Global Refractory Status Drugs Epileptics Market - 2023-2030

Global Refractory Status Drugs Epileptics Market - 2023-2030

Global Refractory Status Epileptics Drugs Market reached US$ XX billion in 2022 and is expected to reach US$ XX billion by 2030, growing with a CAGR of XX% during the forecast period 2023-2030.

Refractory status epilepticus are referred to as persistent seizures that are resistant to two intravenous drugs, one of which is a benzodiazepine. Up to 40% of status epilepticus instances exhibit it, with acute symptomatic etiology being the most likely reason.

Drugs used for the the treatment of refractory status epileptics are benzodiazepines which include lorazepam and diazepam. Moreover, antiepileptic drugs include phenytoin, fosphenytoin, and valproic acid. Furthermore, anaesthetic agents such as midazolam and propofol. Lastly, barbiturates such as pentobarbital and thiopental are some of the treatments available in the market used for the treatment of refractory status epileptics.

Some of the other emerging drugs and methods used for the treatment of refractory status epileptics according to the National Library of Medicines(NLM), include hypothermia, steroids, immunosuppressive agents, electrical and magnetic stimulation therapies, emergent respective epilepsy surgery, ketogenic diet, pyridoxine infusion, cerebrospinal fluid drainage, and magnesium infusion.

Dynamics

Increase in the Announcement of New Methods by the Companies for the Status Epilepticus

An increase in the announcement of new methods by the companies for status epilepticus is expected to drive the market's growth.. For instance, on June 21, 2023, Marinus Pharmaceuticals announced a new method of use patent granted for IV Ganaxolone by the USPTO in status epilepticus.

Increase In FDA Clearance Of Companies' Software With The Inclusion Of Centers for Medicare and Medicaid Services (CMS) NTAP Coverage

An increase in FDA clearance of companies' software with the inclusion of CMS NTAP Coverage is expected to foster the growth of the global refractory status epileptics drugs market.

For instance, in August 2023, the FDA granted 510(k) clearance to Ceribell’s new software, named ClarityPro, for the diagnosis of electrographic status epilepticus (ESE) in adults above the age of 18, which became the first tool available in the market. Moreover, CMS gave new technology add-on payment (NTAP) for ClarityPro for up to $913.90 per eligible medicare patient case. Thus, owing to the above factors it is expected to drive the market's growth over the forecast period.

Stringent Regulatory Requirements

The pharmaceutical sector is governed by a number of laws and regulations, particularly when it comes to creating medications for severe illnesses such as refractory status epilepticus. It can be difficult and time-consuming to obtain regulatory approvals from organizations like the European Medicines Agency (EMA) and the U.S. Food and Drug Administration (FDA). The availability of new RSE medications on the market may be delayed as a result of meeting these requirements, thus reducing treatment for patients options.

Segment Analysis

The global refractory status epileptics drugs market is segmented based on drug type, route of administration, distribution channel and region.

Benzodiazepines From The Drug Type to Hold a Dominant Position in the Market over the Forecast Period.

benzodiazepines from the drug type are expected to dominate the refractory status epileptics drugs market with a market share of 34.5%. For instance, In June 2022, anticonvulsant therapies in the benzodiazepine class successfully suppressed nearly 62% of all episodes of status epilepticus in children. First-line approaches usually include BZDs, which act to slow the excessive nerve cell activity that causes seizures.

Geographical Penetration

North America Holds The Largest Market Share In The Global Refractory Status Epileptics Drugs Market

North America dominates the global refractory status epileptics drugs market with a market share of around 41.3% in 2022. Furthermore, In March 2022, the FDA approved Ztalmy (ganaxolone) to treat seizures associated with cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) in patients 2 years of age and older. CDD is a rare developmental epileptic encephalopathy (dysfunction of the brain) caused by CDKL5 gene mutations. Thus, owing to the above factors North America is expected to hold the largest share in the market over the forecast period.

Competitive Landscape

The major global players in the market include Pfizer, Almatica Pharma LLC., Teva Pharmaceuticals USA, Inc., Genentech, Inc., Viatris Inc., NAYZILAM, SiNi Pharma Pvt Ltd, H. Lundbeck A/S, Wellona Pharma and Bausch Health Companies Inc among others.

Market Segmentation

By Drug Type
• Benzodiazepines
Lorazepam
Diazepam
• Antiepileptic Drugs
Phenytoin
Fosphenytoin
Valproic acid
Others
• Anesthetic Agents
Midazolam
Propofol
• Barbiturates
Pentobarbital
Thiopental
Others

By Route of Administration
• Oral
• Intravenous (IV)
• Intramuscular (IM)
• Sublingual or Buccal
• Others

By Distribution Channel
• Hospital Pharmacy
• Retail Pharmacy
• Online Pharmacy

By Region
• North America
U.S.
Canada
Mexico
• Europe
Germany
UK
France
Italy
Spain
Rest of Europe
• South America
Brazil
Argentina
Rest of South America
• Asia-Pacific
China
India
Japan
Australia
Rest of Asia-Pacific
• Middle East and Africa

Key Developments
• In February 2021, Marinus Pharmaceuticals stated that they have enrolled their first patient in the phase 3 RAISE clinical trial of intravenous (IV) ganaxolone.

Why Purchase the Report?
• To visualize the global refractory status epileptics drugs market segmentation based on drug type, route of administration, distribution channel and region as well as understand key commercial assets and players.
• Identify commercial opportunities by analyzing trends and co-development.
• Excel data sheet with numerous data points of cement market-level with all segments.
• PDF report consists of a comprehensive analysis after exhaustive qualitative interviews and an in-depth study.
• Product mapping available as excel consisting of key products of all the major players.

The global refractory status epileptics drugs market report would provide approximately 61 tables, 61 figures and 227 Pages.

Target Audience 2023
• Manufacturers/ Buyers
• Industry Investors/Investment Bankers
• Research Professionals
• Emerging Companies