Biotechnology Advancements that Enable Sustainability in the Chemicals Industry: Technology Growth Opportunities

Biotechnology Advancements that Enable Sustainability in the Chemicals Industry: Technology Growth Opportunities

Chemicals is a highly regulated industry, and it serves as the backbone of several other end-user sectors, including construction, transportation, healthcare, pharmaceuticals, and agriculture. Although the industry is a leading revenue generator, globally, digitalization, product portfolio diversification, enriched social responsibility, and sustainability have created a major impact on sales and revenue and pushed the industry to transform and acclimatize to the rising trend of innovation. Unlike digitalization and social interactions that affect sales and commercialization, sustainability is a global factor driving innovation in the chemicals industry due to rising consumer awareness of and demand for sustainable products. In addition, government regulations are pushing the industry to adopt sustainable production practices, which will result in a minimal impact on the environment.

Biotechnology is a branch of science that modifies biological organisms, processes, and systems for the development of innovative products. Biotechnology tools, including genetic engineering, bioprocess management, enzyme engineering, molecular biology, and synthetic biology, enhance process efficiency and facilitate product formation. Biotechnology also enables energy savings, aids CO2 emission reduction, facilitates bioproduct innovation, and enables waste management. It is a rapidly evolving industry that is seeing a wave of innovation, start-up funding, sophisticated gene-editing approaches, and integrated computational methods.

Fermentation of microbes to produce alcohols, organic acids, and proteins has been a global industrial practice for large-scale production. Similarly, the use of biocatalysts for the transformation of stereoselective compounds and active ingredients is widely used as a replacement for metal catalysts. Although biotechnology has evolved into a powerful tool that can be used to develop bioproducts through transformative process and design strategies, its use in chemical industries or chemical processes has been slow, which can be attributed to the robust operational capabilities of the chemicals industry that limits transformational advancements.

The use of innovative technologies such as synthetic biology, gene editing, and enzyme engineering is growing, and companies and start-ups are applying them in the design and synthesis of microbial constructs, thereby enabling bio-based product formation. Furthermore, the use of computational tools to screen and analyze large biological datasets and biosystem interactions is showcasing rapid design validation and production. Therefore, the increased efficiency and specificity of biotechnological tools holds significant potential to move the chemicals industry toward sustainability. Biotechnology also allows the use of renewable resources as feedstock and efficiently recycles or upcycles industrial waste and bioproducts through engineered enzymes without impacting the quality of life. Biotechnology can also decouple economic growth by diversifying product portfolios through demand-driven production with clean ingredients that can be recycled in future. The production of active ingredients, functional chemicals, and alternative proteins minimizes the use of land, water, and energy, thereby enhancing sustainability.

This research service focuses on identifying biotechnology approaches and tools that will transform the chemicals industry. The study offers insight into technology, challenges, and adoption strategies for chemical production processes and their impact on sustainability. The commercial landscape of biotechnological advancements in food safety and tracking is also examined. Frost & Sullivan has also identified key areas of biotechnology advancements, including process engineering strategies such as biocatalysis and fermentation and design engineering approaches such as strain engineering and -omics technologies.

The research service answers the following questions:
Which factors are driving the large-scale adoption of advanced biotechnology processes in the chemicals industry? ?
What initiatives are industry participants undertaking to accelerate adoption??
What are the expected outcomes of biotechnology tools and approaches in comparison to existing chemical processes and strategies??
How do biotechnology advancements help to achieve a circular economy and sustainability goals? ?
What challenges is the chemicals industry facing in terms of the adoption of biotechnology?


  • Strategic Imperatives
    • Why Is It Increasingly Difficult to Grow?
    • The Strategic Imperative 8
    • The Impact of the Top 3 Strategic Imperatives on the Chemicals Industry
    • Growth Opportunities Fuel the Growth Pipeline Engine
    • Research Methodology
  • Research Scope and Segmentation
    • Research Context and Key Questions the Study Will Answer
    • Biotechnology Tools that Enable Newfound Process Strategies, Efficient Product Development, and Waste Management
  • Growth Opportunity Analysis
    • The Chemical Industry is Witnessing a Transformation due to Digitalization, Value Chain Expansion, and Collaboration.
    • Key Focus Areas of the Global Chemicals Industry
    • Digital and Biotechnology Tools, Waste Management, and Manufacturing Advances are Emerging as Sustainability Enablers in the Chemicals Industry.
    • Renewable Feedstock and Innovation in Materials are being Adopted to Increase the Sustainability of End Products.
    • The Adoption of Biotechnology Approaches can Significantly Boost Sustainability Efforts.
    • Industry Initiatives and Regulations Favor the Adoption of Biotechnology Tools in Chemical Processing and Manufacturing.
    • Leading Chemical Companies Adopting Synthetic Biology Tools for Product Development
    • Infrastructure Investment, Internal Policy Governance, and Collaboration Increase Awareness and Adoption of Biotechnology Approaches.
    • Key Biotechnology Approaches Driving Sustainability in the Chemicals Industry
    • Fermentation and Biocatalysis Drive the Large-scale Production of Bio-based Products through the Strategic Use of Strain Engineering and -omics Tools.
  • Process Engineering Approaches: Biocatalysis
    • Chemical Transformations Using Biomolecules and Cells are Gaining Prominence due to High Product Purity and Production Circularity.
    • Enzyme and Whole-cell Biocatalysts Minimize Energy Consumption and Environmental Damage and Enhance Industrial Sustainability.
    • Biocatalytic Transformations are Used in Raw Material Processing, Product Development, and Waste Recycling.
    • Biocatalysis is Transforming the Chemicals Industry through Green and Sustainable Processes and Practices.
    • Digital Tools for the Accurate and Early Detection of Enzymes will Accelerate Industrial-scale Enzyme Production.
  • Process Engineering Approaches: Fermentation
    • The Transformation of a Substrate into Desired Chemicals by Microorganisms is a Widely Adopted Industrial Process Strategy.
    • Fermentation-based Chemicals and Products for Use in Diverse Industries
    • The Fermentation Process Facilitates Recyclability and Reuse, thereby Enhancing Industrial Sustainability.
    • Automated Cloud-connected Fermenters with Feedback Control and Simplified Downstream Processing Boost the Adoption of Industrial Fermentation.
  • Process Engineering: Innovation Landscape
    • Collaborations between Process Experts and Product Manufacturers are Advancing the Adoption of Fermentation and Biocatalysis.
    • Improved Enzyme Stabilization, Recombinant Enzyme Technology, and Fermentation are Driving Sustainability in Production.
    • Public and Private Investments are Driving the R&D and the Commercialization of Bio-based Chemicals.
    • Investments are also Targeting Large-scale Production and the Acceleration of R&D Efforts.
    • Case Study 1: Solugen, US
    • Case Study 2: Bota Biosciences, China
  • Design Engineering Approaches: Strain Engineering and -Omics Technologies
    • Design Engineering is being Leveraged to Improve Bioprocess Conditions
    • Strain and Microbial Engineering Design are being Used to Produce Industrial Chemicals.
    • Strain and Host Engineering Enhances Chemical Production and Restores Ecological Balance, thereby Boosting Sustainability.
    • Investments in Synthetic and Systems Biology are Accelerating Largescale Adoption.
    • Funding and VC Investments are also Focusing on the Scaling up of Production Processes.
    • Strategic Partnerships between Biotechnology Companies and Product Manufacturers are Accelerating the Development of Bio-based Products.
    • The Combinatorial Use of Process Engineering and Synthetic Biology can Improve the Performance Characteristics of Biochemicals.
    • Case Study 3: Amyris, US
    • Robust Microbial and Computational Frameworks will Enhance the Large-scale Adoption of -Omics and Synthetic Biology Platforms.
  • Analyst Perspective
    • Biotechnology Approaches can Transform the Chemical Industry's Value Chain and make it More Circular.
    • Improved Infrastructure for Feedstock Storage and Dedicated R&D for Process Engineering will Augment Biotechnology Approaches.
    • Recommendations to Enhance the Adoption of Biotechnology in the Chemicals Industry
  • Growth Opportunity Universe
    • Growth Opportunity 1: Advances in the Engineering of Enzymes and the Production of Hybrid Biocatalysts
    • Growth Opportunity 2: Integrated Bioprocess Production with Feedback Loop, Cloud Server, and AI-based Analytics
    • Growth Opportunity 3: Advances in Gene Editing, Strain Engineering, and Metabolic Flux Analysis
    • Growth Opportunity 4: Systems Biology and Multi-Omics Technology as Futuristic Computational Tools
  • Appendix
    • Technology Readiness Levels (TRL): Explanation
  • Next Steps
    • Your Next Steps
    • Why Frost, Why Now?

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