Global Colorimetric Immunoassays (CI) Analyzer Market- 2022-2029

Global Colorimetric Immunoassays (CI) Analyzer Market- 2022-2029

Market Overview

The global colorimetric immunoassays (CI) analyzer market size was valued at US$ XX million in 2021 and is estimated to reach US$ XX million by 2029, growing at a CAGR of XX % during the forecast period (2022-2029).

In colorimetric assays, reagents that change colour in the presence of the analyte are used. They're commonly used in biochemistry to check for enzymes, specific compounds, antibodies, hormones, and various other analytes. Colorimetric immunoassays for detecting tumor markers have traditionally been based on enzyme-linked immunosorbent assays.

Market Dynamics

The factors influencing the global colorimetric immunoassays (CI) analyzer market are the increasing application of colorimetric immunoassays in detecting tumor markers and the growing prevalence of diseases.

The increasing application of colorimetric immunoassays in the detection of a tumor marker is expected to drive the market growth

Tumor markers are substances produced by the body in response to cancer growth or cancer tissue itself and are usually proteins. Tumor markers can be found in blood, urine, or tissue samples, and their discovery and detection may lead to earlier cancer diagnosis and better therapeutic intervention. Due to their ease of use and high efficiency, colorimetric immunoassays for tumor marker detection have gotten much attention. Traditional colorimetric immunoassays for tumor marker detection are based on enzyme-linked immunosorbent assays, and nanotechnology's great achievement has further opened up opportunities for the development of such immunoassays.

Based on enzyme-linked immunosorbent assay (ELISA), many colorimetric assays for detecting tumor markers have been proposed. Meanwhile, nanotechnology is bringing new possibilities for highly sensitive tumor marker detection. Many nanomaterials have been used in colorimetric assays to detect tumor markers due to their excellent properties. Because of their unique optical properties, Au-NPs are the most used nanomaterials for the colorimetric detection of tumor markers. The optical properties of nanoparticles are strongly influenced by their size and aggregation state, with smaller individual nanoparticles appearing wine red and larger particles or aggregates of smaller particles appearing purple to deep blue. Furthermore, because of their high biocompatibility, Au-NPs can be combined with a wide range of biomacromolecules, including nuclear acids and enzyme-linked antibodies, greatly expanding their potential for colorimetric tumor marker detection.

The problems associated with colorimetric immunoassays are expected to hamper the market growth

Traditional ELISA-based colorimetric immunoassays may have a serious sensitivity problem, making it impossible to detect low concentrations of tumor markers in the early stages of cancer. As a result, most research efforts have gone into developing new signal amplification methods for colorimetric immunoassays. For instance, a novel cascading ELISA yielded detection limits of between 100 fM and 10 pM for prostate-specific antigen (PSA) and Alpha-fetoprotein (AFP) in human serum by incorporating an enzyme-cascading step into the ELISA system. Hence, the market is expected to be hampered.

COVID-19 Impact Analysis

Mass testing was essential to combat the pandemic caused by the coronavirus SARS-CoV-2, which was discovered at the end of 2019. To achieve this goal, it is necessary to develop reliable, quick, and low-cost tools for detecting viral particles in biological material and identifying people who can spread the infection. A colorimetric biosensor based on SARS-CoV-2-induced gold nanoparticle (AuNP) interaction is an excellent tool for detecting viral particles in nasal and throat swabs. The optical density of the mixed solution was measured at 560 nm and compared to the threshold cycle (Ct) of a Real Time-PCR (the gold standard for detecting the presence of viruses), revealing that the colorimetric method can detect very low viral load with a detection limit that is comparable to that of RT-PCR. Because the method is sensitive to the infecting viral particle rather than its RNA, the findings shed new light on the current and potential future pandemics and microbiology, as the biosensor demonstrates to be a powerful yet simple tool for measuring viral particle concentration. Hence, it is expected to have a positive impact on covid-19.

Segment Analysis

Based on application, the Cancer segment is expected to dominate the market growth

The increasing prevalence of cancer and the growing application of colorimetric immunoassays (CI) is expected to drive market growth. In the United States, an estimated 1,806,590 new cancer cases will be diagnosed in 2020, with 606,520 people dying from the disease. In clinical laboratory diagnosis, colorimetric sensors for tumor markers have shown promising results compared to traditional systems. Because the goal cancer marker is determined with high sensitivity, but without advanced/expensive techniques through an easy optical colour change, colorimetric immunoassay-based approaches show promising results. Furthermore, colorimetric biosensors can quickly detect proteins in biological fluids with high sensitivity, and they are expected to play a growing role in tumor diagnosis.

Moreover, a colorimetric multiplexed immunoassay method for sequential detection of tumor markers is very simple and easy to operate. The test solution is first infused with magnetic microparticles that have been conjugated with biotinylated antibodies. These complexes are separated from non-specific proteins after fast magnetic collection. Two antigens, carcinoembryonic antigen and -fetoprotein, can be detected with the naked eye using different enzymatic reactions of 3,3′,5,5′-tetramethylbenzidine (TMB) and o-phenylenediamine (OPD) catalysed by horseradish peroxidase molecules loaded on the surfaces of gold nanoparticles. The spectrophotometric measurements revealed a detection limit as low as 0.02 ng/mL. For the detection of serum samples, this proposed method has high specificity and reproducibility and excellent efficiency of 94 minutes. As a result, in clinical applications, this new multiplexed immunoassay method could be a promising approach for the diagnosis of cancer and other diseases. Hence, the increasing application of colorimetric immunoassay in cancer is expected to dominate the market.

Geographical Analysis

North America region is expected to hold the largest market share in the global colorimetric immunoassays (CI) analyzer market

The increasing prevalence of diseases and the increasing research and development is expected to drive the market growth in this region. According to CDC, in 2018, there were 1,708,921 new cancer cases reported in the United States and 599,265 cancer-related deaths. 436 new cancer cases were reported for every 100,000 people, with 149 people dying from cancer. Immunoassays (IAs) are used in clinical diagnostics and biopharmaceutical analysis, among other bioanalytical applications. Hence, the increasing prevalence of disease and the use of colorimetric immunoassays (CI) in this region is expected to drive market growth.

Competitive Landscape

The global colorimetric immunoassays (CI) analyzer market is moderately competitive with mergers, collaborations, and product launches. Some key players are F. Hoffmann-La Roche Ltd., Siemens AG, Abbott Laboratories, Inc, Beckman Coulter, Inc, Ortho-Clinical Diagnostics, Inc, BioMerieux SA, PerkinElmer, Inc.

PerkinElmer, Inc.

Overview: PerkinElmer, Inc., formerly Perkinelmer, is an American multinational corporation that specializes in diagnostics, life science research, food, environmental, and industrial testing. It has detection, imaging, informatics, and service capabilities.

Product Portfolio: PerkinElmer provides a variety of ELISA alternative immunoassay technologies, allowing to choose the best immunoassay platform for your needs. PerkinElmer offers immunoassay technology platforms, pre-configured kits, and customizable reagents for superior results, including sample compatibility, sample volume, throughput, detectable range, signal window, signal stability, reproducibility, automation compatibility, and desired speed of results.

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