The global Cell Culture Media Market was valued at 4.2 billion in 2022 and it is anticipated to grow up to USD 12.7 billion by 2032, at a CAGR of 11.7% during the forecast period.
Cell culture media is a liquid solution that contains all the nutrients and growth factors necessary to support the growth of cells in vitro. The composition of cell culture media varies depending on the specific requirements of the cells being cultured, but typically includes a source of energy (e.g. glucose), amino acids, vitamins, minerals, and growth factors.
Market Trends and Drivers
The expansion of clear, regulatory approval paths for biosimilars in emerging markets is generating more opportunities for biosimilar monoclonal antibodies. Moreover, the reduction of manufacturing costs has become one of the most significant technological advantages for a biosimilar manufacturer. Therefore, the capability to imitate the biologically active molecule at the lowermost possible cost via cell culture has become important for efficient biosimilar development. In the last few years, stem cell therapy has become an advanced and promising scientific research area. The development of treatment methods has induced great opportunities. Moreover, there is growing interest in improving the stem cell culture, because this technology is being used extensively in research for studying the stem cell biology, as well as for therapeutic applications. In addition, funding related to this research filed has augmented in recent years which has further accelerated the growth of research.
Market Restraints and Challenges
Cell culture media is a complex mixture of nutrients, growth factors, hormones, and other factors that are essential for the growth and maintenance of cells in vitro. The composition of cell culture media is carefully balanced to support the specific needs of the cells being cultured. One of the key challenges in cell culture media is the lack of standardization. There is no one-size-fits-all cell culture media, and each cell type has specific nutritional requirements. This can make it difficult to compare results from different laboratories and to replicate experiments. Another challenge is the cost of cell culture media. Cell culture media is typically more expensive than other types of media, such as tissue culture media, because it is more complex and often contains more expensive ingredients.
The report analyses the global Cell Culture Media Market based on Type Product, Application, End-user, and Region.
Global Cell Culture Media Market by Type
Based on the type, the Cell Culture Media market is divided into liquid media, and semi-solid and solid media. Of these, the liquid media segment captured the highest revenue share of xx% in 2022. An increasing number of biologics and biosimilars manufacturers, both downstream and upstream, are switching from premixed powders to liquid media owing to the factors such as rapid mycobacterial growth and high rate of isolation. Moreover, it eradicates a few process steps, and also reduces the probability of hazardous exposure, and makes manufacturing and development more flexible and simpler than powdered media. In addition, ready-to-use liquid media also eliminates the need for mixing containers, balances, and installation of water for injection (WFI) loop which is needed for mixing powder media. The segment is also being driven by the strategic activities of the manufacturers, for instance, in June 2021, Sartorius, opened its new site in Israel, which focuses on customized and specialty cell culture mainly for the advanced therapies market. This site will serve as a significant production site for buffers and liquid cell culture.
Global Cell Culture Media Market by Product
By product, the industry is bifurcated into Serum-free Media, Classical Media, Stem Cell Culture Media, Specialty Media, Chemically Defined Media, Others. The SFM segment held the highest revenue share of xx% in 2022. The use of SFM signifies a significant tool, which allows the researchers to perform specific application or grow a specific cell type without using serum. Advantages of using SFM include increased growth and/or productivity, more consistent performance, better control over physiological sensitivity, and to diminish the risk of infection by serum-borne adventitious agents in the culture. In addition, serum-free alternatives better serve the animal welfare which is the major factor driving the adoption of SFM. In addition, the field of gene and cell therapy is rapidly growing, and the Food and Drug Administration regulatory guidelines are demanding more control of raw materials to sustain the reliable and safe manufacturing of drug products. The use of SFM offers an opportunity to produce additional reproducible formulations and fewer batch-to-batch variability.
Global Cell Culture Media Market by Application
Based on application, the industry is categorized into biopharmaceutical production, diagnostics, drug screening and development, tissue engineering and regenerative medicine, and others. The biopharmaceutical production segment dominated the market with a share of xx% in 2021. The biopharmaceutical industry’s demand for more reproducible and better-defined media to meet the expanding production levels while reducing the risk of contamination in the downstream processes is significantly increasing the demand for this market. Moreover, strategic activities by key biopharmaceutical companies also drive the segment growth. For instance, in July 2021 Cytiva and Pall Corporation invested USD 1.5 billion for over two years to meet the rising demand for biotechnology solutions. The two companies plan to invest USD 400+ million for culture media in powder or liquid along with expanding its operations in the U.S., Austria, and U.K.
Global Cell Culture Media Market by End-user
Based on end-user, the Cell Culture Media market is divided into Pharmaceutical And Biotechnology Companies, Hospitals And Diagnostic Laboratories, Research And, Academic Institutes, and Others. The pharma and biopharma companies segment captured the highest revenue share of 34.2% in 2021. The expansion of the current manufacturing capacities for biopharmaceuticals drives the demand for cell culture products. For instance, in September 2020, Cytiva, announced the expansion of its manufacturing capacity and hiring personnel in significant areas to support the growth of the biotechnology industry. The company has planned investment of around USD 500 million for five years to increase the manufacturing capacity. In addition, increasing clinical trials will further offer lucrative opportunities in the review period. For instance, in 2021, the number of industry-sponsored trials in progress for regenerative medicine augmented by 100 as compared to 2020, bringing the total to 1,320. There were 1,328 regenerative medicine trials in progress worldwide supported by non-industry groups such as government entities and academic centers.
Geographical Analysis of Global Cell Culture Media Market
Region-wise, it is studied across North America, Europe, Asia Pacific, and the Rest of the World. In Asia Pacific, the market is estimated to grow fast owing to the increase in awareness associated with the use of the cell culture technique. Furthermore, strategic activities by key players to expand their presence in the Asia Pacific countries to capture high market share is expected to offer lucrative opportunities. For instance, In December 2021, Fujifilm Irvine Scientific, Inc., in China started the construction to build its new bioprocessing center, with the aim to ensure cell culture media optimization support for biotherapeutic drug development, vaccines, and advanced therapies.
Major Players in the Global Cell Culture Media Market
Market players are focusing on strategic collaborations to enhance their product offerings. Some prominent participants in the global Cell Culture Media market include Avantor Performance Materials, LLC, Becton, Dickinson and Company, Bio-Rad Laboratories Inc., Corning Incorporated, Fujifilm Holdings Corporation, GE Healthcare, HiMedia Laboratories Pvt., Ltd, Lonza Group Ltd. and Merck & Co., Inc. among others.
COVID-19 Impact:
The outbreak of COVID-19 pandemic has improved the demand for well-established cell-based vaccine production technologies. Moreover, it has given rise to a few scientific innovations, particularly in the production and testing of vaccine technology. For instance, the Vero cell line originated from the African green monkey kidney and has been extensively used for viral vaccine manufacturing. It has also been used for the development of various SARS-CoV variants. ProVeroTM1 Serum-free Medium manufactured by Lonza Bioscience is a protein-free medium, of non-animal origin designed to support the growth of Vero cells and MDCK. Furthermore, cell culture produced AAV vectors have also gained thrust as one of the most effective protein and gene delivery tools in vaccine manufacturing as well as gene therapy. Additionally, key market players are expanding its production capabilities. For instance, in 2021, Sartorius increased its production in all regions due to elevated demand in its core business and to additional customer needs related to COVID-19 therapeutics and COVID-19 vaccines.
Recent Developments:
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