Progressive Pulmonary Fibrosis (PPF) - Market Insights, Epidemiology, and Market Forecast–2032

Progressive Pulmonary Fibrosis (PPF) - Market Insights, Epidemiology, and Market Forecast–2032

DelveInsight’s ‘Progressive pulmonary fibrosis (PPF) - Market Insights, Epidemiology, and Market Forecast–2032’ report deliver an in-depth understanding of the Progressive pulmonary fibrosis (PPF), historical and forecasted epidemiology as well as the Progressive pulmonary fibrosis (PPF) market trends in the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan.

The Progressive pulmonary fibrosis (PPF) market report provides current treatment practices, emerging drugs, and market share of the individual therapies, current and forecasted 7MM Progressive pulmonary fibrosis (PPF) market size from 2019 to 2032. The Report also covers current Progressive pulmonary fibrosis (PPF) treatment practice, market drivers, market barriers, SWOT analysis, reimbursement and market access, and unmet medical needs to curate the best of the opportunities and assesses the underlying potential of the market.

Geography Covered

• The United States
• EU5 (Germany, France, Italy, Spain, and the United Kingdom)
• Japan

Study Period: 2019–2032

Progressive pulmonary fibrosis (PPF) - Disease Understanding and Treatment Algorithm

Progressive pulmonary fibrosis (PPF) consist of a diverse group of interstitial lung diseases (ILDs) characterized by a similar clinical phenotype of accelerated respiratory failure, frequent disease exacerbation and earlier mortality.

Interstitial lung disease is believed to be caused by long-term exposure to hazardous materials, such as asbestos or coal dust, or it can be caused by an auto-immune disease such as rheumatoid arthritis. Once lung scarring occurs, it is generally irreversible.

Progressive pulmonary fibrosis (PPF) are composed of Idiopathic Interstitial Pneumonias such as non-specific interstitial pneumonia and unclassifiable interstitial pneumonia, and inhalation lung diseases such as chronic hypersensitivity pneumonia, and connective tissue disease-associated ILD such as rheumatoid arthritis-related ILD and SSc-related ILD, and sarcoidosis and so on. Many interstitial lung diseases (ILDs) are characterized by chronic progressive fibrosis. The type-specific segmentation majorly includes, Idiopathic Interstitial Pneumonias (IIPs), Autoimmune ILDs, Hypersensitivity Pneumonitis, Sarcoidosis, and other ILDs.

Progressive pulmonary fibrosis (PPF) Diagnosis

Imaging tests such as X-ray and a high-resolution computed tomography (CT scan), is key to, and sometimes the first step in, the diagnosis of interstitial lung disease. The severity level of Progressive pulmonary fibrosis (PPF) is calculated on the basis of FVC score. However, identifying and determining the cause of interstitial lung disease can be challenging, as a large number of disorders fall into this broad category. Hence differential diagnosis is needed.

The differential diagnosis of Interstitial Lung Diseases requires a multidisciplinary approach, usually involving pulmonologist, radiologist, and pathologist. The evaluations include clinical presentation, specific history assessment, smoking status, lung function evaluation, serological test results, imaging and if required, lung biopsy.

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Progressive pulmonary fibrosis (PPF) Treatment

Treatment for Interstitial Lung Diseases varies depending on the type of Interstitial Lung Disease diagnosed and the severity. Lung damage from Interstitial Lung Diseases is often irreversible and progressive, so treatment normally centers on relieving symptoms, improving quality of life and slowing the disease's progression. Medications, such as corticosteroids, can be used to decrease inflammation in the lungs.

Nintedanib (Ofev) is the only approved drug in the Progressive pulmonary fibrosis (PPF) treatment landscape. Along with Ofev the current market is mainly attributed to corticosteroids and immunosuppressant for treatment. Novel uses of antifibrotic therapies are emerging due to a paucity of evidence-based treatments for multiple Interstitial Lung Disease subtypes. The market is anticipates launch of several emerging therapies in the Progressive pulmonary fibrosis (PPF) treatment domain in the forecast period.

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Progressive pulmonary fibrosis (PPF) Epidemiology

The disease epidemiology covered in the report provides historical as well as forecasted epidemiology segmented by Total Prevalent Cases of Interstitial Lung Disease (ILD), Total Diagnosed Prevalent Cases of Interstitial Lung Disease (ILD), Type-specific Diagnosed Prevalent Cases of Interstitial Lung Disease (ILD), Total Diagnosed Prevalent Cases of Progressive pulmonary fibrosis (PPF) in the 7MM covering the United States, EU5 countries (Germany, France, Italy, Spain, and the United Kingdom), and Japan from 2019 to 2032.

Key Findings

• In the assessment done by DelveInsight, the estimated total diagnosed prevalent cases of Progressive pulmonary fibrosis (PPF) in the 7MM were 127,754 in 2021.
• The highest total diagnosed prevalent cases of Progressive pulmonary fibrosis (PPF) were accounted by the US in 2021 (71,657 cases), which are expected to show a rise in the future.
• Among the European countries, Germany had the highest diagnosed prevalent cases of PPF with 11,115 cases, followed by the United Kingdom, which had prevalent population of 9,872 in 2021. On the other hand, Spain had the lowest prevalent population (6,401 cases).
• Japan had 10,296 total diagnosed prevalent cases of Progressive pulmonary fibrosis (PPF) in 2021, accounting for approximately 8% in 7MM.

Progressive pulmonary fibrosis (PPF) Epidemiology

The epidemiology segment also provides the Progressive pulmonary fibrosis (PPF) epidemiology data and findings across the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan.

Progressive pulmonary fibrosis (PPF) Drug Chapters

The drug chapter segment of the Progressive pulmonary fibrosis (PPF) report encloses the detailed analysis of Progressive pulmonary fibrosis (PPF) drugs, mid-phase, and late-stage pipeline drugs. It also helps to understand the Progressive pulmonary fibrosis (PPF) clinical trial details, expressive pharmacological action, agreements and collaborations, approval, and patent details of each included drug and the latest news and press releases.

Progressive pulmonary fibrosis (PPF) Emerging Drugs

BI 1015550: Boehringer Ingelheim

BI 1015550 is an investigational, oral, phosphodiesterase 4B (PDE4B) inhibitor with combined antifibrotic and anti-inflammatory effects being developed by Boehringer Ingelheim. It has the potential to address both pulmonary fibrosis – an irreversible scarring of lung tissue that negatively impacts lung function – and inflammation associated with Progressive pulmonary fibrosis (PPF) (ILDs). BI 1015550 represents the first molecule in the class of PDE4B inhibitors that is being studied for IPF and other progressive fibrosing ILDs. Breakthrough Therapy Designation was granted to BI 1015550 in February 2022 for the treatment of idiopathic pulmonary fibrosis (IPF) by the US Food and Drug Administration (FDA).

Products detail in the report…

List to be continued in the report…

Progressive pulmonary fibrosis (PPF) Market Outlook

Progressive pulmonary fibrosis (PPF) consist of a diverse group of interstitial lung diseases (ILDs) characterized by a similar clinical phenotype of accelerated respiratory failure, frequent disease exacerbation and earlier mortality.

ILD and its progressing forms, form a substantial proportion of disabling chronic lung disease leading to significant morbidity and mortality. From the current treatment market scenario, Nintedanib is the only approved treatment in the chronic fibrotic ILDs in the 7MM. Myriads of patients with PPFs are currently orphan of evidence-based treatments and are left with options of receiving corticosteroids and/or off-label immunosuppressive therapies with variable outcomes and are the mainstay of treatment in PPFs. These unmet treatment gaps accentuates the launch of emerging therapies.

In the upcoming treatment landscape, there are plethora of companies investigating agents for use in the PPF which includes Boehringer Ingelheim, Bristol-Myers Squibb, FibroGen, Hoffmann-La Roche Ltd., Pliant Therapeutics, Inc., United Therapeutics, Vicore Pharma AB. There are many more pharma companies which are conducting clinical trials for therapies of PPF.

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Key Findings

• The therapeutic market size of Progressive pulmonary fibrosis (PPF) in the 7MM was USD 891 million in 2021.
• The United States accounts for the highest market size of Progressive pulmonary fibrosis (PPF) approximately 77% of the total market size in 7MM in 2021, in comparison to the other major markets i.e., EU5 countries (the United Kingdom, Germany, Italy, France, and Spain), and Japan.
• Among the EU5 countries, Germany had the highest market size with USD 37 million in 2021, while Spain had the lowest market size of Progressive pulmonary fibrosis (PPF) with USD 28 million in 2021.
• The market size for Progressive pulmonary fibrosis (PPF) in Japan was estimated to be USD 43 Million in 2021, which accounts for 5% of the total 7MM market.
• With the expected launch of upcoming therapies, such as BI 1015550 the total market size of Progressive pulmonary fibrosis (PPF) is expected to show change in the upcoming years.

The United States Market Outlook

This section provides the total Progressive pulmonary fibrosis (PPF) market size and market size by therapies in the United States.

EU-5 Market Outlook

The total Progressive pulmonary fibrosis (PPF) market size and market size by therapies in Germany, France, Italy, Spain, and the United Kingdom are provided in this section.

Japan Market Outlook

The total Progressive pulmonary fibrosis (PPF) market size and market size by therapies in Japan are provided.

Progressive pulmonary fibrosis (PPF) Drugs Uptake

This section focuses on the rate of uptake of the potential drugs recently launched in the Progressive pulmonary fibrosis (PPF) or expected to get launched in the market during the study period 2019–2032. The analysis covers Progressive pulmonary fibrosis (PPF) market uptake by drugs; patient uptake by therapies; and sales of each drug.

This helps in understanding the drugs with the most rapid uptake, reasons behind the maximal use of new drugs and allows the comparison of the drugs based on market share and size which again will be useful in investigating factors important in market uptake and in making financial and regulatory decisions.

Progressive pulmonary fibrosis (PPF) Development Activities

The report provides insights into different therapeutic candidates in phase II, and phase III stages. It also analyzes key players involved in developing targeted therapeutics.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition, and merger, licensing, and patent details for Progressive pulmonary fibrosis (PPF) emerging therapies.

Reimbursement Scenario in Progressive pulmonary fibrosis (PPF)

Approaching reimbursement proactively can have a positive impact both during the late stages of product development and well after product launch. In the report, we consider reimbursement to identify economically attractive indications and market opportunities. When working with finite resources, the ability to select the markets with the fewest reimbursement barriers can be a critical business and price strategy.

Competitive Intelligence Analysis

We perform competitive and market Intelligence analysis of the Progressive pulmonary fibrosis (PPF) market by using various competitive intelligence tools that include–SWOT analysis, PESTLE analysis, Porter’s five forces, BCG Matrix, Market entry strategies, etc. The inclusion of the analysis entirely depends upon the data availability.

Scope of the Reports

• The report covers the descriptive overview of Progressive pulmonary fibrosis (PPF), explaining its signs and symptoms, causes, classification, and currently available therapies.
• Comprehensive insight has been provided into the Progressive pulmonary fibrosis (PPF) epidemiology and treatment.
• Additionally, an all-inclusive account of both the current and emerging therapies for Progressive pulmonary fibrosis (PPF) is provided, along with the assessment of new therapies, which will have an impact on the current treatment landscape.
• A detailed review of the Progressive pulmonary fibrosis (PPF) market; historical and forecasted is included in the report, covering the 7MM drug outreach.
• The report provides an edge while developing business strategies, by understanding trends shaping and driving the 7MM Progressive pulmonary fibrosis (PPF) market.

Report Highlights

• The robust pipeline with novel MOA and oral ROA and increasing prevalence will positively drive the Progressive pulmonary fibrosis (PPF) market.
• The companies and academics are working to assess challenges and seek opportunities that could influence Progressive pulmonary fibrosis (PPF) R&D. The therapies under development are focused on novel approaches to treat/improve the disease condition and underlying cause.
• Major players are involved in developing therapies for Progressive pulmonary fibrosis (PPF) s. The launch of emerging therapies will significantly impact the Progressive pulmonary fibrosis (PPF) market.
• Our in-depth analysis of the pipeline assets across different stages of development (phase III and phase II), different emerging trends, and comparative analysis of pipeline products with detailed clinical profiles, key cross-competition, launch date along with product development activities will support the clients in the decision-making process regarding their therapeutic portfolio by identifying the overall scenario of the research and development activities.

Progressive pulmonary fibrosis (PPF) Report Insights

• Patient Population
• Therapeutic Approaches
• Progressive pulmonary fibrosis (PPF) Pipeline Analysis
• Progressive pulmonary fibrosis (PPF) Market Size and Trends
• Market Opportunities
• Impact of upcoming Therapies

Progressive pulmonary fibrosis (PPF) Report Key Strengths

• 11-Years Forecast
• 7MM Coverage
• Progressive pulmonary fibrosis (PPF) Epidemiology Segmentation
• Key Cross Competition
• Highly Analyzed Market
• Drugs Uptake

Progressive pulmonary fibrosis (PPF) Report Assessment

• Current Treatment Practices
• Unmet Needs
• Pipeline Product Profiles
• Market Attractiveness
• Market Drivers and Barriers
• SWOT analysis

Key Questions

Market Insights:

• What was the Progressive pulmonary fibrosis (PPF) market share (%) distribution in 2019 and how it would look like in 2032?
• What would be the Progressive pulmonary fibrosis (PPF) total market size as well as market size by therapies across the 7MM during the forecast period (2022–2032)?
• What are the key findings pertaining to the market across the 7MM and which country will have the largest Progressive pulmonary fibrosis (PPF) market size during the forecast period (2022–2032)?
• At what CAGR, the Progressive pulmonary fibrosis (PPF) market is expected to grow at the 7MM level during the forecast period (2022–2032)?
• What would be the Progressive pulmonary fibrosis (PPF) market outlook across the 7MM during the forecast period (2022–2032)?
• What would be the Progressive pulmonary fibrosis (PPF) market growth till 2032 and what will be the resultant market size in the year 2032?
• How would the market drivers, barriers, and future opportunities affect the market dynamics and subsequent analysis of the associated trends?

Epidemiology Insights:

• What is the disease risk, burden, and unmet needs of Progressive pulmonary fibrosis (PPF)?
• What is the historical Progressive pulmonary fibrosis (PPF) patient population in the United States, EU5 (Germany, France, Italy, Spain, and the UK), and Japan?
• What would be the forecasted patient population of Progressive pulmonary fibrosis (PPF) at the 7MM level?
• What will be the growth opportunities across the 7MM with respect to the patient population pertaining to Progressive pulmonary fibrosis (PPF)?
• Out of the above-mentioned countries, which country would have the highest prevalent population of Progressive pulmonary fibrosis (PPF) during the forecast period (2022–2032)?
• At what CAGR the population is expected to grow across the 7MM during the forecast period (2022–2032)?

Current Treatment Scenario, Marketed Drugs, and Emerging Therapies:

• What are the current options for the treatment of Progressive pulmonary fibrosis (PPF) along with the approved therapy?
• What are the current treatment guidelines for the treatment of Progressive pulmonary fibrosis (PPF) in the US, Europe, And Japan?
• What are the Progressive pulmonary fibrosis (PPF) marketed drugs and their MOA, regulatory milestones, product development activities, advantages, disadvantages, safety, and efficacy, etc.?
• How many companies are developing therapies for the treatment of Progressive pulmonary fibrosis (PPF)?
• How many emerging therapies are in the mid-stage and late stages of development for the treatment of Progressive pulmonary fibrosis (PPF)?
• What are the key collaborations (Industry–Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Progressive pulmonary fibrosis (PPF) therapies?
• What are the recent therapies, targets, mechanisms of action and technologies developed to overcome the limitation of existing therapies?
• What are the clinical studies going on for Progressive pulmonary fibrosis (PPF) and their status?
• What are the key designations that have been granted for the emerging therapies for Progressive pulmonary fibrosis (PPF)?
• What are the 7MM historical and forecasted market of Progressive pulmonary fibrosis (PPF)?

Reasons to buy

• The report will help in developing business strategies by understanding trends shaping and driving the Progressive pulmonary fibrosis (PPF).
• To understand the future market competition in the Progressive pulmonary fibrosis (PPF) market and an Insightful review of the key market drivers and barriers.
• Organize sales and marketing efforts by identifying the best opportunities for Progressive pulmonary fibrosis (PPF) in the US, Europe (Germany, Spain, Italy, France, and the United Kingdom), and Japan.
• Identification of strong upcoming players in the market will help in devising strategies that will help in getting ahead of competitors.
• Organize sales and marketing efforts by identifying the best opportunities for the Progressive pulmonary fibrosis (PPF) market.
• To understand the future market competition in the Progressive pulmonary fibrosis (PPF) market.