Global Bioresorbable Polymer Market - 2022-2029

Global Bioresorbable Polymer Market - 2022-2029

Market Overview

The Global Bioresorbable Polymer Market is expected to reach at a CAGR of XX% during the forecast period 2022-2029.

Bioresorbable polymers, also called bioresorbable or degradable polymers, are polymer materials that can be absorbed by the body so that the materials will disappear over time. The polymers have also been extensively researched for biomaterials applications. Many of these materials are ideal implants and invasive electrodes because they are well-characterized and have already been authorized for use by the FDA. Many polymers have already been utilized for neural applications such as peripheral nerve guidance conduits. The most popular polymers for neural applications are PLA, PLGA and PCL.

Research in the use of presently available biomaterials and developing novel bioresorbable polymers has helped drive the establishment of tissue engineering. Despite a broad range of possible choices, there is a tendency to determine those bioresorbable polymers with a history of regulatory approval instead of letting the application guide the choice of material. Moreover, the latter approach may require lengthy and costly polymer development work. Nonetheless, continued research on new bioresorbable polymers will be necessary to gain precise control over cell response and cell interactions with surrounding tissues for tissue-engineering applications.

Market Dynamics

The need for a viable alternative to traditional implants is expected to boost the bioresorbable polymer market during the forecast period.

Need for a viable alternative to traditional implants

Bioresorbable polymer implants are rapidly becoming a viable alternative to traditional implants in many applications. These implants must only be used for a short time, ranging from weeks to months. Bioresorbable polymers are another example of biomimicry in bone implant design. Patients with orthopedic implants made of traditional materials such as stainless steel or titanium must have the implants removed when the bone has healed. Other disadvantages of these materials include palpability and interference with imaging devices, such as magnetic resonance imaging.

Bioresorbable implants could be used to overcome the constraints. Polymers such as polyglycolic acid (PGA), poly-l-lactic acid (PLLA), poly-d-lactic acid, polycyanoacrylates, polyanhydrides, polypropylene fumarate and others are often used as bioresorbable materials. The materials differ from the metals by being absorbed by the body, characterized by the degradation time. When these polymers contact the body, they undergo depolymerization and disintegrate into carbon dioxide and water.

In 2018, REVA Medical, Inc announced the foremost implant of its recently launched Fantom Encore bioresorbable scaffold in Italy. REVA's Tyrocore polymer is different from the polylactic acid polymer and is used to construct first-generation BRS. Fantom Encore's advanced features, including thinner strut profiles, have improved outcomes.

Higher cost of bioresorbable polymers compared to traditional materials

The higher cost of bioresorbable polymers than conventional medical polymers will be a major restraining factor in the forecasted period. Due to the relatively high cost of bioresorbable polymers, which can exceed US$1,000 per lb (US$2,200 per kg), small-scale twin-screw extruders between 16 mm and 27 mm are only used. Desiccant and vacuum driers are required before melt blending since these polymers tend to degrade when exposed to moisture. Bioresorbable compounds must be air-cooled, unlike non-resorbable polymers, which are frequently water-cooled after departing the extruder in a strand form. Pelletized strands destined for completed device manufacturing must be adequately dried and packed to avoid premature degradation due to air moisture exposure.

Despite their promising applicability trends, these polymers have certain drawbacks, such as low mechanical properties, rapid degradation rates, high hydrophilic capacity and in some cases, poor mechanical characteristics, especially in humid settings, making their use unviable.

COVID-19 Impact Analysis

The bioresorbable polymers market was stable during the COVID-19 but was hampered during the initial months owing to less demand from its applications. Disruptions impacted the market due to delays in scheduled surgeries, which reduced the demand for surgical products. However, the market has witnessed growth in drug delivery applications, with companies utilizing bioresorbable polymers to fight against the pandemic.

For instance, in 2021, Nutriband signed a deal with Diomics to develop the Diocheck technology, which aids in evaluating COVID-19 antibody levels over time. The test can determine if an individual has produced a circulating amount of COVID-19 specific antibodies over 24 to 36 hours using Diomics' FDA-cleared Diomat bioresorbable polymer. The Diocheck Transdermal Test can help monitor COVID-19 infections and immunization efficacy via a visible COVID-19 antibody indicator patch. Moreover, in 2020, Diomics Corp. announced to nose out the novel coronavirus ahead of vaccines by using nanosized biopolymer beads to provide monoclonal antibody protection against COVID-19 via an easy-to-administer nasal spray. Unique Prophylactic Approach Couples IgG Antibodies from Active Motif with Diomics' Proprietary Bioresorbable Polymer to Block Virus at its Point of Entry.

Segment Analysis

The global bioresorbable polymer market is segmented based on type, form, application and region.

PLA bioresorbable holds a significant market share because of its good biocompatibility and ease of implant formation

By type, the global bioresorbable polymer market is segmented into Polylactic Acid (PLA), Polyglycolic Acid (PGA), Polylactic-co-glycolic Acid (PLGA), Polycaprolactone(PCL) and Others.

PLA is a thermoplastic, high-strength, high-modulus polymer produced annually from renewable sources to produce articles for use in industrial packaging or biocompatible/bioabsorbable medical devices. Bacterial fermentation produces lactic acid, which is then converted to the lactide dimer to eliminate the water molecule, otherwise preventing high molecular weight polymers. PLA is a polymer utilized in the surgical field for bone anastomosis implants (screws, rods, plates). PLA owes its popularity to its good biocompatibility (the best among polymers) and the ease of implant formation.

Various companies utilize bioresorbable PLA for medical applications due to its superior properties. For instance, in 2019, Evonik announced the launch of the first bioresorbable portfolio of PLA-PEG copolymers for implantable medical device applications. The portfolio expands Evonik's ability to support medical device customers to enhance their implantable product's safety, biocompatibility and performance. RESOMER PLA-PEG copolymers combine the hydrophobic properties of polylactide polymers with polyethylene glycol's hydrophilic (water attractant) properties.

Geographical Analysis

The rising number of coronary diseases is boosting the need for bioresorbable polymers in North America

The Individuals with Disabilities Education Act found roughly 37,000 people aged 3 to 21 with orthopedic impairments during the 2019/20 academic year. Bioresorbable polymers are widely utilized for chlorhexidine chips, sutures and other applications in the orthopedics industry. According to the National Heart, Lung and Blood Institute, coronary heart disease causes over 370,000 fatalities in the U.S per anum. Angioplasty or a metal stent to expand the artery is a common treatment for coronary artery disease. Scar tissue might grow within the stent, causing the artery to narrow again. After placing the stent, drug-eluting stents release medication for a few months to fight scar tissue formation.

The first bioresorbable stent to treat coronary artery disease was authorized by the US Food and Drug Administration in 2016. The Absorb GT1 Bioresorbable Vascular Scaffold System, which delivers the medicine everolimus to reduce scar tissue formation, takes about three years for the body to absorb. However, Various companies are now attaining FDA approval for coronary systems. For instance, in 2021, BIOTRONIK received U.S. Food and Drug Administration (FDA) approval for its Orsiro Mission bioabsorbable polymer coronary drug-eluting stent system. The Orsiro DES is the studied stents available throughout numerous randomized controlled trials (RCTs), registries and meta-analyses.

Competitive Landscape

As presented in the developing stage, the global bioresorbable polymer market is moderately competitive. The market is consolidated and has the presence of multinational companies. Major players in the market include Corbion N.V., Evonik Industries AG, Foster Corporation, KLS Martin Group, DSM Biomedical, Inc, Ashland Global Holdings Inc., Zeus Industrial Products, Inc, Seqens Group, REVA Medical, LLC, Poly-Med Incorporated, Bezwada Biomedical, LLC, Nomisma Healthcare Pvt. Ltd., BMG Incorporated, among others.

The major players in the market are known to incorporate numerous market strategies to achieve growth in the global bioresorbable polymer market; these include product launches, acquisitions, expansions and collaborations.

For instance, in January 2021, Ashland announced the expansion of its Viatel bioresorbable polymer manufacturing site and relocated R&D from Dublin to the National Science Park, Ireland.

Evonik Industries AG

Overview: Evonik is a specialty chemicals company active in more than 100 countries worldwide. The company has segmented its business segments into the following major categories: nutrition & care, performance materials, resource efficiency and sources. The company has its largest production sites in Marl, Wesseling, Mobile, Antwerp, Rheinfelden, Shanghai and Singapore.

Product Portfolio:

RESOMER BIORESORBABLE POLYMER: The polymers are bioresorbable aliphatic polyesters comprised of various ratios of lactide and glycolide monomers, PLA stereochemistries and end-group functionalization.

Recent Development:

In 2021, Evonik expanded its portfolio of bioresorbable polymers with customizable properties to aid customer innovation. The new powders are available globally for 3D printing through selective laser sintering. The polymer print powders build on the success of the RESOMER PrintPowder C 212 F.

Why Purchase the Report?

To visualize the global bioresorbable polymer market segmentation by type, form, application and region and understand key commercial assets and players.

Identify commercial opportunities in the global bioresorbable polymer market by analyzing trends and co-development.

Excel data sheet with numerous bioresorbable polymer market-level data points with four segments.

PDF report consisting of cogently put together market analysis after exhaustive qualitative interviews and in-depth market study.

Product mapping available in excel consists of key products of all the major market players.

The global bioresorbable polymer market report would provide approximately 61 tables, 55 figures and almost 212 pages.

Target Audience 2022

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