Liver Cirrhosis - Drug Pipeline Landscape, 2023

Liver Cirrhosis - Drug Pipeline Landscape, 2023

Cirrhosis, also known as liver cirrhosis or hepatic cirrhosis and end-stage liver disease, is a condition characterised by impaired liver function caused by the formation of scar tissue known as fibrosis as a result of liver disease damage.

Cirrhosis is caused by alcoholic liver disease, non-alcoholic steatohepatitis (NASH), heroin abuse, chronic hepatitis B, and chronic hepatitis C.

Cirrhosis symptoms emerge slowly until liver damage is extensive. Signs and symptoms include tiredness, weakness, loss of appetite, weight loss, and nausea.

Cirrhosis is initially detected through a routine blood test. The other tests, including magnetic resonance elastography (MRE), MRI, CT, and ultrasound, are recommended. To identify the severity, extent, and cause of liver damage, a biopsy is preferred.

The goal of cirrhosis treatment is to slow or prevent the worsening of the condition. A healthy diet is recommended, consisting of a high-protein, high-fiber diet plus supplementation with branched-chain amino acids. Antibiotics are recommended for infections; other medications include carvedilol. Liver transplantation is recommended in cases of uncontrolled conditions.

Report Highlights

Global Insight Service’s, Liver Cirrhosis - Drug Pipeline Landscape, 2023 report provides an overview of the Liver Cirrhosis pipeline drugs. This report covers detailed insights on Liver Cirrhosis drugs under development, assessment by target, mechanism of action, route of administration and molecule type. Product pipeline by companies, stage of development and key regulatory designations, deals and milestones have been presented to provide insights and thus help industry participants in their decision making. Liver Cirrhosis pipeline report helps gain insights on drugs which are under development stage of drug development process across globally.

Methodology

The research process includes extensive secondary research on public domain and other authentic sources to add or update the pipeline products information. The secondary research sources include, but are not limited to company websites, annual reports, financial reports, company pipeline chart, investor presentations and SEC filings, journals and conferences, and clinical trials registries.

Scope

The pipeline landscape report provides analysis of pipeline products based on several stages of development ranging from Discovery to Pre-Registration. The report provides a review of pipeline therapeutics by companies based on information derived from company and industry-specific sources. The pipeline report covers assessment of therapeutics by mechanism of action (MoA), drug target, route of administration (RoA) and molecule type. Comprehensive profiles of the pipeline products with details such as company overview, development stage; molecule type, target, mechanism of action, route of administration, dosage form, regulatory designations, key deals, clincial trials, and key upcoming milestones are included.

Reasons to Buy
Helps to find and recognize significant therapeutics under development. Thorough understanding of pipeline structure and helps in developing corrective measures for pipeline projects.
Effective R&D strategies can be developed with deep knowledge of competitor information, analysis, and insights.
Plan collaborations with various industry partners that have role in some or the other stage of drug development such as contract manufacturing, co-development, contract research organization and commercialization etc.
Helps to create in-licensing and out-licensing opportunities by identifying prospective partners with attractive projects to expand business potential and scope.

Please Note: This report will be delivered by publisher within 3-4 business days of order confirmation.


1. Introduction
1.1 Liver Cirrhosis – Pipeline Drugs, 2023-Coverage
2. Disease Overview – Liver Cirrhosis
2.1 Causes
2.2 Signs and Symptoms
2.3 Diagnosis
2.4 Disease Management
3. Liver Cirrhosis – Pipeline Drugs Development - Overview
3.1 Comparative Analysis by Stage of Development
3.2 Number of Products under Development by Companies, 2023
3.3 Products under Development by Companies, 2023
4. Assessment of Therapeutics
4.1 Assessment by Target
4.2 Assessment by Mechanism of Action
4.3 Assessment by Molecule Type
4.3 Assessment by Route of Administration
5. Drug Profiles
5.1 Clinical Stage Drugs – Phase III
5.1.1 Albutein
5.1.2 Belapectin
5.1.3 Cellgram-LC
5.1.4 GB1211
5.1.5 Lanifibranor
5.2 Clinical Stage Drugs – Phase II
5.2.1 ADR-001
5.2.2 Aldafermin
5.2.3 Allogeneic Umbilical Cord Mesenchymal Stem Cell
5.2.4 Autologous BM MSC
5.2.5 BIV-201
5.2.6 BMS-986263
5.2.7 Dapagliflozin
5.2.8 Efruxifermin
5.2.9 HepaStem
5.2.10 LPCN 1148
5.2.11 Macrophage Cell Therapy
5.2.12 SEMA + CILO/FIR
5.2.13 TNP-2092
5.2.14 UC-MSCs
5.2.15 ZiboDapa
5.3 Clinical Stage Drugs – Phase I
5.3.1 EBI-02
5.3.2 Human Umbilical Cord Mesenchymal Stem Cells
5.3.3 OP-724
5.3.4 PHIN-214
5.3.5 Recombinant Human Serum Albumin
5.3.6 Saroglitazar Magnesium
5.3.7 SZN-043
5.3.8 TLY012
5.3.9 VIR-2218 + VIR-3434
5.3.10 VS-01
5.4 Early-Stage Drugs – Preclinical
5.4.1 CB2 agonist antibody
5.4.2 CBM-201
5.4.3 CytoHep
5.4.4 Linerixibat
5.4.5 MultiGeneLiver (MGL)
5.4.6 OC101
5.4.7 Rencofilstat
5.4.8 TAK-242
5.5 Early-Stage Drugs – Discovery
5.5.1 RNA Therapies
6. Key Regulatory Designations
7. Key Deals
8. Key Upcoming Milestones
9. Key Companies Involved
9.1 Abalone Bio Inc
9.2 Akaza Bioscience Ltd
9.3 Akero Therapeutics Inc
9.4 AstraZeneca
9.5 BioVie Inc
9.6 Bristol-Myers Squibb Co
9.7 CellionBioMed Inc
9.8 D&D Pharmatech Co Ltd
9.9 Galectin Therapeutics Inc
9.10 Galecto Inc
9.11 GlaxoSmithKline
9.12 Grifols SA
9.13 Hepion Pharmaceuticals Inc
9.14 International Stem Cell Corp
9.15 Inventiva Pharma
9.16 Lipocine Inc
9.17 NGM Biopharmaceuticals Inc
9.18 Novo Nordisk AS
9.19 Ochre Bio Ltd
9.20 Ohara Pharmaceutical Co Ltd
9.21 Oncocross Co Ltd
9.22 PharmaIN
9.23 Pharmicell Co Ltd
9.24 Promethera Biosciences SA
9.25 Protgen Ltd
9.26 PT. Prodia Stem Cell Indonesia
9.27 Resolution Therapeutics Ltd
9.28 Rohto Pharmaceutical Co Ltd
9.29 Sclnow Biotechnology Co Ltd
9.30 Stem Med Pte. Ltd
9.31 Surrozen Inc
9.32 TenNor Therapeutics Ltd
9.33 Therabest Co Ltd
9.34 VCANBIO Cell & Gene Engineering Corporation Ltd
9.35 Versantis AG
9.36 VESSL Therapeutics Ltd
9.37 Vir Biotechnology Inc
9.38 Zydus Therapeutics Inc
10. Dormant Drugs
10.1 Inactive Drugs
10.2 Discontinued Drugs
11. Appendix
List of Tables
Table 1. 2 Number of Products under Development by Companies
Table 1. 3 Products under Development by Companies
Table 1. 4 Products by Targets
Table 1. 5 Products by Mechanism of Action
Table 1. 6 Products by Molecule Type
Table 1. 7 Products by Route of Administration
Table 2.1 Clinical Trial Details – Albutein/Grifols SA
Table 2.2 Clinical Trial Details – Belapectin/Galectin Therapeutics Inc
Table 2.3 Clinical Trial Details – Cellgram-LC/Pharmicell Co Ltd
Table 2.4 Clinical Trial Details – GB1211/Galecto Inc
Table 2.5 Clinical Trial Details – Lanifibranor/Inventiva Pharma
Table 2.6 Clinical Trial Details – ADR-001/Rohto Pharmaceutical Co Ltd
Table 2.7 Clinical Trial Details – Aldafermin/NGM Biopharmaceuticals Inc
Table 2.8 Clinical Trial Details – Allogeneic Umbilical Cord Mesenchymal Stem Cell/PT. Prodia Stem Cell Indonesia
Table 2.9 Clinical Trial Details – Autologous BM MSC/Stem Med Pte. Ltd
Table 2.10 Clinical Trial Details – BIV-201/BioVie Inc
Table 2.11 Clinical Trial Details – BMS-986263/Bristol-Myers Squibb Co
Table 2.12 Clinical Trial Details – Dapagliflozin/AstraZeneca
Table 2.13 Clinical Trial Details – Efruxifermin/Akero Therapeutics Inc
Table 2.14 Clinical Trial Details – HepaStem/Promethera Biosciences SA
Table 2.15 Clinical Trial Details – LPCN 1148/Lipocine Inc
Table 2.16 Clinical Trial Details – Macrophage Cell Therapy/Resolution Therapeutics Ltd
Table 2.17 Clinical Trial Details – SEMA + CILO/FIR/Novo Nordisk AS
Table 2.18 Clinical Trial Details – TNP-2092/TenNor Therapeutics Ltd
Table 2.19 Clinical Trial Details – UC-MSCs/VCANBIO Cell & Gene Engineering Corporation, Ltd
Table 2.20 Clinical Trial Details – ZiboDapa/AstraZeneca
Table 2.21 Clinical Trial Details – Human Umbilical Cord Mesenchymal Stem Cells/Sclnow Biotechnology Co Ltd
Table 2.22 Clinical Trial Details – OP-724/Ohara Pharmaceutical Co Ltd
Table 2.23 Clinical Trial Details – PHIN-214/PharmaIN
Table 2.24 Clinical Trial Details – Recombinant Human Serum Albumin/Protgen Ltd
Table 2.25 Clinical Trial Details – Saroglitazar Magnesium/Zydus Therapeutics Inc
Table 2.26 Clinical Trial Details – VIR-2218 + VIR-3434/Vir Biotechnology Inc
Table 3. 1 Regulatory Designations
Table 4. 1 Inactive Drugs
Table 4. 2 Discontinued Drugs
List of Figures
Figure 1. 1 Number of Products under Development for Liver Cirrhosis, 2023
Figure 1. 2 Products by Top 5 Targets and Stage of Development for Liver Cirrhosis, 2023
Figure 1. 3 Products by Top 5 Mechanism of Action and Stage of Development for Liver Cirrhosis, 2023
Figure 1. 4 Products by Top 5 Molecule Type and Stage of Development for Liver Cirrhosis, 2023
Figure 1. 5 Products by Top 5 Route of Administration and Stage of Development for Liver Cirrhosis, 2023

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