Multiple Sclerosis - Drug Pipeline Landscape, 2023

Multiple Sclerosis (MS) is an autoimmune disorder in which the immune system attacks the myelin sheath that surrounds and protects the nerve fibers, causing inflammation eventually affecting the brain, spinal cord and optic nerves which disrupts the flow of information within the brain, and between the brain and body. It can be of four types: Clinically Isolated syndrome, Relapsing-remitting Multiple Sclerosis, Secondary progressive Multiple Sclerosis and Primary progressive Multiple Sclerosis.

The exact cause of Multiple Sclerosis is still unclear but the risk factors include family history, genetic factors, vitamin D and B12 deficiency, age, obesity, smoking, infections, other autoimmune diseases.

The most common symptoms of Multiple Sclerosis include spasticity/muscle spasms, pain, muscle weakness, numbness, fatigue, tingling, blurred or poor vision, cognitive and mood disturbances, balance and co-ordination issues.

Multiple Sclerosis can be diagnosed by the doctors with a physical and neurological examination, with questions of symptoms and medical history. Diagnostic tests include blood tests, spinal tap (lumbar puncture), MRI scans, spinal fluid analysis, evoked potential tests, optical coherence tomography.

The most common treatments options for Multiple Sclerosis are disease-modifying therapies, interferon beta medications, monoclonal antibodies, stem cell therapy, plasma exchange.

Report Highlights

Global Insight Service’s, "Multiple Sclerosis - Drug Pipeline Landscape, 2023" report provides an overview of the Multiple Sclerosis pipeline drugs. This report covers detailed insights on Multiple Sclerosis drugs under development, assessment by target, mechanism of action, route of administration and molecule type.Product pipeline by companies, stage of development and key regulatory designations, deals and milestones have been presented to provide insights and thus help industry participants in their decision making. Multiple Sclerosis pipeline report helps gain insights on drugs which are under development stage of drug development process across globally.

Methodology

The research process includes extensive secondary research on public domain and other authentic sources to add or update the pipeline products information. The secondary research sources include, but are not limited to company websites, annual reports, financial reports, company pipeline chart, investor presentations and SEC filings, journals and conferences, and clinical trials registries.

Scope

The pipeline landscape report provides analysis of pipeline products based on several stages of development ranging from Discovery to Pre-Registration. The report provides a review of pipeline therapeutics by companies based on information derived from company and industry-specific sources. The pipeline report covers assessment of therapeutics by mechanism of action (MoA), drug target, route of administration (RoA) and molecule type. Comprehensive profiles of the pipeline products with details such as company overview, development stage; molecule type, target, mechanism of action, route of administration, dosage form, regulatory designations, key deals, clincial trials, and key upcoming milestones are included.

Reasons to Buy

Helps to find and recognize significant therapeutics under development. Thorough understanding of pipeline structure and helps in developing corrective measures for pipeline projects.

Effective R&D strategies can be developed with deep knowledge of competitor information, analysis, and insights.

Plan collaborations with various industry partners that have role in some or the other stage of drug development such as contract manufacturing, co-development, contract research organization and commercialization etc.

Helps to create in-licensing and out-licensing opportunities by identifying prospective partners with attractive projects to expand business potential and scope.

Please Note: This report will be delivered by publisher within 3-4 business days of order confirmation.


List of Tables
List of Figures
1. Introduction
1.1 Multiple Sclerosis – Pipeline Drugs, 2023 - Coverage
2. Disease Overview – Multiple Sclerosis
2.1 Causes
2.2 Signs and Symptoms
2.3 Diagnosis
2.4 Disease Management
3. Multiple Sclerosis – Pipeline Drugs Development - Overview
3.1 Comparative Analysis by Stage of Development
3.2 Number of Products under Development by Companies, 2023
3.3 Products under Development by Companies, 2023
4. Assessment of Therapeutics
4.1 Assessment by Target
4.2 Assessment by Mechanism of Action
4.3 Assessment by Molecule Type
4.3 Assessment by Route of Administration
5. Drug Profiles
5.1 Late Stage Drugs – Pre-Registration
5.1.1 Natalizumab Biosimilar-PB006
5.2 Clinical Stage Drugs – Phase III
5.2.1 BCD-132
5.2.2 CNM-Au8
5.2.3 Dimethyl Fumarate (Pediatric)
5.2.4 Evobrutinib
5.2.5 Fenebrutinib
5.2.6 Glatiramer Acetate Depot
5.2.7 Masitinib
5.2.8 Metenkefalin and Tridecactide Combination
5.2.9 NeuroVax
5.2.10 Ocrelizumab (Subcutaneous)
5.2.11 Ofatumumab (Pediatric)
5.2.12 Peginterferon Beta-1a
5.2.13 Remibrutinib
5.2.14 Siponimod (Pediatric)
5.2.15 Tolebrutinib
5.2.16 Vidofludimus Calcium
5.3 Clinical Stage Drugs – Phase II
5.3.1 ATA188
5.3.2 ATL1102
5.3.3 CARTREG Cell Therapy
5.3.4 Elezanumab
5.3.5 Frexalimab
5.3.6 Hematopoetic Stem Cell Infusion
5.3.7 Ibudilast
5.3.8 IMCY-0141
5.3.9 IMS001
5.3.10 MP101
5.3.11 Nebido
5.3.12 NurOwn
5.3.13 Orelabrutinib
5.3.14 SAR443820
5.3.15 Telitacicept
5.3.16 Temelimab
5.3.17 Vafidemstat
5.3.18 XNW1011
5.4 Clinical Stage Drugs – Phase I
5.4.1 Abivertinib
5.4.2 ACT-1004-1239
5.4.3 ACT-101
5.4.4 AGX-201
5.4.5 AK-119
5.4.6 ANK-700
5.4.7 BIIB061
5.4.8 BIIB091
5.4.9 BIIB107
5.4.10 GM607
5.4.11 GRX-917
5.4.12 GSK3888130
5.4.13 HuL001
5.4.14 LP-168
5.4.15 MP1032
5.4.16 NVG 291
5.4.17 PIPE-307
5.4.18 RED4MS
5.4.19 RG6035
5.4.20 T20K
5.5 Early Stage Drugs – IND/CTA Filed
5.5.1 B001-A
5.6 Early Stage Drugs – Preclinical
5.6.1 ABA-101
5.6.2 ABX-002
5.6.3 AC0058
5.6.4 Acazicolcept
5.6.5 Acrolein Ccavenging Therapy
5.6.6 Allogeneic Umbilical Cord Mesenchymal Stem Cells
5.6.7 AlloRx
5.6.8 AMA 003
5.6.9 Amilo-5MER
5.6.10 AMX0035
5.6.11 ApTOLL
5.6.12 Arsenic trioxide
5.6.13 Avir
5.6.14 AVT-001
5.6.15 BFF1
5.6.16 BOS-421
5.6.17 Bryostatin-1
5.6.18 BSC-3301
5.6.19 BVA-101
5.6.20 BVA-201
5.6.21 BX U001
5.6.22 BY-102
5.6.23 CAR-T-REG Cell Therapy
5.6.24 CLX-NEU-06
5.6.25 CS 12192
5.6.26 CYMS 101
5.6.27 EmtinB
5.6.28 Farudodstat
5.6.29 FREQ 162
5.6.30 FTX 101
5.6.31 GB 7208
5.6.32 Glunozumab
5.6.33 IC 100
5.6.34 IFB-048
5.6.35 IMP761
5.6.36 J2H-1801
5.6.37 KT 474
5.6.38 KYC (N-acetyl-lysyltyrosylcysteine Amide)
5.6.39 LABP-66
5.6.40 Lucid MS
5.6.41 METI-204
5.6.42 MGCP (Mannan/β-Glucan Containing Polysaccharides)
5.6.43 mRNA-1195
5.6.44 MRx 0002
5.6.45 MultiStem Cell Therapy
5.6.46 MYMD-1
5.6.47 Navacims
5.6.48 NC-B8
5.6.49 NDC-1308
5.6.50 NgR1 Platform
5.6.51 NLY01
5.6.52 NOVO 118
5.6.53 NV-002
5.6.54 Ocrelizumab Biosimilar PB018
5.6.55 OCS-05
5.6.56 PAS-002
5.6.57 PIPE-791
5.6.58 PPI-1025
5.6.59 SC-379
5.6.60 SCM-010
5.6.61 SDC 1801
5.6.62 Small Molecule Therapeutics
5.6.63 SPU-16
5.6.64 SVT 201
5.6.65 Synthetic PreImplantation Factor (sPIF)
5.6.66 TASIN
5.6.67 TI-235
5.6.68 TRE-515
5.6.69 Tyrosine Kinase 2 (TYK2) Inhibitor
5.6.70 Undisclosed
5.6.71 Undisclosed
5.6.72 Undisclosed
5.6.73 VB-601
5.6.74 VX5/5261
5.6.75 xB3 004
5.6.76 XT-150
5.7 Early Stage Drugs – Discovery
5.7.1 AB126
5.7.2 AT-1226
5.7.3 EQ 8
5.7.4 ET-101
5.7.5 Gene Therapy
5.7.6 GlycoDC Therapeutic Vaccine
5.7.7 Gp130 Modulator
5.7.8 MabionCD20
5.7.9 NanoCanna
5.7.10 Natural Killer Cell Therapy
5.7.11 NRP2945
5.7.12 PDE4B Inhibitor
5.7.13 Undisclosed
5.7.14 Undisclosed
5.8 Unknown Stage Drugs
5.8.1 Foralumab
5.8.2 Mitoxantrone Hydrochloride Liposome Injection
6. Key Regulatory Designations
7. Key Deals
8. Key Upcoming Milestones
9. Key Companies Involved
9.1 4D Pharma PLC
9.2 AB Science
9.3 Abata Therapeutics
9.4 AbbVie
9.5 AgoneX Biopharmaceuticals Inc
9.6 Ahead Therapeutics
9.7 Akaal Pharma Pty Ltd
9.8 Alector Inc
9.9 Alpha Cancer Technologies Inc
9.10 Alpine Immune Sciences
9.11 Altheia Science SRL
9.12 Amarna Therapeutics
9.13 Amylyx Pharmaceuticals Inc
9.14 Anokion SA
9.15 Antisense Therapeutics Ltd
9.16 AnTolRx
9.17 Aphios Corporation
9.18 AptaTargets
9.19 Aruna Bio Inc
9.20 Aslan Pharmaceuticals Ltd
9.21 Atara Biotherapeutics
9.22 Athersys Inc
9.23 Autobahn Therapeutics
9.24 Avotres Inc
9.25 AxoProtego Therapeutics
9.26 Barricade Therapeutics Corp
9.27 Bayer
9.28 Baylx
9.29 Beijing InnoCare Pharma Tech Co., Ltd.
9.30 Biocad
9.31 Biogen
9.32 BioIncept LLC
9.33 Biovista
9.34 Bisichem Co Ltd
9.35 Bosnalijek D.D
9.36 Boston Pharmaceuticals Inc
9.37 BoYen Therapeutics Inc
9.38 Brainstorm-Cell Therapeutics
9.39 CarthroniX Inc
9.40 Cellerys AG
9.41 Cellix Bio
9.42 Chipscreen Biosciences
9.43 Cinnagen
9.44 Clene Nanomedicine
9.45 CSPC Pharmaceutical Group Ltd
9.46 CuroNZ Ltd
9.47 Cyxone AB
9.48 DC4U BV
9.49 Dragonfly Therapeutics
9.50 Eikonoklastes Therapeutics
9.51 ENCEFA
9.52 ENDECE
9.53 Ever Supreme Bio Technology Co., Ltd.
9.54 Evopoint Bioscience Co Ltd
9.55 f5 Therapeutics
9.56 FibroBiologics
9.57 Find Therapeutics
9.58 Frequency Therapeutics
9.59 FSD Pharma Inc
9.60 GABA Therapeutics Inc
9.61 Galmed Pharmaceuticals Ltd
9.62 Genervon Biopharmaceuticals LLC
9.63 GeNeuro SA
9.64 GlaxoSmithKline
9.65 Gossamer Bio
9.66 Guangzhou Lupeng Pharmaceutical Company LTD.
9.67 Hoffmann-La Roche
9.68 HuniLife Biotechnology, Inc.
9.69 Idorsia Pharmaceutical Ltd
9.70 Imcyse SA
9.71 Immune Response BioPharma, Inc
9.72 Immunic AG
9.73 ImmunoBiome Inc
9.74 Immutep Ltd
9.75 ImStem Biotechnology
9.76 InFlectis BioScience
9.77 J2H Biotech
9.78 Jupiter Biomedical Research
9.79 Kymera Therapeutics
9.80 Landos Biopharma
9.81 Lys Therapeutics SAS
9.82 Mabion SA
9.83 Mapi Pharma Ltd.
9.84 MediciNova
9.85 MedImmune
9.86 Med-Life Discoveries LP
9.87 Medsenic
9.88 Merck KGaA
9.89 MetiMedi Pharmaceuticals Co Ltd
9.90 MetrioPharm AG
9.91 Mitochon Pharmaceuticals Inc
9.92 Moderna Inc
9.93 MyMD Pharmaceuticals Inc
9.94 NervGen Pharma
9.95 Neuraly Inc
9.96 Neuro Vigor LLC
9.97 Neuron23
9.98 NeuroScientific Biopharmaceuticals Ltd
9.99 Novartis
9.100 Novellus Therapeutics Ltd
9.101 Novoron Bioscience
9.102 Oculis Pharma
9.103 Oryzon Genomics S. A
9.104 Ossianix Inc
9.105 Parvus Therapeutics Inc
9.106 Pasithea Therapeutics Corp
9.107 Pheno Therapeutics Ltd
9.108 Pipeline Therapeutics, Inc.
9.109 Polpharma Biologics S.A.
9.110 PolTREG SA
9.111 RemeGen Co., Ltd.
9.112 ReNetX Bio
9.113 ReNeuroGen LLC
9.114 Sana Biotechnology Inc
9.115 Sanofi
9.116 Sarepta Therapeutics
9.117 Sareum
9.118 Shanghai Pharmaceuticals Holding
9.119 Silo Pharma Inc
9.120 Sorrento Therapeutics Inc
9.121 Stem Cell Medicine Ltd.
9.122 Synaptogenix
9.123 Talaris Therapeutics Inc.
9.124 TeraImmune
9.125 Tetra Therapeutics
9.126 Tevogen Bio
9.127 Tiziana Life Sciences Ltd
9.128 Trethera
9.129 TxCell
9.130 Vaccinex
9.131 Vaccitech plc
9.132 Vascular Biogenics Ltd
9.133 Vitro Biopharma Inc
9.134 Xalud Therapeutics
9.135 ZyVersa Therapeutics
10. Dormant Drugs
10.1 Inactive Drugs
10.2 Discontinued Drugs
11. Appendix
List of Tables
Table 1.1 Number of Products Under Development for Multiple Sclerosis
Table 1.2 Number of Products under Development by Companies
Table 1.3 Products under Development by Companies
Table 1.4 Products by Targets
Table 1.5 Products by Mechanism of Action
Table 1.6 Products by Molecule Type
Table 1.7 Products by Route of Administration
Table 2.1 Clinical Trial Details - BCD-132/Biocad
Table 2.2 Clinical Trial Details - CNM-Au8/Clene Nanomedicine
Table 2.3 Clinical Trial Details - Dimethyl Fumarate (Pediatric)/Biogen
Table 2.4 Clinical Trial Details - Evobrutinib/Merck KGaA
Table 2.5 Clinical Trial Details - Fenebrutinib/Hoffmann-La Roche
Table 2.6 Clinical Trial Details - Glatiramer Acetate Depot/Mapi Pharma Ltd.
Table 2.7 Clinical Trial Details - Masitinib/AB Science
Table 2.8 Clinical Trial Details - Metenkefalin and Tridecactide Combination/Bosnalijek D.D
Table 2.9 Clinical Trial Details - NeuroVax/Immune Response BioPharma, Inc
Table 2.10 Clinical Trial Details - Ocrelizumab (Subcutaneous)/Hoffmann-La Roche
Table 2.11 Clinical Trial Details - Ofatumumab (Pediatric)/Novartis
Table 2.12 Clinical Trial Details - Peginterferon Beta-1a/Cinnagen
Table 2.13 Clinical Trial Details - Remibrutinib/Novartis
Table 2.14 Clinical Trial Details - Siponimod (Pediatric)/Novartis
Table 2.15 Clinical Trial Details - Tolebrutinib/Sanofi
Table 2.16 Clinical Trial Details - Vidofludimus Calcium/Immunic AG
Table 2.17 Clinical Trial Details - ATA188/Atara Biotherapeutics
Table 2.18 Clinical Trial Details - ATL1102/Antisense Therapeutics Ltd
Table 2.19 Clinical Trial Details - Elezanumab/AbbVie
Table 2.20 Clinical Trial Details - Frexalimab/Sanofi
Table 2.21 Clinical Trial Details - Hematopoetic Stem Cell Infusion/Talaris Therapeutics Inc.
Table 2.22 Clinical Trial Details - Ibudilast/MediciNova
Table 2.23 Clinical Trial Details - IMCY-0141/Imcyse SA
Table 2.24 Clinical Trial Details - IMS001/ImStem Biotechnology
Table 2.25 Clinical Trial Details - Nebido/Bayer
Table 2.26 Clinical Trial Details - NurOwn/Brainstorm-Cell Therapeutics
Table 2.27 Clinical Trial Details - Orelabrutinib/Beijing InnoCare Pharma Tech Co., Ltd.
Table 2.28 Clinical Trial Details - SAR443820/Sanofi
Table 2.29 Clinical Trial Details - Telitacicept/RemeGen Co., Ltd.
Table 2.30 Clinical Trial Details - Temelimab/GeNeuro SA
Table 2.31 Clinical Trial Details - Vafidemstat/Oryzon Genomics S. A
Table 2.32 Clinical Trial Details - AK-119/Akaal Pharma Pty Ltd
Table 2.33 Clinical Trial Details - ANK-700/Anokion SA
Table 2.34 Clinical Trial Details - BIIB061/Biogen
Table 2.35 Clinical Trial Details - GSK3888130/GlaxoSmithKline
Table 2.36 Clinical Trial Details - HuL001/HuniLife Biotechnology, Inc.
Table 2.37 Clinical Trial Details - LP-168/Guangzhou Lupeng Pharmaceutical Company LTD.
Table 2.38 Clinical Trial Details - PIPE-307/Pipeline Therapeutics, Inc.
Table 2.39 Clinical Trial Details - RG6035/Hoffmann-La Roche
Table 3.1 Regulatory Designations
Table 4.1 Inactive Drugs
Table 4.2 Discontinued Drugs
List of Figures
Figure 1.1 Number of Products under Development for Multiple Sclerosis, 2023
Figure 1.2 Products by Top 5 Targets and Stage of Development for Multiple Sclerosis, 2023
Figure 1.3 Products by Top 5 Mechanism of Action for Multiple Sclerosis, 2023
Figure 1.4 Products by Top 5 Molecule Type for Multiple Sclerosis, 2023
Figure 1.5 Products by Top 5 Route of Administration for Multiple Sclerosis, 2023

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