Diabetic Foot Ulcer - Drug Pipeline Landscape, 2023

Diabetic Foot Ulcer - Drug Pipeline Landscape, 2023

A diabetic foot ulcer is an open sore or wound that occurs in patients with diabetes and is commonly located on the bottom of the foot. It is one of the health complications caused due to uncontrolled diabetes, people with diabetes may also suffer from lower extremity arterial disease, which is a condition that leads to reduced blood flow. These problems make the feet vulnerable to skin sores, also known as ulcers. They usually occur under the big toes and surrounding areas.

Diabetic foot ulcers are mostly caused by poor blood circulation, hyperglycaemia, and nerve damage. Nerve damage reduces sensitivity to foot pain and results in painless wounds that can cause ulcers.

Diabetic foot ulcers are of two types, neuropathic ulcers, and vascular ulcers. The most visible sign of a serious foot ulcer is black tissue (called eschar) surrounding the ulcer. This forms because of an absence of healthy blood flow to the area around the ulcer.

Doctors most often diagnose diabetic foot ulcer by physical examination of toes, feet, and legs to check for an ulcer or blister present and blood tests, magnetic resonance imaging (MRI) and radiograph.

There are several treatment options for diabetic foot ulcer. The most common investigative treatments include antibiotics, antiplatelets, or anticlotting medications to treat the ulcer if the infection progresses even after preventive or anti pressure treatments. The primary treatment includes blood sugar control, removing dead tissue from the wound, dressings, and removing pressure from the wound through techniques such as total contact casting. Surgery in some cases may improve outcomes.

Major pharmaceutical companies are involved in the development of potential drug candidates to improve the Diabetic Foot Ulcer treatment such as ON101, ENERGI-F703, APO-2, BB-101 and others. Key players involved in the development of therapies to treat Diabetic Foot Ulcer are Aposcience AG, Aurealis Therapeutics AG, Blue Blood Biotech Corp, Energenesis Biomedical Co Ltd, Oneness Biotech and others. One drug is under late-stage pre-registration, nine drugs are in Phase III clinical trials and 10+ drugs are in Phase II clinical trials and some other drugs are under Phase I, IND/CTA Filed, preclinical and discovery stages of development.

In December 2022, Oneness Biotech Co Ltd received a Malaysian patent titled "TOPICAL FORMULATION FOR PROMOTING WOUND HEALING" on Fespixon cream (Research code: ON101).

Report Highlights

Global Insight Service's, Diabetic Foot Ulcer - Drug Pipeline Landscape, 2023 report provides an overview of the Diabetic Foot Ulcer pipeline drugs. This report covers detailed insights on Diabetic Foot Ulcer drugs under development, assessment by target, mechanism of action, route of administration and molecule type. Product pipeline by companies, stage of development and key regulatory designations, deals and milestones have been presented to provide insights and thus help industry participants in their decision making. Diabetic Foot Ulcer pipeline report helps gain insights on drugs which are under development stage of drug development process across globally.

Methodology

The research process includes extensive secondary research on public domain and other authentic sources to add or update the pipeline products information. The secondary research sources include, but are not limited to company websites, annual reports, financial reports, company pipeline chart, investor presentations and SEC filings, journals and conferences, and clinical trials registries.

Scope

The pipeline landscape report provides analysis of pipeline products based on several stages of development ranging from Discovery to Pre-Registration. The report provides a review of pipeline therapeutics by companies based on information derived from company and industry-specific sources. The pipeline report covers assessment of therapeutics by mechanism of action (MoA), drug target, route of administration (RoA) and molecule type. Comprehensive profiles of the pipeline products with details such as company overview, development stage; molecule type, target, mechanism of action, route of administration, dosage form, regulatory designations, key deals, clinical trials, and key upcoming milestones are included.

Reasons to Buy
Helps to find and recognize significant therapeutics under development. Thorough understanding of pipeline structure and helps in developing corrective measures for pipeline projects.
Effective R&D strategies can be developed with deep knowledge of competitor information, analysis, and insights.
Plan collaborations with various industry partners that have role in some or the other stage of drug development such as contract manufacturing, co-development, contract research organization and commercialization etc.
Helps to create in-licensing and out-licensing opportunities by identifying prospective partners with attractive projects to expand business potential and scope.

Please Note: This report will be delivered by publisher within 3-4 business days of order confirmation.


1. Introduction
1.1 Diabetic Foot Ulcer - Pipeline Drugs, 2023 - Coverage
2. Disease Overview - Diabetic Foot Ulcer
2.1 Causes
2.2 Signs and Symptoms
2.3 Diagnosis
2.4 Disease Management
3. Diabetic Foot Ulcer - Pipeline Drugs Development - Overview
3.1 Comparative Analysis by Stage of Development
3.2 Number of Products under Development by Companies, 2023
3.3 Products under Development by Companies, 2023
4. Assessment of Therapeutics
4.1 Assessment by Target
4.2 Assessment by Mechanism of Action
4.3 Assessment by Molecule Type
4.3 Assessment by Route of Administration
5. Drug Profiles
5.1 Late Stage Drugs - Pre-Registration
5.1.1 ON101
5.2 Clinical Stage Drugs - Phase III
5.2.1 ALLO-ASC-DFU
5.2.2 Contezolid Acefosamil/Contezolid
5.2.3 ENERGI-F703
5.2.4 Engensis
5.2.5 Galnobax
5.2.6 SkinTE
5.2.7 SR0379
5.2.8 Stempeucel
5.2.9 TTAX01
5.3 Clinical Stage Drugs - Phase II
5.3.1 Allo-APZ2
5.3.2 APO-2
5.3.3 AUP-16
5.3.4 CHF6467
5.3.5 CSTC1
5.3.6 EscharEx
5.3.7 Granexin
5.3.8 ILP100
5.3.9 MT8
5.3.10 Nitric oxide
5.3.11 Phage Therapy
5.3.12 Pravibismane
5.3.13 SLI-F06
5.3.14 TG-873870
5.3.15 TP-102
5.3.16 VT-141
5.3.17 WOUNDAGEL
5.4 Clinical Stage Drugs - Phase I
5.4.1 BB-101
5.4.2 CorLiCyte
5.4.3 CSA-144
5.4.4 CYP-006TK
5.4.5 Platelet Derived Growth Factor TPG
5.4.6 R327
5.4.7 TOP-N53
5.5 Early Stage Drugs - IND/CTA Filed
5.5.1 C2C-ASC
5.6 Early Stage Drugs - Preclinical
5.6.1 3K3A-APC
5.6.2 AV-001
5.6.3 Becaplermin
5.6.4 BFP001
5.6.5 BFP101
5.6.6 Cathepsin K inhibitor
5.6.7 CTX-001
5.6.8 Human FGF-1
5.6.9 MSC Exosomal Topical Suspension
5.6.10 PCS-PH08
5.6.11 SymHeal
5.6.12 Tobramycin/Triclosan
5.6.13 Topical anti-Staphylococcus bacteriophage therapy
5.6.14 V-10
5.6.15 XF-73
5.7 Early Stage Drugs - Discovery
5.7.1 Chitosan hydrogel-EVs
5.7.2 CTX-004
5.7.3 Drug for Diabetic Foot Ulcer
5.7.4 Gene Therapy
5.7.5 Host Defense Peptides
5.7.6 Microsphere Sustained-Release Formulation
5.7.7 Recombinant Plasminogen
6. Key Regulatory Designations
7. Key Deals
8. Key Upcoming Milestones
9. Key Companies Involved
9.1 Adaptive Phage Therapeutics Inc
9.2 Alan Laboratories Inc
9.3 Anterogen Co Ltd
9.4 Aposcience AG
9.5 Aurealis Therapeutics AG
9.6 Bio-Bank Corp
9.7 Biofilm Pharma
9.8 BioTissue Inc
9.9 Blue Blood Biotech Corp
9.10 Cell2Cure ApS
9.11 Cellresearch Corp Pte Ltd
9.12 Ceria Therapeutics Inc
9.13 Charsire Biotechnology Corp
9.14 Chiesi Farmaceutici SpA
9.15 CSA Biotechnologies LLC
9.16 Cynata Therapeutics Ltd
9.17 Destiny Pharma Plc
9.18 Energenesis Biomedical Co Ltd
9.19 Helixmith Co Ltd
9.20 Ilya Pharma
9.21 Madam Therapeutics BV
9.22 MangoGen Pharma Inc
9.23 MediWound Ltd
9.24 Microbion Corp
9.25 MimeTech Srl
9.26 NangioTx Inc
9.27 NovaLead Pharma Pvt Ltd
9.28 Nutriwyo LLC
9.29 Omnio AB
9.30 Oneness Biotech
9.31 Perpetuum BV
9.32 Pherecydes Pharma SA
9.33 PolarityTE
9.34 Qilu Cell Therapy Technology Co Ltd
9.35 Recce Pharmaceuticals Ltd
9.36 Remedor Biomed Ltd
9.37 RHEACELL GmbH & Co KG
9.38 Riptide Bioscience Inc
9.39 SaNOtize Research and Development Corp
9.40 Scarless Laboratories Inc
9.41 Selsym Biotech Inc
9.42 Shanghai MicuRx Pharmaceutical Co Ltd
9.43 Shionogi & Co Ltd
9.44 Stempeutics Research Pvt Ltd
9.45 TaiGen Biotechnology Co., Ltd
9.46 TechnoPhage SA
9.47 Therapeutic Systems Research Laboratories Inc
9.48 Topadur Pharma AG
9.49 USV Pty Limited
9.50 Vasomune Inc
9.51 Venturis Therapeutics Inc
9.52 Vitti Labs LLC
9.53 Xequel Bio
9.54 Zhittya Genesis Medicine Inc
9.55 ZZ Biotech LLC
10. CRO's Involved
10.1 Alira Health
10.2 Comac Medical
10.3 FGK Clinical Research GmbH
10.4 VectorB2B
11. Dormant Drugs
11.1 Inactive Drugs
11.2 Discontinued Drugs
11. Appendix
List of Tables
Table 1.1 Number of Products under Development by Diabetic Foot Ulcer
Table 1.2 Number of Products under Development by Companies
Table 1.3 Products under Development by Companies
Table 1.4 Products by Targets
Table 1.5 Products by Mechanism of Action
Table 1.6 Products by Molecule Type
Table 1.7 Products by Route of Administration
Table 2.1 Clinical Trial Details - ALLO-ASC-DFU/Anterogen Co Ltd
Table 2.2 Clinical Trial Details - Contezolid Acefosamil/Contezolid/Shanghai MicuRx Pharmaceutical Co., Ltd
Table 2.3 Clinical Trial Details - ENERGI-F703/Energenesis Biomedical Co Ltd
Table 2.4 Clinical Trial Details - Engensis/Helixmith Co Ltd
Table 2.5 Clinical Trial Details - SkinTE/PolarityTE
Table 2.6 Clinical Trial Details - TTAX01/BioTissue Inc
Table 2.7 Clinical Trial Details - allo-APZ2/RHEACELL GmbH & Co KG
Table 2.8 Clinical Trial Details - APO-2/Aposcience AG
Table 2.9 Clinical Trial Details - AUP-16/Aurealis Therapeutics AG
Table 2.10 Clinical Trial Details - CHF6467/Chiesi Farmaceutici SpA
Table 2.11 Clinical Trial Details - CSTC1/Charsire Biotechnology Corp
Table 2.12 Clinical Trial Details - EscharEx /MediWound Ltd
Table 2.13 Clinical Trial Details - ILP100/Ilya Pharma
Table 2.14 Clinical Trial Details - Nitric oxide/SaNOtize Research and Development Corp
Table 2.15 Clinical Trial Details - Phage Therapy /Adaptive Phage Therapeutics, Inc.
Table 2.16 Clinical Trial Details - Pravibismane/Microbion Corp
Table 2.17 Clinical Trial Details - TP-102/TechnoPhage SA
Table 2.18 Clinical Trial Details - WOUNDAGEL/Remedor Biomed Ltd
Table 2.19 Clinical Trial Details - BB-101/Blue Blood Biotech Corp
Table 2.20 Clinical Trial Details - CorLiCyte/Cellresearch Corp Pte Ltd
Table 2.21 Clinical Trial Details - CYP-006TK/Cynata Therapeutics Ltd
Table 3.1 Regulatory Designations
Table 4.1 Trials by CRO
Table 4.2 Discontinued Drugs
Table 5.1 Inactive Drugs
List of Figures
Figure 1.1 Number of Products under Development for Diabetic Foot Ulcer, 2023
Figure 1.2 Products by Top 5 Targets and Stage of Development for Diabetic Foot Ulcer, 2023
Figure 1.3 Products by Top 5 Mechanism of Action and Stage of Development for Diabetic Foot Ulcer, 2023
Figure 1.4 Products by Top 5 Molecule Type and Stage of Development for Diabetic Foot Ulcer, 2023
Figure 1.5 Products by Top 5 Route of Administration and Stage of Development for Diabetic Foot Ulcer, 2023

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