Global Spatial Genomics and Transcriptomics Market - 2022-2029

Global Spatial Genomics and Transcriptomics Market - 2022-2029

Market Overview

The global spatial genomics & transcriptomics market is estimated to reach US$ XX million by 2029, growing at a CAGR of 9.35% during the forecast period (2022-2029).

Spatial transcriptomics is a ground-breaking molecular profiling technology that allows scientists to map all gene activity in a tissue sample and analyze it and spatial genomics is a new field of molecular biology that tries to examine the genomic information of single cells in their natural tissue context.

Market Dynamics

The spatial genomics and transcriptomics market will rise rapidly because of the emerging potential of spatial genomic analysis as a cancer diagnostic tool and the arrival of the fourth generation of sequencing.The spatial patterns of the genome have been recognized for treating various medical conditions, resulting in the use of spatial information as a diagnostic biomarker for a variety of diseases. There is a growing insistence for biomarkers, which allow for more accurate differentiation of benign tumors from malignant tumors, increasing the demand for spatial genomic analysis as a cancer diagnostic tool. As a result, the aggregate demand for robust cancer diagnostic solutions contributes to the overall market's growth.

Technological advancements in sequencing technologies will boost market growth.

Key market participants are concentrating on expanding their spatial transcriptomics and genomics footprints through strategic partnerships and collaborations with other players. Furthermore, the companies are developing strategies to broaden their customer base worldwide. Dovetail Genomics, for example, announced the global availability of its Dovetail HiChIP and Micro-C Kits in February 2020.

Dovetail Micro-C kits provide better resolution of chromatin contacts at the mononucleosome level. In contrast, HiChIP technology combines the Micro-C and ChIP-seq technologies into a single workflow, allowing assaying protein-directed alterations to chromatin architecture and assessing their impact on gene expression.

Furthermore, rapid advances in fluorescence in-situ hybridization, microscopy-based live DNA imaging, and other biochemical techniques have aided the advancement of spatial genomics. Spatial genomics and transcriptomics are rapidly evolving research fields that aim to provide deeper insights into the cellular machinery, spatial organization, differentiation, and localization at the genomic and transcriptomics levels in tissues and cells. Spatial transcriptomics is a broad term used to describe methods for assigning cell types to specific locations across tissue samples. Spatial transcriptomics is a revolutionary technology that allows in-depth research into cell composition, physiology, and disease development. The increasing prevalence of chronic diseases such as aggressive cancers, cardiovascular disorders, neurological disorders, and malignant tumors has increased the demand for biomarker identification. It has simplified drug discovery and development processes to evaluate drug safety and efficacy even further. This is expected to drive demand for spatial transcriptomics technologies and market growth during the forecast period.

The scarcity of trained specialists and a lack of awareness about modern sequencing technologies will likely hamper the market growth.

However, over the projection period, a scarcity of trained specialists and a lack of awareness about modern sequencing technologies are expected to limit market growth to some extent. Since spatial genomics and transcriptomics are still developing fields of study, knowledge is scarce, which may impede market growth throughout the projection period. Furthermore, over the projected period, high equipment costs and a low rate of adoption of transcriptomics technologies in developing countries are expected to limit market growth to some extent.

COVID-19 Impact Analysis

The COVID-19 outbreak has deranged workflows in the healthcare sector worldwide. The disease has forced several industries, including several sub-domains of health care, to close their doors temporarily. The global spatial genomics and transcriptomics market fell in 2020 due to the global economic recession caused by COVID-19. Furthermore, the COVID-19 outbreak disrupted the supply chain in various end-user industries, including academic and research, pharmaceutical and biotechnological, and others. The pandemic's impact and the slowing of global research activities have harmed the operations and financial performance of many market participants. The closure of academic and research institutes has resulted in a decrease in the sales of consumables and reagents used in spatial genomics and transcriptomics analysis. However, the market will recover in 2021 due to an increase in the use of spatial genomics and transcriptomics to profile COVID-19 tissue autopsies and an increase in biomarker identification and use in drug discovery and development programs.

Segment Analysis

The spatial transcriptomics segment is expected to grow at the fastest CAGR during the forecast period (2022-2029)

The spatial transcriptomics segment dominated the market due to its widespread adoption in the transcriptomic study of single cells when compared to spatial genomic methods. The availability of automated sequencing methodologies, such as laser capture microdissection technique (LCM), to meet the expanding demand for nucleic acid sequencing of biological specimens or single cells can also be attributed to the growth of this segment.

The need for robust, automated and scalable library preparation solutions has increased as the sequencing of nucleic acids from single cells or specific biological specimens has increased. Furthermore, a better understanding of tissue heterogeneity has led to several novel sequencing workflows aimed at inferring or preserving spatial information. This has also resulted in a faster revenue flow in this segment.

Determining the spatial arrangement of molecules in cells and tissue samples is the foundation of biological research and clinical practice. It has piqued the interest of several entities involved in genetics. Furthermore, advances in genome perturbation tools, such as the CRISPR/Cas9 system, facilitate the adoption of spatial genomic tools, driving the segment.

Geographical Analysis

North America region holds the largest market share of global spatial genomics and transcriptomics market

North America is expected to contribute the most revenue to the global market over the forecast period, owing to increased investment in genomic R&D initiatives, a growing emphasis on disease pathology research, and technological advancements in biomedical techniques and sequencing technologies. The region's strong presence of key companies is also expected to support market growth in the coming years. In April 2021, Vizgen, a biotech company based in the United States that develops solutions for next-generation spatially resolved, single-cell transcriptomics, has closed a USD 37 million Series B funding round, which will be used to accelerate infrastructure development in preparation for the commercial launch of the MERSCOPE Platform to advance spatial genomics research. The website provides information on various tissue-based research and translation medicine topics, including neurology, oncology, and immunology.

The Asia Pacific is expected to grow rapidly during the forecast period. International collaboration and partnership between Asian research institutes and global companies to propel technology usage across Asian countries are driving revenue in this region. In February 2020, for example, the RIKEN Center for Integrative Medical Sciences (IMS) joined the S2 Genomics Early Technology Access Program to assess and establish single-cell sequencing applications on S2 Genomics' Singulator tissue preparation system. This project assessed the system's performance and created a new set of applications for the company's platform.

Competitive Landscape

The spatial genomics and transcriptomics market is fiercely competitive, with several main players. Few big firms currently dominate the market in terms of market share. Some of the key players which are contributing to the growth of the market include NanoString Technologies Inc, S2 Genomics Inc, Akoya Biosciences, ION path Inc, Fluidigm Corporation, 10X Genomics Inc, BioSpyder Technologies, Rebus Biosystems LLC, Resolve Biosciences, Vizgen Corporation. The major players are adopting several growth strategies such as product launches, acquisitions, and collaborations, which are contributing to the growth of the spatial genomics and transcriptomics market globally. For instance, in February 2020, ReadCoor, Inc. debuted its first product line, which includes the RC2 instrument and multi-omic spatial sequencing assays. To operate, the instrument uses the company's Fluorescent In Situ Sequencing (FISSEQ) technology.

Key Developments

In August 2020, Cancer Transcriptome Atlas is a new product from NanoString Technologies based on the company's GeoMx Digital Spatial Profiler (DSP) platform. It is optimized for readout on Illumina's next-generation sequencing (NGS) technology.

In Februray 2020, S2 Genomics has introduced the Singulator 100 System, which automates the processing of solid tissue samples into suspensions of single cells or nuclei with high yields and from small samples for a variety of single-cell biology and genomic analyses.

In April 2017, NuGEN Technologies, Inc. has released the Trio RNA-Seq kits and the Universal Plus mRNA-Seq kits, which aid in RNA-Seq analyses from monotonous samples isolated from sources. Trio RNA-Seq provides an extremely delicate complete transcriptomics solution that is best suited for applications with low profusion transcripts, such as biomarker evaluation or viral transcript detection in liquid biopsy samples.

NanoString Technologies Inc

Overview: NanoString Technologies is a publicly-traded company that makes life science technologies for molecular diagnostics and translational research. The company's technology can be used for various applications in basic research, translational medicine, and in vitro diagnostics.

Product Portfolio:

GeoMx: By generating entire digital transcriptomes and profiling data for 100s of verified Protein analytes from up to 12 tissue slides each day, NanoString's GeoMx Digital Spatial Profiler (DSP) combines the finest spatial and molecular profiling technology. Researchers can quickly and quantitatively examine the biological implications of tissue heterogeneity using this unique mix of high-plex and high-throughput spatial profiling.

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