PRMT5 protein inhibitors - Pipeline Insight, 2024

PRMT5 protein inhibitors - Pipeline Insight, 2024



DelveInsight’s, “PRMT5 protein inhibitors - Pipeline Insight, 2024” report provides comprehensive insights about 9+ companies and 10+ pipeline drugs in PRMT5 protein inhibitors pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered
  • Global coverage
PRMT5 protein inhibitors Understanding

PRMT5 protein inhibitors: Overview

Protein arginine methyltransferase 5 (PRMT5) is a critical regulatory protein linked to genome organization, cell cycle regulation, and stem cell differentiation1. It forms an active complex with MEP50 and transfers methyl groups from S-adenosylmethoinine (SAM) to histone proteins, transcription factors, and other regulatory proteins. These methylations form mono and symmetrically di-methylated arginine residues. Dysregulation of PRMT5 activity is associated with many cancers including lymphomas, lung cancer, and breast cancer. Additionally, PRMT5 is linked to kidney disease, heart disease, and neurological disorders including Huntington’s and Alzheimer’s. Recent scientific breakthroughs have caused PRMT5 to emerge as a promising new drug target. New findings in both the specific inhibition of PRMT5 and in metabolic pathways linked to its activity have brought new attention to this important protein.

Report Highlights
  • The companies and academics are working to assess challenges and seek opportunities that could influence PRMT5 protein inhibitors R&D. The therapies under development are focused on novel approaches for PRMT5 protein inhibitors.
PRMT5 protein inhibitors Emerging Drugs Chapters

This segment of the PRMT5 protein inhibitors report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

PRMT5 protein inhibitors Emerging Drugs
  • PRT811: Prelude Therapeutics
PRT811, Prelude’s second clinical product candidate, is an oral PRMT5 inhibitor under development for patients with PRMT5-dependent cancers, including central nervous system (CNS) tumors such as glioblastoma multiforme (GBM) and primary CNS lymphoma. PRT811 is designed to have high potency and selectivity and optimized brain exposure. PRT811 is being studied in a Phase 1 clinical trial in solid tumors, including GBM and primary central nervous system lymphomas (PCNSL).
  • Pemrametostat: GlaxoSmithKline
Pemrametostat (formerly GSK 3326595) is an oral inhibitor of protein arginine methyltransferase 5 (PRMT 5), being developed by GlaxoSmithKline. Currently, it is in Phase II stage of clinical trial evaluation to treat Non-Hodgkin's lymphoma and solid tumors.

Further product details are provided in the report……..

PRMT5 protein inhibitors: Therapeutic Assessment

This segment of the report provides insights about the different PRMT5 protein inhibitors drugs segregated based on following parameters that define the scope of the report, such as:
  • Major Players working on PRMT5 protein inhibitors
There are approx. 9+ key companies which are developing the PRMT5 protein inhibitors. The companies which have their PRMT5 protein inhibitors drug candidates in the most advanced stage, i.e. Phase II include, GlaxoSmithKline.
  • Phases
DelveInsight’s report covers around 10+ products under different phases of clinical development like
  • Late-stage products (Phase III and
  • Mid-stage products (Phase II and
  • Early-stage products (Phase I/II and Phase I) along with the details of
  • Pre-clinical and Discovery stage candidates
  • Discontinued & Inactive candidates
  • Route of Administration
PRMT5 protein inhibitors pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
  • Infusion
  • Intradermal
  • Intramuscular
  • Intranasal
  • Intravaginal
  • Oral
  • Parenteral
  • Subcutaneous
  • Topical
  • Molecule Type
Products have been categorized under various Molecule types such as
  • Vaccines
  • Monoclonal Antibody
  • Peptides
  • Polymer
  • Small molecule
  • Product Type
Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

PRMT5 protein inhibitors: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase III, II, I, preclinical and discovery stage. It also analyses PRMT5 protein inhibitors therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging PRMT5 protein inhibitors drugs.

PRMT5 protein inhibitors Report Insights
  • PRMT5 protein inhibitors Pipeline Analysis
  • Therapeutic Assessment
  • Unmet Needs
  • Impact of Drugs
PRMT5 protein inhibitors Report Assessment
  • Pipeline Product Profiles
  • Therapeutic Assessment
  • Pipeline Assessment
  • Inactive drugs assessment
  • Unmet Needs
Key Questions

Current Scenario and Emerging Therapies:
  • How many companies are developing PRMT5 protein inhibitors drugs?
  • How many PRMT5 protein inhibitors drugs are developed by each company?
  • How many emerging drugs are in mid-stage, and late-stage of development for the treatment of PRMT5 protein inhibitors?
  • What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the PRMT5 protein inhibitors therapeutics?
  • What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for PRMT5 protein inhibitors and their status?
  • What are the key designations that have been granted to the emerging drugs?
Key Players
  • Prelude Therapeutics
  • GlaxoSmithKline
  • Pfizer
  • Amgen
  • Mirati Therapeutics
  • Jubilant Biosys
  • Agios Pharmaceuticals
  • Tango Therapeutics
  • Lead Pharma
  • Argonaut Therapeutics
Key Products
  • PRT811
  • Pemrametostat
  • AMG 193
  • PRT 543
  • PF 06939999
  • MRTX 1719
  • MRTX 4646
  • JPRMT 5i
  • AT101
  • TNG908
  • JBI 778


Introduction
Executive Summary
PRMT5 protein inhibitors: Overview
Structure
Mechanism of Action
Pipeline Therapeutics
Comparative Analysis
Therapeutic Assessment
Assessment by Product Type
Assessment by Stage and Product Type
Assessment by Route of Administration
Assessment by Stage and Route of Administration
Assessment by Molecule Type
Assessment by Stage and Molecule Type
PRMT5 protein inhibitors – DelveInsight’s Analytical Perspective
Late Stage Products (Phase III)
Comparative Analysis
Drug name: Company name
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
Comparative Analysis
Pemrametostat: GlaxoSmithKline
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Early Stage Products (Phase I)
Comparative Analysis
PRT811: Prelude Therapeutics
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Pre-clinical and Discovery Stage Products
Comparative Analysis
AMG 193: Amgen
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Inactive Products
Comparative Analysis
PRMT5 protein inhibitors Key Companies
PRMT5 protein inhibitors Key Products
PRMT5 protein inhibitors- Unmet Needs
PRMT5 protein inhibitors- Market Drivers and Barriers
PRMT5 protein inhibitors- Future Perspectives and Conclusion
PRMT5 protein inhibitors Analyst Views
PRMT5 protein inhibitors Key Companies
Appendix

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