflow, market participants are actively working to address the current problems connected with the implementation of technology. In the upcoming years, it is anticipated that technology for chronic disease prognosis would be widely adopted in hospitals and clinics. Growth is anticipated to be fueled by ongoing studies into the use of this technology in various medical states.
Geographical Analysis of Global Long Read Sequencing Market
Region-wise, it is studied across North America, Europe, Asia Pacific, and the Rest of the World. North America dominated the regional market with a share of xx% in 2022 due to the presence of major players such as Pacific Biosciences in the area, the availability of a strong informatics network, and well-established rules for the approval and marketing of genomic testing products and services. In addition, it is projected that the growing academic and clinical use of genomic techniques in the U.S. will accelerate the expansion of the North American market. Due to rising investments in the development of cutting-edge diagnostic techniques as well as increased penetration of major players in the region's growing markets, Asia Pacific is predicted to grow at the quickest rate. Japan is an emerging market in the Asia Pacific with a booming genomics industry. The Japanese market for long-read sequencing is anticipated to experience significant expansion in the near future as a result of the growing demand for precision medicine and the need for a better knowledge of genetics.
Similar to this, technical developments in the nation, fueled by numerous strategic alliances, are anticipated to propel market expansion. For example, in May 2022, Pacific Biosciences collaborated with the Japanese organizations iLAC and Robotic Biology Institute to investigate the automation of the sample preparation workflow for Sequel II and IIe long read sequencing with the use of a robotic laboratory technician.
Major Players in the Global Long Read Sequencing Market
Market players are focusing on strategic collaborations to enhance their product offerings. Some prominent participants in the global market are Long Read Sequencing market include Oxford Nanopore Technologies Limited; Pacific Biosciences of California, Inc.; Quantapore, Inc.; Stratos Genomics, Inc.; MicrobesNG; Institute of Integrative Biology of the Cell (I2BC); BaseClear B.V.; Future Genomics Technologies B.V.; Garvan Institute of Medical Research; Genome Transcriptome Facility of Bordeaux; NextOmics; and Takara Bio, Inc. among others.
COVID-19 Impact:
The eruption of the plague led the government around the globe to constantly focus on investing on the development of the vaccines. The Long Read Sequencing can be used to invent the vaccines or the medicine required for the COVID-19 virus. Moreover, during this situation about 115 vaccine candidates and 155 particles are in the Research and Development pipeline. The claim for the organization of covid-19 is rolling due to the global death controls getting increased from the onset of the contagion. There has been concession in the production of the other drugs but the medicine such as Hydrocholroquine rose at a higher amount, as it can be used in the management of COVID-19. Hence, the pharmaceutical industry and biotechnology industries are anticipated to experience a significant evolution in the near future.
Recent Developments:
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