Global angiotensin ii receptor blockers market - 2024-2031

Global angiotensin ii receptor blockers market - 2024-2031

The global angiotensin ii receptor blockers market reached US$YY million in 2023 and is expected to reach US$YY million by 2031, growing at a CAGR ofYY% during the forecast period 2024-2031.

Angiotensin II receptor blockers, or angiotensin II receptor antagonists, are medications used to treat hypertension and heart failure. They are also used to treat chronic kidney disease and are prescribed after a heart attack.

Candesartan, Losartan, and Valsartan are a few of them. An ARB is a drug whose name ends in ""Sartan."" Angiotensin II hormone actions are mitigated by RBs. Due to its significant blood artery constriction, this hormone raises blood pressure.

Further elevation of blood pressure is caused by angiotensin II's promotion of the body's retention of water and salt. When a hormone binds to certain receptors, like the AT1 receptors in blood vessels, the kidneys, heart, and kidneys, ARBs block that hormonal activation. The action of angiotensin II can be blocked to lower blood pressure and prevent renal and cardiac damage.

Market Dynamics: Drivers

Increasing Demand for Drugs to Treat High Blood Pressure and Heart Failure

Multiple factors drive the demand for the angiotensin ii receptor blockers market. Angiotensin II receptor blockers inhibit the effects of angiotensin II. It causes blood vessels to constrict, which can lead to hypertension. ARBs aid in expanding blood vessels, lowering blood pressure, and making it easier for the heart to pump blood.

Angiotensin II receptor blockers relax the veins and arteries, lowering blood pressure and making it easier for the heart to pump blood. Angiotensin is a chemical in the body that causes blood vessels to constrict. This constriction can raise blood pressure and make the heart work harder. To treat heart failure, drugs known as angiotensin receptor blockers (ARBs) such as losartan, candesartan, eprosartan, irbesartan, telmisartan, and valsartan are commonly used.

Heart failure is a major and growing public health issue. The overall prevalence of clinically identified heart failure is estimated to be 3–20 cases/1000 population, but this rises to more than 100 cases/1000 in those over 65. Hence, with the growing prevalence of heart failure, the global angiotensin II receptor blockers market is expected to grow.

The market for ARB II medications will also expand as a result of expanding initiatives by public and private institutions as well as increased global awareness of hypertension. The hypertension awareness emblem will be discontinued by Glenmark Pharmaceuticals in May 2022.

A hypertension awareness campaign was also conducted in India in May 2022 by the Namya Smile Foundation (NSF). The organization conducted a camp to check the blood pressure and made them aware of various aspects of high blood pressure.

Restraints

Factors such as the various side effects associated with angiotensin drugs, regulatory challenges, competition from substitutes, lack of awareness about the usage of medicine, drug recalls and competition from generic drugs are expected to hamper the market.

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Segment Analysis

The angiotensin ii receptor blockers market is segmented based on type, application, end-user, and region.

The valsartan segment accounted for approximately 43.2% of the angiotensin II receptor blockers market share

The Valsartan segment is expected to hold the largest market share over the forecast period. Valsartan, known as Diovan, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease. It is an acceptable first-line treatment for high blood pressure. It is taken orally.

It is an angiotensin II receptor blocker used alone or in combination with other medications to treat hypertension and lower cardiovascular mortality after a heart attack. Valsartan is available in 40mg, 80mg, 160mg, and 320mg and is available as a hard capsule. Novartis manufactures brand-name drugs containing the active ingredient valsartan. Diovan, Diovan HCT, Entresto, Exforge, and Exforge HCT are their brand-name valsartan products.

Additionally, various strategies adopted by the key market players such as product launches and mergers and acquisitions support the market growth. In this Valsartans segment, other sartan drugs help to drive the market growth.

For instance, Hanmi Pharmaceutical declared in May 2022 that it will begin selling Amosartan, the popular medication for hypertension, in China under the Meiyaping brand. It was the first blood pressure combination medication produced domestically to be sold in China.

Dr.Reddy's launched Valsatan tables into the U.S. market. These individuals need treatment for heart failure and elevated blood pressure in December 2021. With this launch, Dr. Reddy's market share in the US market has increased and patients have access to a less expensive substitute for the FDA-approved brand drug Diovan.

Geographical Analysis

North America accounted for approximately 40.7% of the angiotensin ii receptor blockers market share

North America region is expected to hold the largest market share over the forecast period. The increasing prevalence of kidney disease, heart failure, and hypertension is expected to drive the market growth in this region.

For instance, according to the National Institute on Diabetes and Digestive and Kidney Diseases, chronic kidney disease (CKD) affects more than one in every seven adults in the United States, totaling an estimated 37 million people.

In April 2021, United Therapeutics Corporation announced that the United States Food and Drug Administration approved its drug for the treatment of pulmonary hypertension associated with interstitial lung disease, known as Tyvaso (Treprostinil).

In addition, as per the travel therapeutics press release in February 2023, IgAN is a rare kidney disease (RKD) and a leading cause of kidney failure due to glomerular disease, affecting up to 150,000 people in the U.S., with approximately 30,000 to 50,000 of such patients estimated to be addressable under the indication approved via accelerated approval.

CKD risk is even higher for Americans who have diabetes or high blood pressure, the two most common causes of kidney disease. Reducing blood pressure caused by systemic vasodilation with an ARB contributes to its beneficial effects in treating kidney disease. Furthermore, ARB-induced renal vasodilation increases renal blood flow, which improves renal ischemia and hypoxia.

Moreover, the increasing FDA approvals in this region are expected to drive market growth. For instance, on December 24th, 2021, Lupin received preliminary approval from the US Food and Drug Administration (FDA) for its Abbreviated New Drug Application (ANDA) Azilsartan Medoxomil Tablets, 40 mg, and 80 mg, to market a generic equivalent of Edarbi Tablets.

The other factors such as increasing awareness among the people about hypertension in the region. For instance, in November 2021, New public service announcements (PSAs) were released by the American Heart Association (AHA), American Medical Association (AMA), HHS Office of Minority Health (OMH), Health Resources & Services Administration (HRSA), and the Ad Council to encourage people to take charge of their health by self-monitoring their blood pressure and talking with a healthcare provider about their numbers.

COVID-19 Impact Analysis

The COVID-19 pandemic significantly impacted the angiotensin ii receptor blockers market. Angiotensin Receptor Blockers (ARBs) have significant pleiotropic protective effects in addition to their antihypertensive properties, including inflammation reduction. ARBs directly protect the lungs from severe acute respiratory syndrome caused by viral infections, including coronavirus infections.

ARB administration enhances ACE2's protective effect. For these reasons, ARB therapy must be maintained in patients with hypertension, diabetes, and renal disease, all of which are comorbidities of the current COVID-19 pandemic.

The ability of ARBs to reduce inflammation and endothelial and epithelial dysfunction in many organs is a significant benefit. ARBs directly protect the lung endothelial barrier integrity after acute injuries caused by many viruses. Hence, the angiotensin II receptor blockers market is expected to grow due to the COVID-19 impact.

Market Segmentation

By Type
• Valsartan
• Azilsartan
• Candesartan
• Eprosartan
• Irbesartan
• Losartan
• Olmesartan
• Telmisartan
• Others

By Application
• Heart Failure
• Hypertension
• Kidney Disease
• Others

By End-Users
• Hospitals
• Specialty Clinics
• Ambulatory Surgical Centers
• Other

By Region
• North America
U.S.
Canada
Mexico
• Europe
Germany
U.K.
France
Spain
Italy
Rest of Europe
• South America
Brazil
Argentina
Rest of South America
• Asia-Pacific
China
India
Japan
South Korea
Rest of Asia-Pacific
• Middle East and Africa

Competitive Landscape

The major global players in the angiotensin II receptor blockers market include Novartis AG, Daiichi Sankyo Co. Ltd, Lupin Ltd, Novartis AG, Takeda Pharmaceutical Co. Ltd, AstraZeneca, Sanofi S.A., Merck & Co., Inc., Boehringer Ingelheim, Abbive Inc, Zydus Cadila among others.

Key Developments

 On March 26, 2024, Otsuka Pharmaceutical Co., Ltd. announced that Novartis Pharma K.K. has received approval for Entresto Granular Tablets for Pediatric Use 12.5 mg / 31.25 mg (generic name: sacubitril valsartan sodium hydrate, hereinafter referred to as Entresto Granular Tablets), an angiotensin receptor neprilysin inhibitor (ARNI).

 On February 17, 2023, Travere Therapeutics, Inc. announced that the U.S. Food and Drug Administration (FDA) has granted accelerated approval to FILSPARI (spartan) to reduce proteinuria in adults with primary IgAN at risk of rapid disease progression, generally a urine protein-to-creatinine ratio (UPCR) ≥1.5 g/g.

 On February 16th, 2021, the FDA-approved Novartis Entresto (sacubitril/valsartan) helped to reduce the risk of cardiovascular hospitalization and death for heart failure in adult patients with chronic heart failure.



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