Global DNA Methylation Sequencing Market - 2021-2028
Market Overview
The global DNA methylation sequencing market size was valued US$ XX million in 2020 and is estimated to reach US$ XX million by 2028, growing at a CAGR of XX% during the forecast period (2021-2028).
DNA methylation is a heritable epigenetic marker that involves DNA methyltransferases covalently transferring a methyl group to the C-5 position of the cytosine ring of DNA (DNMTs). In humans, cytosines are primarily methylated in any context of the genome. More than 98 percent of DNA methylation occurs in somatic cells in a CpG dinucleotide context.
Market Dynamics
The existing DNA methylation market is favored by several factors, including a global increase in cancer prevalence, declining sequencing costs, and increasing sequencing output. Furthermore, an increasing number of product approvals and launches in the global DNA methylation market will provide a lucrative growth opportunity for this market. Furthermore, the market is being driven by an increase in early-stage biomarkers in cancer profiling.
Increase in prevalance of cancer in the market will drive the market growth
Oncology is one of the disciplines where DNA methylation technology is widely employed to develop therapeutic options for rectifying the cancer epigenome's transcriptional aberrations. Changes in gene function or expression and cellular transformation lead to cancer when epigenetic alterations, such as DNA methylation and histone modification, are disrupted. The importance of DNA methylation technology in oncology may be seen in developing inhibitors of DNA methyltransferases and histone deacetylases (HDACs), which have been proven to be clinically effective in cancer treatment. According to the World Health Organization, approximately 1.8 million new cancer cases were diagnosed worldwide in 2018. According to the WHO, nearly 70% of cancer deaths occur in low- and middle-income countries. Only one in five low- and middle-income countries has the data needed to drive cancer-related policies. This global and widespread threat of cancer remains a major motivator for developing new cancer therapies that aid in risk assessment, early diagnosis, and effective treatment monitoring.
Government funding is also one of the main growth factors for the DNA methylation market. Increased government funding will help research institutes and key players develop and market novel assays useful for diagnosing various tumors. As funding increases, the cancer profiling market will become more liquid, and companies will develop new testing methods to identify the underlying mutations that may cause the disease. As a result, all of these factors are expected to contribute to market growth during the forecast period.This contributes to the growth of the global DNA methylation sequencing market.
High cost of instrument is likely to hamper the market growth
In developing economies, research and development spending primarily rely on funding from outside sources. Although governments and private bodies try to fund research programs, many research firms and academic institutes face budget constraints. They cannot afford advanced and high-priced equipment and technologies, which harms the growth of these industries and their expansion in developing countries. Furthermore, there is a scarcity of skilled professionals in this industry, further impeding its growth. As a result, interpreting complex data takes time, and researchers face challenges, resulting in slow industry growth.
COVID-19 Impact Analysis
Covid-19 has had an important impact on the industry's growth, economy, health, and mental well-being. In this difficult situation, every industry strives to provide the highest quality and safest services possible. The Covid –19 epidemic has harmed the DNA methylation industry's growth. Government regulations have hampered the movement of people and goods around the country. Due to the shutdown, the manufacturing process, supply chain, and import and export of goods and services suffered .Furthermore, people with hereditary abnormalities or long-term ailments were put on wait while the virus-infected population was given priority. On the other hand, researchers have developed the application and use of PCR and other genetic testing technologies in determining the nature of coronavirus and treatment options. Because of its use in virus diagnosis, PCR has become extremely important during pandemics. This fueled the market's expansion and increased demand for DNA methylation worldwide.
Segment Analysis
The polymerase chain reaction segment is expected to grow at the fastest CAGR during the forecast period (2021-2028)
Polymerase Chain Reaction (PCR) and microarray are two DNA methylation techniques. Due to an increase in its application in diagnostics and DNA sequencing processes, the PCR segment held the largest market share in 2020. The expansion of DNA methylation was sparked by an increase in demand for PCR technology in diagnostics and genomics. PCR technique gained tremendous importance as a diagnostic method during Covid-19.
After bisulfite treatment, PCR-based approaches are commonly employed to investigate DNA methylation on a gene-by-gene basis. Bisulfite sequencing, methylation-specific PCR, real-time PCR-based MethyLight, and methylation-sensitive high-resolution melting PCR are variations of this approach. Several whole-epigenome profiling technologies, such as MethylC-seq reduced representation bisulfite sequencing (RRBS) and the Infinium Human methylation 450 K bead chip, are now available, allowing for the discovery of epigenetic drivers of disease processes as well as biomarkers that could be used in clinical practice.These factors are driving the growth of this segment.
Geographical Analysis
North America region holds the largest market share of global DNA methylation sequencing market
Due to the majority of companies in this region, North America accounted for the biggest market share in 2020. Furthermore, the region's vast network of manufacturing and R&D facilities and a surge in product launch and approvals and demand for protein expression systems all contribute to the growth of the DNA methylation market. The rise of the DNA methylation sector is fueled by the increased production of vaccines, antibodies, insulin, and hormones in this region. Furthermore, the United States is widely regarded as the world's top spender on healthcare facilities and research. During the projected period, the reasons mentioned above will contribute to the growth of the DNA methylation market.
The Asia Pacific area has the second-largest market share. Aside from technology developments, the DNA methylation sequencing service category is predicted to increase at a phenomenal rate over the study's forecast period. In addition to the areas mentioned above, Europe and South America held a significant market share in the worldwide DNA methylation market throughout the study period.
Competitive Landscape
The DNA methylation sequencing market is highly competitive with presence of local as well as global companies. Some of the key players which are contributing to the growth of the market include Abcam plc,Active Motif Inc, Agilent Technologies Inc, Bio-Rad Laboratories Inc,Diagenode Diagnostics SA, EpiGentek Group Inc,Exact Sciences Corporation, F.Hoffmann-La Roche Ltd,Illumina Inc, Merck KGaA, New England Biolabs Inc, Pacific Biosciences of California Inc, Perkin Elmer Inc, QIAGEN N.V., Thermo Fisher Scientific Inc, Zymo Research Research Corporation.
The major players are adopting several growth strategies such as product launches, acquisitions, and collaborations, which are contributing to the growth of the DNA methylation sequencing market globally. For instance,
In April 2019, New England Biolabs has released a new product called 'NEBNext Enzymatic Methyl-seq (EM-seqTM)' as a methylation analysis alternative to bisulfite sequencing.
In Jan 2018, Thermo Fisher Scientific and Illumina have announced an official agreement to market AmpliSeq technology to researchers for scientific projects.
In November 2019, PerkinElmer, Inc. has released a new product called ""NEXTFLEX® ChIP-Seq Kit."" The newly released product is used to precisely scan interactions between protein, DNA, and RNA, allowing for interpreting regulatory events that are important in many biological processes and disease states.
Illumina Inc
Overview: Illumina, Inc. offers sequencing and array-based genetic and genomic analysis products. Its goods and services enable the adoption of genomic solutions in research and clinical settings for applications in the oncology, life sciences, reproductive health, agriculture, and other growing segments through its products and services. The company offers genotyping and sequencing services, instrument service contracts, development and licensing agreements, and devices and consumables for genetic analysis. Pharmaceutical, biotechnology, commercial molecular diagnostic laboratories, and consumer genomics enterprises are among its customers, as are genomic research institutes, academic institutions, government laboratories, and hospitals.
Product Portfolio:
TruSeq Methyl Capture EPIC Library Prep : Targeted methylation sequencing (Methyl-Seq) provides a cost-effective, balanced alternative to whole-genome bisulfite sequencing and methylation arrays for screening and biomarker discovery studies. TruSeq Methyl Capture EPIC Library Prep aids researchers who want to learn more about how methylation affects gene regulation.
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Target Audience
Service Providers/ Buyers
Industry Investors/Investment Bankers
Education & Research Institutes
Research Professionals
Emerging Companies
Manufacturers
Market Segmentation
Global DNA Methylation Sequencing Market- By Product
Instruments
Consumables
Software
Global DNA Methylation Sequencing Market– By Technology
Polymerase chain reaction
Microarray
Others
Global DNA Methylation Sequencing Market- By Application
Oncology Research
Non-Oncology Research
Clinical Application
Translational Research
Global DNA Methylation Sequencing Market– By End User
Pharmaceutical and Biotechnology Companies
Research Centers
Contract Research Organizations
Others
Global DNA Methylation Sequencing Market- By Region
North America
Europe
Asia-Pacific
Middle East & Africa
South America
- 1. Global DNA Methylation Sequencing Market Methodology and Scope
- 1.1. Research Methodology
- 1.2. Research Objective and Scope of the Report
- 2. Global DNA Methylation Sequencing Market– Market Definition and Overview
- 3. Global DNA Methylation Sequencing Market– Executive Summary
- 3.1. Market Snippet by Product
- 3.2. Market snippet by Technology
- 3.3. Market snippet by Application
- 3.4. Market snippet by End User
- 3.5. Market Snippet by Region
- 4. Global DNA Methylation Sequencing Market– Market Dynamics
- 4.1. Market Impacting Factors
- 4.1.1. Drivers
- 4.1.1.1. Increase in cancer prevalence globally
- 4.1.1.2. Increasing government funding for healthcare
- 4.1.1.3. Declining costs and increasing output of sequencing
- 4.1.2. Restraints:
- 4.1.2.1. High cost of instrument.
- 4.1.2.2. Lack of high complexity testing centers and skilled professional in high growth regions.
- 4.1.2.3. Low adoption in diagnostic application.
- 4.1.3. Opportunity
- 4.1.4. Impact Analysis
- 5. Global DNA Methylation Sequencing Market– Industry Analysis
- 5.1. Porter's Five Forces Analysis
- 5.2. Supply Chain Analysis
- 5.3. Pricing Analysis
- 5.4. Regulatory Analysis
- 5.5. Reimbursement Analysis
- 6. Global DNA Methylation Sequencing Market– COVID-19 Analysis
- 6.1. Analysis of Covid-19 on the Market
- 6.1.1. Before COVID-19 Market Scenario
- 6.1.2. Present COVID-19 Market Scenario
- 6.1.3. After COVID-19 or Future Scenario
- 6.2. Pricing Dynamics Amid Covid-19
- 6.3. Demand-Supply Spectrum
- 6.4. Government Initiatives Related to the Market During Pandemic
- 6.5. Manufacturers Strategic Initiatives
- 6.6. Conclusion
- 7. Global DNA Methylation Sequencing Market– By Product
- 7.1. Introduction
- 7.1.1. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Product Segment
- 7.1.2. Market Attractiveness Index, By Product Segment
- 7.2. Instruments*
- 7.2.1. Introduction
- 7.2.2. Market Size Analysis, US$ Million, 2018-2028 and Y-o-Y Growth Analysis (%), 2020-2028
- 7.3. Consumables
- 7.4. Software
- 8. Global DNA Methylation Sequencing Market– By Technology
- 8.1. Introduction
- 8.1.1. Market Size Analysis, and Y-o-Y Growth Analysis (%),By Technology
- 8.1.2. Market Attractiveness Index, By Technology
- 8.2. Polymerase Chain Reaction*
- 8.2.1. Introduction
- 8.2.2. Market Size Analysis, US$ Million, 2018-2028 and Y-o-Y Growth Analysis (%), 2020-2028
- 8.3. Microarray
- 8.4. Others
- 9. Global DNA Methylation Sequencing Market– By Application
- 9.1. Introduction
- 9.1.1. Market Size Analysis, and Y-o-Y Growth Analysis (%),By Application
- 9.1.2. Market Attractiveness Index, By Application
- 9.2. Oncology Research
- 9.2.1. Introduction
- 9.2.2. Market Size Analysis, US$ Million, 2018-2028 and Y-o-Y Growth Analysis (%), 2020-2028
- 9.3. Non-Oncology Research
- 9.4. Clinical Application
- 9.5. Translational Research
- 9.6. Others
- 10. Global DNA Methylation Sequencing Market– By End User
- 10.1. Introduction
- 10.1.1. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End User
- 10.1.2. Market Attractiveness Index, By End User Segment
- 10.2. Pharmaceutical and Biotechnology Companies*
- 10.2.1. Introduction
- 10.2.2. Market Size Analysis, US$ Million, 2018-2028 and Y-o-Y Growth Analysis (%), 2020-2028
- 10.3. Research Centers
- 10.4. Contract Research Organizations
- 10.5. Others
- 11. Global DNA Methylation Sequencing Market– By Region
- 11.1. Introduction
- 11.1.1. Market Size Analysis, US$ Million, 2018-2028 and Y-o-Y Growth Analysis (%), 2020-2028, By Region
- 11.1.2. Market Attractiveness Index, By Region
- 11.2. North America
- 11.2.1. Introduction
- 11.2.2. Key Region-Specific Dynamics
- 11.2.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Product
- 11.2.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Technology
- 11.2.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Application
- 11.2.6. Market Size Analysis ,and Y-o-Y Growth Analysis (%), By End User
- 11.2.7. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country
- 11.2.7.1. U.S.
- 11.2.7.2. Canada
- 11.2.7.3. Mexico
- 11.3. Europe
- 11.3.1. Introduction
- 11.3.2. Key Region-Specific Dynamics
- 11.3.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Product
- 11.3.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Technology
- 11.3.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Application
- 11.3.6. Market Size Analysis, and Y-o-Y Growth Analysis (%),By End User
- 11.3.7. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country
- 11.3.8.
- 11.3.8.1. Germany
- 11.3.8.2. U.K.
- 11.3.8.3. France
- 11.3.8.4. Italy
- 11.3.8.5. Spain
- 11.3.8.6. Rest of Europe
- 11.4. South America
- 11.4.1. Introduction
- 11.4.2. Key Region-Specific Dynamics
- 11.4.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Product
- 11.4.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Technology
- 11.4.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Application
- 11.4.6. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End User
- 11.4.7. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country
- 11.4.7.1. Brazil
- 11.4.7.2. Argentina
- 11.4.7.3. Rest of South America
- 11.5. Asia Pacific
- 11.5.1. Introduction
- 11.5.2. Key Region-Specific Dynamics
- 11.5.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Product
- 11.5.4. Market Size Analysis, and Y-o-Y Growth Analysis (%),By Technology
- 11.5.5. Market Size Analysis, and Y-o-Y Growth Analysis (%),By Application
- 11.5.6. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End User
- 11.5.7. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country
- 11.5.7.1. China
- 11.5.7.2. India
- 11.5.7.3. Japan
- 11.5.7.4. Australia
- 11.5.7.5. Rest of Asia Pacific
- 11.6. Middle East and Africa
- 11.6.1. Introduction
- 11.6.2. Key Region-Specific Dynamics
- 11.6.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Product
- 11.6.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Technology
- 11.6.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Application
- 11.6.6. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End User
- 12. Global DNA Methylation Sequencing Market– Competitive Landscape
- 12.1. Key Developments and Strategies
- 12.2. Company Share Analysis
- 12.3. Product Benchmarking
- 12.4. Key Companies to Watch
- 13. Global DNA Methylation Sequencing Market- Company Profiles
- 13.1. Illumina Inc*
- 13.1.1. Company Overview
- 13.1.2. Product Portfolio and Description
- 13.1.3. Key Highlights
- 13.1.4. Financial Overview
- 13.2. Agilent Technologies
- 13.3. Abcam plc
- 13.4. Thermo Fisher Scientific
- 13.5. Active Motif Inc
- 13.6. Bio-Rad Laboratories Inc
- 13.7. Diagenode Diagnostics SA
- 13.8. EpiGentek Group Inc
- 13.9. Exact Sciences Corporation
- 13.10. Pacific Biosciences of California Inc.
- 13.11. F.Hoffmann-La Roche Ltd
- 13.12. Merck KGaA
- 13.13. QIAGEN N.V.
- 13.14. Zymo Research Corporation
- 13.15. Perkin Elmer Inc
- 13.16. New England Biolabs Inc
- LIST NOT EXHAUSTIVE
- 14. Global DNA Methylation Sequencing Market– DataM
- 14.1. Appendix
- 14.2. About Us and Services
- 14.3. Contact Us
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