Advanced Kidney Cancer - Pipeline Insight, 2024

Advanced Kidney Cancer - Pipeline Insight, 2024

DelveInsight’s, “Advanced Kidney Cancer - Pipeline Insight, 2024” report provides comprehensive insights about 50+ companies and 55+ pipeline drugs in Advanced Kidney Cancer pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered

Global coverage

Advanced Kidney Cancer: Understanding

Advanced Kidney Cancer: Overview

Advanced Kidney Cancer (also known as advanced renal cell carcinoma) is the most common type of cancer arising in the kidney, making up more than 9 out of 10 renal cancers in adults. Other types include transitional cell carcinomas of the renal pelvis, which behave like bladder cancers. Renal sarcoma is another rare tumor of the kidney. Cigarette and cigar smoking are the strongest risk factors for renal cell carcinoma (RCC), with obesity, especially in women, being another major risk factor. Eliminating tobacco smoking and excess body weight could potentially halve the incidence of kidney cancers. Other contributing risk factors include high blood pressure, chronic renal failure, and occupational exposure to certain chemicals. Moderate alcohol consumption, a diet rich in fruits and vegetables, and long-term fatty fish consumption are associated with reduced RCC risk. Mutations in the VHL gene are implicated in the development of both sporadic and familial clear cell RCC, while the MET gene is a feature of the familial type of papillary RCC.

Prescribing systemic therapy for advanced or metastatic RCC requires oncology specialists knowledgeable about the disease, drug, toxicities, interactions, and treatment monitoring. Patients benefit from a multidisciplinary approach with nursing, dietary, and pharmacy support for optimal management. Regular patient evaluations are crucial to identify and manage toxicities effectively, ensuring patient safety and treatment efficacy. Providing comprehensive information on potential side effects, prevention, and management to patients and caregivers is essential for informed decision-making and care.

Accurate staging is crucial for the effective management of renal cell carcinoma (RCC), with stage-dependent therapeutic options. In Stage 1a, tumors confined to the kidney are treated with curative intent through complete surgical resection, preferably with nephron-sparing partial nephrectomy. Surveillance includes abdominal CT or MRI within six months of initiation and annual imaging thereafter. For Stage 1b, partial or radical nephrectomy is recommended, with follow-up imaging schedules varying post-surgery. Stages 2 and 3 typically involve radical nephrectomy, with specific follow-up imaging protocols. In Stage 4, systemic targeted molecular therapies like VEGF-TKIs or rapamycin inhibitors are preferred over immunotherapy, with nephrectomy followed by immunotherapy showing improved survival. Follow-up includes pretreatment imaging and regular monitoring every 6 to 16 weeks based on clinical status.

""Advanced Kidney Cancer- Pipeline Insight, 2024"" report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Advanced Kidney Cancer pipeline landscape is provided which includes the disease overview and Advanced Kidney Cancer treatment guidelines. The assessment part of the report embraces, in depth Advanced Kidney Cancer commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Advanced Kidney Cancer collaborations, licensing, mergers and acquisition, funding, designations and other product related details.

Report Highlights

The companies and academics are working to assess challenges and seek opportunities that could influence Advanced Kidney Cancer R&D. The therapies under development are focused on novel approaches to treat/improve Advanced Kidney Cancer.

Advanced Kidney Cancer Emerging Drugs Chapters

This segment of the Advanced Kidney Cancer report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II/III, II, I, preclinical and discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Advanced Kidney Cancer Emerging Drugs

Savolitinib: AstraZeneca

Savolitinib is an oral, potent, and highly selective MET TKI that has demonstrated clinical activity in advanced solid tumors. It blocks atypical activation of the MET receptor tyrosine kinase pathway that occurs because of mutations or gene amplification. The drug is currently being evaluated under Phase III clinical trial for the treatment of advanced kidney cancer.

Relatlimab: Bristol-Myers Squibb

Relatlimab is a lymphocyte activation gene-3 (LAG-3) blocking antibody and is expressed in a recombinant CHO cell line. The drug is currently being evaluated under Phase II clinical trial for the treatment of patients with advanced kidney cancer.

JANX008: Janux Therapeutics

JANX008 is an EGFR-TRACTr that is designed to overcome CRS and known on-target EGFR healthy tissue toxicities. Epidermal growth factor receptor (EGFR) is a clinically validated target highly expressed on many solid tumors that are being underserved by current therapies. JANX008 targets EGFR for the treatment of multiple solid cancers including, but not limited to, colorectal cancer (CRC), squamous cell carcinoma of the head and neck (SCCHN), non-small cell lung cancer (NSCLC), and renal cell carcinoma (RCC). The drug is currently being evaluated under Phase I clinical trial for the treatment of Advanced Kidney Cancer.

Further product details are provided in the report……..

Advanced Kidney Cancer: Therapeutic Assessment

This segment of the report provides insights about the different Advanced Kidney Cancer drugs segregated based on following parameters that define the scope of the report, such as:

Major Players in Advanced Kidney Cancer

There are approx. 50+ key companies which are developing the therapies for Advanced Kidney Cancer. The companies which have their Advanced Kidney Cancer drug candidates in the most advanced stage, i.e. Phase III include, AstraZeneca.

Phases

DelveInsight’s report covers around 55+ products under different phases of clinical development like

Late stage products (Phase III)

Mid-stage products (Phase II)

Early-stage product (Phase I) along with the details of

Pre-clinical and Discovery stage candidates

Discontinued & Inactive candidates

Route of Administration

Advanced Kidney Cancer pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

Intravenous

Subcutaneous

Oral

Intramuscular

Molecule Type

Products have been categorized under various Molecule types such as

Monoclonal antibody

Small molecule

Peptide

Product Type

Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Advanced Kidney Cancer: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Advanced Kidney Cancer therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Advanced Kidney Cancer drugs.

Advanced Kidney Cancer Report Insights

Advanced Kidney Cancer Pipeline Analysis

Therapeutic Assessment

Unmet Needs

Impact of Drugs

Advanced Kidney Cancer Report Assessment

Pipeline Product Profiles

Therapeutic Assessment

Pipeline Assessment

Inactive drugs assessment

Unmet Needs

Key Questions

Current Treatment Scenario and Emerging Therapies:

How many companies are developing Advanced Kidney Cancer drugs?

How many Advanced Kidney Cancer drugs are developed by each company?

How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Advanced Kidney Cancer?

What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Advanced Kidney Cancer therapeutics?

What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?

What are the clinical studies going on for Advanced Kidney Cancer and their status?

What are the key designations that have been granted to the emerging drugs?

Key Players

Janux Therapeutics

Infinity Pharmaceuticals

Merck Sharp & Dohme

Xencor

Exelixis

X4 Pharmaceuticals

Nykode Therapeutics

Tarus Therapeutics

AstraZeneca

RemeGen

NiKang Therapeutics

NGM Biopharmaceuticals

MedImmune

Key Products

JANX008

IPI-549

Belzutifan

XmAb 808

XL092

X4P-001

VB10.NEO

TT-10

Savolitinib

RC198

NKT2152

NGM707

MEDI5752

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