The global Blood-Brain Barrier Technologies Market was valued at USD 4.8 Billion in 2022 and it is anticipated to grow up to USD 9.9 Billion by 2032, at a CAGR of 7.5% during the forecast period.
Blood-brain barrier (BBB) is one of the main components of the neurovascular unit and serves as the blood-brain interface to mediate communication between the central nervous system and the periphery. It prevents pathogens and toxic chemical compounds from entering the brain, and thus, protects the brain against several blood-borne disorders. Blood-brain barrier is formed by the capillary wall’s endothelial cells, astrocytes, and pericytes, which are present in the capillary basement membrane. The blood-brain barrier also helps in blocking the flow of chemical compounds from the circulatory system to the brain or cerebrospinal fluid.
Market Trends and Drivers
Growing awareness regarding neurological disorders, increasing healthcare expenditure, advancements in medical technology, and increasing investment in blood-brain barrier technology development are some key factors driving market revenue growth. Blood-brain barrier plays an essential role in protecting the brain from harmful compounds and blood-borne disorders. It blocks the flow of compounds from circulatory systems to the Cerebrospinal Fluid (CSF) or brain by exchanging particular components controlled by BBB or blood CSF barrier. This makes treatment for brain disorders complex due to the specialized uptake of drugs by the blood-brain barrier. Recent advancements in drug delivery techniques enable drugs to be transferred directly to cerebrospinal fluids. There are several approaches to create a passage for delivering drugs to the brain such as passive diffusion and bispecific antibody RMT approach, Trojan horse approach, and increasing permeability. In Trojan horse approach, the drug is merged to a molecule that is able to cross the blood-brain barrier through a transporter protein.
Market Restraints and Challenges
The complications in brain medication delivery are hindering the market growth. The blood-brain barrier (BBB) has been a great hurdle for brain drug delivery. The BBB in healthy brain is a diffusion barrier essential for protecting normal brain function by impeding most compounds from transiting from the blood to the brain; only small molecules can cross the BBB.
The report analyses the global Blood-Brain Barrier Market based on technology, application, end-use, and region.
Global Blood-Brain Barrier Technologies Market by Technology
Based on technology, the global blood-brain barrier (BBB) market is segmented into bispecific antibody RMT approach, Passive Diffusion, Trojan horse approach, increasing permeability, passive diffusion, and others. The increasing permeability segment is expected to register the fastest revenue CAGR in the global market over the forecast period. Rise in research & development activities for more advanced drugs & therapeutics for various neurological diseases, and growing significance of increasing permeability mechanism in blood-brain barrier permeation are among the key factors contributing to this segment revenue growth.
Global Blood-Brain Barrier Technologies Market by Application
Based on application, the global blood-brain barrier (BBB) market is segmented into Alzheimer disease, epilepsy, Parkinson disease, multiple sclerosis, Hunters syndrome, and brain cancer. The Parkinson disease segment accounted for the largest revenue share in the global market in 2020. Rising prevalence of neurological disorders including Parkinson’s disease, growing awareness of early detection and treatment of neurological and CNS disorders, rising demand for advanced drugs and therapeutics for Parkinson’s disease are among the major factors supporting revenue growth of this segment.
Global Blood-Brain Barrier Technologies Market by End-use
By end-use, the market is segmented as hospitals, surgical centers, research institutes, and others. The Research Institutes segment would hold a considerable share of the market in 2021, and it is likely to continue its dominance in the market during the forecast period as well. Moreover, increasing healthcare expenditure for long term care patients, growing investment in pharmaceutical research & development, raising awareness for chronic neurological diseases, and growing awareness campaigns for neurological disorders are expected to drive the regional market in the future. Growing research and application in the domain is anticipated to fuel the applications of nanoparticles, thereby driving the drug delivery across the blood-brain barrier market.
Geographical Analysis of Global Blood-Brain Barrier Technologies Market
Region-wise, it is studied across North America, Europe, Asia Pacific, and the Rest of the World. Among regional markets, the North America blood-brain barrier (BBB) market accounted for the largest revenue share in the global market in 2020. The regional market revenue growth is majorly attributed to factors such as increasing geriatric population, rising cases of neurological diseases including Alzheimer’s disease, Parkinson’s disease, and Hunter’s syndrome, growing awareness of early diagnosis and treatment of neurological and CNS disorders such as epilepsy/seizures, catalepsy, and brain tumor, and rise in public and private investments in pharmaceutical R&D activities. Presence of advanced healthcare facilities and leading market players in the region, including Bristol-Myers Squibb, Allon Therapeutics, Inc., and Angiochem Inc., further boosts the North America market revenue growth.
Major Players in the Global Blood-Brain Barrier Technologies Market
The key players in the Blood-Brain Barrier Market are Allon Therapeutics, Inc., Angiochem Inc., Armagen Technologies, Inc., Bristol-Myers Squibb, BiOasis Technologies, Inc., Sanofi Genzyme, CarThera, Cephalon Inc., Nanomerics, and F. Hoffman La-Roche AG., among others.
COVID-19 Impact
Social distancing and restrictions severely disrupted businesses and operations. Lockdowns caused disruptions in transportation and logistics. Impacted manufacturing activities and mining operations globally. Took a toll on economy of various countries. Caused sudden and drastic downturn in economic activity. Disrupted agriculture, fisheries, dairy, and other sectors. Caused loss of employment and financial crisis. Supply impacts were further compounded owing to reduced disposable income. Emergence of variants continue to cause concerns and impact normal routines.
Recent Developments
- In November 2022, BioArctic receives new patent in the US for blood-brain barrier transport technology.
- In Feb 2021, Denali Therapeutics completed a phase 1 trial of a broad portfolio of product candidates that are engineered to cross the blood-brain barrier for neurodegenerative diseases.
- In May 2020, Denali Therapeutics unveils blood-brain barrier delivery system.
Q1. How big is the Blood-Brain Barrier Technologies Market?Ans. The global Blood-Brain Barrier Market was valued at USD 4.8 Billion in 2022 and it is anticipated to grow up to USD 9.9 Billion by 2032, at a CAGR of 7.5% during the forecast period.Q2. What is the Blood-Brain Barrier Technologies Market growth rate?Ans. The growth rate of the Blood-Brain Barrier market is 7.5%Q3. Which region holds a major market share for the market?Ans. North America holds a major market share of the Blood-Brain Barrier Technologies Market in 2022.Q4. Which segment accounted for the largest Blood-Brain Barrier Technologies Market share?Ans. By application, the vaccine segment accounted for the largest Blood-Brain Barrier Market share.Q5. Who are the key players in the kidney stones management market?Ans. The global Blood-Brain Barrier Technologies Market report includes players are among others.Q6. What are the factors driving the Blood-Brain Barrier Technologies Market growth?Ans. Rising prevalence of neurological diseases such as Alzheimer’s disease, Parkinson’s disease, and brain tumors is one of the major factors supporting the global market revenue growth.Q7. What are the key growth strategies of Blood-Brain Barrier Technologies Market players?Ans. The key growth strategies of Blood-Brain Barrier Technologies Market players are product launch and product approval.Q8. Which region will provide more business opportunities for the Blood-Brain Barrier Technologies Market during the forecast period?Ans. The Asia-Pacific region will provide more business opportunities for the Blood-Brain Barrier Technologies Market during the forecast period.
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- Chapter 1. Blood-Brain Barrier Technologies Market Overview
- 1.1. Objectives of the Study
- 1.2. Market Definition and Research & Scope
- 1.3. Research Limitations
- 1.4. Research Methodologies
- 1.4.1. Secondary Research
- 1.4.2. Market Size Estimation Technique
- 1.4.3. Forecasting
- 1.4.4. Primary Research and Data Validation
- Chapter 2. Executive Summary
- 2.1. Summary
- 2.2. Key Highlights of the Market
- Chapter 3. Premium Insights on the Market
- 3.1. Market Attractiveness Analysis, By Region
- 3.2. Market Attractiveness Analysis, By Technology
- 3.3. Market Attractiveness Analysis, By Application
- 3.4. Market Attractiveness Analysis, By End-use
- Chapter 4. Blood-Brain Barrier Technologies Market Outlook
- 4.1. Blood-Brain Barrier Market Segmentation
- 4.2. Market Dynamics
- 4.2.1. Market Drivers
- 4.2.1.1. Driver 1
- 4.2.1.2. Driver 2
- 4.2.1.3. Driver 3
- 4.2.2. Market Restraints
- 4.2.2.1. Restraint 1
- 4.2.2.2. Restraint 2
- 4.2.3. Market Opportunities
- 4.2.3.1. Opportunity 1
- 4.2.3.2. Opportunity 2
- 4.3. Porter’s Five Forces Analysis
- 4.3.1. Threat of New Entrants
- 4.3.2. Threat of Substitutes
- 4.3.3. Bargaining Power of Buyers
- 4.3.4. Bargaining Power of Supplier
- 4.3.5. Competitive Rivalry
- 4.4. PESTLE Analysis
- 4.5. Value Chain Analysis
- 4.5.1. Raw Industry Vertical Suppliers
- 4.5.2. Manufacturers
- 4.5.3. Wholesalers and/or Retailers
- 4.6. Impact of COVID-19 on the Blood-Brain Barrier Market
- 4.7. Impact of the Russia and Ukraine War on the Blood-Brain Barrier Market
- Chapter 5. Blood-Brain Barrier Technologies Market By Technology
- 5.1. Market Overview
- 5.2. Bispecific Antibody RMT Approach
- 5.2.1. Key Market Trends & Opportunity Analysis
- 5.2.2. Market Size and Forecast, By Region, 2022-2032 ($Million)
- 5.3. Trojan Horse Approach
- 5.3.1. Key Market Trends & Opportunity Analysis
- 5.3.2. Market Size and Forecast, By Region, 2022-2032 ($Million)
- 5.4. Increasing Permeability
- 5.4.1. Key Market Trends & Opportunity Analysis
- 5.4.2. Market Size and Forecast, By Region, 2022-2032 ($Million)
- 5.5. Passive Diffusion
- 5.5.1. Key Market Trends & Opportunity Analysis
- 5.5.2. Market Size and Forecast, By Region, 2022-2032 ($Million)
- 5.6. Others
- 5.6.1. Key Market Trends & Opportunity Analysis
- 5.6.2. Market Size and Forecast, By Region, 2022-2032 ($Million)
- Chapter 6. Blood-Brain Barrier Technologies Market By Application
- 6.1. Market Overview
- 6.2. Yeast
- 6.2.1. Market Trends & Opportunity Analysis
- 6.2.2. Market Size and Forecast, By Region, 2022-2032 ($Million)
- 6.3. Alzheimer’s Disease
- 6.3.1. Market Trends & Opportunity Analysis
- 6.3.2. Market Size and Forecast, By Region, 2022-2032 ($Million)
- 6.4. Epilepsy
- 6.4.1. Market Trends & Opportunity Analysis
- 6.4.2. Market Size and Forecast, By Region, 2022-2032 ($Million)
- 6.5. Parkinson’s Disease
- 6.5.1. Market Trends & Opportunity Analysis
- 6.5.2. Market Size and Forecast, By Region, 2022-2032 ($Million)
- 6.6. Multiple Sclerosis
- 6.6.1. Market Trends & Opportunity Analysis
- 6.6.2. Market Size and Forecast, By Region, 2022-2032 ($Million)
- 6.7. Hunter’s Syndrome
- 6.7.1. Market Trends & Opportunity Analysis
- 6.7.2. Market Size and Forecast, By Region, 2022-2032 ($Million)
- 6.8. Brain Cancer
- 6.8.1. Market Trends & Opportunity Analysis
- 6.8.2. Market Size and Forecast, By Region, 2022-2032 ($Million)
- Chapter 7. Blood-Brain Barrier Market By End-use
- 7.1. Market Overview
- 7.2. Hospitals
- 7.2.1. Key Market Trends & Opportunity Analysis
- 7.2.2. Market Size and Forecast, By Region, 2022-2032 ($Million)
- 7.3. Surgical centers
- 7.3.1. Key Market Trends & Opportunity Analysis
- 7.3.2. Market Size and Forecast, By Region, 2022-2032 ($Million)
- 7.4. Research Institutes
- 7.4.1. Key Market Trends & Opportunity Analysis
- 7.4.2. Market Size and Forecast, By Region, 2022-2032 ($Million)
- 7.5. Others
- 7.5.1. Key Market Trends & Opportunity Analysis
- 7.5.2. Market Size and Forecast, By Region, 2022-2032 ($Million)
- Chapter 8. Blood-Brain Barrier Market, By Region
- 8.1. Overview
- 8.2. North America
- 8.2.1. Key Market Trends & Opportunity Analysis
- 8.2.2. North America Blood-Brain Barrier Market Size and Forecast By Technology, 2022-2032, ($Million)
- 8.2.3. North America Blood-Brain Barrier Market Size and Forecast By Application, 2022-2032, ($Million)
- 8.2.4. North America Blood-Brain Barrier Market Size and Forecast By End-use, 2022-2032, ($Million)
- 8.2.5. North America Blood-Brain Barrier Market Size and Forecast by Country, 2022-2032, ($Million)
- 8.2.6. The U.S.
- 8.2.6.1. The U.S. Blood-Brain Barrier Market Size and Forecast By Technology, 2022-2032, ($Million)
- 8.2.6.2. The U.S. Blood-Brain Barrier Market Size and Forecast By Application, 2022-2032, ($Million)
- 8.2.6.3. The U.S. Blood-Brain Barrier Market Size and Forecast By End-use, 2022-2032, ($Million)
- 8.2.7. Canada
- 8.2.7.1. Canada Blood-Brain Barrier Market Size and Forecast By Technology, 2022-2032, ($Million)
- 8.2.7.2. Canada Blood-Brain Barrier Market Size and Forecast By Application, 2022-2032, ($Million)
- 8.2.7.3. Canada Blood-Brain Barrier Market Size and Forecast By End-use, 2022-2032, ($Million)
- 8.2.8. Mexico
- 8.2.8.1. Mexico Blood-Brain Barrier Market Size and Forecast By Technology, 2022-2032, ($Million)
- 8.2.8.2. Mexico Blood-Brain Barrier Market Size and Forecast By Application, 2022-2032, ($Million)
- 8.2.8.3. Mexico Blood-Brain Barrier Market Size and Forecast By End-use, 2022-2032, ($Million)
- 8.3. Europe
- 8.3.1. Key Market Trends & Opportunity Analysis
- 8.3.2. Europe Blood-Brain Barrier Market Size and Forecast By Technology, 2022-2032, ($Million)
- 8.3.3. Europe Blood-Brain Barrier Market Size and Forecast By Application, 2022-2032, ($Million)
- 8.3.4. Europe Blood-Brain Barrier Market Size and Forecast By End-use, 2022-2032, ($Million)
- 8.3.5. Europe Blood-Brain Barrier Market Size and Forecast by Country, 2022-2032, ($Million)
- 8.3.6. Germany
- 8.3.6.1. Germany Blood-Brain Barrier Market Size and Forecast By Technology, 2022-2032, ($Million)
- 8.3.6.2. Germany Blood-Brain Barrier Market Size and Forecast By Application, 2022-2032, ($Million)
- 8.3.6.3. Germany Blood-Brain Barrier Market Size and Forecast By End-use, 2022-2032, ($Million)
- 8.3.7. France
- 8.3.7.1. France Blood-Brain Barrier Market Size and Forecast By Technology, 2022-2032, ($Million)
- 8.3.7.2. France Blood-Brain Barrier Market Size and Forecast By Application, 2022-2032, ($Million)
- 8.3.7.3. France Blood-Brain Barrier Market Size and Forecast By End-use, 2022-2032, ($Million)
- 8.3.8. U.K.
- 8.3.8.1. U.K. Blood-Brain Barrier Market Size and Forecast By Technology, 2022-2032, ($Million)
- 8.3.8.2. U.K. Blood-Brain Barrier Market Size and Forecast By Application, 2022-2032, ($Million)
- 8.3.8.3. U.K. Blood-Brain Barrier Market Size and Forecast By End-use, 2022-2032, ($Million)
- 8.3.9. Spain
- 8.3.9.1. Spain Blood-Brain Barrier Market Size and Forecast By Technology, 2022-2032, ($Million)
- 8.3.9.2. Spain Blood-Brain Barrier Market Size and Forecast By Application, 2022-2032, ($Million)
- 8.3.9.3. Spain Blood-Brain Barrier Market Size and Forecast By End-use, 2022-2032, ($Million)
- 8.3.10. Italy
- 8.3.10.1. Italy Blood-Brain Barrier Market Size and Forecast By Technology, 2022-2032, ($Million)
- 8.3.10.2. Italy Blood-Brain Barrier Market Size and Forecast By Application, 2022-2032, ($Million)
- 8.3.10.3. Italy Blood-Brain Barrier Market Size and Forecast By End-use, 2022-2032, ($Million)
- 8.3.11. Rest of Europe
- 8.3.11.1. Rest of Europe Blood-Brain Barrier Market Size and Forecast By Technology, 2022-2032, ($Million)
- 8.3.11.2. Rest of Europe Blood-Brain Barrier Market Size and Forecast By Application, 2022-2032, ($Million)
- 8.3.11.3. Rest of Europe Blood-Brain Barrier Market Size and Forecast By End-use, 2022-2032, ($Million)
- 8.4. Asia-Pacific
- 8.4.1. Key Market Trends & Opportunity Analysis
- 8.4.2. Asia-Pacific Blood-Brain Barrier Market Size and Forecast by Country, 2022-2032, ($Million)
- 8.4.3. Asia-Pacific Blood-Brain Barrier Market Size and Forecast By Application, 2022-2032, ($Million)
- 8.4.4. Asia-Pacific Blood-Brain Barrier Market Size and Forecast By Technology, 2022-2032, ($Million)
- 8.4.5. Asia-Pacific Blood-Brain Barrier Market Size and Forecast By End-use, 2022-2032, ($Million)
- 8.4.6. China
- 8.4.6.1. China Blood-Brain Barrier Market Size and Forecast By Technology, 2022-2032, ($Million)
- 8.4.6.2. China Blood-Brain Barrier Market Size and Forecast By Application, 2022-2032, ($Million)
- 8.4.6.3. China Blood-Brain Barrier Market Size and Forecast By Technology Industry Vertical, 2022-2032, ($Million)
- 8.4.7. India
- 8.4.7.1. India Blood-Brain Barrier Market Size and Forecast By Technology, 2022-2032, ($Million)
- 8.4.7.2. India Blood-Brain Barrier Market Size and Forecast By Application, 2022-2032, ($Million)
- 8.4.7.3. India Blood-Brain Barrier Market Size and Forecast By End-use, 2022-2032, ($Million)
- 8.4.8. Japan
- 8.4.8.1. Japan Blood-Brain Barrier Market Size and Forecast By Technology, 2022-2032, ($Million)
- 8.4.8.2. Japan Blood-Brain Barrier Market Size and Forecast By Application, 2022-2032, ($Million)
- 8.4.8.3. Japan Blood-Brain Barrier Market Size and Forecast By End-use, 2022-2032, ($Million)
- 8.4.9. South Korea
- 8.4.9.1. South Korea Blood-Brain Barrier Market Size and Forecast By Technology, 2022-2032, ($Million)
- 8.4.9.2. South Korea Blood-Brain Barrier Market Size and Forecast By Application, 2022-2032, ($Million)
- 8.4.9.3. South Korea Blood-Brain Barrier Market Size and Forecast By End-use, 2022-2032, ($Million)
- 8.4.10. Rest of APAC
- 8.4.10.1. Rest of APAC Blood-Brain Barrier Market Size and Forecast By Technology, 2022-2032, ($Million)
- 8.4.10.2. Rest of APAC Blood-Brain Barrier Market Size and Forecast By Application, 2022-2032, ($Million)
- 8.4.10.3. Rest of APAC Blood-Brain Barrier Market Size and Forecast By End-use, 2022-2032, ($Million)
- 8.5. Rest of the World
- 8.5.1. Key Market Trends & Opportunity Analysis
- 8.5.2. Rest of the World Blood-Brain Barrier Market Size and Forecast By Technology, 2022-2032, ($Million)
- 8.5.3. Rest of the World Blood-Brain Barrier Market Size and Forecast By Application, 2022-2032, ($Million)
- 8.5.4. Rest of the World Blood-Brain Barrier Market Size and Forecast By End-use, 2022-2032, ($Million)
- 8.5.5. Rest of the World Blood-Brain Barrier Market Size and Forecast by Country, 2022-2032, ($Million)
- 8.5.6. Latin America
- 8.5.6.1. Latin America Blood-Brain Barrier Market Size and Forecast By Technology, 2022-2032, ($Million)
- 8.5.6.2. Latin America Blood-Brain Barrier Market Size and Forecast By Application, 2022-2032, ($Million)
- 8.5.6.3. Latin America Blood-Brain Barrier Market Size and Forecast By End-use, 2022-2032, ($Million)
- 8.5.7. Middle East
- 8.5.7.1. Middle East Blood-Brain Barrier Market Size and Forecast By Technology, 2022-2032, ($Million)
- 8.5.7.2. Middle East Blood-Brain Barrier Market Size and Forecast By Application, 2022-2032, ($Million)
- 8.5.7.3. Middle East Blood-Brain Barrier Market Size and Forecast By End-use, 2022-2032, ($Million)
- 8.5.8. Africa
- 8.5.8.1. Africa Blood-Brain Barrier Market Size and Forecast By Technology, 2022-2032, ($Million)
- 8.5.8.2. Africa Blood-Brain Barrier Market Size and Forecast By Application, 2022-2032, ($Million)
- 8.5.8.3. Africa Blood-Brain Barrier Market Size and Forecast By End-use, 2022-2032, ($Million)
- Chapter 9. Competitive Landscape
- 9.1. Market Overview
- 9.2. Market Share Analysis/Key Player Positioning
- 9.3. Vendor Benchmarking
- 9.4. Developmental Strategy Benchmarking
- 9.4.1. New Product Development
- 9.4.2. Product Launches
- 9.4.3. Business Expansions
- 9.4.4. Partnerships, Joint Ventures, and Collaborations
- 9.4.5. Mergers and Acquisitions
- Chapter 10. Company Profiles
- 10.1. Allon Therapeutics, Inc.
- 10.1.1. Company Snapshot
- 10.1.2. Financial Performance
- 10.1.3. Product Offerings
- 10.1.4. Key Strategic Initiatives
- 10.1.5. SWOT Analysis
- 10.2. Angiochem Inc.
- 10.2.1. Company Snapshot
- 10.2.2. Financial Performance
- 10.2.3. Product Offerings
- 10.2.4. Key Strategic Initiatives
- 10.2.5. SWOT Analysis
- 10.3. Armagen Technologies, Inc.
- 10.3.1. Company Snapshot
- 10.3.2. Financial Performance
- 10.3.3. Product Offerings
- 10.3.4. Key Strategic Initiatives
- 10.3.5. SWOT Analysis
- 10.4. Bristol-Myers Squibb
- 10.4.1. Company Snapshot
- 10.4.2. Financial Performance
- 10.4.3. Product Offerings
- 10.4.4. Key Strategic Initiatives
- 10.4.5. SWOT Analysis
- 10.5. BiOasis Technologies, Inc.
- 10.5.1. Company Snapshot
- 10.5.2. Financial Performance
- 10.5.3. Product Offerings
- 10.5.4. Key Strategic Initiatives
- 10.5.5. SWOT Analysis
- 10.6. Sanofi Genzyme
- 10.6.1. Company Snapshot
- 10.6.2. Financial Performance
- 10.6.3. Product Offerings
- 10.6.4. Key Strategic Initiatives
- 10.6.5. SWOT Analysis
- 10.7. CarThera
- 10.7.1. Company Snapshot
- 10.7.2. Financial Performance
- 10.7.3. Product Offerings
- 10.7.4. Key Strategic Initiatives
- 10.7.5. SWOT Analysis
- 10.8. Cephalon Inc.
- 10.8.1. Company Snapshot
- 10.8.2. Financial Performance
- 10.8.3. Product Offerings
- 10.8.4. Key Strategic Initiatives
- 10.8.5. SWOT Analysis
- 10.9. Nanomerics
- 10.9.1. Company Snapshot
- 10.9.2. Financial Performance
- 10.9.3. Product Offerings
- 10.9.4. Key Strategic Initiatives
- 10.9.5. SWOT Analysis
- 10.10. F. Hoffman La-Roche AG.
- 10.10.1. Company Snapshot
- 10.10.2. Financial Performance
- 10.10.3. Product Offerings
- 10.10.4. Key Strategic Initiatives
- 10.10.5. SWOT Analysis
- *The list of company is subject to change during the final compilation of the report
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