Polycystic Kidney Disease - Drug Pipeline Landscape, 2022

Polycystic Kidney Disease - Drug Pipeline Landscape, 2022

Polycystic Kidney Disease (PKD or PCKD) also known as polycystic kidney syndrome, is a genetic disorder. This causes the flued filled cysts within the kidney. This is a form of chronic kidney disease which results in the reduction of kidney function, which may lead to kidney failure. PKD is mainly of two types: autosomal dominant PKD (ADPKD) and autosomal recessive PKD (ARPKD).

PKD is caused due to the abnormal genes which produces abnormal protein. This abnormal protein has an adverse effect on tubule development.

Signs and symptoms include high blood pressure, abdominal pain, back pain, blood in urine, excessive urination and headaches.

PKD can be diagnosed using imaging test such as CT scan of abdomen, MRI and ultrasound. Genetic testing is also done in some situations. A physical examination is also preferred including liver, heart murmurs and elevated blood pressure.

PKD treatment focuses on the slowing of the disease progression through maintaining normal blood pressure, low-salt intake, weight control, dietary protein restriction. Anti-hypertensive agents, pain killers and antibiotics are recommended.

Report Highlights

Global Insight Service’s, Polycystic Kidney Disease (PKD) - Drug Pipeline Landscape, 2022 report provides an overview of the Polycystic Kidney Disease (PKD) pipeline drugs. This report covers detailed insights on Polycystic Kidney Disease (PKD) drugs under development, assessment by target, mechanism of action, route of administration and molecule type. Product pipeline by companies, stage of development and key regulatory designations, deals and milestones have been presented to provide insights and thus help industry participants in their decision making. Polycystic Kidney Disease (PKD) pipeline report helps gain insights on drugs which are under development stage of drug development process across globally.

Methodology

The research process includes extensive secondary research on public domain and other authentic sources to add or update the pipeline products information. The secondary research sources include, but are not limited to company websites, annual reports, financial reports, company pipeline chart, investor presentations and SEC filings, journals and conferences, and clinical trials registries.

Scope

The pipeline landscape report provides analysis of pipeline products based on several stages of development ranging from Discovery to Pre-Registration. The report provides a review of pipeline therapeutics by companies based on information derived from company and industry-specific sources. The pipeline report covers assessment of therapeutics by mechanism of action (MoA), drug target, route of administration (RoA) and molecule type. Comprehensive profiles of the pipeline products with details such as company overview, development stage; molecule type, target, mechanism of action, route of administration, dosage form, regulatory designations, key deals, clinical trials, and key upcoming milestones are included.

Reasons to Buy
Helps to find and recognize significant therapeutics under development. Thorough understanding of pipeline structure and helps in developing corrective measures for pipeline projects.
Effective R&D strategies can be developed with deep knowledge of competitor information, analysis, and insights.
Plan collaborations with various industry partners that have role in some or the other stage of drug development such as contract manufacturing, co-development, contract research organization and commercialization etc.
Helps to create in-licensing and out-licensing opportunities by identifying prospective partners with attractive projects to expand business potential and scope.

Please Note: This report will be delivered by publisher within 3-4 business days of order confirmation.


List of Tables
List of Figures
1. Introduction
1.1 Polycystic Kidney Disease – Pipeline Drugs, 2022-Coverage
2. Disease Overview – Polycystic Kidney Disease
2.1 Causes
2.2 Signs and Symptoms
2.3 Diagnosis
2.4 Disease Management
3. Polycystic Kidney Disease – Pipeline Drugs Development - Overview
3.1 Comparative Analysis by Stage of Development
3.2 Number of Products under Development by Companies, 2022
3.3 Products under Development by Companies, 2022
4. Assessment of Therapeutics
4.1 Assessment by Target
4.2 Assessment by Mechanism of Action
4.3 Assessment by Molecule Type
4.4 Assessment by Route of Administration
5. Drug Profiles
5.1 Clinical Stage Drugs – Phase III
5.1.1 Bardoxolone
5.1.2 Tolvaptan
5.2 Clinical Stage Drugs – Phase II
5.2.1 GLPG2737
5.2.2 Tesevatinib
5.2.3 XRx-008
5.3 Clinical Stage Drugs – Phase I
5.3.1 AL01211
5.3.2 RGLS8429
5.4 Early-Stage Drugs – Preclinical
5.4.1 AMB-05X
5.4.2 ANG-3070
5.4.3 AP304
5.4.4 AT-20494
5.4.5 Drug for Polycystic Kidney Disease
5.4.6 Drug for Polycystic Kidney Disease
5.4.7 ELX-02
5.4.8 PDE4 Activators
5.4.9 PXL770
5.4.10 Small Molecule for Polycystic Kidney Disease
5.5 Early-Stage Drugs – Discovery
5.5.1 Drug for Polycystic Kidney Disease
5.5.2 Drug for Polycystic Kidney Disease
5.5.3 Drug for Polycystic Kidney Disease
5.5.4 Drug for Polycystic Kidney Disease
5.5.5 MT-003
5.5.6 Small Molecule for Polycystic Kidney Disease
5.5.7 Small Molecule for Polycystic Kidney Disease
6. Key Regulatory Designations
7. Key Deals
8. Key Upcoming Milestones
9. Key Companies Involved
9.1 AceLink Therapeutics Inc
9.2 Amathus Therapeutics Inc
9.3 AmMax Bio Inc
9.4 Angion Biomedica Corp
9.5 Chimerna Therapeutics Inc
9.6 Chinook Therapeutics Inc
9.7 Eloxx Pharmaceuticals Inc
9.8 Galapagos NV
9.9 Healx Ltd
9.10 IC-MedTech Inc
9.11 Johnson & Johnson
9.12 Mironid Ltd
9.13 Mitotherapeutix LLC
9.14 Otsuka Pharmaceutical Co Ltd
9.15 Pano Therapeutics Inc
9.16 Perha Pharmaceuticals
9.17 Poxel SA
9.18 Reata Pharmaceuticals Inc
9.19 Regulus Therapeutics Inc
9.20 Sanofi
9.21 Shanghai Alebund Pharmaceuticals Ltd
9.22 Surrozen Inc
9.23 XORTX Therapeutics Inc
10. Dormant Drugs
10.1 Inactive Drugs
10.2 Discontinued Drugs
11. Appendix
List of Tables
Table 1. 2 Number of Products under Development by Companies
Table 1. 3 Products under Development by Companies
Table 1. 4 Products by Targets
Table 1. 5 Products by Mechanism of Action
Table 1. 6 Products by Molecule Type
Table 1. 7 Products by Route of Administration
Table 2.1 Clinical Trial Details - Bardoxolone/Reata Pharmaceuticals Inc
Table 2.2 Clinical Trial Details - Tolvaptan/Otsuka Pharmaceutical Co Ltd
Table 2.3 Clinical Trial Details - GLPG2737/Galapagos NV
Table 2.4 Clinical Trial Details - Tesevatinib/Sanofi
Table 2.5 Clinical Trial Details - AL01211/AceLink Therapeutics Inc
Table 2.6 Clinical Trial Details - RGLS8429/Regulus Therapeutics Inc
Table 3. 1 Regulatory Designations
Table 4. 1 Inactive Drugs
List of Figures
Figure 1. 1 Number of Products under Development for Polycystic Kidney Disease , 2022
Figure 1. 2 Products by Top 5 Targets and Stage of Development for Polycystic Kidney Disease , 2022
Figure 1. 3 Products by Top 5 Mechanism of Action for Polycystic Kidney Disease , 2022
Figure 1. 4 Products by Top 5 Molecule Type for Polycystic Kidney Disease , 2022
Figure 1. 5 Products by Top 5 Route of Administration for Polycystic Kidney Disease , 2022

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