Beta-Lactamase Inhibitor - Pipeline Insight, 2024

Beta-Lactamase Inhibitor - Pipeline Insight, 2024



DelveInsight’s, “Beta-Lactamase Inhibitor - Pipeline Insight, 2024” report provides comprehensive insights about 12+ companies and 12+ pipeline drugs in Beta-Lactamase Inhibitor pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered
  • Global coverage
Beta-Lactamase Inhibitor Understanding

Beta-Lactamase Inhibitor: Overview

Beta-lactamases are an important group of bacterial enzymes, which preferentially cleave the beta-lactam ring of penicillins, cephalosporins, or other medically important beta-lactam antibiotics.

Function - Beta-lactamase provides antibiotic resistance by breaking the antibiotics' structure. These antibiotics all have a common element in their molecular structure: a four-atom ring known as a β-lactam. Through hydrolysis, the enzyme lactamase breaks the β-lactam ring open, deactivating the molecule's antibacterial properties.

Beta-Lactamase Inhibitors - Beta-lactamase inhibitors are drugs that are co-administered with beta-lactam antimicrobials to prevent antimicrobial resistance by inhibiting serine beta-lactamases, which are enzymes that inactivate the beta-lactam ring, which is a common chemical structure to all beta-lactam antimicrobials. This activity outlines the different types of beta-lactamase inhibitors.

Beta-Lactamase Inhibitor Emerging Drugs Chapters

This segment of the Beta-Lactamase Inhibitor report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Beta-Lactamase Inhibitor Emerging Drugs
  • Durlobactam/sulbactam: Entasis Therapeutics
Durlobactam (DUR; previously designated ETX2514) is a novel, broad-spectrum and potent inhibitor of Class A, C, and D β-lactamases. Sulbactam (SUL) is a β-lactam antibiotic with activity against Acinetobacter baumannii; however, β-lactamase-mediated resistance to sulbactam is now widespread rendering it generally ineffective. In preclinical studies, durlobactam inhibits the β-lactamases commonly found in A. baumannii thus restoring sulbactam’s activity. The company is developing SUL-DUR (previously designated ETX2514SUL), a combination of β-lactam antibiotic and a β-lactamase inhibitor for the treatment of serious infections cuased by Acinetobacter, including multidrug-resistant (MDR) strains. Currently, it is in phase 3 stage of development for the treatment of Acinetobacter infections.
  • Ceftibuten/VNRX 7145: VenatoRx Pharmaceuticals
VNRX-7145, an orally bioavailable beta-lactamase inhibitor (BLI) that in a fixed combination with the third generation orally bioavailable cephalosporin, ceftibuten, has the potential to rescue activity of the partner antibiotic against extended spectrum beta-lactamases (ESBLs) and key carbapenem-resistant Enterobacterales (CRE), including those expressing Klebsiella pneumoniae carbapenemase (KPC) and Oxacillinase (OXA) carbapenemases.

Further product details are provided in the report……..

Beta-Lactamase Inhibitor: Therapeutic Assessment

This segment of the report provides insights about the different Beta-Lactamase Inhibitor drugs segregated based on following parameters that define the scope of the report, such as:
  • Major Players working on Beta-Lactamase Inhibitor
There are approx. 12+ key companies which are developing the Beta-Lactamase Inhibitor. The companies which have their Beta-Lactamase Inhibitor drug candidates in the most advanced stage, i.e. phase III include, Entasis Therapeutics.
  • Phases
DelveInsight’s report covers around 12+ products under different phases of clinical development like
  • Late-stage products (Phase III and
  • Mid-stage products (Phase II and
  • Early-stage products (Phase I/II and Phase I) along with the details of
  • Pre-clinical and Discovery stage candidates
  • Discontinued & Inactive candidates
  • Route of Administration
Beta-Lactamase Inhibitor pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
  • Infusion
  • Intradermal
  • Intramuscular
  • Intranasal
  • Intravaginal
  • Oral
  • Parenteral
  • Subcutaneous
  • Topical.
  • Molecule Type
Products have been categorized under various Molecule types such as
  • Vaccines
  • Monoclonal Antibody
  • Peptides
  • Polymer
  • Small molecule
  • Product Type
Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Beta-Lactamase Inhibitor: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Beta-Lactamase Inhibitor therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Beta-Lactamase Inhibitor drugs.

Report Highlights
  • The companies and academics are working to assess challenges and seek opportunities that could influence Beta-Lactamase Inhibitor R&D. The therapies under development are focused on novel approaches for Beta-Lactamase Inhibitor.
Beta-Lactamase Inhibitor Report Insights
  • Beta-Lactamase Inhibitor Pipeline Analysis
  • Therapeutic Assessment
  • Unmet Needs
  • Impact of Drugs
Beta-Lactamase Inhibitor Report Assessment
  • Pipeline Product Profiles
  • Therapeutic Assessment
  • Pipeline Assessment
  • Inactive drugs assessment
  • Unmet Needs
Key Questions

Current Scenario and Emerging Therapies:
  • How many companies are developing Beta-Lactamase Inhibitor drugs?
  • How many Beta-Lactamase Inhibitor drugs are developed by each company?
  • How many emerging drugs are in mid-stage, and late-stage of development for Beta-Lactamase Inhibitor?
  • What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Beta-Lactamase Inhibitor therapeutics?
  • What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for Beta-Lactamase Inhibitor and their status?
  • What are the key designations that have been granted to the emerging drugs?
Key Players
  • Entasis Therapeutics
  • VenatoRx Pharmaceuticals
  • Qpex Biopharma
  • Boston Pharmaceuticals
  • Merck Sharp and Dohme
  • Fedora Pharmaceuticals
  • Allecra Therapeutics
  • AbbVie
  • Arixa Pharmaceuticals
  • LegoChem Biosciences
  • Yuhan
  • Allergan
  • AstraZeneca
  • Antabio
  • Infex Therapeutics
Key Products
  • Durlobactam/sulbactam
  • Ceftibuten/VNRX 7145
  • QPX 7728
  • BOS 572
  • MK-7655A
  • Nacubactam
  • AAI-202
  • ATM-AVI
  • ARX 1796
  • LCB18 0055
  • YH-1177D
  • CEF-104
  • ANT2681


Introduction
Executive Summary
Beta-Lactamase Inhibitor: Overview
Structure
Mechanism of Action
Pipeline Therapeutics
Comparative Analysis
Therapeutic Assessment
Assessment by Product Type
Assessment by Stage and Product Type
Assessment by Route of Administration
Assessment by Stage and Route of Administration
Assessment by Molecule Type
Assessment by Stage and Molecule Type
Beta-Lactamase Inhibitor – DelveInsight’s Analytical Perspective
In-depth Commercial Assessment
Beta-Lactamase Inhibitor companies’ collaborations, Licensing, Acquisition -Deal Value Trends
Beta-Lactamase Inhibitor Collaboration Deals
Company-Company Collaborations (Licensing / Partnering) Analysis
Company-University Collaborations (Licensing / Partnering) Analysis
Late Stage Products (Phase III)
Comparative Analysis
Durlobactam/sulbactam: Entasis Therapeutics
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
Comparative Analysis
CEF-104 : Allergan
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Early Stage Products (Phase I)
Comparative Analysis
QPX 7728: Qpex Biopharma
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Pre-clinical and Discovery Stage Products
Comparative Analysis
LCB18 0055: LegoChem Biosciences
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Inactive Products
Comparative Analysis
Beta-Lactamase Inhibitor Key Companies
Beta-Lactamase Inhibitor Key Products
Beta-Lactamase Inhibitor- Unmet Needs
Beta-Lactamase Inhibitor- Market Drivers and Barriers
Beta-Lactamase Inhibitor- Future Perspectives and Conclusion
Beta-Lactamase Inhibitor Analyst Views
Beta-Lactamase Inhibitor Key Companies
Appendix

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